Serum IL-6 levels of atopic patients with recurrent aphthous stomatitis (RAS)

Introduction: Atopy is a genetic tendency of allergic condition with specific clinical manifestations such as atopic dermatitis (AD), allergic rhinitis (AR), and bronchial asthma (BA). Atopic individuals might experience other health problems that coincide with atopic manifestations, including the appearance of recurrent aphthous stomatitis (RAS) which is an oral mucosal disease that can also be influenced by allergies. This study was aimed to be the preliminary study regarding the level of IL-6 serum in atopic patients who were also having RAS. Methods: Thirty subjects were recruited and grouped into three groups with ten subjects each were group of atopic (dermatitis, allergic rhinitis, or bronchial asthma) with RAS, atopic without RAS, and control. Blood specimens were obtained with an approved institutional board review protocol. This research was cross-sectional research with consecutive sampling method conducted at Dr Hasan Sadikin Hospital Bandung. Results: There were significant differences in IL-6 log levels in all three groups (p < 0.001). The higher IL-6 levels in the group of atopic with RAS might be due to the influence of atopy because this condition can increase the acute inflammation of RAS. IL-6 is a pro-inflammatory marker found in the circulation of atopic and RAS patients. Conclusion: Serum IL-6 levels in the group of atopic patients with RAS is higher than in other groups. Keywords: Serum, IL-6, atopic, recurrent aphthous stomatitis

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Sensitization to inhaled allergens in asthmatic children in southern Jordan: a cross-sectional study

Multidisciplinary Respiratory Medicine ◽

10.4081/mrm.2019.56 ◽

2019 ◽

Vol 14 ◽

Author(s):

Enas M. Al-Zayadneh ◽

Nedal Awad Alnawaiseh ◽

Areej Hamed Altarawneh ◽

Ibrahim Hamed Aldmour ◽

Eman M. Albataineh ◽

...

Keyword(s):

Allergic Rhinitis ◽

Asthma Control ◽

Bronchial Asthma ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Systemic Steroids ◽

The Past ◽

Allergic Condition ◽

History Of

Background: Sensitization to inhaled allergens in children with bronchial asthma significantly affects asthma pathogenesis, severity and persistence into late childhood and adulthood. The present study determined the prevalence of sensitization to inhaled allergens in children with bronchial asthma and wheezing episodes in order to investigate the effect of positive sensitization on the severity and control of asthma symptoms and to screen for other associated allergic conditions. Methods: A cross-sectional study was conducted, including children between 6 months and 14 years of age attending the chest clinic of Al-Karak, south of Jordan, between November 2013 and February 2016. Skin prick tests (SPTs) using 11 standardized allergen extracts were conducted in 277 children. The severity of asthma was determined based on the Global Initiative for Asthma (GINA) assessment and the Childhood Asthma Control Test (C-ACT) in addition to the history of use of systemic steroids and hospital admissions within the past 12 months. Results: Sixty-seven percent of children with bronchial asthma reported sensitization to one or more of the inhaled allergens. The most common allergens were olive pollens (18%), cat fur (13.5%), and Dermatophagoides pteronyssinus (11.9%). There was a significant increase in allergen sensitization with age (p < 0.001). The most common concomitant allergic condition among children was allergic rhinitis (71.5%); however, allergic conjunctivitis was the only allergic condition that correlated with the skin test reactivity (p = 0.01). A family history of bronchial asthma was confirmed in 40.4% of children. Children with positive SPTs had lower ACT scores and reported more frequent use of systemic steroids and admissions to hospital within the past 12 months; however, this effect was not statistically significant (p > 0.05). Conclusions: Sensitization to inhaled allergens is highly prevalent in children with asthma and wheezing episodes in southern Jordan and may be correlated with the severity of the disease. Therefore, appropriate measures to recognize and avoid these allergens are highly recommended. Most children in our study suffered from concomitant allergic rhinitis, indicating that an appropriate diagnosis and treatment of allergic rhinitis could significantly improve asthma control and thus the quality of life of these children.

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Atopic dermatitis: new horizons of therapy

Medical alphabet ◽

10.33667/2078-5631-2019-1-7(382)-29-32 ◽

2019 ◽

Vol 1 (7) ◽

pp. 29-32 ◽

Cited By ~ 4

Author(s):

L. S. Kruglova ◽

E. M. Gensler

Keyword(s):

Blood Pressure ◽

Immune Response ◽

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Targeted Therapy ◽

Inflammatory Response ◽

Bronchial Asthma ◽

New Horizons ◽

The Past

Over the past decades, the first breakthrough milestone in the treatment of severe forms of atopic dermatitis (AD) has been targeted therapy aimed at inhibiting IL-4 and IL-13. This was made possible thanks to advances in the understanding of the pathogenesis of AD, the driver of which is the Th2-type immune response, which also underlies such manifestations of atopy as bronchial asthma, allergic rhinitis, and polynosis. In the case of the Th2-type immune response, cytokines IL-4 and IL-13 are secreted, which are the main promoters of the inflammatory response in AD. Inhibition of IL-4 and IL-13 leads to the prevention of inflammation and is an effective approach to therapy. The use of therapy aimed at inhibition of cytokines allows you to effectively cope with the manifestations of severe and moderately severe blood pressure.

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Trends of sensitization pattern to aeroallergens among the patients with allergic rhinitis and/or bronchial asthma in Bangalore: A cross sectional study

Medical Journal Armed Forces India ◽

10.1016/j.mjafi.2020.11.017 ◽

2021 ◽

Author(s):

Gianchand Shikha ◽

Himanshu Swami

Keyword(s):

Allergic Rhinitis ◽

Bronchial Asthma ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Sensitization Pattern

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A study on prevalence and effects of allergic rhinitis and asthma on quality of life among secondary school’s student in Kinta District, Perak

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v10ispl1.1706 ◽

2019 ◽

Vol 10 (SPL1) ◽

Author(s):

Soe AK ◽

Aizat AF ◽

Bellahcene MA ◽

Atiqah N ◽

Husna N

Keyword(s):

Quality Of Life ◽

Allergic Rhinitis ◽

Secondary School ◽

Bronchial Asthma ◽

Secondary School Students ◽

School Students ◽

Cross Sectional ◽

Chronic Respiratory Diseases ◽

Validated Questionnaire

Allergic rhinitis (AR) and bronchial asthma (BA) are common inflammatory chronic respiratory diseases, and they are significant public health challenges on a global scale. The prevalence of these diseases are on the rise in all regions of the world, affecting all ages but more commonly among children and adolescences. Both AR and BA affect patients to a different extent with variable restrictions in the physical, emotional, and social aspects of the patient's life. They may be seen as two presentations of the same disease by sharing common epidemiologic, histologic, physiologic, and immunopathologic linkages. To determine the prevalence and impact of allergic rhinitis, asthma and allergic rhinitis with asthma on quality of life among secondary school students in Kinta District, Perak. A cross-sectional study was done among secondary school students from randomly selected three schools in Kinta District, Ipoh, Perak. A well-vetted and validated questionnaire was used to collect the data, and statistical analysis was done to determine the prevalence and impact of AR, BA, or both. A total of 250 secondary school students were involved in this study. Malays were the majority among the participants. The prevalence of AR alone, BA alone, and disease co-occurance were 27.2%, 9.2%, and 8%, respectively. Nearly 20% of the participants were troublesome but low scale in terms of quality of life followed by disturbed sleep, restricted participation in school, and daily activities. Only 6% of the participants experienced sleep disturbance due to asthma, but daily anti-asthmatic medication was essential in only 1.2%. This study showed that although a relatively high prevalence of allergic rhinitis and bronchial asthma. There was no significant low quality of life among sufferers.

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APPLICATION OF VITAMIN D IN DIFFERENT DOSAGE TO TREAT CHILDREN WITH ALLERGIC DISEASES

Wiadomości Lekarskie ◽

10.36740/wlek202007114 ◽

2020 ◽

Vol 73 (7) ◽

pp. 1377-1383

Author(s):

Olexandra V. Tiazhka ◽

Zoriana V. Selska

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Blood Serum ◽

Bronchial Asthma ◽

Vitamin D3 ◽

Allergic Diseases ◽

Acute Disease ◽

Disease Remission ◽

Significant Difference ◽

Different Doses

The aim: To study the dynamics of the level of 25(ОН)D, ІL-4, ІL-10, and IgG in the blood serum of children with allergic diseases and to study the clinical effect of vitamin D3 administration n different dosage in this category of patients. Materials and methods: 153 children aged 3-16 with such allergic diseases as bronchial asthma, atopic dermatitis and allergic rhinitis have been examined. The level of 25(ОН) D was determined using the electrochemiluminescence method, while the levels of ІL-4, ІL-10 and IgG were assessed using enzyme-linked immunoassay. Results: In the contrasting of the initial level of 25(ОН)D in the blood serum of patients after administration of 2,000 IU of vitamin D3 over 2 months, after summer and after treatment with cholecalciferol in higher doses (4,000–5,000 IU) over 2 months, significant difference was established between the indicators by the Friedman criterion (λ2 = 41.211; P < 0.05). In the similar contrasting of ІL-4 indicators, a significant difference between them was traced (P < 0.05) in the period of acute disease as well as the downward tendency in the period of remission. In the similar contrasting of ІL-10 indicators, a significant difference between them was traced (P < 0.05) in the acute period and in the period of disease remission. In the similar contrasting of IgG indicators, a downward tendency was traced in the period of acute disease and significant decrease (P < 0.05) – in the period of disease remission. In the contrasting of 25(ОН)D and ІL-4, ІL-10 figures a strong reverse correlation relationship was traced. The therapeutic effect of the administration of vitamin D3 medication in different doses in children with allergic diseases was traced. Conclusions: The data obtained shows that in the treatment of children with bronchial asthma, allergic rhinitis and atopic dermatitis the complex therapy should include vitamin D3 medications in different doses within a long-term course of treatment.

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GAMBARAN STOMATITIS AFTOSA REKUREN DAN STRES PADA NARAPIDANA DI LEMBAGA PEMASYARAKATAN KELAS II B BITUNG

e-GIGI ◽

10.35790/eg.3.1.2015.6453 ◽

2014 ◽

Vol 3 (1) ◽

Author(s):

Melky G. Junhar ◽

Pieter L. Suling ◽

Aurelia S. R. Supit

Keyword(s):

Oral Cavity ◽

Sampling Method ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Mild Stress ◽

Severe Stress ◽

Cross Sectional ◽

Class Iib ◽

As Stress ◽

Moderate Stress

Abstract: Prisoners are individuals who have been convicted of crimes and were sentenced to prison so they lost their freedom. Lost of freedom can cause stress. Stress is the ability of a person to survive under pressure without causing disturbance. Recurrent aphthous stomatitis (RAS) is a manifestation in the oral cavity which is usually triggered by some predisposing factors such as stress. This study aimed to describe recurrent aphthous stomatitis and stress among prisoners in prison class IIB Bitung. This study was cross-sectional with total sampling method. All prisoners who had experienced recurrent aphtous stomatitis (RAS) while in prison class IIB Bitung. The results showed that among the 56 respondents there were 53 male respondents (94.64%) and 3 female respondents (5.36%); 19 (33.93%) got mild stress, 18 (32.14%) moderate stress, 16 (28.58%) severe stress, and 3 (5.35%) very severe stress.Keywords: prisoner, stress, recurrent aphthous stomatitis (RAS)Abstrak: Narapidana adalah individu yang telah terbukti melakukan tindak pidana dan kemudian oleh pengadilan dijatuhi hukuman atau pidana serta kehilangan kebebasan. Kehilangan kebebasan menimbulkan terjadinya stres pada narapidana. Stres merupakan kemampuan individu untuk bertahan dalam menghadapi berbagai tekanan tanpa mengakibatkan gangguan. Stomatitis aftosa rekuren (SAR) merupakan manifestasi yang timbul dalam rongga mulut yang biasanya dipicu oleh beberapa faktor predisposisi, salah satunya stres. Tujuan penelitian yaitu mengetahui gambaran stomatitis aftosa rekuren dan stres pada narapidana di Lembaga Pemasyarakatan (LP) Kelas IIB Bitung. Jenis penelitian ini menggunakan desain potong lintang. Semua narapidana yang pernah mengalami Stomatitis Aftosa Rekuren (SAR) saat berada di Lembaga Pemasyarakatan kelas II B Bitung. Hasil penelitian menunjukkan bahwa dari 56 responden terdapat 53 responden berjenis kelamin laki-laki (94,64%) dan terdapat 3 responden berjenis kelamin perempuan (5,36%). Hasil pengukuran stres menunjukkan bahwa dari 56 responden 19 responden (33,93%) mengalami tingkat stres ringan, 18 responden (32,14%) mengalami tingkat stres sedang, 16 responden (28,58%) mengalami tingkat stres berat dan 3 responden (5,35%) mengalami tingkat stres sangat berat.Kata kunci: narapidana, stres, stomatitis aftosa rekuren.

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Atopic Disease and Anemia in Korean Patients: Cross-Sectional Study with Propensity Score Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17061978 ◽

2020 ◽

Vol 17 (6) ◽

pp. 1978

Author(s):

Kiyon Rhew ◽

Joshua D Brown ◽

Jung Mi Oh

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Propensity Score ◽

Atopic Disease ◽

Cross Sectional Study ◽

Deficiency Anemia ◽

Sectional Study ◽

Cross Sectional ◽

Propensity Score Weighting ◽

Increased Risk

Atopic disease is associated with chronic inflammation, and anemia has been reported in patients with inflammatory disorders such as rheumatoid arthritis, chronic obstructive pulmonary disease, and irritable bowel disease. The objective of this study was to determine whether atopic disease is associated with an increased risk of anemia. A cross-sectional study with propensity score weighting was conducted using a health insurance review agency claims dataset comprised of randomized patients who used the Korean national health system at least once in 2016. The association between atopic disease (asthma, atopic dermatitis, allergic rhinitis) and anemia (iron deficiency anemia (IDA) and/or anemia of inflammation (AI)) was examined. A total of 1,468,033 patients were included in this study. The IDA/AI prevalence was 3.1% (45,681 patients). After propensity score weighting, there were 46,958 and 45,681 patients in the non-anemic and anemic groups, respectively. The prevalence of IDA/AI in patients with atopic dermatitis, allergic rhinitis, or asthma had an odds ratio (OR) of 1.40 (95% confidence interval (CI), 1.33–1.48; p < 0.001), 1.17 (95% CI, 1.14–1.21; p < 0.001), and 1.32 (95% CI, 1.28–1.36; p < 0.001), respectively. In addition, the prevalence of IDA increased with higher numbers of atopic diseases. In conclusion, the prevalence of IDA/AI was higher in patients with atopic disease, even after adjusting for demographic characteristics and other risk factors. Further study is needed to distinguish between IDA and AI and to enhance understanding of the etiology of anemia in patients with inflammatory conditions.

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