scholarly journals Overview of the most significant coronavirus infections in veterinary medicine

2020 ◽  
Vol 74 (1) ◽  
pp. 1-17
Author(s):  
Jakov Nisavic ◽  
Nenad Milic ◽  
Andrea Radalj
Keyword(s):  
The Novel ◽  
Species Barrier ◽  
Replication Process ◽  
Neurologic Diseases ◽  
Increased Risk ◽  
Long Time ◽  
Therapeutic Measures ◽  
Novel Virus ◽  
Efficient Expansion

Background. Coronaviruses (CoVs) have been recognized in veterinary virology for a long time and comprise a large group of RNA viruses responsible for enteric, respiratory, hepatic, and neurologic diseases in a variety of animal species and humans. These viruses are very adaptable considering their highly error-prone replication process and recombination ability, resulting in remarkable mutability and efficient expansion of their host range and tissue tropism. Scope and Approach. In the recent past, after the outbreaks caused by SARS-CoV in 2002 and MERS-CoV in 2012, CoVs became a research focus in the scientific community. Moreover, the ongoing SARS-CoV-2 pandemic raised more questions concerning the threats posed by these viruses. Several significant examples of coronaviruses jumping the species barrier and changing their tropism have been reported in the past, and novel viruses of both animals and humans have appeared as a consequence. This paper reviews some of the examples of CoV mutability and the most notable animal coronaviruses of veterinary relevance. Key Findings and Conclusions. There is still no proof that the novel virus SARS-CoV-2 can be transmitted to humans from domestic animals, and its recent cross-species jump is currently being intensively researched. Intensified and diverse human activities that lead to the disruption of ecosystems contribute to the increased risk of contact with animals that might represent virus reservoirs. The need for constant surveillance of CoVs and expanded studies of their virological traits, mutation mechanisms, diversity, prophylactic and therapeutic measures highlight the key role of both veterinarians and medical doctors in order to preserve the health of the human population.

scholarly journals COVID-19 and the Heart

2020 ◽  
pp. 1-5 ◽  
Author(s):  
Chaitanya Rojulpote ◽  
Karthik Gonuguntla ◽  
Shivaraj Patil ◽  
Abhijit Bhattaru ◽  
Paco Bravo
Keyword(s):  
Cardiovascular System ◽  
The Novel ◽  
Health Crisis ◽  
Risk Of Death ◽  
Increased Risk ◽  
The World ◽  
Significant Burden ◽  
Coronary Syndromes ◽  
Novel Virus ◽  
Underlying Mechanisms

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus disease 2019 (COVID-19) has resulted in a global health crisis. Prior to the arrival of this viral pandemic, the world was already plagued with a significant burden of cardiovascular disease. With the introduction of the novel virus, the world now faces a double jeapordy. Early reports have suggested an increased risk of death in individuals with underlying cardio-metabolic disorders. The exact effects of COVID-19 on the cardiovascular system are not well determined, however lessons from prior viral epidemics suggest that such infections can trigger acute coronary syndromes, arrhythmias and heart failure via direct and indirect mechanisms. In this article, we aimed to discuss the effects and potential underlying mechanisms of COVID -19 as well as potential implications of treatments targeted against this virus on the cardiovascular system.

scholarly journals Beckett between the Lines

2004 ◽  
Vol 10 ◽  
Author(s):  
Zsolt Sógor
Keyword(s):  
Samuel Beckett ◽  
Point Of View ◽  
The Novel ◽  
Long Time ◽  
Oriented Approach

This paper wishes to analyse two early novels by Samuel Beckett; Murphy and Watt. It takes a chronological point of view from which it argues that the later of the two, Watt, is closer to Beckett's mature voice, mainly due to its relation with language. This means, in other words, that though in Murphy quite a lot of emphasis is to fall on the role of language, in Watt, with a bit of exaggeration, there is hardly anything else to concentrate on but the language of the novel and language as such in general. The emphasis on language leads to considering Beckett's relation to languages. Since Watt was for a long time the last longer prose work that Beckett wrote in English, the paper regards this novel as a harbinger of the approaching change for French. Or rather, the approaching bilingual state, because, as it is argued, Beckett may be said to have been approaching an in-between state in, or beyond, the two languages of composition. Taking the author's bilingualism into consideration means, however, an author-oriented approach - this is what the paper undertakes to present; to find Beckett's fingerprints between the lines.

scholarly journals The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes

Cells ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 2528
Author(s):  
Yvonne Adu-Agyeiwaah ◽  
Maria B. Grant ◽  
Alexander G. Obukhov
Keyword(s):  
Elevated Serum ◽  
Premature Mortality ◽  
Proteolytic Processing ◽  
Diabetic Patients ◽  
Metabolic Dysfunction ◽  
The Novel ◽  
Disease Outcomes ◽  
Increased Risk ◽  
Patients With Diabetes

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 (COVID-19) pandemic, with more than 50 million cases reported globally. Findings have consistently identified an increased severity of SARS-CoV-2 infection in individuals with diabetes. Osteopontin, a cytokine-like matrix-associated phosphoglycoprotein, is elevated in diabetes and drives the expression of furin, a proprotein convertase implicated in the proteolytic processing and activation of several precursors, including chemokines, growth factors, hormones, adhesion molecules, and receptors. Elevated serum furin is a signature of diabetes mellitus progression and is associated with a dysmetabolic phenotype and increased risk of diabetes-linked premature mortality. Additionally, furin plays an important role in enhancing the infectivity of SARS-CoV-2 by promoting its entry and replication in the host cell. Here, we hypothesize that diabetes-induced osteopontin and furin protein upregulation results in worse outcomes in diabetic patients with SARS-CoV-2 infection owing to the roles of these protein in promoting viral infection and increasing metabolic dysfunction. Thus, targeting the osteopontin-furin axis may be a plausible strategy for reducing mortality in SARS-CoV-2 patients with diabetes.

scholarly journals Molecular Docking Studies of some Antiviral and Antimalarial Drugs Via Bindings to 3CL-Protease and Polymerase Enzymes of the Novel Coronavirus (SARS-CoV-2)

2020 ◽  
Vol 10 (5) ◽  
pp. 6444-6459 ◽  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Antimalarial Drugs ◽  
The Novel ◽  
Rapid Spread ◽  
Novel Virus ◽  
Novel Coronavirus ◽  
3Cl Protease ◽  
Insight Into

The rapid spread of the novel coronavirus (SARS-CoV-2) as a serious threat to the world public health is in dire need of finding potential therapeutic agents. Chinese have tested several antiviral and antimalarial drugs as potent inhibitors for the novel virus, such as remdesivir, chloroquine, hydroxychloroquine, umifenovir and favipiravir. In this study, we used the molecular docking models to study the binding interactions between these pharmaceuticals, as well as our proposed remdesivir analogue (AZCV-20) with the 3CLpro and RNA-dependent RNA polymerase (RdRp) of the SARS-CoV-2, using MEO and Autodock4 methods. Our study provides insight into the possible role of structural flexibility and efficacy during interactions between 3CLpro, RdRp and the drugs.

scholarly journals COVID-19 Pandemic in Nigeria: Misconception Among Individuals, Impact on Animals and the Role of Mathematical Epidemiologists

2021 ◽  
Author(s):  
Oluwasegun Micheal Ibrahim ◽  
Damilola Daniel Ekundayo
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
World Health ◽  
The Novel ◽  
Good People ◽  
The World ◽  
Novel Virus ◽  
The Government ◽  
Health Organization ◽  
The Impact

In March 2020, the World Health Organization declared coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2, to be a pandemic. Since the declaration, Nigeria economy has been greatly impacted thus resulting in a recession. This paper considers a couple of misconceptions among Nigerian people in the COVID-19 pandemic era thereby causing the spread of the novel virus and hence making the situation difficult for the government to handle. In particular, we discuss the first and second waves of the pandemic as it affects the Nigerian people. The impact of the pandemic on animals and the role of mathematical epidemiologists in combatting the spread is discussed herein. We give some recommendations that could be adopted by the government and the good people of Nigeria to reduce the further spread of the virus.

The Role of the XPF Gene Polymorphism (Xrcc4) Ser835ser in the Risk of Malignant Transformation of Cells in the Colorectal Cancer

2015 ◽  
Vol 87 (2) ◽  
Author(s):  
Jacek Kabziński ◽  
Ireneusz Majsterek ◽  
Adam Dziki ◽  
Michał Mik
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Gene Polymorphism ◽  
Risk Groups ◽  
Control Group ◽  
Preventive Program ◽  
Increased Risk ◽  
Long Time ◽  
Repair Systems

AbstractParticipation of DNA repair systems in the pathogenesis of cancer has been a suspected phenomenon for a long time. Decreased efficiency in DNA repair translates to their ability to fix and consequently leads to mutations and the process of carcinogenesis. Linking individual polymorphisms of DNA repair systems with an increased risk of colorectal cancer will allow the classification of patients to high-risk groups and their placement under preventive program.The aim of the study was to determine the effect of XPF gene polymorphism Ser835Ser on increasing the risk of colorectal cancer in the Polish population.Material and methods. as the material blood collected from 146 patients diagnosed with colon cancer was used. The control group consisted of 149 healthy subjects. Genotyping was performed by Taq- Man method.Results. The results indicate that genotype TCC/TCT is associated with an decreased risk of colorectal cancer (OR 0.574; CI 95% 0.335-0.984; p=0.043).Conclusions. Based on these results, we conclude that the XPF gene polymorphism Ser835Ser may be associated with a decreased risk of colorectal cancer

scholarly journals Combating the COVID-19 Pandemic: The Role of the SARS Imprint

2021 ◽  
Author(s):  
Hong Ru ◽  
Endong Yang ◽  
Kunru Zou
Keyword(s):  
Stock Market ◽  
The Novel ◽  
Asian Countries ◽  
Social Distancing ◽  
Related Information ◽  
Novel Virus ◽  
Cross Country ◽  
Fundamental Mechanism

We provide evidence of delayed attention and inaction in response to COVID-19 in countries that did not experience SARS in 2003. Using cross-country data, we find that individuals in countries that had SARS infections in 2003 searched more intensively for COVID-19-related information on Google in late January 2020, the time of the first known outbreak in Wuhan, China. Early attention to the novel virus, as measured by Google searches, is associated with deeper stock market drops in countries with SARS experience. In contrast, people in countries without SARS experience started to pay more attention much later, in March. Moreover, governments in these countries responded significantly more slowly in implementing social distancing policies to combat domestic COVID-19 outbreaks than governments in countries with SARS experience. Moreover, such early responses of individuals and governments in countries with SARS experience are prevalent within continent, even in non-Asian countries. Furthermore, people in countries with SARS experience are more compliant with social distancing rules. These timely attention and proactive responses of individuals and governments are more pronounced in countries that reported deaths caused by SARS, which left deeper imprints. Our findings suggest that the imprint of similar viruses’ experience is a fundamental mechanism underlying timely responses to COVID-19. This paper was accepted by Haoxiang Zhu, finance.

scholarly journals Age, Comorbidities, and Mortality Correlation in COVID-19 Patients: A Review

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Vidyulata Salunkhe ◽  
Keyword(s):  
Age Groups ◽  
Economic Policies ◽  
The Novel ◽  
Risk Of Death ◽  
Grand Total ◽  
Risk Of Mortality ◽  
Number Of Patients ◽  
Increased Risk ◽  
Novel Virus ◽  
Underlying Diseases

Background: The risk of death due to COVID-19 among hospitalized patients is known to be higher in older adults and those with underlying health conditions. Understanding the percentage of patients who are at increased risk of death due COVID-19 and how this varies between age groups will inform the healthcare community how to evaluate the risk of COVID-19, and better design healthcare and economic policies. Methods: We conducted a literature search for studies published between December 2019 until May 16, 2020 in PubMed, Embase, and Cochrane (CENTRAL). Descriptive statistics were performed. Results: We reviewed 14 studies of which 13 were retrospective and one was prospective. Eleven studies were conducted in Wuhan, China. A grand total of 11,938 COVID-19 confirmed patients were reviewed. Among these patients, 7637 (64%) were males. Our review reported hypertension (41%), diabetes (21%), cardiac diseases (14%), COPD (8%), chronic kidney disease (4%) and cerebrovascular disease (10%) as the most common underlying diseases among patients who died during hospitalization due to COVID-19. The total number of patients died in the hospital was 1744 (15%). Among patients who died in the hospital, 1% patients were 30-39 years, 16% patients were 40-59 years and 83% patients were more than 60 years of age. Conclusions: Older patients with underlying diseases appear to be at higher risk of mortality from COVID-19. Comorbidities are significant predictors of mortality in COVID-19 patients. There is an urgent need to know the epidemiology of the novel virus and characterize its potential impact.

A Review On Role of polymers in the Pharmaceutical Applications

2020 ◽  
Vol 01 ◽  
Author(s):  
Hourieh Alkadi
Keyword(s):  
Drug Delivery ◽  
Dose Titration ◽  
Target System ◽  
The Novel ◽  
Living Body ◽  
Pharmaceutical Application ◽  
Pharmaceutical Applications ◽  
Long Time ◽  
Effective Level

: Development of a new drug molecule is costly and requires long time. Many attempts have been done to improve the safety of effective level of "old" drugs, utilizing various ways like individualizing drug therapy, curative drug control, and dose titration. But, Recently an important efforts have been pointed to discover the novel of drug releasing systems, in which it can be supplied to a target system in human body, with controlling the level and time of delivery. Polymers, whether synthetic or natural, have a great importance in pharmaceutical applications especially in the field of drug delivery. The use of polymers in pharmaceutical application extent from using them as binders in tablets to viscosity and flow controlling factors in liquids, and they can be used in suspensions and emulsions; also in some cases they can be used as film coatings. Moreover, they may be used as membranes implanted within the living body. Current work highlights the importance of drug delivery systems and the role of polymers in it.

Sign in / Sign up

Export Citation Format

Share Document