Clinical aspects and main diagnostic methods of Chediak-Higashi Syndrome

The article presents the analysis of the native and foreign literature data and also the results of our own research devoted to studying the role of herpes virus infection in the appearance and course of glomerulonephritis in children. There has been described pathogenesis and clinical aspects of virus associated glomerulonephritis in children. Much attention has been paid to the diagnostic methods of herpes virus infection in glomerulonephritis. The importance of association of immunosuppressive and antiviral therapy has been underlined.

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Case report – Prolonged SARS-CoV-2 positive PCR after resolution of symptoms

Discussion of Clinical Cases ◽

10.5430/dcc.v7n1p1 ◽

2020 ◽

Vol 7 (1) ◽

pp. 1

Author(s):

Federica Gigli ◽

Daniele Laszlo ◽

Daniele Avenoso

Keyword(s):

Case Report ◽

Clinical Case ◽

Diagnostic Methods ◽

Clinical Aspects ◽

Nasopharyngeal Swab

The recent SARS-CoV-2 pandemic is a new challenge for clinicians worldwide. Although the clinical aspects are well described by different groups, there are still some areas of uncertainty about the interpretation of diagnostic methods. Herein, we describe the clinical case of a 45-year-old lady that contracted SARS-CoV-2 infection with a prolonged PCR positive nasopharyngeal swab but lack of COVID-19 defining events.

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Latent Tuberculosis Infection (LTBI) and Its Potential Targets: An Investigation into Dormant Phase Pathogens

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557519666190625165512 ◽

2019 ◽

Vol 19 (19) ◽

pp. 1627-1642 ◽

Cited By ~ 2

Author(s):

Gopichand Gutti ◽

Karan Arya ◽

Sushil Kumar Singh

Keyword(s):

Drug Targets ◽

Latent Tuberculosis Infection ◽

Latent Tuberculosis ◽

Diagnostic Methods ◽

Tuberculosis Infection ◽

Clinical Aspects ◽

First Line Therapy ◽

Novel Drug ◽

Insight Into ◽

Novel Drug Targets

One-third of the world’s population harbours the latent tuberculosis infection (LTBI) with a lifetime risk of reactivation. Although, the treatment of LTBI relies significantly on the first-line therapy, identification of novel drug targets and therapies are the emerging focus for researchers across the globe. The current review provides an insight into the infection, diagnostic methods and epigrammatic explanations of potential molecular targets of dormant phase bacilli. This study also includes current preclinical and clinical aspects of tubercular infections and new approaches in antitubercular drug discovery.

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Solid pseudopapillary neoplasia of the pancreas: a review

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.66.1.87 ◽

2020 ◽

Vol 66 (1) ◽

pp. 87-94 ◽

Cited By ~ 1

Author(s):

Vera Lucia Chagas ◽

Fernando Colonna Rosman ◽

Maria da Gloria da Costa Carvalho

Keyword(s):

Phenotypic Heterogeneity ◽

Diagnostic Methods ◽

University Hospital ◽

Google Scholar ◽

Clinical Aspects ◽

Solid Pseudopapillary Neoplasm ◽

Review Of The Literature ◽

Molecular Alterations ◽

The University

SUMMARY OBJECTIVES To review the literature and the diagnosis of conventional histopathological routine and immunohistochemistry of the cases diagnosed with Solid Pseudopapillary Neoplasm of the Pancreas (SPNP). METHODS The review of the literature was done using the Pubmed and solid Google-Scholar databases, through the historical, clinical aspects and diagnostic methods of SPNP. The review of SPNP cases diagnosed in the University Hospital Clementino Fraga Filho was carried out from 1977 to 2018. RESULTS Intratumoral phenotypic heterogeneity of SPNP was evidenced in the cases studied, taking into account macroscopic, microscopic, and immunohistochemical patterns. CONCLUSIONS The results show the importance of the examination of several fragments obtained from different regions of the neoplasia since not all of them present the same molecular alterations.

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Sensitive skin and its management

10.25259/csdm_42_2021 ◽

2021 ◽

Vol 1 ◽

pp. 53

Author(s):

Iffat Hassan ◽

Kewal Krishan

Keyword(s):

Psychosocial Factors ◽

Climate Changes ◽

Skin Barrier ◽

Diagnostic Methods ◽

Clinical Aspects ◽

Healthy Skin ◽

Contributing Factors ◽

Sensitive Skin ◽

Factors Affecting ◽

Chemical Stimuli

Sensitive skin is a self-diagnosed condition and is usually not accompanied by any obvious physical signs of irritation. Patients with this syndrome usually have unpleasant sensations whenever exposed to any physical, thermal or chemical stimuli that normally cause no provocation on healthy skin. Cosmetics, skin barrier impairment, and climate changes are the main contributing factors for skin hyperactivity. Although diagnosis is challenging due to lack of any specific or preferred diagnostic methods and interventions, recent studies on different clinical aspects of sensitive skin have provided new approaches to the diagnosis, management and interventions targeting the pathophysiology and treatment of sensitive skin syndrome. In general, patients with sensitive skin need an individual approach, keeping in view the various biomedical, neural, and psychosocial factors affecting sensitive skin.

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Management of patients at high risk of developing skin melanoma: organizational and clinical aspects

Medical Council ◽

10.21518/2079-701x-2021-8-21-26 ◽

2021 ◽

pp. 21-26

Author(s):

A. V. Michenko ◽

O. V. Zhukova ◽

M. N. Ostretsova ◽

O. L. Novozhilova

Keyword(s):

High Risk ◽

Early Diagnosis ◽

Medical Care ◽

Survival Rates ◽

Skin Neoplasms ◽

Diagnostic Methods ◽

Clinical Aspects ◽

Skin Melanoma ◽

Patients At Risk ◽

Self Examination

Early diagnosis of skin melanoma is one of the most reliable ways to improve the prognosis for the life of patients with this tumor. Organization of medical care for patients with a high risk of developing melanoma, together with the use of non-invasive diagnostic methods and teaching the patient the principles of prevention and early diagnosis of skin malignancies should improve the survival rates of patients with melanoma. The article discusses the experience of implementing the Organizational model of medical care for patients with skin neoplasms in Moscow, as well as the key rules for managing patients at risk of developing skin melanoma with special emphasis on recommendations to patients for regular self-examination of the skin, lifestyle correction and the use of photoprotective agents.

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Clinical aspects and treatment of alveolar echinococcosis: the current state of knowledge and difficulties in the diagnosis and management of cases in Poland

Postępy Higieny i Medycyny Doświadczalnej ◽

10.5604/01.3001.0013.9008 ◽

2020 ◽

Vol 74 ◽

pp. 49-56

Author(s):

Małgorzata Sulima ◽

Katarzyna Sikorska ◽

Wacław Nahorski ◽

Sebastian Borys

Keyword(s):

Alveolar Echinococcosis ◽

Imaging Techniques ◽

Financial Burden ◽

Exploratory Laparotomy ◽

Diagnostic Methods ◽

Clinical Aspects ◽

Serological Tests ◽

Current State ◽

Therapeutic Guidelines ◽

The University

The aim of the study is to summarize the current state of knowlege in the diagnosis and monitoring of patients with alveolar echinococcosis (AE), using serological tests and imaging techniques, and to present the most recent therapeutic guidelines based on a literature review. The paper discusses the challenges in diagnosing and treating AE encountered in clinical practice in Poland, based on the analysis of medical records of 86 patients with AE, who were hospitalized in the University Centre for Maritime and Tropical Medicine (UCMTM) between 2000 and 2018. In Poland, AE is usually diagnosed at the advanced stage, when optimal, radical surgery is not an option. Diagnosis of AE is often preceded by invasive diagnostic methods, such as biopsy or exploratory laparotomy, which may result in the infection spreading. Pharmacological treatment is associated with potential adverse effects and is a significant financial burden for the patient due to the lack of reimbursement. There is a need to raise the awareness of AE among physicians performing imaging studies and to facilitate access to modern techniques enabling the assessment of the parasitic process.

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Epidemiology of echinococcosis in Iran: a systematic review and meta-analysis

BMC Infectious Diseases ◽

10.1186/s12879-019-4458-5 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 4

Author(s):

Shima Mahmoudi ◽

Setareh Mamishi ◽

Maryam Banar ◽

Babak Pourakbari ◽

Hossein Keshavarz

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Cyst Formation ◽

Analysis Data ◽

Diagnostic Methods ◽

Control Measures ◽

Clinical Aspects ◽

Monitoring And Control ◽

Eligibility Criteria ◽

Larval Stages

Abstract Background Echinococcosis is a zoonotic disease caused by the larval stages of taeniid cestodes of the genus Echinococcus. The two major types of infection in humans are cystic echinococcosis (CE) or hydatidosis and alveolar echinococcosis (AE). It is endemic in some parts of the world, such as the Middle East, with Iran being a part of it. This systematic review and meta-analysis were conducted to determine the prevalence of CE and AE echinococcosis and their epidemiological and clinical aspects in Iran. Methods Electronic databases, including MEDLINE (via PubMed), SCOPUS, Web of Science, SID and Mag Iran (two Persian scientific search engines) were searched from 1 January 1990 to 8 August 2017. The prevalence of CE and AE echinococcosis was estimated using the random effects meta-analysis. Heterogeneity was evaluated by subgroup analysis. Data were analyzed by STATA version 12. Results Of the 2051 records identified in the mentioned electronic databases, Seventy-eight articles met our eligibility criteria, with a total of 214124individuals. The meta-analysis was performed on only 37 out of 78 included studies. The pooled prevalence of CE and AE in Iran was 5% [95% confidence interval )CI(: 3-6%] and 2% [95% CI: 0-5%], respectively. Subgroup meta-analysis revealed that the prevalence of CE was significantly higher in North [9%, 95% CI: 4-18%] and West of Iran [6%, 95% CI: 3-11%], patients younger than 40 years of age [7%, 95% CI: 4-12%], villagers and nomads [6%, 95% CI: 2-12%], and studies that used the combination of serological, clinical, and imaging diagnostic methods [7%, 95% CI: 5-9%]. There were no significant differences between the prevalence of CE among low and high-quality studies. Housewives were the most affected group by hydatidosis (n=24/77, 31%), followed by illiterate people (n=11/77, 14%) and farmers (n= 9/77, 12%). Liver [55%, 95% CI: 46-65%] and lung [28%, 95% CI, 22-35%] were the most common sites of cyst formation. Conclusions Given to the importance of echinococcosis on human health and domestic animals industry, it is necessary to implement monitoring and control measures in this regard.

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Canine Ehrlichiosis in Africa

Advances in Environmental Engineering and Green Technologies - Combating and Controlling Nagana and Tick-Borne Diseases in Livestock ◽

10.4018/978-1-7998-6433-2.ch013 ◽

2021 ◽

pp. 288-310

Author(s):

Jahashi Saidi Nzalawahe ◽

Erick . V. G. Komba ◽

Athumani Msalale Lupindu ◽

Adrian Evance Materu ◽

Abdul S. Katakweba ◽

...

Keyword(s):

Cell Culture ◽

Blood Transfusion ◽

Supportive Therapy ◽

Diagnostic Methods ◽

Domestic Dogs ◽

Clinical Disease ◽

Clinical Aspects ◽

Canine Ehrlichiosis ◽

Wild Canids ◽

Asymptomatic Infections

Canine ehrlichiosis is an infection of canids causing a clinical disease in domestic dogs and asymptomatic infections in wild canids. Currently, the disease assumes a cosmopolitan distribution. This chapter summarises published information on the disease from across Africa. Some studies were able to demonstrate experimental infections in these canids. Different diagnostic methods, cell culture, direct microscopy, serology, hematology, and molecular methods were employed in different studies for detection of ehrlichiosis. Treatment of the disease mainly involved use of oxytetracycline, doxycycline, imidocarb disproportionate, and levamisole. In severe cases, management has involved administration of supportive therapy such as blood transfusion. Generally, though available, the information on different aspects of the disease in the Africa is scant and fragmented. There is still a need to generate more information on the epidemiology, diagnosis, clinical aspects, and treatment of the disease.

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