scholarly journals A clinical study of Shunthyadi churna in the Management of Tamaka shwasa W.S.R. to Bronchial Asthma

2018 ◽  
Vol 4 (2) ◽  
pp. 48-52
Author(s):  
Rajnik Jadav ◽  
◽  
Alankruta Dave ◽  
Jitendra Varsakiya ◽  
◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Airway Hyperresponsiveness ◽  
Modern Science ◽  
Inflammatory Disorder ◽  
Age Group ◽  
Inclusion Criteria ◽  
Chronic Inflammatory Disorder ◽  
Permanent Cure ◽  
Effective Remedy

In classics Tamaka Shwasa is Pitta Sthana Samudbhava Vhadhi, mainly affected Doshas are Vata and Pitta. In modern science Tamaka Swasa is correlate with bronchil ashtha, Symptoms of Tamaka Swasa is nearly similar to. Bronchial asthma a chronic inflammatory disorder of the airways in which the chronic inflammation causes an associated increase in airway hyperresponsiveness that leads to recurrent episodes of asthmatic exacerbation. Modern science has no permanent cure of Tamaka Swasa, thats why it is necessity to search herbal and herbo-minaral preparations for the treatment of disease. It is safe and effective in asthma. Shunthyadi Churna described in Yogratnakara for the treatment of Shwasa. Aim: Role of Shunthyadi Churna in treatment of Tamaka Shwasa. Materials and Methods: Total 23 patients of Tamaka Shwasa age group of 18 to 60 years fulfilling the inclusion criteria were selected for trial. Disscussion: Properties having Shuthyadi Churna is Tikta Katu Rasa, Laghu and Tikna Guna (light and penetrating properties), Ushna Virya (hot potency) and Vatakaphagna (decrease Vata and Kapha Dosha). Shuthyadi Churna is effective in break down the Samprapti of Tamaka Swasa and effective remedy for the patient of bronchial asthma.

scholarly journals A COMPARATIVE CLINICAL STUDY ON THE EFFECTIVENESS OF BHARANGYADI CHOORNA AND VYAGHRI CHOORNA IN TAMAKA SWASA (BRONCHIAL ASTHMA)

2020 ◽  
pp. 70-78
Author(s):  
Devanand E ◽  
K Ravindra Bhat
Keyword(s):  
Clinical Study ◽  
Bronchial Asthma ◽  
Modern Science ◽  
Signs And Symptoms ◽  
Wilcoxon Test ◽  
Control Group ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Comparative Clinical Study ◽  
Group B

Ayurveda classics mentioned various types of Swasa and Tamaka Swasa is one among them. Tamakaswasa is manifested by aggravated Pranavayu by the obstruction of Kapha. In this case treatment should be to clear out Pranavaha srotas, pacify Vata and remove the blockage due to Kapha. In modern science Tamaka Swasa is correlated with Bronchial Asthma. It’s a chronic inflammatory disorder of the airways in which the chronic inflammation causes an associated increase in airway hyper responsiveness that leads to recurrent episodes of asthmatic exacerbation. Modern science has no permanent cure of Tamaka Swasa, that’s why it is necessity to search herbal and herbo-mineral preparations for the treatment of disease. Present Study was conducted to reduce the symptoms of Tamakaswasa. Bharangyadi Choorna and Vyaghri Choorna have the properties of Kapha Vata hara, Agni Deepana, Pachana, Anulomana, Srotoshodhana, anti-asthamatic and anti-inflammatory property. Materials and Method: Patients who have symptoms of Tamakaswasa fulfill the inclusion criteria were given with Bharangyadi Choorna 4gm thrice a day along with Ardraka Swarasa as Anupana in the trail group i.e., group A and Vyaghri Choorna 4gm thrice a day along with honey as Anupana in the control group i.e. group B. It is a comparative clinical study with 30 patients in each group for 30 days. Analyzing the signs and symptoms, PEFR after each 10 days, Wilcoxon test was done for comparing the effectiveness of treatment between two groups. Comparative analysis of the overall effect of the treatments in both the groups was done by statistically done by Mann-Whitney test. Results: There was statistically significant change in all the signs and symptoms and PEFR after treatment and follow up. All the signs and symptoms have P ≤ 0.05. Conclusion: Bharangyadi Choorna has shown highly significant reduction in the symptoms like Swasakrichratha, Peenasa, Kasa, Ghurghuraka, Krichrabhashana, Shushkasya and PEFR. On comparison between the two groups, Bharangyadi choorna showed a better result in improvement of symptoms- Swasakrichratha, Peenasa, Kasa, Ghurghuraka, Krichrabhashana, Shushkasya and objective parameter- PEFR. Hence H2 hold good.

scholarly journals The role of psychic factors in the pathogenesis of bronchial asthma

2011 ◽  
Vol 139 (3-4) ◽  
pp. 209-215 ◽  
Author(s):  
Danijela Vucevic ◽  
Tatjana Radosavljevic ◽  
Dusan Mladenovic ◽  
Vera Todorovic
Keyword(s):  
Bronchial Asthma ◽  
Emotional Stress ◽  
Early Morning ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Asthmatic Patients ◽  
Increased Sensitivity ◽  
Personality Features ◽  
Stress Pathway

Bronchial asthma is a chronic inflammatory disorder of the airways in which many cells play a role, in particular mast cells, eosinophils, neutrophils, T-lymphocytes and epithelial cells. In susceptible individuals this inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness and cough, particularly at night and/or in the early morning. These symptoms are usually associated with variable and extensive limitations of airflow in the bronchi reversible spontaneously or by treatment. It has been shown that restrain of the effectors of stress response participate in the pathogenesis of bronchial asthma. Anger that is not expressed and frustrations may activate the limbic stress pathway. Thus, the released neurotransmitters followed by excitation thus causing psychogenic (mental or emotional) stress. It is also known that emotional stress may be responsible for the exacerbation of asthma. Namely, pronounced emotions cause hyperventilation and hypocapnia inducing bronchospasm. Certain psychological personality features are related to adaptive or inadequate body response to numerous life events. Thus, until the beginning of the last century, bronchial asthma was referred to as asthma nervosa, because clinicians clearly observed the psychological profile of patients with predominant fear of asphyxia and recurrent attacks of paroxysmal dyspnoea. Besides, increased sensitivity, repression of aggressive feelings and expressive empathy have been identified as the most frequent psychological characteristics of asthmatic patients. However, scientists are still far from a full understanding of bronchial asthma pathogenesis. The contribution of psychic factors has become meaningful in the understanding of the development of bronchial asthma. Having in mind that in the majority of patients asthma is a lifelong condition, there is a hope that further investigations of bronchial asthma psychogenesis will improve prevention and treatment of this disease.

scholarly journals Imaging in polymyalgia rheumatica

Reumatismo ◽  
2018 ◽  
Vol 70 (1) ◽  
pp. 51 ◽  
Author(s):  
N. Possemato ◽  
C. Salvarani ◽  
N. Pipitone
Keyword(s):  
Polymyalgia Rheumatica ◽  
Morning Stiffness ◽  
Imaging Techniques ◽  
Review Article ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Pet Ct ◽  
Ct And Mri

Polymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause clinically characterized by pain and prolonged morning stiffness affecting the shoulders and often the pelvic girdle and neck. Imaging has substantially contributed to defining PMR as a disease mainly involving extra-articular structures. This review article analyses the role of the different imaging techniques in the diagnosis and follow-up of patients with PMR with particular emphasis on the role of ultrasound, PET/CT and MRI.

scholarly journals Role of madhuli modaka in the management of asthisoushirya with special reference to osteoporosis: ¬a case study

2019 ◽  
Vol 7 (01) ◽  
Author(s):  
ASHWINI RAMCHANDRA SUTAR
Keyword(s):  
Modern Science ◽  
Age Group ◽  
Mineral Density ◽  
Geriatric Population ◽  
Increased Risk ◽  
Tissue Calcium ◽  
Calcium And Phosphorus ◽  
Prevalence Of Osteoporosis

Geriatric is the branch of medicine concern with the old age care and treatment. This age group where catabolic, degenerative phenomenons get accelerted due to dominate of vat dosha.The asthikshaya occurs due to vataprakop. Because Vatadosh and Asthi dhatu are related to each other. Therefore in Asthi dhatu, there is formation of Aakashyitva (Space) and soushirya (porocity). It results into osteoporosis. In Modern science, Osteoporosis is most common bone disease in Geriatric population. It is characterised by reduced bone mineral density (BMD), micro-architectural deterioration of bone tissue, calcium and phosphorus and increased risk of facture. The prevalence of Osteoporosis and Osteoporosis related facture increases markedly with age, reflecting in the related decline in the bone mass and increased risk of Osteoporosis in the Geriatric population. Madhuli (Eleusine coracona) contain more amount of calcium and phosphorus. So this dravy is usefull in Osteoporosis. So Madhuli modaka showed symptomatically good result in Osteoporosis.

scholarly journals The Effect of Mulaka Beejadi Lepa and Pruthu Nimba Panchaka Churna in the Management of Vicharchika W.S.R. to Eczema 

2018 ◽  
Vol 9 (3) ◽  
pp. 185-190
Author(s):  
Divya V ◽  
Ragamala K C
Keyword(s):  
Diagnostic Criteria ◽  
Skin Diseases ◽  
Age Group ◽  
Inclusion Criteria ◽  
External Application ◽  
Before And After ◽  
Pro Forma ◽  
Great Advance

According to Ayurveda, Vicharchika is a major problem in skin diseases.  All Kusthas are having Tridoshaja origin.The disease Vicharchika to a greater extent resembles eczema/dermatitis.  Despite of great advance in dermatology and the advent of powerful antibiotics, antifungal as well as steroids, Eczema continues to defy the best effect of dermatologists. Hence it is the need of the hour to find out safe and effective medicine for Vicharchika and here comes the role of Ayurveda. The involvement of Vata results in dry, blackish lesion of eczema, itching in those affected areas is due to Kapha and Pitta is responsible for Srava. In classical texts, Ayurveda Acharyas emphasizes shodhana and shamana therapy as the line of treatment at various contexts. So, the study aimed to evaluate efficacy of Mulaka beejadi lepa and Pruthu nimba panchaka churna in vicharchika, 30 children aged 3-16years who were fulfilling the inclusion criteria and diagnostic criteria were selected from Kaumarabhritya OPD and IPD of S.V.Ayurvedic College & Hospital, Tirupati.  Patients were given Mulaka beejadi lepa as external application  and vati prepared with Pruthu nimba panchaka churna 250mg BID  in 3-10years age group and 500mg BID in 11-16yrs age group children for 30days and called for follow up after 15days to note any recurrence.The cases were recorded as per the case Pro forma and observations were recorded. Symptoms were scored and statistically analysed for any change before and after treatment. Mulaka Beejadi lepa as external application and Pruthu Nimba panchaka churna internally are very effective in the management of vicharchika.  

scholarly journals Role of epithelial ion transports in inflammatory bowel disease

2016 ◽  
Vol 310 (7) ◽  
pp. G460-G476 ◽  
Author(s):  
Diogo Magalhães ◽  
José Miguel Cabral ◽  
Patrício Soares-da-Silva ◽  
Fernando Magro
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Ionic Transport ◽  
Current Evidence ◽  
Sodium Absorption ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Potassium Secretion ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with a complex pathogenesis. Diarrhea is a highly prevalent and often debilitating symptom of IBD patients that results, at least in part, from an intestinal hydroelectrolytic imbalance. Evidence suggests that reduced electrolyte absorption is more relevant than increased secretion to this disequilibrium. This systematic review analyses and integrates the current evidence on the roles of epithelial Na+-K+-ATPase (NKA), Na+/H+ exchangers (NHEs), epithelial Na+ channels (ENaC), and K+ channels (KC) in IBD-associated diarrhea. NKA is the key driving force of the transepithelial ionic transport and its activity is decreased in IBD. In addition, the downregulation of apical NHE and ENaC and the upregulation of apical large-conductance KC all contribute to the IBD-associated diarrhea by lowering sodium absorption and/or increasing potassium secretion.

scholarly journals The role of lymphocyte-monocyte ratio on ankylosing spondylitis diagnosis and sacroiliac arthritis staging

2020 ◽  
Author(s):  
Jing Wang ◽  
Yuan Yuan ◽  
Xiaxia Jin ◽  
Guoguang Lu
Keyword(s):  
New York ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Sensitivity And Specificity ◽  
Inflammatory Marker ◽  
Area Under The Curve ◽  
Inflammatory Disorder ◽  
X Ray ◽  
Chronic Inflammatory Disorder

Abstract Background: Ankylosing spondylitis (AS)is a chronic inflammatory disorder involving the sacroiliac joints, lumbar spine, thoracic spine and even cervical spine, and could leading to disability due to the failure of timely treatment. Therefore, early diagnosis is essential to for AS treatment. The lymphocyte-monocyte ratio (LMR) is a systemic inflammatory and immunological indicator for prediction of disease development and progression. However, its role in AS remains unclear. The aim of this study was to investigate the role of LMR in AS diagnosis, disease activity classification and sacroiliac arthritis staging. Methods: Seventy-eight AS patients and 78 sex-age-matched healthy controls (HCs) were enrolled in this study. The diagnosis of AS was performed according to the New York criteria, whereas the staging of sacroiliac arthritis of AS patients was determined by X-ray examination.Comparison of between AS patients and HCs and between patients with high and low stages on LMR levels and other laboratory indicators were carried out. Results: A higher level of NLR, RDW, PLR, MPV, ESR, CRP and lower level of RBC, Hb, Hct, LMR, ALT, AST, TBIL and A/G were noted in the AS patients compared to HCs. A positive correlation was observed between LMR and RBC, Hb, Hct and A/G, while negative correlation was found between LMR and NLR, PLR, AST, TBIL (P< 0.05). The ROC curve showed that the area under the curve of LMR was 0.803(95%CI =0.734-0.872), with a sensitivity and specificity of 62.8% and 87.2%,and the AUC (95%CI) for ESR, CRP and LMR in the combined diagnosis of ankylosing spondylitis were 0.975(0.948-1.000),with the sensitivity and specificity of 94.9% and 97.4% .Levels of WBC and NLR were higher in high X-ray stage patients, whereas levels of LMR was lower (P<0.05) and statistical differences were observed of LMR values among different stages (P<0.05). Conclusions: Our study suggested that LMR is an important inflammatory marker that can be used to diagnosis AS and identify disease activity and X-ray stage of sacroiliac arthritis in AS patients.

scholarly journals The Elliptical Aggregates – Idiopathic Granulomatous Mastitis

2020 ◽  
Vol 1 (1) ◽  
pp. 25-31
Author(s):  
Anubha Bajaj
Keyword(s):  
Granulomatous Inflammation ◽  
Reproductive Age ◽  
Inflammatory Disorder ◽  
Age Group ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Chronic Inflammatory Disorder ◽  
True Incidence ◽  
Breast Fed ◽  
Reproductive Age Group

Idiopathic granulomatous mastitis was initially scripted in 1972 by Kessler and Wolloch and is cogitated as an infrequent, benign, chronic inflammatory disorder. It commonly implicates females of reproductive age group, especially women who have breast fed in the preceding five to six years. Idiopathic granulomatous mastitis is commonly discerned in Asia and Mediterranean region although true incidence is undetermined. Diverse ethnicities delineate a diverse disease prevalence. Elimination of adjunctive causes of granulomatous inflammation makes idiopathic granulomatous mastitis a diagnosis of exclusion. As per the natural history, idiopathic granulomatous mastitis is designated as a self limiting disorder 1.

scholarly journals Anti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials

2021 ◽  
Vol 16 ◽  
Author(s):  
Alberto J Lorenzatti
Keyword(s):  
Clinical Trials ◽  
Arterial Wall ◽  
Plaque Formation ◽  
Phase Iii ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Phase Iii Clinical Trials ◽  
Cytokines And Chemokines ◽  
Pro Inflammatory Cytokines

Atherosclerosis is a chronic inflammatory disorder of the vasculature where cholesterol accumulates in the arterial wall stimulating infiltration of immune cells. This plays an important role in plaque formation, as well as complications caused by its build up. Pro-inflammatory cytokines and chemokines are implicated throughout the progression of the disease and different therapies that aim to resolve this chronic inflammation, reduce cardiovascular (CV) events and improve clinical outcomes have been tested. The results from the pivotal CANTOS trial show that targeting the pro-inflammatory cytokine IL-1β successfully reduces the incidence of secondary CV events. This review briefly assesses the role of inflammation in atherosclerosis, providing a picture of the multiple players involved in the process and offering a perspective on targeting inflammation to prevent atherosclerotic CV events, as well as focusing on the results of the latest Phase III clinical trials.

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