259 EFFECTS OF BIPHASIC PACING IN LARGE ANIMAL SPECIES.

2006 ◽  
Vol 54 (1) ◽  
pp. S302.4-S302 ◽  
Author(s):  
F. Tondato ◽  
L. Rougée ◽  
G. K. Ostrander ◽  
M. Ungs ◽  
M. M. Mower
Keyword(s):  
Rangifer ◽  
1990 ◽  
Vol 10 (3) ◽  
pp. 231 ◽  
Author(s):  
S. Bornstein

The dromedary camel (Camel dromedarius) is extremely well adapted to life in hot and arid lands. In terms of physiological adaptation to heat and water deprivation it surpasses by far every other large animal of which data have been collected. None of the adaptive mechanisms to cope with the environmental stresses are unique to the Arabian camel, but the efficiency of its adaptation is superior. At high ambient temperatures the camels adapt to the scarcity of water by reducing their faecal, urinary and evaporative water losses. During dehydration, the kidneys reduce water losses both by decreasing the glomerual filtration rate and by increasing the tubular reabsorption of water. Also their ability of regulating their body temperature from 34.5-40.7 °C conserves a lot of water, when most needed.


2018 ◽  
Vol 315 (2) ◽  
pp. R165-R190 ◽  
Author(s):  
Annabel J. Sorby-Adams ◽  
Robert Vink ◽  
Renée J. Turner

Acute central nervous system injury, encompassing traumatic brain injury (TBI) and stroke, accounts for a significant burden of morbidity and mortality worldwide. Studies in animal models have greatly enhanced our understanding of the complex pathophysiology that underlies TBI and stroke and enabled the preclinical screening of over 1,000 novel therapeutic agents. Despite this, the translation of novel therapeutics from experimental models to clinical therapies has been extremely poor. One potential explanation for this poor clinical translation is the choice of experimental model, given that the majority of preclinical TBI and ischemic stroke studies have been conducted in small animals, such as rodents, which have small lissencephalic brains. However, the use of large animal species such as nonhuman primates, sheep, and pigs, which have large gyrencephalic human-like brains, may provide an avenue to improve clinical translation due to similarities in neuroanatomical structure when compared with widely adopted rodent models. This purpose of this review is to provide an overview of large animal models of TBI and ischemic stroke, including the surgical considerations, key benefits, and limitations of each approach.


Author(s):  
Juliana H. Giffoni ◽  
Raffaella B. C. Teixeira ◽  
Raphael R. Wenceslau ◽  
Melina A. F. Abrantes ◽  
Jéssica G. Oliveira ◽  
...  

2017 ◽  
Vol 14 (2) ◽  
Author(s):  
Guilherme José da Silva e Sá

Abstract This article presents data collected in ethnographic research begun in 2014 at the Faia Brava Reserve in Portugal. The Faia Brava Reserve has been dedicated to ecological restoration by the association that manages it. This has made the reserve the starting point of an ambitious project for re-naturalizing the western region of the Iberian Peninsula, which foresees the reintroduction of large animal species in Portugal through its integration to the Rewilding Europe network. The article describes some of the steps necessary to the creation of re-naturalization areas, and some of the hypotheses associated to the re-naturalization project in Europe and particularly in Portugal.


1997 ◽  
Vol 16 (1) ◽  
pp. 41-65 ◽  
Author(s):  
Lawrence I. Mortin ◽  
Christopher J. Horvath ◽  
Michael S. Wyand

Undesired pharmacologic activities of novel drugs or biologies may limit development of a therapeutic prior to the characterization of any toxicologic effects. In rodent species, general pharmacology assays have traditionally been used to screen new agents for pharmacologic effects on the central and peripheral nervous systems, the autonomic nervous system and smooth muscles, the respiratory and cardiovascular systems, the digestive system, and the physiologic mechanisms of water and electrolyte balance. In large animal species, such as dogs and nonhuman primates, smaller numbers of animals per study limit their use for screening assays, but these species may play an important role in more detailed mechanistic studies. For drugs and biologies that must be tested in nonhuman primates because of species-specific action of the test agent, functional pharmacologic data are often collected during acute or subacute toxicity studies. This requires careful experimental design to minimize any impact pharmacologic effects or instrumentation may have on the assessment of toxicity. In addition, with many new therapies targeted at immunologic diseases, the pharmacologic effect of therapeutics on the immune system presents new challenges for pharmacologic profiling. The application of pharmacology assays by organ system in both rodent and large animal species are discussed, as well as practical issues in assessing pharmacology endpoints in the context of toxicity studies.


1988 ◽  
Vol 15 (3) ◽  
pp. 239-249 ◽  
Author(s):  
Gbadebo Jonathan Osemeobo

To conserve a resource without having adequate data and finance is difficult and frustrating. The situation of wildlife in Nigeria is nevertheless different. Except in the Yankari, Upper Ogun, and Kwiabaha, Game Reserves, and the Kainji Lake National Park, little efforts have been made to protect the Nigerian animal wildlife resources from human pressure and widespread extinction. To many, what remains of the wild animals are best seen in the few state-owned zoological gardens in Nigeria. However, because most indigenous large animal species—including Elephant, Buffalo, Chimpanzee, Gorilla, Rhinoceros, Leopard, and Ostrich—have not been able to reproduce in the various zoological gardens so far, the hope to conserve these animals is brittle. The questions are, what factors are working against wildlife conservation? Indeed, what hopes exist for Nigerian animal wildlife?Animal wildlife is a declining resource in Nigeria because of unplanned land-use practices. For example, landuses in game reserves are often conflicting and contradictory. Four land-uses: timber extraction, hunting, food-crop production, and settlement, are simultaneously going on in game reserves, with little or no control measures and with no management plans. The excessive demands for land for these conflicting uses have greatly disturbed the ecosystems involved, thus making the survival of the wild animals uncertain. Specifically, the problems of wildlife conservation in Nigeria are: (a) poaching; (b) indiscriminate burning of the vegetation; (c) uncontrolled grazing activities in the reserves; (d) intensive logging for domestic and industrial uses; (e) user rights on the reserves enjoyed by the traditional owners of the land before reservation; (f) lack of adequate funds to manage the reserves; (g) ineffective legislation; (h) lack of trained manpower; (i) urban sprawl; and (j) infrastructural development of roads, electric and telegraph lines, and irrigation schemes, all within the game reserves.The future for Nigerian animal wildlife depends on the nation's ability to conserve what is left either in their natural habitat or, at least, in zoological gardens. The task is not simple under conditions of economic depression, with inadequate manpower and without effective management of game reserves. In these circumstances, the game reserves should be reduced to manageable numbers, while state governments should win public sympathy through adequate conservation publicity and the provision of sufficient vehicles and personnel to manage the game reserves.The policy of land-use in game reserves should be reviewed, while researches should be conducted on (a) the levels of land-use that could be consistent with maintaining wild animals in the reserves, (b) the number and species of animals hunted per year, (c) the population of animal species in the game reserves and their habitat suitability, (d) the endangered and extinct animal species and specific reasons for the decline in their populations, and (e) human problems peculiar to each reserve and ways of minimizing them.


Author(s):  
Mera Usman Muhammed ◽  
Mayaki Abubakar Musa ◽  
Gambo Abdulrahman Abdullahi

This study was carried out to compare the digital rectal (DR) thermometer with non-contact infrared thermometer (IRT) measurements at two locations on the face in some large animal species. Two hundred and forty (240) animals comprising of equal numbers of three species (cattle, camel and horses) of varying age and either sex was used. The IR temperature was taken from two sites [frontal (FIRT) and temporal (TIRT) region] on the animal face. The mean IR temperatures (FIRT and TIRT) were higher than the RT in all the animal species. The two thermometers correlate poorly in all the animal species. Bland-Altman analysis showed high biases and limits of agreement not acceptable for clinical purposes. In conclusion, IRT seems to offer a quick and easy way to determine the animal temperature but clinically it cannot be used interchangeably with DR thermometer at the moment for body temperature measurement in these animal species.


PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0201673 ◽  
Author(s):  
Mark D. Unger ◽  
Naveen S. Murthy ◽  
Rahul Kanwar ◽  
Kasey A. Strand ◽  
Timothy P. Maus ◽  
...  

Reproduction ◽  
2003 ◽  
pp. 489-499 ◽  
Author(s):  
SJ Bedford ◽  
M Kurokawa ◽  
K Hinrichs ◽  
RA Fissore

In oocytes from all mammalian species studied to date, fertilization by a spermatozoon induces intracellular calcium ([Ca(2+)](i)) oscillations that are crucial for appropriate oocyte activation and embryonic development. Such patterns are species-specific and have not yet been elucidated in horses; it is also not known whether equine oocytes respond with transient [Ca(2+)](i) oscillations when fertilized or treated with parthenogenetic agents. Therefore, the aims of this study were: (i) to characterize the activity of equine sperm extracts microinjected into mouse oocytes; (ii) to ascertain in horse oocytes the [Ca(2+)](i)-releasing activity and activating capacity of equine sperm extracts corresponding to the activity present in a single stallion spermatozoon; and (iii) to determine whether equine oocytes respond with [Ca(2+)](i) transients and activation when fertilized using the intracytoplasmic sperm injection (ICSI) procedure. The results of this study indicate that equine sperm extracts are able to induce [Ca(2+)](i) oscillations, activation and embryo development in mouse oocytes. Furthermore, in horse oocytes, injection of sperm extracts induced persistent [Ca(2+)](i) oscillations that lasted for >60 min and initiated oocyte activation. Nevertheless, injection of a single stallion spermatozoon did not consistently initiate [Ca(2+)](i) oscillations in horse oocytes. It is concluded that stallion sperm extracts can efficiently induce [Ca(2+)](i) responses and parthenogenesis in horse oocytes, and can be used to elucidate the signalling mechanism of fertilization in horses. Conversely, the inconsistent [Ca(2+)](i) responses obtained with sperm injection in horse oocytes may explain, at least in part, the low developmental success obtained using ICSI in large animal species.


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