scholarly journals The role of psychic factors in the pathogenesis of bronchial asthma

2011 ◽  
Vol 139 (3-4) ◽  
pp. 209-215 ◽  
Author(s):  
Danijela Vucevic ◽  
Tatjana Radosavljevic ◽  
Dusan Mladenovic ◽  
Vera Todorovic
Keyword(s):  
Bronchial Asthma ◽  
Emotional Stress ◽  
Early Morning ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Asthmatic Patients ◽  
Increased Sensitivity ◽  
Personality Features ◽  
Stress Pathway

Bronchial asthma is a chronic inflammatory disorder of the airways in which many cells play a role, in particular mast cells, eosinophils, neutrophils, T-lymphocytes and epithelial cells. In susceptible individuals this inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness and cough, particularly at night and/or in the early morning. These symptoms are usually associated with variable and extensive limitations of airflow in the bronchi reversible spontaneously or by treatment. It has been shown that restrain of the effectors of stress response participate in the pathogenesis of bronchial asthma. Anger that is not expressed and frustrations may activate the limbic stress pathway. Thus, the released neurotransmitters followed by excitation thus causing psychogenic (mental or emotional) stress. It is also known that emotional stress may be responsible for the exacerbation of asthma. Namely, pronounced emotions cause hyperventilation and hypocapnia inducing bronchospasm. Certain psychological personality features are related to adaptive or inadequate body response to numerous life events. Thus, until the beginning of the last century, bronchial asthma was referred to as asthma nervosa, because clinicians clearly observed the psychological profile of patients with predominant fear of asphyxia and recurrent attacks of paroxysmal dyspnoea. Besides, increased sensitivity, repression of aggressive feelings and expressive empathy have been identified as the most frequent psychological characteristics of asthmatic patients. However, scientists are still far from a full understanding of bronchial asthma pathogenesis. The contribution of psychic factors has become meaningful in the understanding of the development of bronchial asthma. Having in mind that in the majority of patients asthma is a lifelong condition, there is a hope that further investigations of bronchial asthma psychogenesis will improve prevention and treatment of this disease.

scholarly journals A clinical study of Shunthyadi churna in the Management of Tamaka shwasa W.S.R. to Bronchial Asthma

2018 ◽  
Vol 4 (2) ◽  
pp. 48-52
Author(s):  
Rajnik Jadav ◽  
◽  
Alankruta Dave ◽  
Jitendra Varsakiya ◽  
◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Airway Hyperresponsiveness ◽  
Modern Science ◽  
Inflammatory Disorder ◽  
Age Group ◽  
Inclusion Criteria ◽  
Chronic Inflammatory Disorder ◽  
Permanent Cure ◽  
Effective Remedy

In classics Tamaka Shwasa is Pitta Sthana Samudbhava Vhadhi, mainly affected Doshas are Vata and Pitta. In modern science Tamaka Swasa is correlate with bronchil ashtha, Symptoms of Tamaka Swasa is nearly similar to. Bronchial asthma a chronic inflammatory disorder of the airways in which the chronic inflammation causes an associated increase in airway hyperresponsiveness that leads to recurrent episodes of asthmatic exacerbation. Modern science has no permanent cure of Tamaka Swasa, thats why it is necessity to search herbal and herbo-minaral preparations for the treatment of disease. It is safe and effective in asthma. Shunthyadi Churna described in Yogratnakara for the treatment of Shwasa. Aim: Role of Shunthyadi Churna in treatment of Tamaka Shwasa. Materials and Methods: Total 23 patients of Tamaka Shwasa age group of 18 to 60 years fulfilling the inclusion criteria were selected for trial. Disscussion: Properties having Shuthyadi Churna is Tikta Katu Rasa, Laghu and Tikna Guna (light and penetrating properties), Ushna Virya (hot potency) and Vatakaphagna (decrease Vata and Kapha Dosha). Shuthyadi Churna is effective in break down the Samprapti of Tamaka Swasa and effective remedy for the patient of bronchial asthma.

Asthma

2007 ◽  
pp. 117-126
Keyword(s):  
Chronic Inflammation ◽  
Discharge Planning ◽  
Acute Asthma ◽  
Airflow Obstruction ◽  
Early Morning ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Cellular Components ◽  
Symptoms And Signs ◽  
In Pregnancy

Definition 118 Symptoms and signs 118 Diagnosis 119 Management of acute asthma 120 Asthma in pregnancy 125 Discharge planning 125 ‘Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular components play a role. The chronic inflammation causes an associated increase in airway hyper-responsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing, particularly at night or in the early morning. These episodes are usually associated with widespread but variable airflow obstruction that is often reversible either spontaneously or with treatment.’...

scholarly journals Imaging in polymyalgia rheumatica

Reumatismo ◽  
2018 ◽  
Vol 70 (1) ◽  
pp. 51 ◽  
Author(s):  
N. Possemato ◽  
C. Salvarani ◽  
N. Pipitone
Keyword(s):  
Polymyalgia Rheumatica ◽  
Morning Stiffness ◽  
Imaging Techniques ◽  
Review Article ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Pet Ct ◽  
Ct And Mri

Polymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause clinically characterized by pain and prolonged morning stiffness affecting the shoulders and often the pelvic girdle and neck. Imaging has substantially contributed to defining PMR as a disease mainly involving extra-articular structures. This review article analyses the role of the different imaging techniques in the diagnosis and follow-up of patients with PMR with particular emphasis on the role of ultrasound, PET/CT and MRI.

scholarly journals GAMBARAN PERTUMBUHAN PADA ANAK DENGAN RIWAYAT ASMA DI RSUP PROF. DR. R. D. KANDOU

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Prima Kinanti ◽  
Vivekenanda Pateda ◽  
Audrey M. I. Wahani
Keyword(s):  
Data Analysis ◽  
Pediatric Patients ◽  
Normal Growth ◽  
Early Morning ◽  
Primary Diagnosis ◽  
Research Data ◽  
Inflammatory Disorder ◽  
Chest Tightness ◽  
Chronic Inflammatory Disorder ◽  
History Of

Abstract: Asthma is a chronic inflammatory disorder of the airways that causes increased airway hyperresponsiveness which triggers symptoms such as wheezing, breathlessness, chest tightness and coughing, especially at night or early morning. Asthma as a chronic disease in general may affect a child's growth through several factors. The purpose of this study was to determine the growth in children with a history of asthma who were treated in the Division of Pediatric, Prof. Dr. R. D. Kandou Hospital Manado. Research conducted a retrospective descriptive univariate data analysis. Samples were pediatric patients aged 5-18 years with a primary diagnosis of asthma treated in the Division of Pediatric, Prof. Dr. R. D. Kandou Hospital Manado in January 2011 - September 2015. Research data analysis using CDC-2000 growth curve. From the research, based on W / A and H / A, obtained the majority of children with normal growth. Based on the weight / height and BMI, obtained the majority of children with good nutritional status.Keywords: asthma, growth, children.Abstrak: Asma adalah gangguan inflamasi kronik saluran napas yang menyebabkan peningkatan hiperesponsif jalan napas yang menimbulkan gejala berupa mengi, sesak napas, dada terasa berat dan batuk-batuk terutama malam atau dini hari.Asma sebagai penyakit kronik secara umum dapat mempengaruhi pertumbuhan anak melalui beberapa faktor. Tujuan penelitian ini adalah untuk mengetahui pertumbuhan pada anak dengan riwayat asma yang dirawat di Bagian Ilmu Kesehatan Anak RSUP Prof. Dr.R.D. Kandou Manado.Penelitian yang dilaksanakan bersifat deskriptif retrospektif dengan analisis data univariat.Sampel penelitian ini adalah pasien anakusia 5 - 18 tahun dengan diagnosis utama asmayang dirawat di bagian Ilmu Kesehatan Anak Anak RSUP Prof.Dr.R.D. Kandou Manado pada bulan Januari 2011 – September 2015.Analisis data penelitian menggunakan kurva pertumbuhan CDC-2000. Dari hasil penelitian, berdasararkan BB/U dan TB/U, didapatkan mayoritas anak dengan pertumbuhan normal. Berdasarkan BB/TB dan IMT, didapatkan mayoritas anak dengan status gizi baik.Kata Kunci: asma, pertumbuhan, anak.

scholarly journals Role of epithelial ion transports in inflammatory bowel disease

2016 ◽  
Vol 310 (7) ◽  
pp. G460-G476 ◽  
Author(s):  
Diogo Magalhães ◽  
José Miguel Cabral ◽  
Patrício Soares-da-Silva ◽  
Fernando Magro
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Ionic Transport ◽  
Current Evidence ◽  
Sodium Absorption ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Potassium Secretion ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with a complex pathogenesis. Diarrhea is a highly prevalent and often debilitating symptom of IBD patients that results, at least in part, from an intestinal hydroelectrolytic imbalance. Evidence suggests that reduced electrolyte absorption is more relevant than increased secretion to this disequilibrium. This systematic review analyses and integrates the current evidence on the roles of epithelial Na+-K+-ATPase (NKA), Na+/H+ exchangers (NHEs), epithelial Na+ channels (ENaC), and K+ channels (KC) in IBD-associated diarrhea. NKA is the key driving force of the transepithelial ionic transport and its activity is decreased in IBD. In addition, the downregulation of apical NHE and ENaC and the upregulation of apical large-conductance KC all contribute to the IBD-associated diarrhea by lowering sodium absorption and/or increasing potassium secretion.

scholarly journals The role of lymphocyte-monocyte ratio on ankylosing spondylitis diagnosis and sacroiliac arthritis staging

2020 ◽  
Author(s):  
Jing Wang ◽  
Yuan Yuan ◽  
Xiaxia Jin ◽  
Guoguang Lu
Keyword(s):  
New York ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Sensitivity And Specificity ◽  
Inflammatory Marker ◽  
Area Under The Curve ◽  
Inflammatory Disorder ◽  
X Ray ◽  
Chronic Inflammatory Disorder

Abstract Background: Ankylosing spondylitis (AS)is a chronic inflammatory disorder involving the sacroiliac joints, lumbar spine, thoracic spine and even cervical spine, and could leading to disability due to the failure of timely treatment. Therefore, early diagnosis is essential to for AS treatment. The lymphocyte-monocyte ratio (LMR) is a systemic inflammatory and immunological indicator for prediction of disease development and progression. However, its role in AS remains unclear. The aim of this study was to investigate the role of LMR in AS diagnosis, disease activity classification and sacroiliac arthritis staging. Methods: Seventy-eight AS patients and 78 sex-age-matched healthy controls (HCs) were enrolled in this study. The diagnosis of AS was performed according to the New York criteria, whereas the staging of sacroiliac arthritis of AS patients was determined by X-ray examination.Comparison of between AS patients and HCs and between patients with high and low stages on LMR levels and other laboratory indicators were carried out. Results: A higher level of NLR, RDW, PLR, MPV, ESR, CRP and lower level of RBC, Hb, Hct, LMR, ALT, AST, TBIL and A/G were noted in the AS patients compared to HCs. A positive correlation was observed between LMR and RBC, Hb, Hct and A/G, while negative correlation was found between LMR and NLR, PLR, AST, TBIL (P< 0.05). The ROC curve showed that the area under the curve of LMR was 0.803(95%CI =0.734-0.872), with a sensitivity and specificity of 62.8% and 87.2%,and the AUC (95%CI) for ESR, CRP and LMR in the combined diagnosis of ankylosing spondylitis were 0.975(0.948-1.000),with the sensitivity and specificity of 94.9% and 97.4% .Levels of WBC and NLR were higher in high X-ray stage patients, whereas levels of LMR was lower (P<0.05) and statistical differences were observed of LMR values among different stages (P<0.05). Conclusions: Our study suggested that LMR is an important inflammatory marker that can be used to diagnosis AS and identify disease activity and X-ray stage of sacroiliac arthritis in AS patients.

scholarly journals Anti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials

2021 ◽  
Vol 16 ◽  
Author(s):  
Alberto J Lorenzatti
Keyword(s):  
Clinical Trials ◽  
Arterial Wall ◽  
Plaque Formation ◽  
Phase Iii ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Phase Iii Clinical Trials ◽  
Cytokines And Chemokines ◽  
Pro Inflammatory Cytokines

Atherosclerosis is a chronic inflammatory disorder of the vasculature where cholesterol accumulates in the arterial wall stimulating infiltration of immune cells. This plays an important role in plaque formation, as well as complications caused by its build up. Pro-inflammatory cytokines and chemokines are implicated throughout the progression of the disease and different therapies that aim to resolve this chronic inflammation, reduce cardiovascular (CV) events and improve clinical outcomes have been tested. The results from the pivotal CANTOS trial show that targeting the pro-inflammatory cytokine IL-1β successfully reduces the incidence of secondary CV events. This review briefly assesses the role of inflammation in atherosclerosis, providing a picture of the multiple players involved in the process and offering a perspective on targeting inflammation to prevent atherosclerotic CV events, as well as focusing on the results of the latest Phase III clinical trials.

scholarly journals Smoking and Periodontitis Can Play a Synergistic Role in the Development of Psoriasis: A Nationwide Cohort Study

Dermatology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Ju Hee Han ◽  
Jin Woo Park ◽  
Kyung Do Han ◽  
Jun Beom Park ◽  
Miri Kim ◽  
...  
Keyword(s):  
Multivariable Analysis ◽  
Population Based ◽  
Inflammatory Disorder ◽  
National Health Insurance System ◽  
Population Based Study ◽  
Chronic Inflammatory Disorder ◽  
Korean National Health Insurance ◽  
The Relationship ◽  
Increase In Risk

<b><i>Background:</i></b> Periodontitis is a chronic inflammatory disorder involving the periodontium. The precise nature of the association between periodontitis and psoriasis has not been determined. <b><i>Objective:</i></b> This nationwide population-based study investigated the relationship between periodontitis and the risk of psoriasis. <b><i>Methods:</i></b> A health screening database, which is a sub-dataset of the Korean National Health Insurance System database, was used in this study. Subjects with (<i>n</i> = 1,063,004) and without (<i>n</i> = 8,655,587) periodontitis who underwent health examinations from January to December 2009 were followed for 9 years. <b><i>Results:</i></b> In multivariable analysis, compared to the non-periodontitis group, periodontitis patients had a significantly higher risk of developing psoriasis (hazard ratio 1.116, 95% confidence interval 1.101–1.13). Non-smokers with periodontitis had an 11% increase in risk of psoriasis and smokers with periodontitis had a 26.5% increase in risk of psoriasis compared to non-smokers without periodontitis. <b><i>Conclusion:</i></b> Our study highlights periodontitis as a potential independent risk factor for psoriasis, increasing awareness of the synergistic role of smoking and periodontitis in the pathogenesis of psoriasis.

Role of Th2 type Cytokines and IgE in Asthmatic Children

2020 ◽  
Vol 13 (4) ◽  
pp. 1765-1772
Author(s):  
Assem Metwally Abo-Shanab ◽  
Hala Elnady ◽  
Iman Helwa ◽  
Rania Fawzy Mahmoud Abdelkawy ◽  
Hanan Atta ◽  
...  
Keyword(s):  
Family History ◽  
Bronchial Asthma ◽  
Immunoglobulin E ◽  
Statistical Significance ◽  
Allergic Sensitization ◽  
Th2 Cells ◽  
Asthmatic Children ◽  
Asthmatic Patients ◽  
History Of

Bronchial asthma (BA) is usually persistent through allergic sensitization, which is likely to result in bronchial hyper-responsiveness and acute bronchoconstriction due to reactions to specific and non-specific trigger stimuli. Many research focused on the role of T cells; particularly, T helper 2 (Th2) cells which linked to controlling immunoglobulin E (IgE) production due to their role in producing different cytokines, like Interleukin-13 (IL-13), in addition to influencing the function of eosinophils through the actions of IL-5. From this perspective, we decided to study the role of IgE, IL-13, and IL-5 in asthmatic children. IL-5, IL-13, and total IgE have been measured by ELISA technique in the serum of 57 children with bronchial asthma and compared to that of 20 healthy controls. Our results reported that 38/57 (66.67%) of the patient group had a family history for allergy, and parental consanguinity was found in 4/57 families (0.07%). IgE levels showed high statistical significance in asthmatic patients in comparison to controls (p = 0.00001), while IL-13 and IL-5 levels were not significantly different in patients versus control groups (P= 0.96, P = 0.81). Moreover, IgE was found significantly increased in both groups with/without family history for allergy (p = 0.009), whereas IL-13 was significantly elevated only in the group of patients with family history for allergy (0.01). This study demonstrates that asthma is strongly related to the family history of allergy, where IgE, as well as IL-13 levels, were found high in these asthmatic patients suggesting their association with underlying symptoms. Unexpectedly IL-5 was found insignificantly decreased.

scholarly journals Diffusion Lung Capacity of Carbon Monoxide: A Novel Marker of Airways Remodeling in Asthmatic Children?

2012 ◽  
Vol 3 (2) ◽  
pp. ar.2012.3.0033 ◽  
Author(s):  
Giorgio L. Piacentini ◽  
Giovanna Tezza ◽  
Elena Cattazzo ◽  
Ahmad Kantar ◽  
Vincenzo Ragazzo ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Mean Value ◽  
Inflammatory Disorder ◽  
Exhaled Breath ◽  
Chronic Inflammatory Disorder ◽  
Asthmatic Children ◽  
Lung Capacity ◽  
Noninvasive Markers ◽  
Free Environment

Asthma is universally considered a chronic inflammatory disorder of the airways. Several noninvasive markers, such as exhaled nitric oxide (FeNO) and exhaled breath temperature (PletM), have been proposed to evaluate the degree of airway inflammation and remodeling in asthmatic children. The aim of this study was to evaluate the relationship between diffusion lung capacity of carbon monoxide (DLCO) and these inflammatory markers in asthmatic children. We compared data of FeNO, PletM, and DLCO collected in 35 asthmatic children at admission (T0) and discharge (T1) after a period spent in a dust-mite–free environment (Misurina, Italian Dolomites, 1756 m). PletM showed a reduction from 29.48°C at T0 to 29.13°C at T1 (p = 0.17); DLCO passed from 93 to 102 (p = 0.085). FeNO mean value was 29.7 ppb at admission and 18.9 ppb at discharge (p = 0.014). Eosinophil mean count in induced sputum was 4 at T0 and 2 at T1 (p = 0.004). Spearman standardization coefficient beta was 0.414 between eosinophils and FeNO and −0.278 between eosinophils and DLCO. Pearson's correlation index between DLCO and PletM was −0.456 (p = 0.019). A negative correlation between DLCO and PletM was found. However, DLCO did not show a significant correlation with FeNO and eosinophils in the airways. Additional studies are needed to clarify the role of DLCO as a potential tool in monitoring childhood asthma.

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