Preventive Effect of Both Vitamin C and E on Sperm Abnormalities Caused by Nicotine in Male Albino Mice

2017 ◽  
Vol 2017 (Special-2) ◽  
pp. 152-160
Author(s):  
Galawezh Obaid Othman ◽  
◽  
Nadhum jalal Esmaeil ◽  
Keyword(s):  
Vitamin C ◽  
Preventive Effect ◽  
Sperm Abnormalities ◽  
Albino Mice

scholarly journals Vitamin-C Treated Haematology Assessment of Swiss Albino Mice (Mus musculus)

2020 ◽  
Vol 11 (2) ◽  
pp. 9044-9050
Keyword(s):  
Vitamin C ◽  
Blood Cell ◽  
Cell Count ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
The Body ◽  
Blood Cell Count ◽  
Swiss Albino Mice ◽  
Positive Effects ◽  
Albino Mice

Vitamin C is an essential dietary supplement that plays a vital role in battling health conditions. The antioxidant has positive effects on the functioning of the body. The purpose of this study is to investigate the outcome of varying concentrations of Vitamin C on the hematological parameters of Swiss Albino mice. Four albino mice were separated and accommodated in similar caging conditions. Three of them were orally administered with 250mg/kg, 500mg/kg, and 1000mg/kg Vitamin C powder, along with their diet. The fourth one was kept as control, in order to provide a standard value for future comparison. After 30 days of administration of the Vitamin C, the red blood cell count, the white blood cell count, the hemoglobin concentration, the platelet cell count, and the packed cell volume of the blood samples were tested.

scholarly journals Effect of adding Ferula hermonis Boiss roots and some antioxidants to Tris extender on post-cryopreserved sperm abnormalities percentage of Holstein bulls

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
T bdulkareem ◽  
R Khalil ◽  
A Salman
Keyword(s):  
Vitamin C ◽  
Blood Cells ◽  
Reduced Glutathione ◽  
Total Phenolic ◽  
Control Group ◽  
Alcoholic Extract ◽  
Sperm Abnormalities ◽  
Time Period ◽  
Cryopreserved Sperm ◽  
Holstein Bulls

This study was carried out to explore the adding effect of alcoholic extract of Ferula hermonis Boiss roots and some antioxidants to Tris extender on post-cryopreserved sperm abnormalities percentage of Holstein bulls for different preservation periods (cooling at 5°C, 2, 30 and 60 days post cryopreservation, PC). Eight Holstein bulls of 2.5-3 years of age were used in this study. Semen was collected via artificial vagina in one ejaculate per bull per week for the 7-week experimental period. Pooled semen was equally divided into eight treatments using Tris extender. The alcoholic extract of Ferula hermonis Boiss roots (0.03 ml/ 50 ml extender; T2), L-Carnitine (0.06g/ 50 ml extender; T3), reduced glutathione (0.03 g/ 50 ml extender; T4), vitamin C (0.2 g/ 50 ml extender; T5), L-Carnitine; 0.06g/ 50 ml extender + alcoholic extract of Ferula hermonis Boiss roots; 0.03 ml/ 50 ml extender (T6), reduced glutathione; 0.03 g/ 50 ml extender + alcoholic extract of Ferula hermonis Boiss roots; 0.03 ml/ 50 ml extender (T7) and vitamin C; 0.2 g/ 50 ml extender + alcoholic extract of Ferula hermonis Boiss roots; 0.03 ml/ 50 ml extender (T8) were added to Tris extender and comparisons in response were made with the control group (Tris extender, A1). The total phenolic compound of the extract was 124.38 ± 5.05 mg GAE/ g extract and the extract with 0.01 and 0.03% did not hemolyze the red blood cells and had not poisoning effect on blood cells. The T2 group exhibited lesser (P≤ 0.01) percentage of sperm tail midpiece abnormalities as compared with the T1 group at all preservation periods. Moreover, the T3 was also recorded lesser (P≤0.01) sperm's head abnormalities percentage at 60 days PC time period in comparison with the T1 group. On the other hand, T4, T5, T6, T7 and T8 exhibited lesser (P≤0.05) total sperm abnormalities percentage at 60 days PC time period as compared with the T1 group. In conclusion, the adding of alcoholic extract of Ferula hermonis Boiss roots (0.03 ml/ 50 ml extender) and L-Carnitine (0.06g/ 50 ml extender) to Tris extender had an obvious influence in reducing the sperm abnormalities percentage of Holstein bulls at different cooling and cryopreservation periods as compared with the control (T1) group. This may contribute to a positive enhancement in conception and pregnancy rates of the inseminated cows, and consequently increase the owner's economic income.

scholarly journals Correction: The preventive effect of linalool on acute and chronic UVB-mediated skin carcinogenesis in Swiss albino mice

2019 ◽  
Vol 18 (11) ◽  
pp. 2816-2817
Author(s):  
Srithar Gunaseelan ◽  
Agilan Balupillai ◽  
Kanimozhi Govindasamy ◽  
Ganesan Muthusamy ◽  
Karthikeyan Ramasamy ◽  
...  
Keyword(s):  
Skin Carcinogenesis ◽  
Preventive Effect ◽  
Swiss Albino Mice ◽  
Albino Mice

Correction for ‘The preventive effect of linalool on acute and chronic UVB-mediated skin carcinogenesis in Swiss albino mice’ by Srithar Gunaseelan, et al., Photochem. Photobiol. Sci., 2016, 15, 851–860.

Vitamins E and C prevent apoptosis of testicular and ovarian tissues following mancozeb exposure in the first-generation mouse pups

2019 ◽  
Vol 35 (2) ◽  
pp. 136-144 ◽  
Author(s):  
Heydari Mahdi ◽  
Haghpanah Tahereh ◽  
Saddein Esmaiel ◽  
Ezzatabadipour Massood
Keyword(s):  
Vitamin C ◽  
First Generation ◽  
Ovarian Tissue ◽  
Testicular Tissue ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Tunel Staining ◽  
Preventive Effect ◽  
Vitamins E And C ◽  
Apoptosis Detection ◽  
Pregnant Mice

The aim of this study was to evaluate the role of apoptosis in the first-generation pups’ testicular and ovarian tissue changes following mancozeb (MNZ) administration during intrauterine and lactating periods and also the preventive effect of the co-administration of vitamins E and C on these changes. Naval Medical Research Institute (NMRI) pregnant mice were randomly divided into six groups: control, vehicle, MNZ, vitamin E plus MNZ, vitamin C plus MNZ and vitamins E and C plus MNZ. Administered doses of MNZ and vitamins E and C were 500, 200 and 100 mg/kg of body weight, respectively. These agents were administered to the animals by oral gavage every 2 days. Vitamin treatment was carried out 30 min prior to MNZ administration. Treatment was started on the second day of gestation and continued until weaning. Separated testes and ovaries of animals were prepared for apoptosis detection by terminal deoxynucleotidyl transferase end-labeling (TUNEL) staining. The percentage of TUNEL-positive cells was reported using the 4,6-diamidino-2-phenylindole method. As compared to the control and vehicle groups, MNZ induced a significant increase ( p < 0.001) in the number of TUNEL-positive cells. The administration of both vitamins E and C alone and together significantly ( p < 0.001) prevented the apoptotic impacts of MNZ. The preventive effect of the co-administration of these vitamins on the ovary was greater compared to the single administration of vitamins E ( p < 0.001) or C ( p < 0.001). Meanwhile, the results revealed the stronger preventive effect of vitamin C as compared to E on testicular tissue ( p < 0.05). The apoptotic impact of MNZ exposure during intrauterine and lactating periods on first-generation testicular and ovarian tissues was significant. The co-administration of vitamins E and C could prevent MNZ-induced testicular and ovarian changes.

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