Modifying Natural Behavioral Responses by Enforcing Ethical Values

2021 ◽  
Vol 66 (Special Issue) ◽  
pp. 70-71
Author(s):  
Duran Jaume ◽  
◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Point Of View ◽  
Ethical Values ◽  
Fundamental Interest ◽  
Four Dimensions ◽  
Community Behavior ◽  
Behavior Response ◽  
The Central Nervous System ◽  
The Brain

"According to different theories about neuroscience and ethics, we want to introduce the idea that the ethical values are very good levers to conduct human responses to their perceptions. These theories are based on very currently data about science and the central nervous system explained recently by a very important neuroscientist. In a very basic nervous system, the reptilian brain, humans can solve their fundamental interest and necessities, such as survival, breading, community behavior… In a more complex and posterior temporary nervous system, thanks to the known limbic brain, humans have been able to solve and to respond to their emotional problems, creating the memory center of our emotions. After this second moment and as a result of the global anthropological evolution, the cortical brain allows us to think, to deploy the global intelligences and take human decisions. Thanks to these three brain levels and their neurobiological connections, humans have developed other intangible brains, able to experience the ethics, the esthetics, and the spirituality. Our brain works as a whole. We are the result made up of more than 100.000 million connected neurons that form the brains. In some aspects, our four dimensions, the physical, the emotional, the rational and the transcendental faces act together, hand in hand. Our more ponderous decisions aren’t always rational; more than 80% of them are basically emotional. So, our spiritual manners can be showed by biophysically manifestations; conscientious and unconscientious affects us equally. Human brain is genetically prepared to answer. Historically formed to respond, the central nervous system can be explained as the most complex organ to produce responses to multiple previous perceptions. These perceptions can be tangible or not, external or internal, consciences or not, actual or memorized. Our point of view is that we can introduce ethical values as a non-conscientious response. Working from rational and emotional ways our ethical values, we will introduce them in our transcendental brain. All posterior relationship between the brain areas will influence the behavior response to the real perceptions that we are exposed to. So, to summarize, enforced ethical values can unconscientiously modify our behavioral response. "

Gudden's Method in the Investigation of the Anatomy of the Central Nervous System

1881 ◽  
Vol 27 (117) ◽  
pp. 47-51
Author(s):  
James Hyslop
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Point Of View ◽  
Nerve Tissue ◽  
Microscopical Examination ◽  
Friable Material ◽  
Considerable Difficulty ◽  
Close Proximity ◽  
The Central Nervous System ◽  
The Brain

Perhaps there is no system which in recent times has received more attention, from an anatomical as well as from a physiological point of view, than the central nervous system. The brain being built up of cells and fibres of a soft and friable material, imbedded in a still softer substance, and arranged so as to form a complicated network of fibres suspended between and connecting different systems of nuclei, it is not to be wondered at that its minute anatomy, previous to the employment of the various hardening methods now in use, was very imperfectly known. Even now, notwithstanding our present means of hardening nerve tissue, and improved appliances for preparing sections for microscopical examination, we often experience considerable difficulty in its investigation, not the smallest of which is encountered when we endeavour to follow the different nerve fibres and associate them with their proper nuclei. Sometimes this difficulty arises from several bundles of fibres connected with different nuclei running together, or occupying almost the same position and at other times from several nuclei connected with different groups of fibres being placed very close to each other, so that we may have in close proximity nuclei, or the fibres connected with nuclei, which differ greatly in function.

Gudden's Method in the Investigation of the Anatomy of the Central Nervous System

1881 ◽  
Vol 27 (117) ◽  
pp. 47-51
Author(s):  
James Hyslop
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Point Of View ◽  
Nerve Tissue ◽  
Microscopical Examination ◽  
Friable Material ◽  
Considerable Difficulty ◽  
Close Proximity ◽  
The Central Nervous System ◽  
The Brain

Perhaps there is no system which in recent times has received more attention, from an anatomical as well as from a physiological point of view, than the central nervous system. The brain being built up of cells and fibres of a soft and friable material, imbedded in a still softer substance, and arranged so as to form a complicated network of fibres suspended between and connecting different systems of nuclei, it is not to be wondered at that its minute anatomy, previous to the employment of the various hardening methods now in use, was very imperfectly known. Even now, notwithstanding our present means of hardening nerve tissue, and improved appliances for preparing sections for microscopical examination, we often experience considerable difficulty in its investigation, not the smallest of which is encountered when we endeavour to follow the different nerve fibres and associate them with their proper nuclei. Sometimes this difficulty arises from several bundles of fibres connected with different nuclei running together, or occupying almost the same position and at other times from several nuclei connected with different groups of fibres being placed very close to each other, so that we may have in close proximity nuclei, or the fibres connected with nuclei, which differ greatly in function.

Gudden's Method in the Investigation of the Anatomy of the Central Nervous System

1881 ◽  
Vol 27 (117) ◽  
pp. 47-51
Author(s):  
James Hyslop
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Point Of View ◽  
Nerve Tissue ◽  
Microscopical Examination ◽  
Friable Material ◽  
Considerable Difficulty ◽  
Close Proximity ◽  
The Central Nervous System ◽  
The Brain

Perhaps there is no system which in recent times has received more attention, from an anatomical as well as from a physiological point of view, than the central nervous system. The brain being built up of cells and fibres of a soft and friable material, imbedded in a still softer substance, and arranged so as to form a complicated network of fibres suspended between and connecting different systems of nuclei, it is not to be wondered at that its minute anatomy, previous to the employment of the various hardening methods now in use, was very imperfectly known. Even now, notwithstanding our present means of hardening nerve tissue, and improved appliances for preparing sections for microscopical examination, we often experience considerable difficulty in its investigation, not the smallest of which is encountered when we endeavour to follow the different nerve fibres and associate them with their proper nuclei. Sometimes this difficulty arises from several bundles of fibres connected with different nuclei running together, or occupying almost the same position and at other times from several nuclei connected with different groups of fibres being placed very close to each other, so that we may have in close proximity nuclei, or the fibres connected with nuclei, which differ greatly in function.

Glucuronyl 3-sulfate occurs exclusively on distal unmyelinated terminals of selected sensory neurons in the peripheral nervous system

1995 ◽  
Vol 53 ◽  
pp. 958-959
Author(s):  
S.S. Spicer ◽  
B.A. Schulte
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Peripheral Nervous System ◽  
Sensory Neurons ◽  
Sensory Nerves ◽  
Tissue Antigens ◽  
The Central Nervous System ◽  
The Brain ◽  
Leu 7

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.

Central Nerve System Impairment, AMA Guides, Sixth Edition: An Overview

2018 ◽  
Vol 23 (1) ◽  
pp. 10-13
Author(s):  
James B. Talmage ◽  
Jay Blaisdell
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Neurological Impairment ◽  
Sixth Edition ◽  
Central Nerve System ◽  
The Central Nervous System ◽  
The One ◽  
Nerve System ◽  
The Brain

Abstract Injuries that affect the central nervous system (CNS) can be catastrophic because they involve the brain or spinal cord, and determining the underlying clinical cause of impairment is essential in using the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), in part because the AMA Guides addresses neurological impairment in several chapters. Unlike the musculoskeletal chapters, Chapter 13, The Central and Peripheral Nervous System, does not use grades, grade modifiers, and a net adjustment formula; rather the chapter uses an approach that is similar to that in prior editions of the AMA Guides. The following steps can be used to perform a CNS rating: 1) evaluate all four major categories of cerebral impairment, and choose the one that is most severe; 2) rate the single most severe cerebral impairment of the four major categories; 3) rate all other impairments that are due to neurogenic problems; and 4) combine the rating of the single most severe category of cerebral impairment with the ratings of all other impairments. Because some neurological dysfunctions are rated elsewhere in the AMA Guides, Sixth Edition, the evaluator may consult Table 13-1 to verify the appropriate chapter to use.

RAS in the Central Nervous System: Potential Role in Neuropsychiatric Disorders

2018 ◽  
Vol 25 (28) ◽  
pp. 3333-3352 ◽  
Author(s):  
Natalia Pessoa Rocha ◽  
Ana Cristina Simoes e Silva ◽  
Thiago Ruiz Rodrigues Prestes ◽  
Victor Feracin ◽  
Caroline Amaral Machado ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Central Nervous System ◽  
Nervous System ◽  
Therapeutic Potential ◽  
Neuropsychiatric Disorders ◽  
Extensive Literature ◽  
Ang Ii ◽  
Mas Receptor ◽  
The Central Nervous System ◽  
The Brain

Background: The Renin-Angiotensin System (RAS) is a key regulator of cardiovascular and renal homeostasis, but also plays important roles in mediating physiological functions in the central nervous system (CNS). The effects of the RAS were classically described as mediated by angiotensin (Ang) II via angiotensin type 1 (AT1) receptors. However, another arm of the RAS formed by the angiotensin converting enzyme 2 (ACE2), Ang-(1-7) and the Mas receptor has been a matter of investigation due to its important physiological roles, usually counterbalancing the classical effects exerted by Ang II. Objective: We aim to provide an overview of effects elicited by the RAS, especially Ang-(1-7), in the brain. We also aim to discuss the therapeutic potential for neuropsychiatric disorders for the modulation of RAS. Method: We carried out an extensive literature search in PubMed central. Results: Within the brain, Ang-(1-7) contributes to the regulation of blood pressure by acting at regions that control cardiovascular functions. In contrast with Ang II, Ang-(1-7) improves baroreflex sensitivity and plays an inhibitory role in hypothalamic noradrenergic neurotransmission. Ang-(1-7) not only exerts effects related to blood pressure regulation, but also acts as a neuroprotective component of the RAS, for instance, by reducing cerebral infarct size, inflammation, oxidative stress and neuronal apoptosis. Conclusion: Pre-clinical evidence supports a relevant role for ACE2/Ang-(1-7)/Mas receptor axis in several neuropsychiatric conditions, including stress-related and mood disorders, cerebrovascular ischemic and hemorrhagic lesions and neurodegenerative diseases. However, very few data are available regarding the ACE2/Ang-(1-7)/Mas receptor axis in human CNS.

New Advanced Strategies for the Treatment of Lysosomal Diseases Affecting the Central Nervous System

2019 ◽  
Vol 25 (17) ◽  
pp. 1933-1950 ◽  
Author(s):  
Maria R. Gigliobianco ◽  
Piera Di Martino ◽  
Siyuan Deng ◽  
Cristina Casadidio ◽  
Roberta Censi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Polymeric Nanoparticles ◽  
Genetic Diseases ◽  
Point Of View ◽  
Lysosomal Storage ◽  
Enzyme Replacement ◽  
Lysosomal Diseases ◽  
The Central Nervous System ◽  
Enzyme Delivery

Lysosomal Storage Disorders (LSDs), also known as lysosomal diseases (LDs) are a group of serious genetic diseases characterized by not only the accumulation of non-catabolized compounds in the lysosomes due to the deficiency of specific enzymes which usually eliminate these compounds, but also by trafficking, calcium changes and acidification. LDs mainly affect the central nervous system (CNS), which is difficult to reach for drugs and biological molecules due to the presence of the blood-brain barrier (BBB). While some therapies have proven highly effective in treating peripheral disorders in LD patients, they fail to overcome the BBB. Researchers have developed many strategies to circumvent this problem, for example, by creating carriers for enzyme delivery, which improve the enzyme’s half-life and the overexpression of receptors and transporters in the luminal or abluminal membranes of the BBB. This review aims to successfully examine the strategies developed during the last decade for the treatment of LDs, which mainly affect the CNS. Among the LD treatments, enzyme-replacement therapy (ERT) and gene therapy have proven effective, while nanoparticle, fusion protein, and small molecule-based therapies seem to offer considerable promise to treat the CNS pathology. This work also analyzed the challenges of the study to design new drug delivery systems for the effective treatment of LDs. Polymeric nanoparticles and liposomes are explored from their technological point of view and for the most relevant preclinical studies showing that they are excellent choices to protect active molecules and transport them through the BBB to target specific brain substrates for the treatment of LDs.

Ethanolamine: A Potential Promoiety with Additional Effects in the Brain

2020 ◽  
Vol 19 ◽  
Author(s):  
Asfree Gwanyanya ◽  
Christie Nicole Godsmark ◽  
Roisin Kelly-Laubscher
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Design ◽  
Cell Signaling ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
The Central Nervous System ◽  
Bioactive Molecule ◽  
Positive Functions ◽  
The Brain

Abstract: Ethanolamine is a bioactive molecule found in several cells, including those in the central nervous system (CNS). In the brain, ethanolamine and ethanolamine-related molecules have emerged as prodrug moieties that can promote drug movement across the blood-brain barrier. This improvement in the ability to target drugs to the brain may also mean that in the process ethanolamine concentrations in the brain are increased enough for ethanolamine to exert its own neurological ac-tions. Ethanolamine and its associated products have various positive functions ranging from cell signaling to molecular storage, and alterations in their levels have been linked to neurodegenerative conditions such as Alzheimer’s disease. This mini-review focuses on the effects of ethanolamine in the CNS and highlights the possible implications of these effects for drug design.

scholarly journals Beyond Oncological Hyperthermia: Physically Drivable Magnetic Nanobubbles as Novel Multipurpose Theranostic Carriers in the Central Nervous System

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2104 ◽  
Author(s):  
Eleonora Ficiarà ◽  
Shoeb Anwar Ansari ◽  
Monica Argenziano ◽  
Luigi Cangemi ◽  
Chiara Monge ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Tumors ◽  
Ad Hoc ◽  
Superparamagnetic Iron Oxide ◽  
Conventional Radiotherapy ◽  
The Central Nervous System ◽  
Magnetic Resonance Imaging Mri ◽  
The Brain

Magnetic Oxygen-Loaded Nanobubbles (MOLNBs), manufactured by adding Superparamagnetic Iron Oxide Nanoparticles (SPIONs) on the surface of polymeric nanobubbles, are investigated as theranostic carriers for delivering oxygen and chemotherapy to brain tumors. Physicochemical and cyto-toxicological properties and in vitro internalization by human brain microvascular endothelial cells as well as the motion of MOLNBs in a static magnetic field were investigated. MOLNBs are safe oxygen-loaded vectors able to overcome the brain membranes and drivable through the Central Nervous System (CNS) to deliver their cargoes to specific sites of interest. In addition, MOLNBs are monitorable either via Magnetic Resonance Imaging (MRI) or Ultrasound (US) sonography. MOLNBs can find application in targeting brain tumors since they can enhance conventional radiotherapy and deliver chemotherapy being driven by ad hoc tailored magnetic fields under MRI and/or US monitoring.

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