scholarly journals MORPHOMETRIC INDICES OF ERYTHROCYTES IN DIFFERENT FORMS OF IRON DEFICIENCY ANEMIA AND MALIGNANT ANEMIA IN COLORECTAL CANCER

10.23856/4330 ◽  
2021 ◽  
Vol 43 (6) ◽  
pp. 235-239
Author(s):  
Artem Andriiaka ◽  
Stanislav Vydyborets
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Peripheral Blood ◽  
Underlying Disease ◽  
Deficiency Anemia ◽  
Control Group ◽  
Observation Group ◽  
Diagnostic And Prognostic Value

Due to the growing incidence of cancer in the world, it is becoming more relevant to study the indicators of secondary changes in blood in malignancies to use them as diagnostic and prognostic markers. The objective of the work is to conduct a morphometric analysis of peripheral blood erythrocytes in patients with iron deficiency anemia (IDA) and malignant anemia in colorectal cancer to identify specific changes and use them in a differential diagnostic practice. As the study material blood of 110 patients (58 men and 52 women) was taken. Among them 53 patients (31 women and 22 men) with IDA were examined, they formed the first (I) observation group and 57 patients (36 men and 21 women) with colorectal cancer, where the course of the underlying disease was burdened by malignant anemia second (II) observation group. The age of the patients under the survey is from 22 to 69 years. All patients were examined before any treatment was prescribed. The control group consisted of 50 healthy primary donors. Results. The data on the clinical significance of laboratory determination of morphometric changes in peripheral blood erythrocytes is highlighted in this paper. Differential-diagnostic and prognostic value of morphometric changes of erythrocytes in peripheral blood with iron deficiency anemia and anemia of malignancies is discussed. Indicators of morphometric characteristics of erythrocytes can be used in the differential diagnosis of anemia.

scholarly journals DYNAMICS OF HISTAMINE LEVEL IN THE BLOOD PLASMA OF MALIGNANT NEOPLASM ANEMIA IN PATIENTS WITH COLORECTAL CANCER

World Science ◽  
2021 ◽  
Author(s):  
Stanislav Vydyborets ◽  
Artem Andriiaka
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Malignant Tumor ◽  
Malignant Neoplasm ◽  
Diagnostic Value ◽  
Tissue Hypoxia ◽  
Biologically Active ◽  
Deficiency Anemia ◽  
Control Group

Colorectal cancer is an extremely urgent issue in modern medicine. This disease is often complicated by anemia, which has specific pathogenetics mechanisms of development and forms a mutual burden syndrome of diseases in cancer patients. The anemic syndrome is accompanied by the development of tissue hypoxia, which in turn activates the processes of oxidative stress and leads to increased release of biologically active compounds, in particular, biogenic amines. One of these is histamine. Its high concentrations cause spasm of the arterioles, which exacerbates tissue hypoxia. We have examined (n=153) patients with colorectal cancer without anemia, (n=75) patients with colorectal cancer complicated bymalignant tumor anemia, and (n=53) patients with iron deficiency anemia. The content of plasma free serotonin fractions was determined by the fluorometric method proposed by Mikhailychenko B.V., Vydyborets S.V. (1999). The patients with iron deficiency anemia and malignant tumor anemia have shown to have a significant increase in plasma free histamine, compared with the control group and the group of patients with colorectal cancer with out anemia. Plasma free histamine was increasing together with the severity of anemia. The article discusses the feasibility of using the content of plasma free histamine, as an option, to assess the state of compensation of secondary metabolic disorders in iron deficiency anemiaand malignant tumor anemia during treatment and its possible differential diagnostic value.

scholarly journals Blood cells enzymes as an indicator of adaptive processes in newborns delivered off by mothers with iron deficiency anemia

2015 ◽  
Vol 96 (2) ◽  
pp. 177-181
Author(s):  
G M Khaybullina
Keyword(s):  
Iron Deficiency ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Deficiency Anemia ◽  
Control Group ◽  
Cytochemical Analysis ◽  
Adaptive Processes ◽  
Blood Neutrophils ◽  
Latent Iron Deficiency

Aim. To explore the enzymes in blood cells of newborns from mothers with iron deficiency anemia.Methods. During the study, 150 infants and their mothers underwent clinical and laboratory examination, of whom 130 infants had antenatal iron deficiency of different severity (main group), 20 children were included in the control group. Cytochemical analysis of peripheral blood was performed on 1st, 3rd, 7th day after birth by smear staining and determination of succinate dehydrogenase in lymphocytes, myeloperoxidase in neutrophils, acid and alkaline phosphatase in neutrophils and lymphocytes by microscopic analysis.Results.Succinate dehydrogenase activity was reduced on the 3rd day of life in lymphocytes of the newborns of the first group who were delivered off by mothers with latent iron deficiency. Average level of acid phosphatase in lymphocytes and neutrophils was higher compared to controls throughout the study (pConclusion. Cytochemical studies of peripheral blood neutrophils and lymphocytes may be used as a screening test to assess the immunity in newborns who were delivered off by mothers with iron deficiency, and for personalized management of patients with comorbidities.

scholarly journals Changes of Serum Ferritin, Hemoglobin, and Serum Iron (SI) and Treatment Effect of Iron Proteinsuccinylate Oral Solution Combined with Vitamin A and D Drops on Children with Nutritional Iron Deficiency Anemia

2022 ◽  
Vol 2022 ◽  
pp. 1-6
Author(s):  
Yan Ma ◽  
Yanbo Ma ◽  
Xiuqing Zhang ◽  
Xuejing Wang ◽  
Zhigang Sun
Keyword(s):  
Iron Deficiency ◽  
Vitamin A ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Treatment Effect ◽  
Serum Iron ◽  
Oral Solution ◽  
Deficiency Anemia ◽  
Control Group ◽  
Observation Group

Objective. The purpose was to evaluate the treatment effect of iron proteinsuccinylate oral solution combined with vitamin A and D drops on children with nutritional iron deficiency anemia. Methods. 124 children treated in the outpatient department of our hospital from January 2017 to January 2020 were selected as the study subjects. They were randomly divided into control and observation two groups. The control group was treated with iron proteinsuccinylate oral solution (1.5 mL/kg) in the morning and evening, respectively. The observation group received adjuvant treatment with oral vitamin A and D drops based on the treatment of the control group. The treatment effect of proteinsuccinylate oral solution combined with vitamin A and D drops was evaluated by the serum iron (SI), serum ferritin (SF), and transferrin (TRF) levels, the values of CD3+, CD4+, and CD4+/CD8+, and other evaluation indicators. Results. After treatment, the SI and SF levels of children in both groups significantly increased ( P < 0.01 ) while the TRF level significantly decreased ( P < 0.01 ), and the SI and SF levels in the observation group increased more significantly, and the TRF level decreased more significantly compared with those in the control group ( P < 0.01 ). After treatment, the values of CD3+, CD4+, and CD4+/CD8+ of children in both groups significantly increased compared with those before treatment ( P < 0.01 ), and the values of CD3+, CD4+, and CD4+/CD8+ increased more significantly in the observation group compared with those in the control group ( P < 0.01 ). In addition, the evaluation results of treatment effect showed that the markedly effective rate in the observation group was significantly higher than that in the control group ( P < 0.01 ). Conclusion. Iron proteinsuccinylate oral solution combined with vitamin A and D drops can better improve the anemia symptoms in children, with high application value.

scholarly journals Role of Serum Transferrin Receptor in Diagnosing and Differentiating Iron Deficiency Anemia from Anemia of Chronic Disease in Patients with Chronic Kidney Disease

2017 ◽  
Vol 7 (2) ◽  
pp. 132-137
Author(s):  
Abdul Latif ◽  
Muhammad Rafiqul Alam ◽  
Asia Khanam ◽  
Farhana Hoque ◽  
Muhammad Abdur Rahim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Chronic Disease ◽  
Kidney Disease ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Transferrin Receptor ◽  
Deficiency Anemia ◽  
Control Group ◽  
Anemia Of Chronic Disease ◽  
Female Ratio

Background: Anemia is common in patients with chronic kidney disease (CKD) and this is generally anemia of chronic disease, but iron deficiency anemia (IDA) is also common. Soluble transferrin receptor (sTfR) is a useful marker for IDA. Present study was undertaken to assess the utility of sTfR as a marker of IDA in selected group of Bangladeshi patients with CKD.Methods: This cross-sectional study was conducted in the Department of Nephrology, BSMMU, Dhaka, Bangladesh from January 2013 to December 2014. Patients with anemia admitted in nephrology department whether on hemodialysis or not and medicine department of BSMMU were taken for study. The study population was further divided into two groups; Group A, patients who are having IDA and Group B, patients with ACD and a control group was also selected. Data were collected by face to face interview and laboratory investigations with a self-administered questionnaire.Results: The mean age of the patients in two study groups were 38.40±13.23 and 34.85±10.52 years respectively and male-female ratio were 0.5:1 and 1:0.5. Mean sTfR level was higher (4.81± 1.64 ?g/ml) in patients with IDA than (2.89±1.40 ?g/ml) in patients with ACD (p <0.0001). In our study mean ferritin level was 599.59± 449.15?g/L in ACD patients whereas 101.23±119.42 in IDA patients (p<0.0001). Total iron binding capacity (TIBC) was more in ACD patients with sTfRe”3?g/ml as compared to ACD patients with sTfR<3?g/ml. Transferrin saturation (TSAT) level was significantly decreased in ACD patients with sTfR ?3?g/ml as compared to ACD patients with sTfR<3?g/ml.Conclusion: sTfR has a comparable ability to S. ferritin in diagnosing IDA and ACD. However, sTfR and serum ferritin alone cannot definitely exclude co-existing iron deficiency in ACD. As sTfR is not affected by infection and/or inflammation, thus providing a non-invasive alternative to bone marrow study.Birdem Med J 2017; 7(2): 132-137

scholarly journals Iron, Ferritin and Hepcidin Levels in Patients with Iron Deficiency Anemia

2021 ◽  
Vol 8 (5) ◽  
pp. 137-139
Author(s):  
Rabaa Khaled Abdel Salam ◽  
Saria Naji Mohsin
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Transport ◽  
Blood Parameters ◽  
Deficiency Anemia ◽  
Control Group ◽  
Blood Picture ◽  
Cellular Kinetics ◽  
And Storage

This study was conducted to identify the role of some blood parameters, levels of some hormones, proteins, and cellular kinetics that have a role in iron transport and storage, in addition to their relationship with each other and with blood and sex parameters for patients with severe and moderate iron deficiency anemia, and to compare the parameters with healthy people. The study period lasted for the period from (December 2020 until March 2021) The presence of iron deficiency anemia was confirmed by examining the blood picture and the criteria of hepcidin and ferritin. The results showed a significant decrease in the in the concentration of hepcidin, ferritin and iron in patients compared to the control group.

THE GASTROINTESTINAL EFFECTS OF IRON-DEFICIENCY ANEMIA

PEDIATRICS ◽  
1964 ◽  
Vol 33 (1) ◽  
pp. 83-99
Author(s):  
J. L. Naiman ◽  
F. A. Oski ◽  
L. K. Diamond ◽  
G. F. Vawter ◽  
H. Shwachman
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Control Group ◽  
Poor Correlation ◽  
Iron Treatment ◽  
High Incidence ◽  
Before And After ◽  
And Function ◽  
Duodenal Biopsies

A group of 14 infants and children with nutritional iron-deficiency anemia were studied with respect to gastrointestinal function and structure both before and after iron treatment. A high incidence of abnormalities was found, consisting of gastric achlorhydria, impaired absorption of xylose and vitamin A, and steatorrhea. Duodenal biopsies revealed varying degrees of chronic duodenitis and mucosal atrophy. There was poor correlation between structure and function. Following treatment with oral iron most of the abnormalities reverted to normal. A control group of 8 children with long-standing anemias not due to iron deficiency were subjected to similar studies, most of which yielded normal results. These observations indicate a diffuse and reversible enteropathy in children as a result of iron deficiency. The pathogenesis and practical implications are discussed.

scholarly journals The Effect of Iron Deficiency Anemia Early in the Third Trimester on Small for Gestational Age and Birth Weight: A Retrospective Cohort Study on Iron Deficiency Anemia and Fetal Weight

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Ilknur Col Madendag ◽  
Mefkure Eraslan Sahin ◽  
Yusuf Madendag ◽  
Erdem Sahin ◽  
Mustafa Bertan Demir ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Fetal Weight ◽  
Deficiency Anemia ◽  
Control Group ◽  
Third Trimester ◽  
Mild Anemia ◽  
Moderate Anemia ◽  
Anemia Group

Aim. The aim of the present study was to evaluate the relationship between iron deficiency anemia and small for gestational age (SGA) in early third trimester pregnancies. Methods. A total of 4800 pregnant women who met the inclusion criteria were analyzed retrospectively. We included pregnant women who had iron deficiency anemia between 26+0 and 30+0 weeks of gestation and delivered singletons between 37+0 and 41+6 weeks of gestation. Patients were divided into four groups according to anemia level: (1) hemoglobin (Hb) < 7 mg/dl (n = 80), (2) Hb 7–9.9 mg/dl (n = 320), (3) Hb 10–10.9 mg/dl (n = 1300), and (4) Hb > 11 mg/dl (n = 3100, control group). The primary outcome of this study was the presence of SGA. Results. The demographic and obstetric characteristics were similar among all the groups. Maternal age, BMI <30 kg/m2, nulliparity rates, and previous cesarean delivery rates were similar among groups. Ethnicity was significantly different in the severe and moderate anemia groups (<0.001). Mean fetal weight was 2900 ± 80 g in the severe anemia group, 3050 ± 100 g in the moderate anemia group, 3350 ± 310 g in the mild anemia group, and 3400 ± 310 g in the control group. Fetal weight was significantly lower in the severe and moderate anemia groups compared to the mild anemia and control groups (<0.001). The SGA rate was 18.7% in the severe anemia group, 12.1% in the moderate anemia group, 5.3% in the mild anemia group, and 4.9% in the control group. SGA was significantly higher in the severe and moderate anemia groups compared to the mild anemia and control groups (<0.001). Conclusion. The results of this study indicated that early third trimester severe and moderate iron deficiency anemia was associated with SGA. Iron deficiency anemia in pregnant women may lead to low birth weight.

scholarly journals Fermented Goat Milk Consumption Enhances Brain Molecular Functions during Iron Deficiency Anemia Recovery

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2394 ◽  
Author(s):  
Moreno-Fernández ◽  
López-Aliaga ◽  
García-Burgos ◽  
Alférez ◽  
Díaz-Castro
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Goat Milk ◽  
Nervous System Development ◽  
Cow Milk ◽  
Deficiency Anemia ◽  
Control Group ◽  
Brain Functions ◽  
Mao A ◽  
Molecular Functions

Iron deficiency anemia (IDA) is one of the most prevalent nutritional deficiencies worldwide. Iron plays critical roles in nervous system development and cognition. Despite the known detrimental consequences of IDA on cognition, available studies do not provide molecular mechanisms elucidating the role of iron in brain functions during iron deficiency and recovery with dairy components. In this study, 100 male Wistar rats were placed on a pre-experimental period of 40 days and randomly divided in two groups: a control group receiving a normal-Fe diet, (45 mg/kg), and an Fe-deficient group receiving a low-Fe diet (5 mg/kg). At day 40, 10 rats per group were sacrificed to anemia control, and 80 rats were divided into eight experimental groups fed with fermented goat or cow milk-based diets, with normal Fe content or Fe overload (450 mg/kg) for 30 days. IDA decreased most of the parameters related to brain molecular functions, namely dopamine, irisin, MAO-A, oxytocin, β-endorphin, and α-MSH, while it increased synaptophysin. These alterations result in an impairment of brain molecular functions. In general, during anemia recovery, fermented goat milk diet consumption increased dopamine, oxytocin, serotonin, synaptophysin, and α-MSH, and decreased MAO-A and MAO-B, suggesting a potential neuroprotective effect in brain functions, which could enhance brain molecular functions.

Tu1806 YOUNG ONSET COLORECTAL CANCER RISK AMONG INDIVIDUALS WITH IRON DEFICIENCY ANEMIA AND HEMATOCHEZIA

2020 ◽  
Vol 158 (6) ◽  
pp. S-1169
Author(s):  
Joshua Demb ◽  
Lin Liu ◽  
Caitlin C. Murphy ◽  
Chyke Doubeni ◽  
Maria Elena Martinez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Cancer Risk ◽  
Iron Deficiency Anemia ◽  
Colorectal Cancer Risk ◽  
Deficiency Anemia ◽  
Young Onset

scholarly journals Pengaruh Aplikasi Android Aneminfo terhadap Pengetahuan dan Sikap Remaja Putri terkait Anemia Defisiensi Besi

2020 ◽  
Vol 15 (2) ◽  
pp. 65-69
Author(s):  
Rizki Septia Saraswati ◽  
Apoina Kartini ◽  
Farid Agushybana
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Young Women ◽  
Intervention Group ◽  
Deficiency Anemia ◽  
Control Group ◽  
Android Application ◽  
Educational Media ◽  
Knowledge And Attitudes ◽  
Validated Questionnaire

Background: Iron deficiency anemia is one of the nutritional problems that still occur in Indonesia which is common in young women. Early nutrition education is needed to prevent these problems. The purpose of this study was to analyze the effect of the android-based educational media "Aneminfo" on the knowledge and attitudes of young women regarding iron deficiency anemia. Method: This research was conducted with a quasi-experimental design with a pre-post control group design with a sample of 37 people for each group taken from 2 vocational schools in the city of Semarang. The intervention was carried out using educational media in the form of the “Aneminfo” android application. Changes in knowledge and attitudes between before and after the intervention were measured using a validated questionnaire and tested using the Wilcoxon and Mann-Whitney tests. Results: The results showed a significant increase in knowledge in the intervention group (p = 0.001), and there was a significant increase in attitude in the intervention group (p = 0.011) compared to the control group. The conclusion of this study is the Aneminfo android application can be an alternative media for the government and health workers in providing education about iron deficiency anemia to increase adolescent knowledge and prevent anemia from an early age.

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