Universal screening for SARS-CoV-2 in pregnant women should be weighed by population incidence of the disease

Aim: 1. To determine Thyroid dysfunction and antiTPO antibody status in pregnant women. 2. To know the benefit of LT4 therapy in maternal pregnancy outcome (antiTPO ab+ve vs antiTPO ab-ve groups) and 3. To determine the maternal and fetal outcomes in hypothyroid pregnant women and to decide whether universal screening of pregnant women for hypothyroidism is required or not. Materials and methods: A prospective study was done in mamata general hospital in the dept. of obg, over a period of 1 ½ years.105 antenatal women were included in the study. Outcome in these pregnancies were observed and analysed using appropriate statistical method. Results: There were only 3 patients with spontaneous abortions, 3 patients with pregnancy induced hypertention and only 1 patient had preterm delivery. There was more of thyroid dysfunction in anti TPO Ab +ve cases. But there was no significant adverse effect on pregnancy outcome in patients who were treated. Conclusion: Though our study included only a small number of antenatal women who were screened for thyroid abnormality since it was only a pilot study done in our hospital since our area is endemic for thyroid disorders due to iodine deficiency we recommend Universal screening to rule out thyroid dysfunction in pregnancy because the maternal and fetal complications can be reduced by early screening, diagnosing and correcting thyroid abnormality. DOI: http://dx.doi.org/10.3329/bjms.v13i1.14173 Bangladesh Journal of Medical Science Vol. 13 No. 01 January2014: 49-52

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Reference values and universal screening of thyroid function in the first trimester of the population of pregnant women in Toledo (Spain)

Endocrinología y Nutrición (English Edition) ◽

10.1016/j.endoen.2015.04.008 ◽

2015 ◽

Vol 62 (7) ◽

pp. 358-360

Author(s):

Julia Sastre-Marcos ◽

Florentino Val-Zaballos ◽

Miguel Ángel Ruiz-Ginés ◽

José Saura-Montalbán ◽

Mariano Veganzones-Pérez

Keyword(s):

Pregnant Women ◽

Thyroid Function ◽

Reference Values ◽

Universal Screening ◽

First Trimester

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Universal Screening Program in Pregnant Women and Newborns at-Risk for Sickle Cell Disease: First Report from Northern Italy

Hemoglobin ◽

10.1080/03630269.2017.1405820 ◽

2017 ◽

Vol 41 (4-6) ◽

pp. 230-233 ◽

Cited By ~ 6

Author(s):

Mariachiara Lodi ◽

Elena Bigi ◽

Giovanni Palazzi ◽

Lara Vecchi ◽

Riccardo Morandi ◽

...

Keyword(s):

At Risk ◽

Sickle Cell Disease ◽

Pregnant Women ◽

Sickle Cell ◽

Universal Screening ◽

Screening Program ◽

Northern Italy ◽

Cell Disease ◽

First Report

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Reference values and universal screening of thyroid dysfunction in pregnant women

Endocrinología y Nutrición (English Edition) ◽

10.1016/j.endoen.2014.06.006 ◽

2014 ◽

Vol 61 (6) ◽

pp. 336-338

Author(s):

Gonzalo Díaz-Soto ◽

Encarna Largo ◽

Cristina Álvarez-Colomo ◽

Isabel Martínez-Pino ◽

Daniel de Luis

Keyword(s):

Pregnant Women ◽

Reference Values ◽

Universal Screening ◽

Thyroid Dysfunction

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Do we need to screen and treat pregnant women for subclinical hypothyroidism? A cross sectional study in a rural tertiary centre in Kerala, India

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20170470 ◽

2017 ◽

Vol 6 (3) ◽

pp. 781

Author(s):

Radha K. R. ◽

Nishu Sugunan ◽

Resmy C. R.

Keyword(s):

Pregnant Women ◽

Subclinical Hypothyroidism ◽

Universal Screening ◽

Cross Sectional Study ◽

P Value ◽

Sectional Study ◽

Maternal Complications ◽

Cross Sectional ◽

Neonatal Hypothyroidism ◽

In Pregnancy

Background: Hypothyroidism (HT) is associated with maternal and perinatal morbidity. Subclinical HT rather than overt occur in pregnancy, because overt HT causes infertility. Treatment of overt HT was beneficial in reducing the fetal and maternal complications, Usefulness of correcting subclinical hypothyroidism was doubtful, hence Universal screening of pregnant women was not recommended.Methods: Cross sectional study, conducted in the department of obstetrics and gynecology, Government Medical College, Thrissur, Kerala, India. 50 consecutive cases of subclinical hypothyroidism in pregnancy were analyzed for Thyroid function, antenatal, natal, postnatal complications. Perinatal complications, including neonatal hypothyroidism also noted. Statistical analysis done using computer software Epi info3.4. Data expressed in its frequency and percentage, continuous data in mean.Results: All women in the study group received levothyroxine during pregnancy from time of diagnosis. At the time of delivery 84% women were euthyroid and 16% hypothyroid. Complications like anemia 36%, abruption 4%, and postpartum hemorrhage 6% showed a statistically significant association, while pre-eclampsia 20%, preterm labor 22% had no statistically significant association. Comparing the women who are euthyroid as a result of levothyroxine supplementation to women inadequately treated, complications like anemia (33% versus 50%, p value 0.042), abruption (0% versus 4%, p value0.023), PPH (2% versus 6%, p value 0.014) were significantly less in well controlled.Conclusions: Significant association was noted between inadequately treated hypothyroidism and maternal complications like anaemia, placental abruption, placenta previa, PPH, preterm delivery, and caesarean section rate for foetal distress. Universal screening of pregnant women for thyroid status is recommended.

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Gestational diabetes mellitus - need for universal screening - a clinical study in a tertiary care centre

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20211522 ◽

2021 ◽

Vol 10 (5) ◽

pp. 1973

Author(s):

Kondapuram Veena ◽

Srilakshmi Ambarkar ◽

Srilakshmi Ambarkar

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Gestational Age ◽

Universal Screening ◽

Tertiary Care ◽

Antenatal Visit ◽

Oral Glucose ◽

Glucose Load

Background: To study the prevalence of gestational diabetes mellitus among antenatal mothers and to assess the importance of universal screening to detect gestational diabetes mellitus (GDM).Methods: A total of 300 antenatal women irrespective of gestational age were screened for GDM at their antenatal visit during the period of January 2020 to June 2020. All women were screened with 75gm oral glucose load irrespective of last meal followed by blood glucose estimation by glucose oxidase peroxidase method 2 hours following glucose load. A cut-off of 140mg/dl or more were labelled as gestational diabetes mellitus as per DIPSI guidelines.Results: Out of 300 antenatal women tested, 24 women (8%) were positive for gestational diabetes mellitus. During the first, second and third trimesters 12.5%, 33.33% and 54.17% were diagnosed with gestational diabetes mellitus respectively. The number of gestational diabetes mellitus patients for the age groups ≤20 years, 21-25 years, 26-30 years and >30 years are 2 (8.33%), 3 (12.5%), 8 (33.33%) and 11 (45.83%) respectively. The number of pregnant women tested positive for gestational diabetes mellitus with BMI ≤18.5, 18.6-24.9, 25-29.9 and 30-35 are 2 (8.33%), 4(16.67%), 8(33.33%) and 10(41.67%) respectively.Conclusions: Prevalence of GDM in our study is 8%. About 29.16% of GDM did not have any risk factors. This emphasizes the importance of universal screening for GDM of all pregnant women irrespective of gestational age. There is an increased association of GDM with age, BMI, family history and parity according to our study.

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Clinical Characteristics of Pregnant Women With COVID-19 In Japan: A Nationwide Questionnaire Survey

10.21203/rs.3.rs-146179/v1 ◽

2021 ◽

Author(s):

Tatsuya Arakaki ◽

Junichi Hasegawa ◽

Akihiko Sekizawa ◽

Tomoaki Ikeda ◽

Isamu Ishiwata ◽

...

Keyword(s):

Pregnant Women ◽

Early Pregnancy ◽

Screening Test ◽

Universal Screening ◽

Clinical Characteristics ◽

Severe Infection ◽

Late Pregnancy ◽

Maternal Characteristics ◽

Route Of Infection ◽

Positive Rate

Abstract Background: Few reports have presented an overall view of pregnant women with coronavirus disease 2019 (COVID-19) across an entire country and throughout the entire gestation period. Furthermore, no such reports are available for Japan. We examined the clinical characteristics and outcomes of pregnant women with COVID‑19 on a national scale in Japan.Methods: A nationwide questionnaire-based survey for all 2,185 maternity services in Japan was conducted between July and August 2020. Information regarding maternal characteristics and epidemiological, clinical, treatment, and perinatal outcomes of pregnant women diagnosed with COVID-19 between 16 January and 30 June 2020 were collected. Main outcome measures were incidence of pregnant women with COVID-19 and infant infection, positive rate of the universal screening test for asymptomatic pregnant women, identification of infection route and rates of maternal death, and severe cases.Results: Responses from 1,418 institutions were assessed (65% of all delivery institutions in Japan). Seventy-two pregnant women were reported to have been diagnosed with COVID-19. The positive rate of the universal screening test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among asymptomatic pregnant women was 0.03% (2/7428). The most common route of infection was familial (57%). Fifty-eight pregnant women with COVID-19 were symptomatic, of whom five (8.6%) had a severe infection and one died (a tourist). Severe respiratory symptoms, oxygen administration, and pneumonia were frequently reported in the third trimester and postpartum period compared with in early pregnancy (22.2% vs 2.5% [P=0.03], 38.9% vs 7.5% [P=0.01], and 50.0% vs 7.5% [P<0.01], respectively). All pregnant women with COVID-19 underwent caesarean sections, regardless of symptoms. There were no SARS-CoV-2 transmissions to newborns.Conclusions: In Japan, the number of cases of COVID-19 infection in pregnant women is very low. Compared with early pregnancy, late pregnancy may be a risk factor for exacerbation of symptoms and familial transmission is the most common route of infection. The importance of infection prevention should be emphasised, especially in women in late pregnancy, their families, and any cohabitants.Trial registration: None

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