scholarly journals Dietary Insulinemic Potential and Risk of Total and Cause-Specific Mortality in the Nurses' Health Study and the Health Professionals Follow-up Study

2021 ◽  
Author(s):  
Yi Wan ◽  
Fred K. Tabung ◽  
Dong Hoon Lee ◽  
Teresa T. Fung ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Health Professionals ◽  
Insulin Response ◽  
Premature Death ◽  
Health Study ◽  
Follow Up Study ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Specific Mortality ◽  
Design And Methods

<b>Objective: </b>Insulin response is related to overall health. Diet modulates insulin response. We aimed to investigate whether insulinemic potential of diet are associated with risk of all-cause and cause-specific mortality. <p><b>Research Design and Methods: </b>We prospectively followed 63,464 women from the Nurses’ Health Study (1986-2016) and 42,880 men from the Health Professionals Follow-up Study (1986-2016). Diet was assessed by food frequency questionnaires every 4 years. The insulinemic potential of diet was evaluated using a food-based empirical dietary index for hyperinsulinemia (EDIH), which was pre-defined based on predicting circulating C-peptide concentrations.</p> <p><b>Results</b>:<b> </b>During <a>2,792,550</a> person-years of follow-up, 38,329 deaths occurred. In the pooled multivariable-adjusted analyses, a higher dietary insulinemic potential was associated with an increased risk of mortality from all-cause (hazard ratio [HR] comparing extreme quintiles: 1.33; 95% confidence interval [CI]: 1.29, 1.38; P-trend<0.001), cardiovascular disease (CVD) (HR: 1.37; 95% CI: 1.27, 1.46; P-trend<0.001), and cancers (HR: 1,20; 95% CI: 1.13, 1.28; P-trend<0.001). <a>These associations were independent of body mass index and remained significant after further adjustment for other well-known dietary indices. </a>Furthermore, <a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a>compared with participants whose EDIH scores were stable over an 8-year period, those with the greatest increases had a higher subsequent risk of all-cause (HR: 1.13; 95%CI: 1.09, 1.18; P-trend<0.001)</a> and CVD (HR: 1.10; 95% CI: 1.01, 1.21; P-trend=0.006) mortality.</p> <p><b>Conclusions:</b> Higher insulinemic potential of diet was associated with increased risk of all-cause, CVD, and cancer mortality. Adopting a diet with low insulinemic potential might be an effective approach to improve overall health and prevent premature death.</p>

scholarly journals Dietary Insulinemic Potential and Risk of Total and Cause-Specific Mortality in the Nurses' Health Study and the Health Professionals Follow-up Study

2021 ◽  
Author(s):  
Yi Wan ◽  
Fred K. Tabung ◽  
Dong Hoon Lee ◽  
Teresa T. Fung ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Health Professionals ◽  
Insulin Response ◽  
Premature Death ◽  
Health Study ◽  
Follow Up Study ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Specific Mortality ◽  
Design And Methods

<b>Objective: </b>Insulin response is related to overall health. Diet modulates insulin response. We aimed to investigate whether insulinemic potential of diet are associated with risk of all-cause and cause-specific mortality. <p><b>Research Design and Methods: </b>We prospectively followed 63,464 women from the Nurses’ Health Study (1986-2016) and 42,880 men from the Health Professionals Follow-up Study (1986-2016). Diet was assessed by food frequency questionnaires every 4 years. The insulinemic potential of diet was evaluated using a food-based empirical dietary index for hyperinsulinemia (EDIH), which was pre-defined based on predicting circulating C-peptide concentrations.</p> <p><b>Results</b>:<b> </b>During <a>2,792,550</a> person-years of follow-up, 38,329 deaths occurred. In the pooled multivariable-adjusted analyses, a higher dietary insulinemic potential was associated with an increased risk of mortality from all-cause (hazard ratio [HR] comparing extreme quintiles: 1.33; 95% confidence interval [CI]: 1.29, 1.38; P-trend<0.001), cardiovascular disease (CVD) (HR: 1.37; 95% CI: 1.27, 1.46; P-trend<0.001), and cancers (HR: 1,20; 95% CI: 1.13, 1.28; P-trend<0.001). <a>These associations were independent of body mass index and remained significant after further adjustment for other well-known dietary indices. </a>Furthermore, <a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a>compared with participants whose EDIH scores were stable over an 8-year period, those with the greatest increases had a higher subsequent risk of all-cause (HR: 1.13; 95%CI: 1.09, 1.18; P-trend<0.001)</a> and CVD (HR: 1.10; 95% CI: 1.01, 1.21; P-trend=0.006) mortality.</p> <p><b>Conclusions:</b> Higher insulinemic potential of diet was associated with increased risk of all-cause, CVD, and cancer mortality. Adopting a diet with low insulinemic potential might be an effective approach to improve overall health and prevent premature death.</p>

scholarly journals Dietary Insulinemic Potential and Risk of Total and Cause-Specific Mortality in the Nurses' Health Study and the Health Professionals Follow-up Study

Diabetes Care ◽  
2021 ◽  
pp. dc211530
Author(s):  
Yi Wan ◽  
Fred K. Tabung ◽  
Dong Hoon Lee ◽  
Teresa T. Fung ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Health Professionals ◽  
Health Study ◽  
Follow Up Study ◽  
Specific Mortality

scholarly journals A Prospective Analysis of Meat Mutagens and Colorectal Cancer in the Nurses’ Health Study and Health Professionals Follow-up Study

2016 ◽  
Vol 124 (10) ◽  
pp. 1529-1536 ◽  
Author(s):  
Ngoan Tran Le ◽  
Fernanda Alessandra Silva Michels ◽  
Mingyang Song ◽  
Xuehong Zhang ◽  
Adam M. Bernstein ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Health Professionals ◽  
Health Study ◽  
Prospective Analysis ◽  
Follow Up Study

scholarly journals Use of glucosamine and chondroitin supplements in relation to risk of colorectal cancer: Results from the Nurses' Health Study and Health Professionals follow-up study

2016 ◽  
Vol 139 (9) ◽  
pp. 1949-1957 ◽  
Author(s):  
Elizabeth D. Kantor ◽  
Xuehong Zhang ◽  
Kana Wu ◽  
Lisa B. Signorello ◽  
Andrew T. Chan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Health Professionals ◽  
Health Study ◽  
Follow Up Study

scholarly journals Lack of gene–diuretic interactions on the risk of incident gout: the Nurses’ Health Study and Health Professionals Follow-up Study

2015 ◽  
Vol 74 (7) ◽  
pp. 1394-1398 ◽  
Author(s):  
Ying Bao ◽  
Gary Curhan ◽  
Tony Merriman ◽  
Robert Plenge ◽  
Peter Kraft ◽  
...  
Keyword(s):  
Genetic Predisposition ◽  
Health Professionals ◽  
Risk Scores ◽  
Health Study ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
P Values ◽  
Follow Up Study

BackgroundDiuretic-induced gout might occur only among those with a genetic predisposition to hyperuricaemia, as suggested by a recent study with 108 self-reported gout cases.MethodsWe examined the role of urate genes on the risk of diuretic-induced incident gout in 6850 women from the Nurses’ Health Study (NHS) and in 4223 men from the Health Professionals Follow-up Study (HPFS). Two published genetic risk scores (GRSs) were calculated using urate-associated single-nucleotide polymorphisms for 8 (GRS8) and 29 genes (GRS29).ResultsOur analyses included 727 and 354 confirmed incident gout cases in HPFS and NHS, respectively. The multivariate relative risk (RR) for diuretic use was 2.20 and 1.69 among those with GRS8 < and ≥ the median (p for interaction=0.27). The corresponding RRs using GRS29 were 2.19 and 1.88 (p for interaction=0.40). The lack of interaction persisted in NHS (all p values >0.20) and in our analyses limited to those with hypertension in both cohorts. SLC22A11 (OAT4) showed a significant interaction only among women but in the opposite direction to the recent study.ConclusionsIn these large prospective studies, individuals with a genetic predisposition for hyperuricaemia are not at a higher risk of developing diuretic-induced gout than those without.

scholarly journals Adulthood Weight Change and Risk of Colorectal Cancer in the Nurses' Health Study and Health Professionals Follow-up Study

2015 ◽  
Vol 8 (7) ◽  
pp. 620-627 ◽  
Author(s):  
Mingyang Song ◽  
Frank B. Hu ◽  
Donna Spiegelman ◽  
Andrew T. Chan ◽  
Kana Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Weight Change ◽  
Health Professionals ◽  
Health Study ◽  
Follow Up Study
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