Deregulated HOXB7 expression predicts poor prognosis of patients with malignancies of digestive system

2019 ◽  
Vol 74 (5) ◽  
Author(s):  
Fang-Teng Liu ◽  
Han-Min Chen ◽  
Ying Xiong ◽  
Zheng-Ming Zhu
Keyword(s):  
Poor Prognosis ◽  
Digestive System

Maxillary Metastasis of Esophageal Cancer: Report of the First Case and Literature Review

2019 ◽  
Vol 21 (10) ◽  
pp. 801-805 ◽  
Author(s):  
Hong Hu ◽  
Jing Wang ◽  
Xiao-Yun Zhou ◽  
Meng-Ting Tong ◽  
Chong-Ya Zhai ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Differential Diagnosis ◽  
Bone Metastasis ◽  
Poor Prognosis ◽  
Digestive System ◽  
Diagnostic Techniques ◽  
Hematogenous Metastasis ◽  
First Case ◽  
System Tumor ◽  
Marker Detection

Background: Esophageal cancer (EC) is a common digestive system tumor, characterized by high invasion, apparent lethality, and poor prognosis. Direct diffusion is the major metastatic mechanism of early EC, whereas advanced EC is spread mainly by lymphatic metastasis, but also can be transferred to the liver, lungs, bones, and so on, by hematogenous metastasis. The incidence of bone metastasis in esophageal cancer is low, and maxillary metastasis of EC is more rare. Objective: To explore the differential diagnosis in ECMM, the rare metastasis of EC, and the possible mechanisms and predictors of bone metastasis. Methods: The clinical materials of a male patient with maxillary metastasis of esophageal cancer (ECMM) were analyzed. Then, the possible mechanism of the ECMM was discussed. Conclusion: ECMM may belong to the hematogenous metastasis. The early detection of rare sites of metastasis of EC should be prioritized in tumor marker detection, imaging, pathology, and other diagnostic techniques.

scholarly journals Undifferentiated Pleomorphic Sarcoma of Pancreas: A Case Report and Review of the Literature for the Last Updates

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Behnam Sanei ◽  
Amirhosein Kefayat ◽  
Melika Samadi ◽  
Parvin Goli ◽  
Mohammad Hossein Sanei ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Poor Prognosis ◽  
Digestive System ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Pancreatic Tumors ◽  
Review Of The Literature ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pancreas Head ◽  
Pleomorphic Sarcoma

The most prevalent type of soft tissue sarcoma is undifferentiated pleomorphic sarcoma (UPS) or previously known as malignant fibrous histiocytoma. It accounts over 20% of all soft tissue sarcomas and occurs most frequently in the extremities, trunk, and retroperitoneum. However, it has been rarely observed in the digestive system. Pancreas sarcoma represents less than 1% of all pancreatic tumors, and primary UPS of the pancreas is even rarer. It exhibits high recurrence and poor prognosis. In this case, a 72-year-old woman with a UPS tumor which was located in the pancreas head and neck without adhesion to the retroperitoneum will be discussed.

scholarly journals B7-H3 and digestive system cancers

2021 ◽  
Vol 19 ◽  
pp. 205873922110005
Author(s):  
Liyun Zhou ◽  
Zhenhua Jiang ◽  
Jing Gu ◽  
Wenhui Gu ◽  
Shuangyin Han
Keyword(s):  
T Cell ◽  
Early Diagnosis ◽  
Family Member ◽  
Poor Prognosis ◽  
Digestive System ◽  
Immune Reaction ◽  
Molecular Targets ◽  
Vital Function ◽  
Diagnosis And Prognosis ◽  
B7 Family

Digestive system cancers (DSC) are the most common cancers worldwide and often associated with poor prognosis because of their characteristics of invasive and metastatic. Thus, it is particularly necessary to find novel molecular targets for early diagnosis, as well as targeted treatment of DSC. B7-H3, which was previously referred to as a modulatory ligand that regulate T-cell-mediated immune reaction, is a B7-family member of co-stimulatory biomolecules, and in recent years it was found that its concentration was remarkably up modulated in serum, as well as tissues of DSC patients. Numerous studies have documented that B7-H3 has a vital function in the DSC. Herein, we summarize the current literature on diagnosis and prognosis potential of B7-H3 in DSC including those of the esophagus, gastric, liver, pancreas, and colon.

scholarly journals Poor prognosis of hexokinase 2 overexpression in solid tumors of digestive system: a meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (19) ◽  
pp. 32332-32344 ◽  
Author(s):  
Jiayuan Wu ◽  
Liren Hu ◽  
Fenping Wu ◽  
Lei Zou ◽  
Taiping He
Keyword(s):  
Solid Tumors ◽  
Poor Prognosis ◽  
Digestive System ◽  
Meta Analysis ◽  
Hexokinase 2 ◽  
System A

scholarly journals A Risk Signature Established From Three Coagulation-fibrinolysis Genes Predicts Prognosis in Digestive System Pancancer

2022 ◽  
Author(s):  
Xingyun Wang ◽  
Jinli Ji ◽  
Ying Jiang ◽  
Yiyang Zhao ◽  
Zheyao Song ◽  
...  
Keyword(s):  
High Risk ◽  
Poor Prognosis ◽  
Digestive System ◽  
Risk Group ◽  
Epigenetic Modification ◽  
Enrichment Analysis ◽  
Risk Groups ◽  
High Risk Group ◽  
Gene Set Enrichment Analysis ◽  
Cox Analysis

Abstract Venous thromboembolism (VTE) is one of the major complications of digestive system cancer, and coagulation-fibrinolysis genes play an important role in VTE. We used univariate Cox analysis, least absolute shrinkage and selection operator (LASSO), and multivariate Cox analysis to construct 3-PCFGs (prognostic coagulation-fibrinolysis genes) model based on six prognostic coagulation-fibrinolysis genes. Gene set enrichment analysis (GSEA) was used to analyze the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of the high- and low-risk groups. In addition, we classified digestive system pancancer patients into three clusters A, B, and C based on 3-PCFGs by K means. High-risk group and cluster C were associated with poor prognosis in digestive system pancancer. The m6A-related genes ALKBH5, FTO, RBM15, YTHDC1, and YTHDC2 (P<0.001) were highly expressed in the high-risk group and cluster C. The risk score was positively correlated with cancer-associated fibroblasts and endothelial cells. Cluster C had the highest immune score and stromal score. The poor prognosis in the high-risk group and cluster C may be affected by m6A epigenetic modification and immune microenvironment components in the digestive system pancancer.

scholarly journals Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies

2016 ◽  
Vol Volume 9 ◽  
pp. 4277-4288 ◽  
Author(s):  
Jiayuan Wu ◽  
Liren Hu ◽  
Manyu Chen ◽  
Wenjun Cao ◽  
Haicong Chen ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Solid Tumors ◽  
Pyruvate Kinase ◽  
Poor Prognosis ◽  
Digestive System ◽  
Pyruvate Kinase M2

scholarly journals Clinical Significance of UCA1 to Predict Metastasis and Poor Prognosis of Digestive System Malignancies: A Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Xiao-Dong Sun ◽  
Chen Huan ◽  
Wei Qiu ◽  
Da-Wei Sun ◽  
Xiao-Ju Shi ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Clinical Significance ◽  
Poor Prognosis ◽  
Digestive System ◽  
Meta Analysis ◽  
Univariate Analysis ◽  
Disease Free Survival ◽  
Cochrane Library ◽  
Poor Overall Survival ◽  
Free Survival

Purpose. Urothelial carcinoma-associated 1 (UCA1) has been reported to be overexpressed and correlated with progression in various cancers. However, the association between UCA1 expression and some clinicopathological features of digestive system malignancies, such as metastasis and survival, remains inconclusive. Therefore, a meta-analysis was performed to investigate the clinical significance of UCA1 in digestive system malignancies.Methods. Relevant literatures were searched in PubMed, Web of Science, Cochrane Library, and Embase databases updated to May 2016.Results. A total of 1089 patients from 10 studies were included in this meta-analysis. Meta-analysis results showed that digestive system malignancy patients with UCA1 overexpression were significantly more susceptible to developing lymph node metastasis (LNM) (OR = 1.85, 95% CI: 1.28–2.67) and distant metastasis (DM) (OR = 3.14, 95% CI: 1.77–5.58) and suffer from poor overall survival (OS) (HR = 2.31, 95% CI: 1.89–2.82, univariate analysis; HR = 2.24, 95% CI: 1.69–2.98, multivariate analysis) and poor disease-free survival (DFS) (HR = 2.65, 95% CI: 1.59–4.43, univariate analysis; HR = 2.50, 95% CI: 1.62–3.86, multivariate analysis).Conclusion. UCA1 overexpression was correlated with LNM, DM, poor OS, and poor DFS. UCA1 may serve as an indicator for metastasis and poor prognosis in digestive system malignancies.

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