The article is devoted to a genealogy of the attitude toward viruses in social and political practice in light of the new coronavirus pandemic. The disciplinary society and the society of control have taken on a completely new configuration since the HIV crisis in the 1980s. AIDS and now COVID-19 as phenomena of social crisis have had a great impact on (sexual) relationships and have also caused a significant change in the social and political order. Epidemics and pandemics mobilize political structures and constitute power relations, thus changing the way bodies are controlled, establishing new differentiations and redefining what disease is. The authors trace the development of discourses about syphilis, AIDS and COVID-19 to describe how knowledge about the disease is being generated today; it has origins in myth and would be unthinkable without aesthetic visualization and mass media technologies. Syphilis was an exact fit for the paradigm of the disciplinary society, which stigmatized bodily pleasure and abstracted pathology by activating projection mechanisms as a sign of the Other. However, AIDS already differed significantly from that paradigm because other medical technologies are used to define HIV, and that has affected the epistemology of the disease and epidemic. The article considers HIV/AIDS as a transitional model that forms a bridge between the epidemics of the past (leprosy, plague, smallpox, syphilis) and the COVID-19 pandemic. Above all there is a change in the biopolitical regime so that bodies are no longer controlled and regulated through sexuality. COVID-19 is a new form of sociality which is not based on the exclusion of “pathological” forms of sexuality or on “deviant” or “perverted” bodies, but involves the object-based, microlevel of relations between viruses, the immune system, and the human genome, which are then mapped with distortions and substitutions onto social relationships and practices. The authors use the term “delegated control” in a new context and introduce the original term “omniopticum” to describe the new regime of biopolitics and the “control society” in the post-COVID era.