scholarly journals Levels of thyroid-stimulating and thyroid hormones in pregnant women with obesity and their newborns

2019 ◽  
Vol 4 (4) ◽  
pp. 58-63
Author(s):  
O. B. Karelina ◽  
N. V. Artymuk ◽  
O. A. Tachkova ◽  
T. Yu. Marochko ◽  
M. N. Surina
Keyword(s):  
Body Weight ◽  
Thyroid Hormones ◽  
Pregnant Women ◽  
Thyroid Stimulating Hormone ◽  
Obese Women ◽  
Third Trimester ◽  
Normal Body ◽  
Normal Body Weight ◽  
Chemiluminescent Immunoassay ◽  
Stimulating Hormone

Aim: To study the level of thyroid-stimulating and thyroid hormones in pregnant women with obesity and their newborns.Materials and Methods. We consecutively recruited 40 pregnant women and their newborns. Blood sampling in pregnant women was carried out at the end of the third trimester 12 hours after the last meal while in newborns it was conducted immediately after birth. Measurement of serum thyroid-stimulating hormone, thyroxine, triiodothyronine, and free thyroxine was performed using chemiluminescent immunoassay.Results. Thyroid disease was significantly more common in pregnant women with obesity. Clinical and latent hypothyroidism in obese pregnant women was observed 1.5-fold more frequently as compared with those having normal body weight. In keeping with these findings, goiter and elevated thyroxine were also more common in obese pregnant women. Newborns from obese women were more often characterized by a transient hypothyroidism in combination with an augmented thyroid-stimulating hormone.Conclusion. Levels of thyroid-stimulating and thyroid hormones in obese pregnant women and their newborns significantly differ from the patients with normal body weight.

Establishment of Early Pregnancy Related Thyroid Hormone Models and Reference Intervals for Pregnant Women in China Based on Real World Data

2021 ◽  
Vol 53 (04) ◽  
pp. 272-279
Author(s):  
Chaochao Ma ◽  
Xiaoqi Li ◽  
Lixin Liu ◽  
Xinqi Cheng ◽  
Fang Xue ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Pregnant Women ◽  
Early Pregnancy ◽  
Gestational Age ◽  
Dynamic Change ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
Stimulating Hormone

AbstractThyroid hormone reference intervals are crucial for diagnosing and monitoring thyroid dysfunction during early pregnancy, and the dynamic change trend of thyroid hormones during pregnancy can assist clinicians to assess the thyroid function of pregnant women. This study aims to establish early pregnancy related thyroid hormones models and reference intervals for pregnant women. We established two derived databases: derived database* and derived database#. Reference individuals in database* were used to establish gestational age-specific reference intervals for thyroid hormones and early pregnancy related thyroid hormones models for pregnant women. Individuals in database# were apparently healthy non-pregnant women. The thyroid hormones levels of individuals in database# were compared with that of individuals in database* using nonparametric methods and the comparative confidence interval method. The differences in thyroid stimulating hormone and free thyroxine between early pregnant and non-pregnant women were statistically significant (p<0.0001). The reference intervals of thyroid stimulating hormone, free thyroxine and free triiodothyronine for early pregnant women were 0.052–3.393 μIU/ml, 1.01–1.54 ng/dl, and 2.51–3.66 pg/ml, respectively. Results concerning thyroid stimulating hormone and free thyroxine reference intervals of early pregnancy are comparable with those from other studies using the same detection platform. Early pregnancy related thyroid hormones models showed various change patterns with gestational age for thyroid hormones. Early pregnancy related thyroid hormones models and reference intervals for pregnant women were established, so as to provide accurate and reliable reference basis for the diagnosing and monitoring of maternal thyroid disfunction in early pregnancy.

Influence of pregnancy on iron and copper exchange rates in women with normal body weight and women with obesity

2021 ◽  
Vol 66 (4) ◽  
pp. 205-209
Author(s):  
E. L. Makarova ◽  
N. A. Terekhina
Keyword(s):  
Body Weight ◽  
Blood Serum ◽  
Pregnant Women ◽  
Copper Metabolism ◽  
The Body ◽  
Reproductive Age ◽  
Perinatal Complications ◽  
Effective Prevention ◽  
Normal Body ◽  
Normal Body Weight

The number of obese pregnant women increases annually and reaches 20-30%. The metabolism of hormones and minerals changes in the presence of a large amount of adipose tissue in the body of a pregnant woman, which leads to a number of obstetric and perinatal problems. The aim of the work is to study and compare the influence of the gestational process on the indicators of iron and copper metabolism in the blood serum of women with normal body weight and women with obesity. In the blood serum of 125 women of reproductive age, the content of hemoglobin, iron, transferrin, ferritin, copper and ceruloplasmin was determined. The influence of pregnancy on the indicators of iron and copper metabolism in the blood serum of women was revealed. Pregnancy in women with normal body weight increases the content of transferrin and ceruloplasmin. Correlation of ceruloplasmin and ferritin content with body mass index of obese pregnant women was revealed. In pregnancy with concomitant obesity, hyperferritinemia is formed with a reduced content of hemoglobin and serum iron. Knowledge of the indicators of iron and copper metabolism is necessary to optimize the observation of pregnant women, effective prevention and prediction of obstetric and perinatal complications.

scholarly journals Establishment of assay method- and trimester-specific reference intervals for thyroid hormones during pregnancy in Chengdu, China

2020 ◽  
Author(s):  
Cheng Huang ◽  
Ying Wu ◽  
Linong Chen ◽  
Zhiya Yuan ◽  
Shuzhe Yang ◽  
...  
Keyword(s):  
Pregnant Women ◽  
First Trimester ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
Assay Method ◽  
Second Trimester ◽  
Third Trimester ◽  
Free Triiodothyronine ◽  
Stimulating Hormone

Abstract Background: The reference intervals of thyroid hormone will change at different stages of pregnancy because of physiological alterations. On the other hand, the reference intervals of hyroid hormone will also change in different detection systems due to manufacturer’s methodology as well as different race. The objective in this study was to establish the assay method- and trimester-specific reference intervals for thyroid stimulating hormone, free thyroxine, and free triiodothyronine for pregnant women in the Chengdu.Methods: A prospective, population-based cohort study involved 23701 reference samples of pregnant women during the three trimesters and 8646 non-pregnant women with pre-pregnancy clinical and laboratory tests. The 2.5th and 97.5th percentiles were calculated as the reference intervals for thyroid stimulating hormone, free thyroxine, and free triiodothyronine at each trimester of pregnant women according to ATA Guidelines.Results: The reference interval of thyroid stimulating hormone in the 2.5th and 97.5th percentiles has a significant increasing trend from first trimester, to second trimester, and to third trimester, which was 0.08-3.79 mIU/L for first trimester, and 0.12-3.95 mIU/L for second trimester, and 0.38-4.18 mIU/L for third trimester, respectively (P < 0.001). However, the reference intervals of free thyroxine and free triiodothyronine in the 2.5th and 97.5th percentiles have significant decreasing trends from first trimester, to second trimester, and to third trimester, which were 11.87-18.83 pmol/L and 3.77-5.50 pmol/L for first trimester, and 11.22-18.19 pmol/L and 3.60-5.41 pmol/L for second trimester, and 10.19-17.42 pmol/L and 3.37-4.79 pmol/L for third trimester, respectively (both P < 0.001).Conclusion: It is necessary to establish assay method- and trimester-specific reference intervals for thyroid stimulating hormone, free thyroxine, and free triiodothyronine because the reference intervals of these thyroid hormones are significantly different at different stages of pregnancy.

scholarly journals Hepcidin and Feritin Levels in Obese Pregnant Women and Normal Body Weight before Pregnancy

2018 ◽  
Vol 3 (1) ◽  
pp. 22-26
Author(s):  
Hadiyatur Rahma ◽  
◽  
Sarma N Lumbanraja ◽  
Zulfikar Lubis ◽  
◽  
...  
Keyword(s):  
Body Weight ◽  
Pregnant Women ◽  
Normal Body ◽  
Normal Body Weight

scholarly journals The study of pituitary-thyroid hormones ratio based on regression analysis

2015 ◽  
Vol 96 (5) ◽  
pp. 831-837
Author(s):  
F Kh Kamilov ◽  
V N Kozlov ◽  
V N Baymatov ◽  
A N Mamtsev ◽  
D Yu Smirnov
Keyword(s):  
Body Weight ◽  
Regression Analysis ◽  
Thyroid Hormones ◽  
Least Squares ◽  
Least Squares Method ◽  
Thyroid Stimulating Hormone ◽  
Hormone Levels ◽  
Relationship Of ◽  
The Relationship ◽  
Stimulating Hormone

Aim. To work up a mathematical model for calculation of the levels of pituitary-thyroid hormones system by least squares method in rats with experimental hypothyroidism. Methods. To study the relationship of hormones levels regression analysis was used. The search of coefficients was performed using the least squares method. Investigations were carried out on rats, which were divided into six groups of 12 rats each: the first group was control, in the animals of second, third, fourth, fifth and sixth groups hypothyroidism was induced by daily intragastric administration of tiamazol in following doses: 2.5; 20.0; 10.0; 5.0 and 1.0 mg per 100 g of rat body weight for 3 weeks. Results. Regression analysis was carried out, the type of regression as well as parameters were chosen; statistical analysis of the relationship of hormones was conducted based on the obtained results. By comparing the calculation results of the laboratory analysis sufficiently high reliability of the developed model was set up. The deviation of the arithmetic mean value of the level of thyroid stimulating hormone, produced on the basis of experimental and calculated data, is 2.7%. The accuracy of thyroid stimulating hormone levels calculations increased with the decrease of thyrostatic medication dose. The relative error while calculating the free thyroxine levels in the same groups of rats did not exceed 2.15%, accounting for 1.64; 1.34; 0.36 and 2.15%, respectively, when administered daily 20.0; 10.0; 5.0 and 1.0 mg of antithyroid drug per 100 g body weight. One can argue about the reliability of the constructed model to reproduce the performance levels of the hormones of the pituitary-thyroid system. Conclusion. In the absence of modern high sensitive immunochemiluminescent diagnostic methods the results can be used for thyroid-stimulating hormone levels calculation as one of the major markers of the thyroid gland functional state.

Viscerally obese women with normal body weight have greater brachial-ankle pulse wave velocity than nonviscerally obese women with excessive body weight

2007 ◽  
Vol 0 (0) ◽  
pp. 070215015809001-??? ◽  
Author(s):  
Ji-Won Lee ◽  
Hye-Ree Lee ◽  
Jae-Yong Shim ◽  
Jee-Aee Im ◽  
Sang-Hwan Kim ◽  
...  
Keyword(s):  
Body Weight ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Obese Women ◽  
Normal Body ◽  
Excessive Body Weight ◽  
Normal Body Weight

scholarly journals Levels of Thyroid Hormones and Human Chorionic Gonadotropin in Normotensive Pregnant Women

2016 ◽  
Vol 8 (4) ◽  
pp. 324-326
Author(s):  
Akhilesh Kumar Singh ◽  
Bechan Kumar Gautam
Keyword(s):  
Thyroid Hormones ◽  
Pregnant Women ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Hormonal Changes ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
Chemiluminescent Immunoassay

ABSTRACT During pregnancy the hormonal changes take place, resulting in changes in thyroid functions. The present study was conducted to determine thyroid hormones and human chorionic gonadotropin (hCG) in normotensive pregnancy. Fifty normotensive pregnant subjects were included in the study. Age-matched 50 nonpregnant subjects, not having any disease were taken as control. Total triiodothyronine (total T3), total thyroxine (total T4), thyroid stimulating hormone (TSH), and hCG were estimated by using enzyme amplified chemiluminescent immunoassay. The level of thyroid hormones was found significantly increased in normotensive pregnant subjects as compared to that of control group. We therefore conclude that investigations should be done routinely in pregnancy. How to cite this article Singh AK, Agrawal P, Gautam BK, Garg R. Levels of Thyroid Hormones and Human Chorionic Gonadotropin in Normotensive Pregnant Women. J South Asian Feder Obst Gynae 2016;8(4):324-326.

Sign in / Sign up

Export Citation Format

Share Document