scholarly journals Endothelin Level and Its Correlation with Uric Acid in Type 2 Diabetic Multiuse Patients

2020 ◽  
Vol 31 (3) ◽  
pp. 35
Author(s):  
Zahraa Majid Ismail ◽  
Zyad Hussein Jawad ◽  
Ali Jasim Hammood
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Significant Positive Correlation ◽  
Endothelial Damage ◽  
Control Group ◽  
Factors Influencing ◽  
Direct Linkage ◽  
The Mean ◽  
Type 2 Diabetic

This research aims to find the direct linkage among the Uric acid rates with Endothelin (ET-1), which is considered the indication of endothelial dysfunction or endothelial damage in patients with T2-DM. This study, included 96 patients with T2-DM and 96 controls, the mean age ranged (56.73 ± 9.14), (56.42 ± 8.74) respectively. Results showed a highly significant increase in Endothelin (ET-1) levels, uric acid, urea, and systolic blood pressure (SBP) was observed as compared with the control group, while Diastolic blood pressure (DBP) and body mass (BMI) were not substantially increased. Additionally, a significant positive correlation was found between ET-1 with uric acid, urea, SBP, DBP in patients with T2-DM (p < 0.05). Finally, elevated uric acid levels in older people who have chronic blood pressure are one of the factors influencing the increased release of ET-1, thus the development of cardiovascular disease.

Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Hadi Bazyar ◽  
Seyed Ahmad Hosseini ◽  
Sirous Saradar ◽  
Delsa Mombaini ◽  
Mohammad Allivand ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profile ◽  
Atherogenic Index ◽  
Control Group ◽  
Atherogenic Index Of Plasma ◽  
The Mean

Abstract Background In patients with type 2 diabetes mellitus (T2DM) the inflammatory and metabolic responses to epigallocatechin-3-gallate (EGCG) are unknown. Objectives Evaluate the impacts of EGCG on metabolic factors and some biomarkers of stress oxidative in patients with T2DM. Methods In this randomized, double-blind, placebo-controlled trial, 50 patients with T2DM consumed either 2 tablets (300 mg) EGCG (n=25) or wheat flour as placebo (n=25) for 2 months. The total antioxidant capacity (TAC), interleukin-6 (IL-6), lipid profile, mean arterial pressure (MAP), atherogenic index of plasma (AIP) were evaluated before and after the intervention. Results The finding of present study exhibited a significant increase in the serum levels of TAC after the EGCG supplementation (p=0.001). Also, in compare with control group, the mean changes of TAC were significantly higher in supplement group (p=0.01). In intervention group, a significant decrease was observed in the mean levels of triglyceride, total cholesterol, diastolic blood pressure (DBP), AIP, and MAP (p<0.05). Taking EGCG resulted in the mean changes of total cholesterol, MAP and DBP were significantly lower in compare with control group (p<0.05). Conclusions This study recommended that EGCG supplementation may be improved blood pressure, lipid profile, AIP, and oxidative status in patients with T2DM.

scholarly journals Comparative Study of Level of Serum Uric Acid in Type 2 Diabetes Mellitus Associated with Hypertension

2018 ◽  
Vol 9 (2) ◽  
pp. 96-101
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Nazneen Sultana ◽  
Md Jamil Hasan Karami ◽  
Ayatunnessa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Exercise Time ◽  
The Mean ◽  
And Control

Background: The role of uric acid in the progression of prediabetes to diabetes has been known. Serum uric acid has been shown to beassociated with cardiovascular disease, hypertension, and chronic kidney disease. However, conflicting data exist asregards the serum uric acid (UA) levels in type 2 diabetes mellitus, which are associated with risk factors andcomplications.Material & Methods: The present study was designed to look for any association of serum uric acid with hypertension in type 2diabetes mellitus, taking into consideration the relevant clinical, biochemical and the anthropometric data. 110 patientswith type 2 male diabetes mellitus as case and 100 healthy malecontrols were included in this study.Results: This study shows that there were significant differences in mean of age, duration of DM, exercise time, waist hip ratio, systolic blood pressure and diastolic blood pressure within case and control but no significant differences of mean BMI was found between and control. The mean age, duration of DM, exercise time, waist hip ratio, systolic blood pressure and diastolic blood pressure and BMI were (51.83±9.911 years, 6.87±5.54 years, 1.94±.831 hours, .92±.03, 140±6.75 mm of Hg,90±2.41 mm of Hg and 25.43±3.19 Kg/m2 respectively), where as in controls these were (44.81±9.66 yrs, 00 years, 1.12±.327 hours, .91±.03, 130±1.28 mm of Hg, 80±6.18 mm of Hg and 24.96±3.02 Kg/m2 respectively). This table also shows that significant differences in mean of FBS, ABF, HbA1C and S. Uric acid between case and control, but there was no significant differences of mean TG, Cholesterol, HDL and LDL. The mean of FBS, ABF, HbA1C and S. Uric acid among the cases were (8.19±2.48 mmol/L, 11.29±3.47 mmol/L, 7.96±6.04 mg%, 189.72±111.36 mg/dl, 179±43 mg/dl, 38.38±13.77 mg/dl, 102.10±35.79 mg/dl and 8.39±2.61 mg/dl respectively, on the other hand among the control these were 5.91±1.13 mmol/L, 9.19±1.95 mmol/L, 5.93±1.01 mg%, 200±104.49 mg/dl, 183±42.25 mg/dl, 38.14±5.52 mg/dl, 110±33.23 mg/dl and 5.14±.84 mg/dl respectively.Anwer Khan Modern Medical College Journal Vol. 9, No. 2: Jul 2018, P 96-101

scholarly journals Therapeutic Effect of Abelmoschus manihot on Type 2 Diabetic Nonproliferative Retinopathy and the Involvement of VEGF

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Yue Zhao ◽  
Xu Yu ◽  
Yan Lou ◽  
Xinyi Sun ◽  
Boyu Zhu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Treatment Group ◽  
Remission Rate ◽  
Blood Lipid ◽  
Control Group ◽  
Progression Rate ◽  
Biochemical Indicators ◽  
Before And After ◽  
Type 2 Diabetic

Objective. To evaluate the efficacy of Abelmoschus manihot in treating type 2 diabetic nonproliferative retinopathy. Methods. It was a randomized controlled clinical trial. The recruited eighty subjects with type 2 diabetic nonproliferative retinopathy were randomly divided into treatment group and control group. The two groups received basic treatments including control of blood glucose, blood pressure and blood lipid, management of diet, exercise and health education, and monitoring of relevant indicators. Additionally, the treatment group was given oral administration of Abelmoschus manihot. All subjects were followed up on monthly basis for consecutive six months. The related parameters including diabetic retinopathy (DR) incidence rates, “Early Treatment Diabetic Retinopathy Study” (ETDRS) vision scores, retinal thicknesses in macular region, serum vascular endothelial growth factor (VEGF) levels, and biochemical indicators of both groups before and after treatment were accurately collected and statistically analyzed. Results. There were no significant differences of DR severity levels, ETDRS vision scores, macular retinal thicknesses such as cube average thickness (CAT), central subfield thickness (CST), and cube volume (CV), and serum VEGF levels between two groups before treatment. Meanwhile, there were no significant differences of demographic characteristics, case terminations, blood glucose, blood lipid, blood pressure, biochemical indicators of hepatorenal function, hypoglycemic drugs, hypotensive drugs, and other basic treatments between two groups during six months treatment. The present study suggested that the remission rate of DR and the ETDRS vision score in the treatment group were significantly higher than those of the control group (remission rate: 25.4% vs 9.3%, P=0.01; ETDRS score: 78 (72, 82) vs 72 (67, 80), P=0.0002) while the progression rate of DR in the treatment group was significantly lower than that of the control group (progression rate: 4.2% vs 18.7%, P=0.007) after six months treatment. In addition, the CAT, CST, CV, and serum VEGF levels of the treatment group were significantly improved after the treatment (CAT: 286 (278, 302) vs 282 (270, 295) μm, P<0.0001; CST: 251 (239, 274) vs 248 (235, 265) μm, P<0.0001; CV: 10.3 (10.0, 10.9) vs 10.1 (9.7, 10.6) mm3, P<0.0001; VEGF: 0.21 (0.14, 0.58) vs 0.16 (0.10, 0.23) ng/ml, P=0.0026), while there were no significant differences of the control group before and after treatment (CAT: 287 (279, 294) vs 287 (279, 295) μm, P=0.27; CST: 250 (240, 266) vs 252 (238, 266) μm, P=0.72; CV: 10.4 (10.1, 10.6) vs 10.4 (10.1, 10.7) mm3, P=0.53; VEGF: 0.21 (0.13, 0.66) vs 0.23 (0.12, 0.64) ng/ml, P=0.85). Conclusion. The study offered the novel evidence for the therapeutic effect of Abelmoschus manihot on type 2 diabetic nonproliferative retinopathy, which was associated with improved VEGF. This trial is registered with ChiCTR1800019292.

A STUDY OF SERUM URIC ACID LEVELS IN NEWLY DIAGNOSED CASES OF ESSENTIAL HYPERTENSION

2021 ◽  
pp. 72-74
Author(s):  
Deepak Jain ◽  
Ajith Thomas ◽  
Rajinder Singh Gupta
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Essential Hypertension ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Serum Uric Acid ◽  
Control Group ◽  
Newly Diagnosed ◽  
The Mean ◽  
And Control

Background: The association of raised serum uric acid levels with various cardiovascular risk factors has often led to the debate of whether raised serum uric acid levels could be an independent risk factor in essential hypertension. Hence, the present study was conducted for assessing the serum uric acid levels in cases of essential hypertension and comparing them with normal healthy, non-hypertensive controls. Materials & Methods: Sixty patients visiting in the department of general medicine, MMIMSR with newly diagnosed cases of essential hypertension [according to the Indian guidelines on Hypertension(IGH) III-2013] , fullling the inclusion criteria and after verifying the exclusion criteria were nally taken up for the study. Sixty controls of age and sex matched were taken from the same catchment area. Results: The mean age of the subjects of the essential hypertension group and control group was found to be 45.75 years and 47.8 years respectively. Mean systolic blood pressure and diastolic blood pressure among the subjects of the essential hypertension group was 161.3 and 102.3 mm of Hg. Mean systolic blood pressure and diastolic blood pressure among the subjects of the control group was 116.8 and 77.4 mm of Hg. Mean serum uric acid levels among the subjects of the essential hypertension group and control group was found to be 6.45 mg/dL and 5.57 mg/dLrespectively. Signicant results were obtained while comparing the mean serum uric acid levels among the subjects of the essential hypertension group and the control group. Hyperuricemia was present in 38.33 percent of the patients (23 patients) of the essential hypertension group and 13.33 percent of the patients (8 patients) of the control group. Signicant results were obtained while comparing the prevalence of hyperuricemia in between the two study groups.Conclusion: An independent relationship of elevated serum uric acid levels with hypertension and indicates the signicance of maintaining normal serum uric acid concentration to prevent hypertension.

scholarly journals The effects of anethum graveolens (dill) powder supplementation on glycemic control, lipid profile, some antioxidants and inflammatory markers, and gastrointestinal symptoms in type 2 diabetic patients: a double-blind, placebo-controlled trial

2019 ◽  
Author(s):  
Fatemeh Haidari ◽  
Mehrnoosh Zakerkish ◽  
Fatemeh Borazjani ◽  
Kambiz Ahmadi Angali ◽  
Golnaz Amoochi
Keyword(s):  
Lipid Profile ◽  
Intervention Group ◽  
Gastrointestinal Symptoms ◽  
Control Group ◽  
Diabetic Patients ◽  
Anethum Graveolens ◽  
Type 2 Diabetic Patients ◽  
The Mean ◽  
Type 2 Diabetic

Abstract Background: The objective of this study was to investigate the effects of anethum graveolens (dill) powder supplementation on glycemic control, lipid profile, some antioxidants and inflammatory markers, and gastrointestinal symptoms in type 2 diabetic patients. Material and methods: In this study, 42 type 2 diabetic patients were randomly allocated to intervention and control groups and received either 3 gr dill powder or placebo (3 capsules 1 gr) three per day. Fasting blood sugar (FBS), insulin, homeostatic model assessment of insulin resistance (HOMA- IR), lipid profile, hs-C-reactive protein (hs-CRP), total antioxidant capacity (TAC), malondialdehyde (MDA) and gastrointestinal symptoms were measured in all subjects at baseline and post-intervention. Results: The dill powder supplementation significantly decreased the mean serum levels of insulin, HOMA-IR, LDL-C and MDA in the intervention group in compare with baseline (p < 0.05). Also, the mean serum levels of HDL and TAC was significantly increased in the intervention group in compare with baseline (p < 0.05). Colonic motility disorders was the only gastrointestinal symptom that its frequency was significantly reduced by supplementation (P = 0.01). The mean changes of insulin, LDL-c and MDA were significantly lower in intervention group in compare with control group (p < 0.05). In addition, the mean changes of HDL was significantly higher in intervention group in compare with control group (p < 0.05). Conclusion: It is recommended that dill powder supplementation may be effective in control of the glycemic, lipid, stress oxidative and gastrointestinal symptoms in type 2 diabetic patients.

scholarly journals Irisin Levels Related to Glycosylated Hemoglobin in Type 2 Diabetic Obese Women

2020 ◽  
pp. 2150-2155
Author(s):  
Raghd A. Y. Alkhader ◽  
Khitam Abdul Wahab Ali ◽  
Abbas Mahdi Rahmah Al-Kharasani
Keyword(s):  
Glycosylated Hemoglobin ◽  
Control Group ◽  
Obese Women ◽  
Hormone Levels ◽  
The Mean ◽  
Type 2 Diabetic ◽  
Group Serum

The aim of the preset study is to explain the role of irisin hormone levels in type-2 obese diabetic women and compare these levels with those in obese nondiabetic women. In addition, we investigated the relation of irisin levels with those of glycated hemoglobin (HbA1c) and body mass index (BMI) in the patients. Eighty eight subjects were included in this study, including 44 type-2 Iraqi obese diabetic women as a patients group, and 44 obese nondiabetic women as a control group. Serum irisin was measured by Enzyme-linked Immune-Sorbent assay (ELISA), while determination of glycosylated Hemoglobin was carried out by The SD A1c CareTM system. Diabetic type-2 obese women showed a highly significant decrease in the levels of serum irisin when compared to levels in obese non-diabetic women, while no significant changes were observed in the mean±SD values when comparing age and duration of DM. In the patients, a negative correlation was found between serum irisin and HbA1c while no significant correlation was recorded between the hormone levels and BMI.

scholarly journals Influence of Ramadan Fasting on Hemoglobin A1C, Lipid Profile, and Body Mass Index among Type 2 Diabetic Patients in Najran City, Saudi Arabia

2021 ◽  
Vol 9 (B) ◽  
pp. 318-325
Author(s):  
Hatem Mohamed ◽  
Anass M. Abbas ◽  
Mohammed Ayed Huneif ◽  
Seham M. Alqahtani ◽  
Awad Mohamed Ahmed ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Ramadan Fasting ◽  
The Mean ◽  
The Impact ◽  
Type 2 Diabetic

BACKGROUND: Saudi Arabia is known to have one of the highest prevalence of diabetes in the world. The impact of Ramadan fasting on the health of type 2 diabetic patients is an important issue that has not been adequately investigated. AIM: The current study was aimed at assessing the impact of Ramadan fasting on hemoglobin A1C (HbA1c), lipid profile, blood pressure, and body mass index (BMI) in adult Saudis with Type 2 diabetes residing in Najran city. METHODS: This is a descriptive cross-sectional study which enrolled 289 patients who chose to fast during the month of Ramadan and were attending the outpatient clinics of Najran University Hospital. Fasting blood samples were taken 1 month before and 1 month after Ramadan to determine glycated hemoglobin and fasting lipid profile (low-density lipoprotein [LDL], high-density lipoprotein [HDL], triglyceride [TG], and total cholesterol [TC]) and BMI was also calculated. Information regarding demographics and physical activity was obtained through a questionnaire. RESULTS: As many as 176 (60.9%) of the participants reported to be physically inactive during Ramadan. There was a statistically significant (p < 0.05) decrease in the mean percentage of HbA1c when comparing before Ramadan (9.85 ± 2.37%) with after Ramadan (7.65 ± 1.70%). Furthermore, statistically significant difference (p < 0.05) was detected in the mean concentrations of LDL before (3.39 ± 1.06 mmol/L) and after (2.40 ± 0.83 mmol/L) Ramadan. The mean concentration of TC (before = 5.98 ± 2.00 mmol/L; after = 4.05 ± 1.18 mmol/L) and TG (before = 2.97 ± 1.95 mmol/L; after = 2.65 ± 1.65 mmol/L) also reduced after Ramadan. The mean concentrations of HDL (before = 1.78 ± 0.74 mmol/L; after= 2.23 ± 0.23 mmol/L) increased after Ramadan. The mean BMI of the study participants (before = 28.30 ± 6.27; after = 27.43 ± 5.92) decreased slightly after Ramadan. The systolic blood pressure (SBP) (before= 128.10 ± 6.32; after, 123.09 ± 5.71) and diastolic blood pressure (DBP) (before = 81.21 ± 8.51; after = 79.83 ± 7.21) showed a slight reduction after Ramadan. CONCLUSIONS: Type 2 diabetic patients who performed Ramadan fasting displayed a lowering of HbA1c, LDL, TC, and TG, and increased HDL, but had small positive effects on body weight, BMI, as well as SBP and DBP. More studies are needed with a larger population in the future to assess the potential of Ramadan fasting as a therapeutic strategy for managing Type 2 diabetes.

scholarly journals EFFECTS OF ISOLATED AND COMBINED EFFECTS OF AEROBIC DANCING AND RESISTANCE TRAINING ON SYSTOLIC BLOOD PRESSURE OF TYPE-2 DIABETIC PATIENTS

2017 ◽  
Vol 5 (10) ◽  
pp. 11-16
Author(s):  
D. Maniazhagu
Keyword(s):  
Blood Pressure ◽  
Resistance Training ◽  
Systolic Blood Pressure ◽  
Control Group ◽  
Diabetic Patients ◽  
Combined Effects ◽  
Type 2 Diabetic Patients ◽  
Experimental Group ◽  
Type 2 Diabetic

The purpose of study was to find out the effects of isolated and combined effects of aerobic dancing and resistance training on systolic blood pressure of type-2 diabetic patients.  To achieve the purpose of the study, 60 type 2 diabetic patients from Karaikudi town, Sivaganga District, Tamilnadu were selected as subject at random. The study was formulated as pre and posttest random group design, in which sixty subject were divided into four equal groups. The experimental group-1 (n=15, AD, experimental group-2 (n=15, RT), experimental group – 3 (n=15, COM-T) and group-4 (n=15, CG) served as a control group. In this study, three training programme were adopted as independent variable, i.e., aerobic dancing, resistance training and combined training. The systolic blood pressure was chosen as dependent variable. The collected pre and post data was critically analyzed with apt statistical tool of analysis of co-variance. The Scheffe’s post hoc test was used to find out pair-wise comparisons between groups. The results of the present study proved that the three training interventions have produced significantly altered on systolic blood pressure.

Transfer of knowledge from the specialist to the generalist by videoconferencing: effect on diabetes care

2002 ◽  
Vol 8 (6) ◽  
pp. 350-355 ◽  
Author(s):  
Heidemarie Abrahamian ◽  
Andrea Schueller ◽  
Harald Mauler ◽  
Rudolf Prager ◽  
Karl Irsigler
Keyword(s):  
Blood Pressure ◽  
Diabetes Care ◽  
Hospital Admissions ◽  
Diabetic Patients ◽  
Transfer Of Knowledge ◽  
Type 2 Diabetic Patients ◽  
The Mean ◽  
Type 2 Diabetic

We conducted a 12-month prospective interventional study of videoconferencing between primary and secondary care. A treatment network consisting of a diabetes specialist and four general practitioners was established. The communications medium was PC-based videoconferencing via ISDN at 128 kbit/s. A total of 154 type 2 diabetic patients entered the study. The specialist was contacted 94 times via videoconferencing. Metabolic and haemodynamic parameters were significantly improved over the course of the study: the mean HbA1c level fell from 8.1% to 7.8%, systolic blood pressure from 156 to 148 mmHg and diastolic blood pressure from 88 to 83 mmHg. The study demonstrated that therapeutic counselling by videoconferencing is feasible in diabetes care and suggests that it reduces hospital admissions and improves the quality of care.

scholarly journals Association between decreased thyroid stimulating hormone and hyperuricemia in type 2 diabetic patients with early-stage diabetic kidney disease

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiaomeng Feng ◽  
Jing Huang ◽  
Yan Peng ◽  
Yuan Xu
Keyword(s):  
Uric Acid ◽  
Diabetic Kidney Disease ◽  
Early Stage ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
And Control ◽  
Type 2 Diabetic

Abstract Background Serum uric acid (SUA) is associated with the development of diabetic kidney disease (DKD). Thyroid hormones can regulate metabolism and insulin resistance. The relationship between SUA and thyroid function in patients with DKD is still uncertain. In current study, we aimed to investigate the association between thyroid stimulating hormone (TSH) and SUA in type 2 diabetic patients with early-stage DKD. Methods Two hundred fifty-four type 2 diabetic patients with early-stage DKD were enrolled in current study and were further classified as high SUA group (SUA level > 420 μmol/L in males or > 360 μmol/L in females, n = 101) and normal SUA group (SUA level ≤ 420 μmol/L in males or ≤ 360 μmol/L in females, n = 153). Eighty-five control subjects were recruited as control group. The clinical characteristics were obtained via face-to-face surveys and medical records. Results Compared with normal SUA group and control group, high SUA group exhibited the increased SUA level, and the decreased TSH level (P < 0.017 for all), and no significant difference was detected in SUA and TSH between normal SUA group and control group. TSH was negatively associated with SUA (r = − 0.35, P < 0.001) in type 2 diabetic participants with early-stage DKD. Furthermore, the decreased TSH level was independently correlated with higher SUA level (β = − 25.69, P < 0.001), and retained a significant association with hyperuricemia (odds ratio = 1.73, P = 0.002) after adjusting for confounding factors in type 2 diabetic patients with early-stage DKD. Conclusions TSH is negatively correlated with SUA, and decreased TSH is an independent risk factor for hyperuricemia in type 2 diabetic patients with early-stage DKD. These results indicate that thyroid hormones, TSH in particular, might participate in regulating uric acid metabolism in patients with early-stage DKD.

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