scholarly journals Effect of 8-Week Aquatic, Land- based and Combined (Aquatic-Land) Training Programs On Walking Capacity in Women with Multiple Sclerosis (MS): A Burdenko Approach

2017 ◽  
Vol 6 (3) ◽  
pp. 8-15 ◽  
Author(s):  
Raheleh Ghaffari
Keyword(s):  
Multiple Sclerosis ◽  
Exercise Group ◽  
Walking Ability ◽  
Exercise Programs ◽  
Combined Exercise ◽  
Rehabilitation Centers ◽  
Wide Range ◽  
Significant Difference ◽  
Walking Capacity ◽  
The Mean

Multiple sclerosis (MS) is a chronic disease affecting all aspects of life in patients with this disease and causes a wide range of functional problems, including reduced walking capacity. The aim of this study was to compare the effects of 8 weeks aquatic, land-based and combined (aquatic-land (exercise programs according to Burdenko method on the walking capacity measured by 6-Minute Walk Test (6MWT). This was a pre- post design study. Thirty one women diagnosed with MS, age range 30-50 years, EDSS<4.5, and living in Amol, Iran participated in this study. The paired t-test results demonstrated a significant improvement in the walking ability of individuals after aquatic exercises (t = -2.23, α=0.048), land-based exercises (t = -5.31, α= 0.001) and combined exercises (t = -4.00, α = 0.001) compared to the pretest. The results of covariance test indicated that aquatic, land-based and combined exercise programs had different effects on the walking ability (power = 0.80, P = 0.001, and F30, 2 = 8.98). Results of  LSD post hoc analysis further indicated that the mean 6MWT in the land-based  exercise group and combined exercise group was significantly higher than the aquatic exercise group (p<0.05), but no significant difference was found in the mean of 6MWT between land-based exercise group and combined exercise group (p>0.05). According to the results of this study, the combined and land-based exercises can be suggested for people with MS in order to improve their walking capacity. These methods can be suggested as appropriate non-pharmacologic complementary therapies in the rehabilitation centers.

scholarly journals Oligoclonal IgG bands in the cerebrospinal fluid of portuguese patients with multiple sclerosis: negative results indicate benign disease

2005 ◽  
Vol 63 (2b) ◽  
pp. 375-379 ◽  
Author(s):  
Maria José Sá ◽  
Lucinda Sequeira ◽  
Maria Edite Rio ◽  
Edward J. Thompson
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Benign Disease ◽  
Serum Samples ◽  
Negative Results ◽  
Significant Difference ◽  
Relapsing Remitting ◽  
The Mean ◽  
Oligoclonal Igg ◽  
Oligoclonal Igg Bands

We assessed the frequency of cerebrospinal fluid (CSF) restricted oligoclonal IgG bands (IgG-OCB) in Portuguese multiple sclerosis (MS) patients and its relationship with outcome. Paired CSF/serum samples of 406 patients with neurological disorders were submitted to isoelectric focusing with immunodetection of IgG. Ninety-two patients had definite MS; non-MS cases were assembled in groups inflammatory/infectious diseases (ID, n=141) and other/controls (OD, n=173). We found in the MS group: mean duration, 38.9 months; clinically isolated syndromes, 24%; relapsing/remitting course (RR), 65%; in RR patients the mean EDSS was 2.1 and the mean index of progression was 0.31. Positive patterns significantly predominated in MS (82.6%; ID, 40.4%; OD, 3.5%). The sensitivity and the specificity of positive IgG-OCB for MS diagnosis was 82.6% and 79.9%, respectively. The sole statistically significant difference in the MS group was the lower progression index observed in negative cases. We conclude that the frequency of positive IgG-OCB patterns in our MS patients fits most values reported in the literature, and that negative results indicate benign disease.

scholarly journals Effect of Acupressure on Stress and Anxiety of Patients with Multiple Sclerosis: A Sham-controlled Randomized Clinical Trial

2020 ◽  
Vol 10 (3) ◽  
pp. 270-283
Author(s):  
Mohammad Ali Nahayati ◽  
◽  
Seyed Abolfazl Vaghar Seyyedin ◽  
Hamid Reza Bahrami-Taghanki ◽  
Zahra Rezaee ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Test Scores ◽  
Sham Group ◽  
Applied Pressure ◽  
Intervention Group ◽  
T Test ◽  
Significant Difference ◽  
The Mean

Objective: Stress and anxiety are common in patients with Multiple Sclerosis (MS). These complications exacerbate the symptoms of MS. This study aims to evaluate the effect of acupressure on stress and anxiety of MS patients. Methods: In this randomized clinical trial, participants were 106 MS Patients referred to Multiple Sclerosis Society in Mashhad, Iran. After signing an informed consent form, they completed a demographic form and stress, and the Depression Anxiety Stress Scale - 42 items (DASS-42). Then, they were randomly assigned into intervention and sham groups by tossing a coin. Participants in the intervention group were asked apply a pressure on the Shenmen and Yin Tang acupoints for one month (once per day for 15 minutes), while the sham group applied pressure 2.5 cm below the Shenmen acupoint and 3 cm above the Yin Tang acupoint. Participants in each group were then completed the DASS-42 again one hour after the final session. Data were analyzed using chi-square test, Kolmogorov-Smirnov test, independent t-test, and Paired t-test. Results: In the intervention and sham groups, there was no statistically significant difference between the mean pre-test scores of stress (34.73±5.80 vs. 33.06±6.42) and anxiety (27.09±6.99 vs. 25.31±6.88), and neither between the mean post-test scores of stress (29.20±6.21 vs. 33.73±9.44) and anxiety (22.79±5.68 vs. 25.21±6.72) (P>0.05). However, comparison of DASS-42 scores between groups showed that the mean scores of stress and anxiety in the intervention group were significantly lower than in the sham group (P< 0.05). Conclusion: It seems that acupressure can be used along with other therapeutic and pharmacological interventions to reduce stress and anxiety in patients with MS.

Consumer Prices for Surgical Management of End-Stage Hallux Rigidus

2019 ◽  
Vol 13 (4) ◽  
pp. 276-280
Author(s):  
Niall A. Smyth ◽  
Vaishnavi Krishnan ◽  
Johnathon R. McCormick ◽  
Jonathan R. Kaplan ◽  
Amiethab A. Aiyer
Keyword(s):  
Health Care ◽  
Hallux Rigidus ◽  
Treatment Modalities ◽  
Potential Cost ◽  
First Metatarsophalangeal Joint ◽  
Consumer Prices ◽  
Wide Range ◽  
Significant Difference ◽  
The Mean ◽  
End Stage

Background. Hallux rigidus is the most prevalent arthritic condition of the foot. Treatment of end-stage disease traditionally consists of a first metatarsophalangeal joint (MTPJ) arthrodesis; however, the use of a synthetic cartilage implant is becoming more common. With the high prevalence of disease and implementation of new treatment modalities, health care consumers should be aware of the costs associated with management. The purpose of this study was to determine access to the cost and variability in price of first MTPJ arthrodesis and synthetic cartilage implantation. Methods. Forty academic centers were contacted using a standardized patient script. The patient was a 59-year-old female who had failed conservative treatment of hallux rigidus. Each institution was contacted up to 3 times in an attempt to obtain a full bundled operative quote for a first MTPJ arthrodesis and synthetic cartilage implantation. Results. Twenty centers (50%) provided a quote for first MTPJ arthrodesis and 15 centers (38%) provided a quote for synthetic cartilage implantation. Only 14 centers (35%) were able to provide a quote for both procedures. The mean bundled price for MTPJ arthrodesis was $21 767 (range $8417 to $39 265). The mean bundled price for synthetic cartilage implantation was $21 546 (range $4903 to $74 145). There was no statistically significant difference between the bundled price for first MTPJ arthrodesis and synthetic cartilage implantation. Conclusions. There was limited availability of consumer prices for first MTPJ arthrodesis and synthetic implantation, thus impeding health care consumers’ decision making. There was a wide range of quotes for both procedures, indicating potential cost savings. Levels of Evidence: IV, basic science

scholarly journals P277 RV remodeling by echo parameters in endurance and strength sport training

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
M Moshkani Farahani ◽  
M Shirdel
Keyword(s):  
Endurance Exercise ◽  
Performance Status ◽  
Exercise Group ◽  
Strength Group ◽  
Sport Training ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
And Gender ◽  
And Function

Abstract Introduction With regular and long-term exercises, the heart undergoes changes that are called the adaptation of the heart in response to exercise or physiological changes, which contrasts with the pathological changes caused by hypertension and aortic valve stenosis. However, the exact effects of exercise on the structure and function of the heart depend on the type, intensity and duration of exercise, the amount of physical fitness, inheritance, and gender. Materials and Methods In this prospective clinical trial study, 40 subjects, including 20 in the endurance exercise group and 20 in the exercise group, were evaluated. Echocardiography was performed for all of these subjects before and after the exercises that was performed professionally for 8 weeks under the supervision of the trainer and the changes were recorded. The data were analyzed statistically by SPSS20 software. A significant level of 0.05 was considered. Results The mean ± standard deviation of the age was 20/80 ± 1/42 years. Significant decrease in mean RVSM was observed only in the strength group (P = 0.008). There was no significant difference in the endurance group . There was no significant difference between the two groups before the test in the mean TAPSE (P = 0.46). The mean of TAPSE in the endurance group was 0.22 ± 1.99 and in the strength group was 0.31 ± 1.95. There was no significant difference between the two groups (P 0.46). There was no significant difference between the two groups before the test in the mean E / e (P = 0.51). The mean E / e "in the endurance group was 0.47 ± 4.75 and in the strength group was 0.54 ± 5.50, and there was a significant difference between the two groups (P &lt;0.001). The mean SWDT in the endurance group was 0.12 ± 0.95 and in the strength group was 0.11 ± 1.06, and there was a significant difference between the two groups (P = 0.002). There was a significant increase in mean SWDT in the strength group after the test (P &lt;0.001) .There was a significant increase in mean PAP in the strength group (P = 0.007) . There was a significant increase in mean LV mass index in the strength group (P &lt;0.001),with no significant difference between the two groups in mean FAC. Conclusion It seems that any kind of strength and endurance exercise affects the performance status, however, strength exercises have more effects which causes RV dysfunction. All indexes measured changed within normal level except for PAP that had abnormal changes after endurance exercise .

scholarly journals The duration of pubertal growth peak among three skeletal classes

2016 ◽  
Vol 21 (5) ◽  
pp. 67-74 ◽  
Author(s):  
Waqar Jeelani ◽  
◽  
Mubassar Fida ◽  
Attiya Shaikh ◽  
◽  
...  
Keyword(s):  
Class Ii ◽  
Growth Potential ◽  
Class I ◽  
Maturation Stage ◽  
Class Iii ◽  
Pubertal Growth ◽  
Lateral Cephalograms ◽  
Wide Range ◽  
Significant Difference ◽  
The Mean

ABSTRACT Introduction: Pubertal growth peak is closely associated with a rapid increase in mandibular length and offers a wide range of therapeutic modifiability. Objective: The aim of the present study was to determine and compare the mean ages of onset and duration of pubertal growth peak among three skeletal classes. Methods: A retrospective cross-sectional study was conducted using lateral cephalograms of 230 subjects with growth potential (110 males, 120 females). Subjects were categorized into three classes (Class I = 81, Class II = 82, Class III = 67), according to the sagittal relationship established between the maxilla and the mandible. The cervical vertebral maturation stage was recorded by means of Baccetti's method. The mean ages at CS3 and CS4 and the CS3-CS4 age interval were compared between boys and girls and among three skeletal classes. Results: Pubertal growth peak occurred on average four months earlier in girls than boys (p = 0.050). The average duration of pubertal growth peak was 11 months in Class I, seven months in Class II and 17 months in Class III subjects. Interclass differences were highly significant (Cohen's d > 0.08). However, no significant difference was found in the timing of pubertal growth peak onset among three skeletal classes (p = 0.126 in boys, p = 0.262 in girls). Conclusions: Girls enter pubertal growth peak on average four months earlier than boys. Moreover, the duration of pubertal growth peak is on average four months shorter in Class II and six months longer in Class III subjects as compared to Class I subjects.

scholarly journals Dosimetry of Critical Organs in Maxillofacial Imaging with Cone-beam Computed Tomography

2019 ◽  
Vol 9 (1Feb) ◽  
Author(s):  
R Ghanbarnezhad Farshi ◽  
A Mesbahi ◽  
M Johari ◽  
Ü Kara ◽  
N Gharehaghaji
Keyword(s):  
Computed Tomography ◽  
Cone Beam Computed Tomography ◽  
Cone Beam ◽  
Radiation Doses ◽  
Parotid Glands ◽  
Thermoluminescent Dosimeters ◽  
Wide Range ◽  
Significant Difference ◽  
The Mean ◽  
Selection Of

Background: While the benefits of cone-beam computed tomography (CBCT) are well known in maxillofacial imaging, the use of this modality is not risk-free.Objective: The aim of this study was to evaluate the exposure doses received by patients during maxillofacial imaging with CBCT.Methods: Entrance surface dose (ESD) was measured by using thermoluminescent dosimeters (TLDs) attached to the eyes lids, parotid glands and thyroid of 64 patients in two imaging centers (A and B). Phantom dosimetry was performed by a cylindrical poly-methyl methacrylate (PMMA) head-size phantom and an ionization chamber for different exposure parameters. NewTom VGi and Planmeca Promax 3D CBCT scanners were used at centers A and B, respectively.Results: The mean ESD of the eyes, parotid glands and thyroid were 2.57, 2.33 and 0.28 mGy in center A, 0.35, 2.11 and 0.37 mGy in center B, respectively. ESD of the eyes revealed a significant difference in two centers; in center B, it was 86.4% lower than center A. In the phantom dosimetry, the measured doses of NewTom VGi were 2.63 and 2.08 mGy, respectively by changing field of view (FOV) size from 8×8 cm2 (height × diameter) to 6×6 cm2. For Planmeca Promax 3D, it ranged from 0.98 to 3.24 mGy depending on exposure parameters.Conclusion: There is a wide range of radiation doses dependent on the units, patients and selected scan parameters. Inappropriate selection of exposure settings, especially FOV size, can seriously increase patient dose.

scholarly journals Evaluation of Iodine in Distributed Salts in Abarkouh City in 2017-2018

2018 ◽  
pp. 659-665
Author(s):  
Mahrokh Mahrokh Jalili ◽  
Ali Asghar Ebrahimi ◽  
Mohammad Hassan Ehrampoush ◽  
Fariba Abbasi ◽  
Eslami Hadi Eslami ◽  
...  
Keyword(s):  
Iodine Deficiency ◽  
Random Sampling ◽  
Clinical Manifestations ◽  
Iodine Concentration ◽  
T Test ◽  
British Pharmacopoeia ◽  
Wide Range ◽  
Significant Difference ◽  
The Mean ◽  
The City

Introduction: Iodine deficiency and associated disorders, which lead to a wide range of clinical manifestations, have been raised as one of the health and nutritional problems in Iran. Therefore, this study was aimed to investigate the amount of iodine in distributed salts in Abarkouh city in 2017-2018. Materials and Methods: Random sampling was done by census on all 30 distributed brands in Abarkouh city in the different stores across the city. Sixty samples (30 samples after one month from the production date and 30 samples after 6 months from the production date) were collected and transferred to the laboratory. The measurement of iodine was done according to the British Pharmacopoeia recommended method. T-test was used to analyze the data. Results: The Mean iodine concentration in the salts supplied in the Abarkouh was 29.83 ± 19.9 ppm, which was 50% less than the Iran's standard, with a statistically significant difference (P ≤ 0.001). 66.6% of the studied brands did not contain adequate iodine. Six months after production date, the average iodine amount in salts was reduced to 24.26 ± 16.94 ppm, but the reduction was not statistically significant (P = 0.224). Conclusion: Average iodine amount in most of the salts supplied across the Abarkouh city was not acceptable and some salts lacked iodine. Therefore, careful and continuous supervision and monitoring the process of iodized salts production in factories is recommended.

Orem’s Self-Care Model with Multiple Sclerosis Patients’ Balance and Motor Function

2019 ◽  
Vol 33 (1) ◽  
pp. 46-54
Author(s):  
Ardashir Afrasiabifar ◽  
Zahra Mehri ◽  
Hamid Reza Ghaffarian Shirazi
Keyword(s):  
Multiple Sclerosis ◽  
Motor Function ◽  
Intervention Group ◽  
Self Care ◽  
Nursing Intervention ◽  
Control Group ◽  
Care Model ◽  
Significant Difference ◽  
The Mean ◽  
Multiple Sclerosis Patients

Orem’s self-care model has been introduced as a nursing model to empower participants with chronic diseases. This study aims to investigate the effectiveness of nursing interventions using Orem’s self-care model with multiple sclerosis participants’ balance and motor function. Sixty-three participants with multiple sclerosis were randomly assigned to intervention and control groups. The nursing intervention using Orem’s self-care model was performed for eight sessions of 45–60 minutes in the intervention group. In the intervention group, a significant increase (improvement) was observed in the mean scores of balance before (17.09 ± 1.97) and after the intervention (33.75 ± 6.01). A significant decrease (improvement) was observed in the mean of motor functions before (4.12 ± 0.34) and after the intervention (1.59 ± 0.71) ( p = 0.001). However, no significant difference existed in the mean scores of balance ( p = 0.10) and motor function in the control group ( p = 0.20). The nursing intervention using Orem’s self-care model improved balance and motor function of participants with multiple sclerosis.

Variability and temperature dependence of the velocity of retrograde particle transport in myelinated axons

1981 ◽  
Vol 59 (8) ◽  
pp. 857-863 ◽  
Author(s):  
Richard S. Smith ◽  
Paul D. Cooper
Keyword(s):  
Temperature Dependence ◽  
Particle Velocity ◽  
Coefficient Of Variation ◽  
Room Temperature ◽  
Common Mechanism ◽  
Morphological Evidence ◽  
Myelinated Axons ◽  
Wide Range ◽  
Significant Difference ◽  
The Mean

The velocity of the retrograde transport of optically detectable particles was studied in isolated myelinated axons from Xenopus laevis at room temperature and with varying temperature. At room temperature (22–23.1 °C) the mean particle velocity was significantly different in some axons of the same animal. Results pooled from a number of axons did not indicate any significant difference in the average particle velocity in different animals. At room temperature, even though the mean particle velocity might differ between axons, the coefficient of variation of particle velocity in separate fibers tended to remain constant.The temperature dependence of mean particle velocity (V) could be adequately described by the relationship V = 0.26 exp 0.073T – 0.33, where V is in micrometres per second and T is degrees Celsius. Throughout the temperature range at which transport took place (approximately 5–35 °C) the coefficient of variation of particle velocity remained approximately constant at 0.40. All particles ceased their motion abruptly, and to some extent reversibly, at 37 °C. On morphological evidence, none of the effects of temperature appeared to be related to microtubule depolymerization.The results indicate that retrogradely transported particles with a wide range of velocities respond homogeneously to temperature changes. This supports the view that a common mechanism may underlie the motion of all the particles. No evidence was obtained that the differences between axons at room temperature could be attributed to the presence in separate axons of dissimilar proportions of faster and slower particles. Nor was the velocity–temperature characteristic in the region of room temperature sufficiently steep to explain the differences between axons. It is suggested that axons may differ in general mechanical or chemical properties so that the motion of all particles is affected uniformly.

scholarly journals A Controlled Trial of Mitoxantrone in Multiple Sclerosis: Serial MRI Evaluation at One Year

1994 ◽  
Vol 21 (3) ◽  
pp. 266-270 ◽  
Author(s):  
S. Bastianello ◽  
C. Pozzilli ◽  
F. D’Andrea ◽  
E. Millefiorini ◽  
M. Trojano ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gadolinium Dtpa ◽  
Treatment Groups ◽  
Number Of Patients ◽  
Significant Difference ◽  
Relapsing Remitting ◽  
The Mean ◽  
Remitting Multiple Sclerosis ◽  
One Year ◽  
Relapsing Remitting Multiple Sclerosis

Abstract:We present the results of a randomized double-blinded placebo controlled, multicenter trial, of low-dose mitoxantrone (MX), after one year, in 25 patients with relapsing-remitting multiple sclerosis, who had serial enhanced magnetic resonance imaging (MRI). Treatment groups were balanced for age, gender, duration of illness and neurological disability. Five of the 13 MX patients and 10 of the 12 placebo patients had exacerbations during treatment (p < 0.02). The mean change in the extended disability status scale was not significantly different between the MX and placebo treatment groups. Serial Gadolinium-DTPA enhancedMRIdetected no significant difference between the MX treated and placebo groups in the mean total number of new, enlarging, or Gadolinium-DTPA enhancing lesions; there was a trend toward a reduction of new, enlarging and Gadolinium-DTPA enhancing lesions in MX patients. Despite this ameliorating effect, the results indicate that serial Gadolinium-DTPA enhanced MRI, performed over one year in a limited number of patients, could not provide conclusive evidence for a role of MX therapy in relapsing-remitting multiple sclerosis.

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