The efficacy of moxifloxacin in patients with bacterial keratitis

Background/Aim. Keratitis is a sociomedical problem of moderately developed countries. including Serbia, too. The incidence of bacterial keratitis in the world is about 20% in relation to all keratitis, but its frequency in Serbia is still not known. Bearing in mind the complications in the front segment of the eye after bacterial keratitis (ulcer, neovascularization, fibrosis) and decline in visual acuity, it was necessary to assess the efficacy of local therapy by moxifloxacin which will shorten the healing time and reduce complications. The aim of the study was to analyze the efficiency of shortening the treatment of bacterial keratitis with moxifloxacin. Methods. The study was designed as prospective, randomized, double-blind study. The study included 30 patients with diagnosed keratitis and locally applied antibiotic moxifloxacin, and 60 patients in a control group, with locally applied artificial tears. All participants were subjected to complete clinical ophthalmologic analysis (2015/16), for a period of 1?15 days after the application of therapies (healing time of corneal pathology). The following was determined in all patients: degree of hyperemia, degree of epithelial defect, level of corneal sensitivity, level of tear secretion and tear quality, degree of conjunctival secretion, degree of neovascularisation and corneal scarring, degree of visual acuity, score of subjective symptomatology and correlation of ophthalmological findings and subjective symptoms. Results. There was a statistically significant difference in times of therapeutic efficacy/clinical response between the study group patients who received moxifloxacin and the control group patients who received arteficial tears. Conclusion. Local application of moxifloxacin had therapeutic effect (total benefit) both in terms of the effective shortening of the healing time and also the reduction of the complications of bacterial keratitis, without unwanted effects.

Download Full-text

The Influence of Adrenaline on Postoperative Analgesia after Subarachnoid Morphine

Anaesthesia and Intensive Care ◽

10.1177/0310057x9302100119 ◽

1993 ◽

Vol 21 (1) ◽

pp. 79-84 ◽

Cited By ~ 10

Author(s):

M. J. Paech

Keyword(s):

Side Effects ◽

Postoperative Analgesia ◽

Saline Group ◽

Control Group ◽

Double Blind Study ◽

Gynaecological Surgery ◽

Normal Saline Group ◽

Double Blind ◽

Significant Difference ◽

To Receive

A randomised, double-blind study was conducted to investigate the postoperative effects of subarachnoid morphine, with or without adrenaline, after major gynaecological surgery. Seventy-five women having spinal anaesthesia combined with either sedation or general anaesthesia were randomised to receive subarachnoid morphine 0.25 mg with (group MA) or without (group M) adrenaline 200 ūg; or normal saline (group C). Groups M (n=22) and MA (n=25) differed significantly from control (n=23) with respect to the quality and duration of postoperative analgesia (P<0.0002) and to a higher incidence of pruritus (P<0.02). Groups were similar with respect to the incidence of other postoperative side-effects and respiratory data, although the latter showed a trend to less hypoxaemia in the control group. There was no significant difference in any outcome between groups MA and M. It was concluded that, under the study conditions in a post-gynaecological surgery population, the addition of adrenaline to subarachnoid morphine was of no benefit.

Download Full-text

Clinical effect of a herbal dentifrice on the control of plaque and gingivitis: a double-blind study

Pesquisa Odontológica Brasileira ◽

10.1590/s1517-74912003000400004 ◽

2003 ◽

Vol 17 (4) ◽

pp. 314-318 ◽

Cited By ~ 25

Author(s):

Claudio Mendes Pannuti ◽

Joyce Pereira de Mattos ◽

Paula Nini Ranoya ◽

Alberto Martins de Jesus ◽

Roberto Fraga Moreira Lotufo ◽

...

Keyword(s):

Clinical Trial ◽

Clinical Effect ◽

Test Group ◽

Control Group ◽

Double Blind Study ◽

Gingival Index ◽

Control Groups ◽

Double Blind ◽

Double Blind Clinical Trial ◽

Significant Difference

The aim of this randomized, double-blind clinical trial was to evaluate the effect of the Paradontax dentifrice on the reduction of plaque and gingivitis. Subjects were randomly allocated into either the test group (n = 15, Paradontax) or the control group (n = 15, standard dentifrice with fluoride). Plaque levels were measured using the Turesky modification of the Quigley & Hein Plaque Index (PI), and gingivitis was evaluated with the Gingival Index (GI). Subjects were asked to brush their teeth with the allocated dentifrice, three times a day, for 21 days. There was no significant difference between groups in relation to the PI and GI medians, at baseline and at the end of the 21-day period. There was no significant reduction in PI in either the test or control groups. There was a significant decrease in GI in the test group. The authors concluded that there was no difference between the dentifrices in the reduction of plaque and gingivitis.

Download Full-text

Managing irritable bowel syndrome: The impact of micro-physiotherapy

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2015-0044 ◽

2017 ◽

Vol 14 (2) ◽

Cited By ~ 1

Author(s):

Daniel Grosjean ◽

Patrice Benini ◽

Pierre Carayon

Keyword(s):

Irritable Bowel Syndrome ◽

Holistic Approach ◽

Study Groups ◽

Control Group ◽

Double Blind Study ◽

Self Healing ◽

Double Blind ◽

Significant Difference ◽

Irritable Bowel ◽

The Impact

AbstractBackgroundIrritable bowel syndrome (IBS) has a complex pathology, high prevalence and large impact on patients’ quality of life. As conventional therapy may yield unsatisfactory results, a more holistic approach may be desirable. The current study assessed the effect of micro-physiotherapy on the severity of IBS symptoms.MethodsIn a double-blind study, 61 recurrent IBS patients were randomised to two sessions of micro-physiotherapy or sham micro-physiotherapy. Inclusion criteria were the presence of ≥1 IBS symptom from abdominal pain, constipation, diarrhoea or bloating. Exclusion criteria were previous major intestinal surgery and the presence of chronic diseases. The mean patient age was 53.5±15.3 years. Micro-physiotherapy consisted of micro-palpatory examination to identify osteopathic lesions, followed by micro-massage to stimulate self-healing. The control group underwent a sham procedure. The presence and severity of symptoms was assessed at baseline and at 1-month follow-up by the same gastroenterologist.ResultsTwo patients did not complete the study. There was a significant difference in percentage of patients that improved after the first session, at 74 % for the micro-physiotherapy group and 38 % for the sham group, respectively (p=0.005). After the second session, the initial improvement was maintained in both groups, although with no further gains, and the differences between the study groups remained significant (p=0.007).ConclusionsMicro-physiotherapy significantly improves IBS symptoms and should be explored further for use in mainstream healthcare.

Download Full-text

Perioperative Intravenous Low-Dose Ketamine Infusion to Minimize Pain for Septorhinoplasty: A Prospective, Randomized, Double-Blind Study

Ear Nose & Throat Journal ◽

10.1177/0145561320974860 ◽

2020 ◽

pp. 014556132097486

Author(s):

Irem Ates ◽

Muhammed Enes Aydin ◽

Erkan Cem Celik ◽

Mustafa Sitki Gozeler ◽

Ali Ahiskalioglu

Keyword(s):

Side Effects ◽

Low Dose ◽

Blind Study ◽

Control Group ◽

Anesthesia Induction ◽

Double Blind Study ◽

Double Blind ◽

Ketamine Infusion ◽

Pain Scores ◽

Significant Difference

Objectives: Studies investigating the effects of intravenous (IV) ketamine in pain management after septorhinoplasty is limited. This study aims to evaluate the efficacy of low-dose IV infusion of ketamine on pain scores. Methods: This randomized, prospective, double-blind study was conducted with 48 patients who underwent septorhinoplasty. Intravenous ketamine bolus (0.5 mg/kg) was administered to the ketamine group (group K, n = 24) at anesthesia induction, and ketamine infusion was continued (0.25 mg/kg/h) during the surgery. In the control group (group C, n = 24), the same protocol was administered using saline instead of ketamine. Furthermore, 50-mg dexketoprofen trometamol was administered to both groups 30 minutes before the end of the surgery. Then it was repeated at the 12th and 24th hours postoperatively. Pain scores were evaluated with the visual analogue scale. Consumptions intraoperative of opioid and sevoflurane, rescue opioid requirement, patient satisfaction, and side effects were recorded. Results: Pain scores were significantly lower in group K at all postoperative periods ( P < .05). There was no significant difference between the groups in terms of intraoperative sevoflurane and remifentanil consumptions ( P > .05). Rescue opioid analgesic requirements were significantly lower in group K than group C (0/24 vs 6/24, respectively; P = .022). Side effects were similar between the groups ( P > .05). Conclusion: We recommend the administration of low-dose ketamine infusion during septorhinoplasty surgery because it reduces the requirement for rescue opioid analgesia and postoperative pain scores.

Download Full-text

The effect of Reiki on blood hypertension

Acta Paulista de Enfermagem ◽

10.1590/1982-0194201400078 ◽

2014 ◽

Vol 27 (5) ◽

pp. 479-484 ◽

Cited By ~ 3

Author(s):

Léia Fortes Salles ◽

Luciana Vannucci ◽

Amanda Salles ◽

Maria Júlia Paes da Silva

Keyword(s):

Blood Pressure ◽

Repeated Measures ◽

Study Groups ◽

Control Group ◽

Double Blind Study ◽

Double Blind ◽

Anova Model ◽

Significant Difference ◽

Before And After ◽

Experimental Group

Objective Determining the immediate effect of Reiki on abnormal blood pressure. Methods An experimental, double-blind study, in which were included 66 hypertensive patients, randomized to the three following study groups: control, placebo and experimental. The intervention lasted 20 minutes, the control group remained at rest, the placebo group received an imitation of the studied technique (mock Reiki) and the experimental group received the Reiki technique. Blood pressure was measured before and after the intervention by the same person with the same instrument. Results There was a decrease in blood pressure in the three groups and the reduction was greater in the experimental group, followed by the placebo and the control group. The ANOVA model for repeated measures showed a statistically significant difference among the groups (p <0.0001). Conclusion Reiki had a positive effect on reducing abnormal blood pressure, suggesting to be a complementary technique for the control of hypertension.

Download Full-text

Effects of short-term caffeine consumption on speech and sound reception in individuals with normal hearing

Auditory and Vestibular Research ◽

10.18502/avr.v27i3.57 ◽

2018 ◽

pp. 150-156 ◽

Cited By ~ 1

Author(s):

Seyyed Mohammad Reza Taghavi ◽

Ahmad Geshani ◽

Nematollah Rouhbakhsh ◽

Shoreh Jalaie ◽

Akram Pourbakht ◽

...

Keyword(s):

Control Group ◽

Double Blind Study ◽

Noise Tolerance ◽

Short Term ◽

Caffeine Consumption ◽

Double Blind ◽

Significant Difference ◽

Acceptable Noise Level ◽

Before And After ◽

Sound Reception

Background and Aim: Caffeine consumes targeted attention to the signal, which is expected to lead to increased noise tolerance and ultimately improved speech perception. In the current study, the effect of short-term caffeine consumption on speech and noise simultaneous reception function was evaluated using acceptable noise level (ANL) test.Methods: In this interventional double-blind study, 90 cases (45 male, 45 female) aged 18−34 years were randomly assigned into three groups: the test groups, 3 and 5 mg/kg caffeine, and the control group, just placebo. The ANL test was recorded before and one hour after intervention. The results were compared before and after taking caffeine in three groups.Results: The statistical analysis revealed that there was significant difference in ANL result in dose 3 mg/kg caffeine before and one hour after intervention (p=0.043) and there was a significant difference in ANL result in dose 5 mg/kg caffeine before and one hour after intervention (p=0.001). Also, there was a significant difference in ANL before and one hour after taking caffeine between the group receiving 3 mg/kg dose of caffeine and the 5 mg/kg dose of caffeine (p=0.015).Conclusion: According to the findings of the study, after an hour of caffeine consumption, the ANL decreases. In other words, the individuals tolerate higher levels of speech noise. This is also dependent on the dose of caffeine.

Download Full-text

Fatigue, Stigma, and Mood in Patients with Multiple Sclerosis: Effectiveness of Guided Imagery

10.21203/rs.3.rs-1059530/v1 ◽

2021 ◽

Author(s):

Mina Beitollahi ◽

Mansooreh Azizzadeh Forouzi ◽

Batool Tirgari ◽

Yunes Jahani

Keyword(s):

Multiple Sclerosis ◽

Guided Imagery ◽

Intervention Group ◽

Cost Effective ◽

Control Group ◽

Double Blind Study ◽

Double Blind ◽

Cost Effective Method ◽

Significant Difference ◽

The Mean

Abstract Background and objectives : The present study aimed to assess the effectiveness of guided imagery on fatigue, stigma, and mood in patients with multiple sclerosis. Methods This clinical trial is a double-blind study that was conducted on 60 patients with multiple sclerosis referred to the largest center for special diseases in the southeast of Iran in 2020. The convenience sampling method was used to select the participants who were later divided into two groups of intervention (n=30) and control (n=30) using block randomization method. The intervention group listened to the guided imagery audio file at home for 25 minutes. The control group did not receive any intervention. Data were collected by demographic information questionnaires, Fatigue Severity Scale (FSS), Reece Stigma Scale for Multiple Sclerosis (RSS-MS), and the Profile of Mood States (POMS) before and one month after the intervention. Results According to the results, there was no significant difference between the two groups before the intervention in terms of the score of fatigue (P<0.0=67), stigma (P<0.64), and mood (P<0.17). However, after the intervention, a significant differences was observed in this regard (P<0.0001). In the intervention group, the mean score of fatigue decreased from 59.72±18.32 to 35.8±16.15, and the mean score of stigma decreased from 17.31±15.62 to 5.09±8.06, showing a significant reduction in the levels of fatigue (P<0.0001) and stigma (P<0.0001) compared to before intervention. Also, the mean score of mood decreased from 36.90±12.21 to 28.55±11.87, indicating an improvement in the mood of samples in the intervention group (P<0.0001). Conclusions The results indicated that guided imagery, as a cost-effective method, can decrease the fatigue and stigma, and enhance the mood of patients with MS. Therefore, nursing staff can use this method to improve MS patients’ mood and decrease their fatigue and stigma.

Download Full-text

The effect of adding curcumin to sodium valproate in treatment of patients with bipolar disorder in the acute phase of mania: a clinical trial.

10.21203/rs.2.19925/v1 ◽

2020 ◽

Author(s):

Farzad Akbarzadeh ◽

Nabahat Niksun ◽

Fatemeh Behdani ◽

Amir Hoshang Mohammadpour ◽

Mahmoudreza Jaafari ◽

...

Keyword(s):

Sodium Valproate ◽

Control Group ◽

P Value ◽

Double Blind Study ◽

Young Mania ◽

Double Blind ◽

Diagnostic And Statistical Manual ◽

New Therapeutic Approaches ◽

Significant Difference ◽

Inflammatory Processes

Abstract Background: Inflammatory processes in the brain play an important role in etiopathogenesis of many psychiatric disorders including, bipolar mood disorder (BMD) as a life-long episodic disease. An inefficient therapeutic intervention especially for resistant cases makes the necessity of doing more precise investigation to find out new therapeutic approaches apparent. This double-blind study aims to investigate the effect of Crucumin as anti-inflammatory herbal based drug in the treatment of BMD. Results: 78 patients who met the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) criteria for BMD screening to participate in the trial. The participants included 32 patients in the placebo group receiving sodium valproate and crucumin and 38 patients in the control group receiving placebo and sodium valproate. At the beginning of the study and weeks 1, 2, 4 the patients were assessed by a psychiatrist using Young mania score (YMRS). Fifty four patients completed the trial. Mean age in patients group was 36.28±10.73 and in control group was 32.42 ±9.60.Clinical characteristics of the patients, such as age, did not differ between groups P value ≥0.05. Results showed the process of changes were significant different in both group. The results showed that the changes in the resultss of YMRS, MMSE and CGI scores were significant in each group (P value≤0.001), but no significant difference has been detected between the two groups (p≥0.05).Conclusions: this study suggested that crucumin cannot be an effective adjuvant agent in management of patients with BMD under treatment with sodium valproate.

Download Full-text

Antiplaque and antigingivitis effects of a gel containing Punica granatum Linn extract: a double-blind clinical study in humans

Journal of Applied Oral Science ◽

10.1590/s1678-77572006000300003 ◽

2006 ◽

Vol 14 (3) ◽

pp. 162-166 ◽

Cited By ~ 13

Author(s):

Alexandre Daher Yunes Salgado ◽

Juliana Lemos Maia ◽

Sérgio Luís da Silva Pereira ◽

Telma Leda Gomes de Lemos ◽

Olívia Morais de Lima Mota

Keyword(s):

Punica Granatum ◽

Plaque Formation ◽

Control Group ◽

Double Blind Study ◽

Double Blind ◽

Posterior Teeth ◽

Gingival Bleeding ◽

Significant Difference ◽

Experimental Group ◽

Left Quadrant

OBJECTIVES: The antiplaque and antigingivitis effects of a gel containing 10% Punica granatum Linn extract were evaluated using a 21-day partial-mouth experimental model of gingivitis. METHODS: 23 volunteers participated in this cross-over, double-blind study, carried out in 2 phases of 21 days each. For each period of the experiment, an acrylic toothshield was made for each volunteer to carry the test or placebo gel as well as to avoid brushing of the 4 experimental teeth (posterior teeth in the lower left quadrant). The subjects were randomly assigned to use either the placebo gel (control group) or the test gel (experimental group) and were instructed to brush the remaining teeth normally 3 times a day. On days 0 and 21, the visible plaque index (VPI) and gingival bleeding index (GBI) were recorded. RESULTS: The results did not show statistically significant difference between control and experimental groups for either of the indices (VPI and GBI). CONCLUSION: The gel containing 10% Punica granatum Linn extract was not efficient in preventing supragingival dental plaque formation and gingivitis.

Download Full-text

COMPARISON OF THE QUALITY OF LIFE OF PATIENTS IN THE LOCALY ADVANCED BREAST CANCER FORMS AFTER SYSTEM AND INTRALYMPHATIC POLYCHEMOTHERAPY

EUREKA Health Sciences ◽

10.21303/2504-5679.2018.00693 ◽

2018 ◽

Vol 4 ◽

pp. 3-13

Author(s):

Yuriy Dumanskiy ◽

Oleksandr Bondar ◽

Oleksandr Tkachenko ◽

Evhenii Stoliachuk ◽

Vasilii Ermakov

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Locally Advanced ◽

Developed Countries ◽

Control Group ◽

Preoperative Treatment ◽

Discrete Elements ◽

Important Indicator ◽

Significant Difference

In recent years, breast cancer (BC) is the most common cancer pathology and the most common cause of disability among women in developed countries. Finding the most effective ways of interaction between the patient and the doctor creates the preconditions for the necessary analysis of the treatment process from an objective and subjective point of view. Therefore, an important indicator to be taken into account is the quality of life of a patient. To compare the indicators of a comprehensive assessment of the quality of life of patients to the adverse locally advanced forms (LA) of breast cancer before and after systemic intravenous polychemotherapy (SPCTx) and selective endolymphatic polychemotherapy (ELPCTx) in neoadjuvant mode. The study was conducted on the basis of a random analysis of outpatient cards from 112 patients with LA BC T4A-DN0-3M0 who received a comprehensive antitumor treatment on the basis of the Donetsk regional antitumor center and the University Clinic of the Odessa National Medical University from 2000 to 2017, which was proposed a questionnaire at various stages of preoperative treatment. The first (control) group consisted of 65 patients (58 %) with inoperable forms of LA BC, which was performed in neoadjuvant mode by SPCTx. The second (study group) included 47 patients (42 %) with inoperable forms of LA BC, which was performed as a neoadjuvant course ELPCTx. According to the integral indicators of quality of life and quality of health between patients in the control and study groups, there was no statistically significant difference. In a detailed analysis of the indicators of symptomatic scales, the difference between the groups did not exceed the critical. Based on the results of a study conducted among patients receiving endolymphatic chemotherapy in a neoadjuvant mode, the subjective evaluations of treatment in absolute numbers have better reference values without statistical superiority. The study of the integrative indicator of quality of life and its discrete elements is an ergonomic and economical means of heuristic assessment of the health of patients in order to further develop more rational and convenient ways of solving urgent issues of modern oncology by increasing compliance and finding a compromise between the physician and the patient.

Download Full-text