scholarly journals Influence of Emollient on the Preparation and stability of Sodiun Ascorbyl Phospate Cream

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Yanni Dhiani Mardhiani ◽  
Deny Puriyani Azhari ◽  
Silviana Wulansari
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Room Temperature ◽  
Antioxidant Activities ◽  
Skin Barrier ◽  
Penetration Enhancer ◽  
Isopropyl Myristate ◽  
Topical Formulation ◽  
Diffusion Test ◽  
Active Substances

As a type of cosmetic preparation products, cream dosage form is widely used with the addition of active substances having antioxidant activities, such as vitamin C and its derivatives. Sodium ascorbyl phosphate (SAP) can be used in topical formulation due to its more stable properties than ascorbic acid. However, it is difficult to deliver SAP into the dermis in a suficient dose. To overcome the problem, occasionally we can add a penetration enhancer. In some literature, emollients that often added in cosmetic preparations also have another effect as a penetration enhancer. The purpose of this research was to observe wether emollient addition could influence the penetration of SAP in the cream formulation or not. SAP was formulated into four formulations with three different emollients: dimethicone (F1), capric triglyceride (F2), and isopropyl myristate (F3) and a formulation without the addition of emollients (F4). The diffusion test was performed by Franz's diffusion cell method using male wistar rat’s abdominal membrane as a standard model of the skin barrier. The result of stability test showed that SAP cream was stable at room temperature but unstable on freeze thaw condition described by significant different values for all formulas. Nonetheless, the diffusion test showed that F2 with the capric triglyceride as emollient had the highest ability to pass SAP through the membrane, followed by isopropyl miristate. We concluded that emollient addition could influence the penetration of the cream of SAP.Keywords: vitamin c, ascorbic acid, sodium ascorbyl phospate, emollient, penetration enhancer

scholarly journals Valuation of α-Fe2O3@C20H38O11 NC Nano-cellulose Surface Coating on Ascorbic Acid Content of Solanum Lycopersicum Under Storage Conditions

2021 ◽  
Author(s):  
Geetika Guleria ◽  
Dhananjay K. Sharma ◽  
Shweta Thakur ◽  
Poonam Kumari ◽  
Mamta Shandilya ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Ascorbic Acid ◽  
Klebsiella Pneumoniae ◽  
Vitamin C ◽  
Room Temperature ◽  
Tomato Fruit ◽  
Coating Material ◽  
Tomato Fruits ◽  
Nano Coating ◽  
Nano Cellulose

Abstract Competence of synthesized α-Fe2O3@C20H38O11 NC nano-cellulose antimicrobial coating material and its real-time application to extend storage life of Tomato (Solanum lycopersicum) variety Solan Lalima (India) was studied. Fe2O3 NPs (nanoparticles) were synthesized using a hydrothermal method, and α-Fe2O3@C20H38O11 NC nanocomposite was developed and characterized using XRay Diffractions (XRD) and Scanning Electron Microscopy (SEM) techniques. α-Fe2O3@C20H38O11 NC nanocomposite, and CE (cellulose) were analysed for their antimicrobial activity against Klebsiella pneumoniae and Staphylococcus aureus bacteria. NC exhibit 11mm, 13mm zone of inhibition against Klebsiella pneumoniae and Staphylococcus aureus respectively. Tomato fruit samples coated with (5%) UC1A, UC2A, and (3%) UC1B, UC2B two different concentrations of α-Fe2O3@C20H38O11 NC nanocomposite and uncoated sample UC1, UC2 stored at room temperature (25±2 ºC) and refrigerator temperature (4 oC) respectively for ascorbic acid (vitamin C) analysis on days 0, 4, 8, 12 and 16. Our study revealed that a 3% concentration of α-Fe2O3@C20H38O11 NC nanocomposite material quite potent in maintaining quality aspects of the tomato fruit by no decline of vitamin C under refrigerator conditions up to 16th day. FTIR analysis of all samples was done to determine the functional groups present in tomato samples after storage. AAS (Atomic Absorption Spectrometer) was used to analyse the content of Fe, and Zn elements in tomato samples. This work revealed that the 3% α-Fe2O3@C20H38O11 NC nano-cellulose antimicrobial nano-coating had maintained the quality of the coated tomato fruits and retards microbial growth during storage time and helpful in increasing the shelf life of tomato under cold storage as well as at room temperature. Coating material had not any significant effect on micronutrients element concentrations in both temperature studies. Synthesised α-Fe2O3@C20H38O11 NC antimicrobial nano-coating material can be used effectively for long storage of tomato fruits and safe for dietary intake of human.

scholarly journals Functional Quality and Colour Attributes of Two High-Lycopene Tomato Breeding Lines Grown under Greenhouse Conditions

2016 ◽  
Vol 4 (5) ◽  
pp. 365 ◽  
Author(s):  
Ilahy Riadh ◽  
Siddiqui Mohammed Wasim ◽  
Tlili Imen ◽  
Piro Gabriela ◽  
Lenucci Marcello Salvatore ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Antioxidant Activities ◽  
Rio Grande ◽  
Total Vitamin ◽  
Total Carotenoids ◽  
Breeding Lines ◽  
Functional Quality ◽  
Fresh Cut ◽  
Β Carotene

This study investigates the antioxidant components (total carotenoids, lycopene, β-carotene, total phenols, flavonoids, ascorbic acid and total vitamin C) as well as the hydrophilic and lipophilic antioxidant activities (HAA and LAA) of tomato genotypes consisting of one ordinary cultivar Rio Grande and the two high-lycopene breeding lines HLT-F71 and HLT-F72. The correlation of nutritional value to L∗, a∗, b∗ colour indexes and a∗/b∗ ratio was also investigated in whole and fresh cut tomato fruits. Except for β-carotene content, significant differences were found among cultivars for antioxidants. The berries of both HLT-lines recorded higher antioxidant contents, HAA and LAA (TEAC and FRAP assays) than Rio Grande. Under controlled conditions, HLT-F72 reached the highest levels of total carotenoids (165.5 mg β-ca Eq per kg fw), lycopene (150.1 mg per kg fw) and total phenolics (549.7 mg GAE per kg fw). However, HLT-F72 exhibited the highest levels of ascorbic acid (193.3 mg per kg fw), total vitamin C (271.6 mg per kg fw) and flavonoids (450.5 mg RE per kg fw). Line HLT-F71 showed the highest HAA (148.0 µM Trolox per 100 g fw and 4.2 mM FRAP per g fw) and LAA values (258.5 µM Trolox per 100 g fw and 3.2 mM FRAP per g fw respectively). Colour readings in red ripe fresh cut tomato berries particularly a∗, b∗ and the ratio a∗/b∗ could represent an indicator not only for lycopene but also for other phytochemicals and resulting antioxidant activities. HLT-Lines may serve as a starting point for the development of semi-determinate growth habit tomato cultivars with higher functional quality.

scholarly journals Studies on the Stability of Vitamin C at Elevated Concentrations in Canned Tropical Fruit Juices and Nectars

1969 ◽  
Vol 48 (4) ◽  
pp. 327-336
Author(s):  
Abdul R. Rahman ◽  
J. Anziani ◽  
E. Díaz Negrón
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Room Temperature ◽  
Fruit Juices ◽  
The Other ◽  
Tropical Fruit ◽  
The Stability ◽  
Different Levels

Studies were conducted to determine the stability of vitamin C at elevated concentrations in canned tropical fruit juices and nectars. Canned guava nectar, as well as juices of orange, tomato, and pineapple were fortified with ascorbic acid at seven different levels ranging from the original content present in the samples to about 300 mg. per 100 ml. Half of the samples were stored at room temperature and the other similar half at 100°F. for a period of 6 months. The results indicated that the losses of vitamin C were higher in the samples stored at 100°F. than in those stored at room temperature—regardless of the level of concentration. However, in the guava nectar the percentage of vitamin C destruction was relatively higher at lower concentrations and lower at higher concentrations at both temperatures. No such pattern could be observed in the juices. But the losses of vitamin C in the juices at all levels of concentration ranged below 30 percent at room temperature and below 40 percent at 100°F. This is relatively less than the losses that occurred in the guava nectar.

scholarly journals The effect of selected substances on the stability of standard solutions in voltammetric analysis of ascorbic acid in fruit juices

2019 ◽  
Vol 17 (1) ◽  
pp. 655-662
Author(s):  
Radosław Kowalski ◽  
Artur Mazurek ◽  
Urszula Pankiewicz ◽  
Marzena Włodarczyk-Stasiak ◽  
Monika Sujka ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Room Temperature ◽  
Nutritive Value ◽  
Fruit Juices ◽  
Optimum Concentration ◽  
Voltammetric Analysis ◽  
The Stability ◽  
Standard Solutions

AbstractThe objective of the study was to identify suitable additives stabilizing standard solutions of ascorbic acid (AA) that would not cause interference in the analytical process with the use of voltammetry in the determination of the AA content in food products. In addition, the effect of various conditions of storage of selected fruit juices and drinks on the concentration of vitamin C was studied. The study demonstrated that AA degradation was inhibited the most effectively by tartaric acid and its optimum concentration was set to 200 mg L-1. Analysis of selected fruit juices stored in various temperature conditions confirmed that an elevation of temperature and extension of the time of storage caused a decrease in the content of vitamin C in the analyzed samples, while closing the packages caused a limitation of the changes in concentration of this vitamin. On the basis of literature data and of the results obtained in the present study it can be concluded that fruit juices should be stored at a temperature lower than room temperature to retain their nutritive value.

ON THE SPECIFICITY OF DYE TITRATION FOR ASCORBIC ACID

1946 ◽  
Vol 24b (1) ◽  
pp. 37-45 ◽  
Author(s):  
Jules Tuba ◽  
George Hunter ◽  
Helen Ruth Steele
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Room Temperature ◽  
Dehydroascorbic Acid ◽  
Usual Method ◽  
Plant Materials ◽  
Treated Plant

The 2,6-dichlorophenolindophenol method of assay of vitamin C has been critically examined with respect to a number of fresh, boiled, and otherwise treated plant materials. Comparative values are given for ascorbic acid as determined by the usual method, for non-vitamin C reductants, and for dehydroascorbic acid.In the fresh uncooked materials examined, non-vitamin C reductants were not found and only in cabbage, peas, and pigweed leaves did dehydroascorbic exceed 10% of the ascorbic acid value.Boiling produced significant amounts of non-vitamin C reductant in cabbage and peas.In rose hips the dye titration gives an accurate measure of ascorbic acid. The amounts of dehydroascorbic acid and non-vitamin C reductant, even under storage at room temperature for over a year, are insignificant.It is concluded that the 2,6-dichlorophenolindophenol method of assay of vitamin C is highly specific but in the case of certain cooked foodstuffs non-vitamin C dye reductants may, without check by other methods, introduce significant errors.

scholarly journals CONTENT OF VITAMIN C IN BERRIES OF THE GRAPES CULTIVATED IN THE CONDITIONS OF THE SOUTH OF WESTERN SIBERIA

2020 ◽  
pp. 89-96
Author(s):  
Irina Dmitriyevna Borodulina ◽  
Mariya Vasil'yevna Vorotyntseva ◽  
Galina Aleksandrovna Makarova ◽  
Anna Yakovlevna Zemtsova ◽  
Galina Gennad'yevna Sokolova
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Plant Material ◽  
Western Siberia ◽  
Geographical Origin ◽  
Food Product ◽  
Weather Conditions ◽  
Biologically Active ◽  
The South ◽  
Active Substances

Grapes is a highly valuable food product due to the presence in it of a number of biologically active substances, among which vitamins occupy a special place. One of the most important and studied in grapes is vitamin C (ascorbic acid). The ascorbic acid contained in plant tissue participates in redox metabolism, thereby increasing the resistance of plant organisms to infections and low negative temperatures. Studies aimed at determining the concentration of vitamin C in plant material are important both for breeding and for identifying the most sustainable competitive varieties. The purpose of these studies is to study the content of vitamin C in grapes cultivated in the South of Western Siberia. Conducted research with 12 introduced varieties and selected forms growing in the collection of the Research Institute of horticulture of Siberia M.A. Lisavenko, allowed to establish dependence of accumulation of ascorbic acid in berries on weather conditions; to allocate 5 genotypes with high content of vitamin C. It is noted that the ripening period of berries, their color, as well as the direction of use and ecological and geographical origin of varieties and selected forms did not affect the accumulation of vitamin C in the period 2014–2016.

scholarly journals Pengaruh Suhu Penyimpanan Obat Kapsul Komersil Terhadap Organoleptik

2020 ◽  
Vol 2 (1) ◽  
pp. 10-17
Author(s):  
Venny Diah Ningsih
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Room Temperature ◽  
Storage Temperature ◽  
Drug Product ◽  
Ascorbic Acid Content ◽  
Cold Temperature ◽  
Excessive Heat ◽  
Long Time

Medicinal products have quality standards or qualities that are very important to determine the therapeutic effect of a drug. One of the external factors that affect drug quality is temperature, because temperature can affect the instability of the quality of a drug product. This study aims to determine the effect of storage temperature of commercial capsule drugs on organoleptic. The research method uses a quantitative approach and experimental method by measuring the ascorbic acid content of the vitamin C tablet drug samples, with variations in temperature, namely cold (5°C), room temperature (27°C) and excessive heat (48°C) for a long time 180 minutes time. The results showed that temperature had a significant effect on the content of ascorbic acid in commercial vitamin C tablets with the results in sample I cold temperature (5°C) 101.2%, room temperature (27°C) 97.6% and overheating temperature (48°C). 90.5%. In sample II the cold temperature (5°C) was 101.8%, the room temperature (27°C) was 103.3% and the overheat temperature (48°C) was 95.3% after 180 minutes of storage.   Keywords: Temperature, Capsule Medicine, Organoleptic ABSTRAK   Mutu atau kualitas suatu produk obat merupakan faktor penting untuk mengetahui efek terapetik dari suatu obat. Salah satu faktor eksternal yang dapat mempengaruhi mutu obat adalah suhu karena dapat mempengaruhi ketidakstabilan sifat fisikakimia senyawa aktif dalam sediaan. Penelitian ini bertujuan untuk mengetahui pengaruh suhu penyimpanan obat kapsul komersil terhadap organoleptik. Metode penelitian menggunakan pendekatan kuantitatif dan eksperimental dengan cara mengukur kadar asam askorbat dari sampel obat tablet vitamin C dengan variasi suhu yaitu dingin (5°C), suhu ruang (27°C) dan suhu panas berlebih (48°C) dengan lama waktu simpan 180 menit. Hasil penelitian menunjukkan bahwa suhu berpengaruh secara nyata terhadap kandungan asam askorbat dalam obat tablet vitamin C komersil dengan hasil pada sampel I suhu dingin (5°C) 101.2%, suhu ruang (27°C) 97.6% dan suhu panas berlebih (48°C) 90.5%. Pada sampel II suhu dingin (5°C) 101.8%, suhu ruang (27°C) 103.3% dan suhu panas berlebih (48°C) 95.3% setelah 180 menit penyimpanan.   Kata Kunci: Suhu, Obat Kapsul, Organoleptik

scholarly journals Phytochemical analysis of generative bodies and leaves in Acer negundo and A. platanoides

2020 ◽  
pp. 139-148
Author(s):  
Алла Георгиевна Куклина ◽  
Наталья Степановна Цыбулько
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Organic Acids ◽  
Native Species ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Phytochemical Analysis ◽  
Acer Negundo ◽  
Promising Source ◽  
Active Substances

Проведен фитохимический анализ цветков, плодов и листьев по содержанию биологически активных веществ на двух видах клена: инвазионном Acer negundo L. и аборигенном A. platanoides L. (Sapindaceae Juss). У 40 образцов, собранных в 5 популяциях Московского региона, найдены сумма флавоноидов, содержание аскорбиновой кислоты и суммы органических кислот по стандартным методикам Государственной фармакопеи РФ. В данном исследовании впервые обнаружено, что максимальное накопление флавоноидов (1,75-1,94 мг%) фиксируется в мужских цветках A. negundo. Содержание витамина С в цветках (до 53 мг%), плодах и листьях A. negundo на 25-30 % больше, чем в аналогичных органах у A. platanoides. По мере созревания плодов содержание флавоноидов, аскорбиновой кислоты и органических кислот (до 8 %) у инвазионного и аборигенного видов клена снижается почти в 1,5 раза. Листья мужских и женских особей A. negundo по насыщенности флавоноидами, витамином С и органическими кислотами не отличаются. Выявлено, что цветки A. negundo и A. platanoides, являются наиболее перспективным источником биологически активных веществ - флавоноидов, включая катехины, антоцианы, лейкоантоцианы и флавонолы, а также аскорбиновой кислоты. Сбор растительного сырья рекомендуется проводить в экологически чистых фитоценозах, поскольку известно о способности растений A. negundo аккумулировать из почвы и воздуха тяжелые металлы. A phytochemical analysis of flowers, fruits, and leaves revealing the biologically active substances in two types of maple: invasive Acer negundo L. and native A. platanoides L. (Sapindaceae Juss) was carried out. In 40 samples collected in 5 populations of the Moscow Region, a sum of flavonoids, the presence of ascorbic acid, and organic acids were found according to the standard methods of the State Pharmacopoeia of the Russian Federation. We discovered for the first time that the maximum accumulation of flavonoids (1.75-1.94 mg%) is in male flowers of A. negundo. The content of vitamin C in flowers (up to 53 mg%), fruits, and leaves of A. negundo is 25-30% higher than in similar organs in A. platanoides. As the fruit ripens, the content of flavonoids, vitamin C, and organic acids (up to 8%) in invasive and native species of maple decreases by almost 1.5 times. The leaves of male and female trees of A. negundo do not differ in saturation with flavonoids, vitamin C, and organic acids. Flowers of A. negundo and A. platanoides are the most promising source of biologically active substances - flavonoids, including catechins, anthocyanins, leukoanthocyanins, and flavonols, as well as ascorbic acid. The collection of plant substances is recommended in ecologically clean phytocenoses since A. negundo can accumulate heavy metals from soil and air.

scholarly journals Bioactive compounds and antioxidant activity in tomatoes (Lycopersicon esculentum L.) cultivars in natura and after thermal processing

2020 ◽  
Vol 9 (11) ◽  
pp. e44991110192
Author(s):  
Angela Vacaro de Souza ◽  
Jéssica Marques de Mello ◽  
Vitória Ferreira da Silva Fávaro ◽  
Victória Farias da Silva ◽  
Diogo de Lucca Sartori ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Phenolic Compounds ◽  
Lycopersicon Esculentum ◽  
Vitamin C ◽  
Bioactive Compounds ◽  
Thermal Processing ◽  
Antioxidant Activities ◽  
The Impact ◽  
Β Carotene

The aim of the study was to evaluate the impact of processing by cooking in natura fruits on the content of bioactive compounds - vitamin C and ascorbic acid, phenolic compounds, flavonoids, carotenoids and anthocyanins, lycopene and β-carotene - and on antioxidant activity - DPPH and FRAP - of 9 varieties of commercial and non-commercial tomatoes. The fruits were harvested when they reached the point of physiological maturation, selected and evaluated in natura, and after grinding and cooking for 30 minutes. At the end of the experiment it was found that all bioactive compounds analyzed showed quantitative reductions when the fruits were processed, with cherry cultivars - 7, 8 and 9 - those that showed superior results compared to different bioactive compounds evaluated, proving to be interesting to be better explored. Regarding the antioxidant activities, the processed fruits of these cultivars showed less losses showing potential to be submitted to processing.

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