scholarly journals TAMPANG JENUH TRANSFERIN PENDONOR DARAH ANEMIA

Author(s):  
Christina Roosarjani ◽  
Titis Wahyuono ◽  
J B Suparyatmo

Iron deficiency remains one of the most frequent adverse effects of blood donation. Iron status test used on blood donor screeningis haemoglobin concentration. Other iron status parameters are transferrin saturation. The study aims to determine the profile oftransferrin saturation among certain groups of blood donors at the Blood Transfusion Unit of the Indonesian Red Cross SurakartaBranch. The samples were drawn from blood donors at the Blood Transfusion Unit from June to December 2005. A total of 148 specimenswere classified into 3 groups consist of 49 first time blood donations as group I, 50 of fifth time blood donations as group II, and 49of tenth time blood donations as group III. Transferrin saturation was measured by ratio between serum iron and Total Iron BindingCapacity (TIBC). The data analysed by Anova test to distinguish the difference of transferrin saturation among three groups. The resultsshowed the transferrin saturation decreased from group I to group II and from group II to group III. The transferrin saturation amongthree groups showed significantly difference (p=0.000). It can be concluded that there is a decrease in transferrin saturation accordingto the blood donation frequency among blood donors at the Blood Transfusion Unit of the Indonesian Red Cross Surakarta Branch.Transferrin saturation measurement is needed for another parameter of iron deficiency anaemia among blood donors.

2006 ◽  
Vol 76 (3) ◽  
pp. 132-137 ◽  
Author(s):  
Mahmoud Djalali ◽  
Tirang R. Neyestani ◽  
Jamil Bateni ◽  
Fereydoun Siassi

Objective: Blood donation leads to substantial iron loss, as about 0.5 mg iron is lost per each milliliter of blood donated. If not compensated for efficiently, the iron loss may eventually lead to anemia, though non-anemic iron deficiency per se may be problematic. The aim of this study was to evaluate the effects of blood donation, and its frequency over a year’s time, on iron status of Iranian male blood donors attended blood transfusion stations of the Iranian Blood Transfusion Organization (IBTO). Design and setting: A cross-sectional, descriptive, and analytic study was conducted. 91 male volunteer blood donors aged from 20 to 50 years attending three IBTO stations located in central areas of Tehran, and 63 apparently healthy controls that were matched for age, gender, monthly income, height, and weight, were included in the study. Blood donors were divided into 4 groups according to the frequency of blood donation per year; i.e. 1, 2, 3, and 4 with 20, 30, 26, and 15 persons in each group, respectively. Just before blood donation, 10 mL venous blood sample was taken and divided into heparinized and non-heparinized tubes for determination of hemoglobin (Hb), hematocrit (Hct), serum iron (SI), total iron binding capacity (TIBC), ferritin, transferrin saturation (TS), and mean corpuscular hemoglobin concentration (MCHC). Dietary assessment was also done using 3 different questionnaires; i.e. general health, food frequency, and 24hr recall. Results: The levels of Hb, Hct, and iron status indices were all significantly lower in the subjects than in controls and a gradual but significant decrease in iron status indices in each time of blood donation was found. Serum ferritin showed significant correlations with age (r = 0.33, p < 0.001) and body-mass index (BMI) (r = 0.26, p = 0.03) only in the control group. Frequency of blood donation per year was also inversely correlated with Hb (r = -0.67, p < 0.001), Hct (r = -0.65, p < 0.001), MCHC (r = -0.56, p < 0.001), serum ferritin (r = -0.38, p < 0.001), SI (r = -0.62, p < 0.001), and TS (r = -0.61, p < 0.001), but was directly correlated with TIBC (r = 0.56, p < 0.001). Interestingly in blood donors, but not in healthy controls, serum ferritin levels showed weak but statistically significant correlations with daily intake of iron (r = 0.17, p < 0.05) and energy (r = 0.20, p = 0.03). Conclusion: Though repeated blood donations might diminish iron status, it could be safe to donate 2–3 U/year without an appreciable incidence of iron deficiency, provided that the pre-donation Hb and ferritin values are ≥ 14.7 g/dL and 58.9 μg/L, respectively. The male volunteers with Hb ≥ 14.2 g/dL and serum ferritin ≥ 57.2 μg/L could donate 1–2 U/year and those with Hb ≥ 13.1 g/dL and serum ferritin ≥ 35.3 μg/L could donate just once a year. Volunteers who undergo (repeated) blood donation should receive special nutritional care, especially in terms of iron and energy.


Author(s):  
Amrita S Kumar ◽  
A Geetha ◽  
Jim Joe ◽  
Arun Mathew Chacko

Introduction: Blood donation is one of the most significant contributions that a person can make towards the society. A donor generally donates maximum 450 mL of blood at the time of donation. If 450 mL of blood is taken in a donation, men lose 242±17 mg and women lose 217±11 mg of iron. Hence, adequate iron stores are very important in maintenance of the donor’s health. Aim: To assess the influence of frequency of blood donation on iron levels of blood donors by estimating Haemoglobin (Hb) and other blood indices which reflect iron status of blood and serum ferritin which reflects body iron stores. Materials and Methods: The present study was a cross-sectional analytical study, conducted on 150 blood donors, 18-40 years of age presenting to the Blood Bank in Government Medical College, Kottayam, Kerala, India, between December 2016 to December 2017. Total of 150 donors were divided into four groups according to the number of donations per year. Group I were the first time donors with no previous history of blood donation, Group II- included those with history of donation once in the previous year, Group III- those donors with history of donation twice in the previous year and Group IV- those having history of donation thrice in the previous year. Six ml of whole blood collected from each donor, two ml was used for estimating Haemoglobin (Hb), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Hb (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC) in haematology analyser. Serum separated from remaining four mL of blood underwent ferritin analysis by Chemiluminescence Immunoassay (CLIA) method. Iron stores were considered normal at serum ferritin value from 23.9-336ng/mL in males and 11-307ng/mL in females. Statistical analysis was performed in Statistical Package for the Social Sciences (SPSS) version 16.0. Analysis of Variance (ANOVA) test and Pearson correlation test were used to find association between various parameters and collected data. The p-value <0.05 was considered as statistically significant. Results: There was no significant correlation between serum ferritin level and frequency of blood donation. MCH, MCHC showed significant association (p-value 0.039 and 0.007, respectively) with frequency of blood donation. Low positive correlation was seen between Hb and PCV with serum ferritin levels (r=0.381, p-value <0.001 and r=0.354, p-value <0.001, respectively). Conclusion: There is no significant association between frequency of blood donation and serum ferritin levels.


2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Khaled Mohammed Elnaghy ◽  
Ibrahimabd-Elsalam Nasr ◽  
Eman Mohamed Kamal

Abstract Background Blood loss is one of the major problems during operations of spine fusion. Several blood-conservative measures were applied to reduce the incidence of blood loss—among them, acute hypervolemic hemodilution (AHH) and controlled hypotension (CH). This study was designed to detect the effect of combination of AHH with CH induced by remifentanil versus magnesium sulfate on the volume of blood loss, allogeneic blood transfusion, hemodynamics, coagulation, and electrolytes during operations for spine fusion which are risky operations with high incidence of blood loss and blood transfusion. Sixty patients scheduled for posterior fusion of the spine were randomly allocated into three groups of 20 patients each (group I (AHH), group II (AHH combined with remifentanil-based CH), and group III (AHH combined with magnesium sulfate-based CH)). Estimated blood loss and total volume of packed red blood cells (PRBCS) transfused were recorded. Arterial blood pressure (ABP) and heart rate (HR) measures were recorded. Blood samples were obtained for the detection of hemoglobin (Hb) and hematocrit (HCT). Results Estimated blood loss, percentage blood loss, and intraoperative RBC transfusion units were significantly high in group I in relation to group II and group III (Table 2). Cardiac output was significantly higher in group I in relation to group II and group III at 10, 15, 30, 45, and 60 min after start of AHH. MBP and HR results were significantly high in group I in comparison with group II and group III at 30, 45, 60, and 90 min and 2 and 3 h after start of study drugs. CVP results were significantly high in group I in relation to group II and group III at 15, 30, 45, 60, and 90 min after start of AHH. PTT was significantly increased in the three study groups in comparison with baseline inside each group after AHH. Conclusion Combination of AHH with CH induced by remifentanil or magnesium sulfate was associated with reduction in estimated blood loss, and total volume of PRBCS transfused. There was no significant difference between hemodynamic parameters with the use of remifentanil or magnesium sulfate except that SBP, DBP, and MBP results were significantly high with magnesium sulfate at 15 min after drug infusion. There was significant increase in PT and PTT after AHH that was not reflected by significant blood oozing from the operative field, or by difficulty in hemostasis.


2021 ◽  
Vol 1 (4) ◽  
pp. 383-393
Author(s):  
Sari Rahmada Mulyani ◽  
Aditya Aditya ◽  
Festy Ladyani Mustofa ◽  
Zulfian Zulfian

ABSTRACT: PREVALENCE OF POSITIVE HBsAg BETWEEN VOLUNTARY BLOOD DONATIONS AND REPLACEMENT BLOOD DONATIONS AT PMI UTD LAMPUNG PROVINCE 2019-2020 Background: The risk of transmission of HBV infection through blood transfusion depends on many things, including the prevalence of disease in the community, the recipient's immune status, the number of donors per unit of blood, and the effectiveness of the screening used. The main disease transmission will occur during the window period, which is a period immediately after infection in which the donor's blood has been infected but the screening result is still negative.Objective: To determine the prevalence of positive HBsAg between voluntary blood donations and replacement blood donations at the PMI UTD in Lampung Province in 2019-2020. Methodology: The type of research used in this research is quantitative descriptive with cross-sectional design. The sample used in this study were blood donors at UTD PMI Lampung Province in 2019-2020.Results: The prevalence of voluntary blood donation with positive HBsAg in 2019 was obtained as many as 70 people (33.65%) while the prevalence of replacement blood donors with positive HBsAg in 2019 was obtained as many as 8 people (16%). Then, the prevalence of positive HBsAg voluntary blood donors in 2020 was found to be 138 people (66.35%) while the prevalence of positive HBsAg blood donors in 2020 was 42 people (84%).Conclusion: There is a difference in the prevalence of both voluntary blood donors and replacement blood donors between 2019 and 2020. and the prevalence of HBsAg positive in blood donors is different every year. Keywords: Blood Transfusion, Volunteer, Replacement, HBsAg  INTISARI: PREVALENSI HBsAg POSITIF ANTARA DONOR DARAH SUKARELA DENGAN DONOR DARAH PENGGANTI DI UTD PMI PROVINSI LAMPUNG TAHUN 2019-2020 Latar Belakang: Risiko penularan pada infeksi HBV melalui transfusi darah bergantung pada banyak hal, antara lain yaitu adanya prevalensi penyakit pada masyarakat, status imun resipien, jumlah donor tiap unit darah dan keefektifan skrining yang di gunakan. Penularan penyakit yang utama akan timbul pada saat window period, yaitu suatu periode segera terjadi setelah terinfeksi dimana darah donor sudah terinfeksi tetapi hasil skrining masih negative.Tujuan: Mengetahui Prevalensi HBsAg Positif Antara Donor Darah Sukarela Dengan Donor Darah Pengganti Di UTD PMI Provinsi Lampung Tahun 2019-2020.Metodologi: Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif kuantitatif dengan desain cross sectional. Sampel yang digunakan pada penelitian ini adalah pendonor darah di UTD PMI Provinsi Lampung tahun 2019-2020.Hasil: Prevalensi donor darah sukarela dengan HBsAg positif pada tahun 2019 didapatkan sebanyak 70 orang (33,65%) sementara prelavensi donor darah pengganti dengan HBsAg positif pada tahun 2019 didapatkan sebanyak 8 orang (16%). Lalu, prevalensi donor darah sukarela dengan HBsAg positif pada tahun 2020 didapatkan sebanyak 138 orang (66,35%) sementara untuk prevalensi donor darah pengganti dengan HBsAg positif pada tahun 2020 didapatkan sebanyak 42 orang (84%).Kesimpulan: Terdapat perbedaan prevalensi baik donor darah sukarela maupun donor darah pengganti antara tahun 2019 dengan tahun 2020. Dan prevalensi HBsAg Positif pada donor darah berbeda-beda setiap tahun. Kata Kunci     : Donor Darah, Sukarela, Pengganti, HBsAg


2013 ◽  
Vol 3 (6) ◽  
pp. 459-463 ◽  
Author(s):  
S Mangwana

Background: Hemovigilance like quality systems and audits have become an integral part of Blood Transfusion Services in the developed countries and has contributed greatly to its development. Hemovigilance begins with donors and must enable the collection of information on reactions occurring during the donation of blood, selections of donors and to prevent such incidents. The aim of study was to help identify the trends of adverse events , occurring in blood donors at a tertiary-care hospital, to recommend best practices to improve donor care and safety Materials and Methods: This record-based study was conducted on all adverse events related to allogenic whole blood donations performed over 24 months. All whole blood donations were analyzed. All adverse events occurring during or at the end of the donation were noted using a standardized format and analyzed determining significance at p<0.05. Results: Overall rate was 0.3% with vasovagal reactions constituting 82%, and 18% mild syncopal reactions (p<0.001). Immediate vasovagal reaction with injury was very rare (0.007%). Vasovagal reactions showed a significant association with young age, female gender, first time donation status. Mean age of persons recording adverse effects was 30.23 ± 7.49 years as compared to those without adverse effects, 31.14 ± 8.56 years. Conclusion: Donor safety is an essential perquisite to increase voluntary blood donation. AE analysis helps in identifying the blood donors at risk of AE, applying appropriate motivational strategies, predonation counseling, care during and after donation, developing guidelines and hemovigilance programme in countries with limited resources. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8993   Journal of Pathology of Nepal (2013) Vol. 3, 459-463


Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 26-28
Author(s):  
Hamid Ehsan ◽  
Ahsan Wahab ◽  
Muhammad Ammar Shafqat ◽  
Muhammad Khawar Sana ◽  
Farhan Khalid ◽  
...  

Introduction: The blood transfusion (BT) system in Pakistan is fragmented, demand-driven, and depends on weakly regulated transfusion practices. This is primarily a big problem in smaller cities and remote rural areas. Pakistan has one of the highest hepatitis B virus (HBV) and hepatitis C virus (HCV) prevalence worldwide, estimated around 5 & 10 million cases, respectively. There is a considerable risk that transfusion-transmissible infections (TTIs) may have contributed to the current epidemic of HBV & HCV, affecting 7.4 % of the general population, and potential risk of HIV transmission in the country. In this systematic review, we aim to identify the prevalence of TTIs among the blood donor population and associated safety challenges. Method & Material: We conducted a systematic literature search to identify studies related to TTIs and transfusion safety in Pakistan from January 1, 2010, to January 31, 2020. A search was conducted using PubMed and PakMedinet.com (largest medical database of Pakistan); initial search retrieved 981 articles, 166 met the inclusion criteria, and after review by two independent reviewers, 33 articles met the final criteria for qualitative synthesis. Results: Analysis of 33 studies showed the seroprevalence of HBV of 2.04 % (0.81% to 4.22%), HCV of 2.44% (1.29 % to 10%), HIV of 0.038% (0% to 0.18%), syphilis of 1.1% (0.11-3.01%) and malaria of 0.11% (0.05-1.20). The rate of coinfections among blood donors varied from 0.0099% to 0.35 %. The highest number of coinfections were HCV & syphilis, followed by HCV & HBV infections. The rate of TTIs was dependent on the number of donors, donor types (replacement vs. voluntary), screening techniques used, number, and type of TTIs tested. There was a lack of universal screening for common TTIs. Syphilis and malaria were tested only 38 % & 46 % of all the blood donations. The studies with a high number of replacement donors (RDs) noted a high prevalence of TTIs of 2.5 % to 12 % compared to the studies with a high number of voluntary non-remunerated donations (VNRDs) reported TTIs rates of 1.57% to 6.2 %. There was a significant difference in the prevalence of HBV & HCV in VNRDs (0.48%) compared to RDs (4.15%). The rate of VNRDs was 0.10 % to 13%. The majority of blood donations were from male donors, representing more than 70 % of all donations. The female donations varied from 0.03% to 15 % in government/public blood banks than 29 % in private sector blood banks. The HBV & HCV infections and anemia were the most common causes of blood donation deferral. The 69.5 % of donors who tested positive for TTIs in a study reported previous blood donations. The educational status of donors noted to have an association with knowledge about the risk of TTIs. Odds of having limited knowledge about TTIs (OR: 4.04, CI: 1.567-10.435, p&lt;0.01) were greater if donors had a secondary level of education compared to those with tertiary education. 48 % of blood donors did not know about the risk of TTIs through blood transfusion. There was notification of only about 54.25 % of all donors, who tested positive for any TTIs. This was mainly due to a lack of standardized reporting and follow up systems. Conclusion: This systemic review shows a high prevalence of TTIs, especially HBV, HCV & syphilis in the blood donor population. There is a high dependency on RDs, with minimal use of healthy voluntary blood donation practices, inadequate screening of high-risk donors, repeated collections of the blood from RDs, poor quality of screening methods, and limited knowledge of donors about their health. There is a lack of widespread standardized testing and follow up of patients who tested positive on initial testing. Large prospective multicenter clinical trials are required for a better understanding of the TTIs by testing and creating a follow-up system for both blood donors and recipients. Disclosures Anwer: Incyte, Seattle Genetics, Acetylon Pharmaceuticals, AbbVie Pharma, Astellas Pharma, Celegene, Millennium Pharmaceuticals.:Honoraria, Research Funding, Speakers Bureau.


2001 ◽  
Vol 119 (4) ◽  
pp. 132-134 ◽  
Author(s):  
Rodolfo Delfini Cançado ◽  
Carlos Sérgio Chiattone ◽  
Fausto Forin Alonso ◽  
Dante Mário Langhi Júnior ◽  
Rita de Cássia Silva Alves

CONTEXT: Blood donation results in a substantial loss of iron (200 to 250 mg) at each bleeding procedure (425 to 475 ml) and subsequent mobilization of iron from body stores. Recent reports have shown that body iron reserves generally are small and iron depletion is more frequent in blood donors than in non-donors. OBJECTIVE: The aim of this study was to evaluate the frequency of iron deficiency in blood donors and to establish the frequency of iron deficiency in blood donors according to sex, whether they were first-time or multi-time donors, and the frequency of donations per year. DESIGN: From September 20 to October 5, 1999, three hundred blood donors from Santa Casa Hemocenter of São Paulo were studied. DIAGNOSTIC TESTS: Using a combination of biochemical measurements of iron status: serum iron, total iron-binding capacity, transferrin saturation index, serum ferritin and the erythrocyte indices. RESULTS: The frequency of iron deficiency in blood donors was 11.0%, of whom 5.5% (13/237) were male and 31.7% (20/63) female donors. The frequency of iron deficiency was higher in multi-time blood donors than in first-time blood donors, for male blood donors (7.6% versus 0.0%, P < 0.05) and female ones (41.5% versus 18.5%, P < 0.05). The frequency of iron deficiency found was higher among the male blood donors with three or more donations per year (P < 0.05) and among the female blood donors with two or more donations per year (P < 0.05). CONCLUSIONS: We conclude that blood donation is a very important factor for iron deficiency in blood donors, particularly in multi-time donors and especially in female donors. The high frequency of blood donors with iron deficiency found in this study suggests a need for a more accurate laboratory trial, as hemoglobin or hematocrit measurement alone is not sufficient for detecting and excluding blood donors with iron deficiency without anemia.


Author(s):  
Amira Mohammed Badawy

Background: Symptomatic Uterine leiomyomata may lead to many symptoms including abnormal uterine bleeding, mass pressure effects and infertility. Myomectomy is an option for conservative management, however, it is associated with some disadvantages, mainly increased intra-operative blood loss. Intra-myometrial vasopressin injection during myomectomy is an effective method to decrease the intraoperative bleeding due to its vasoconstrictor effect. Octreotide Acetate (OA) is another vasoconstrictor agent that have not been tested for gynaecologic indications. The current study was conducted to assess the efficacy of local injection of OA in reducing blood loss during conventional abdominal myomectomy, and to compare it with local instillation of vasopressin.Methods: 60 cases with symptomatic leiomyomata were recruited and planned for abdominal myomectomy, they were divided randomly into 3 groups, 20 cases in each. Group I, where local vasopressin was used, group II, where OA was used, and group III (the control group), where no specific medication was used and only free Saline was injected locally.Results: The overall results showed that OA group had significantly less operative time and less blood loss compared to control group. However, when compared to cases in group I, operative time and blood loss were significantly higher. Postoperative haemoglobin levels were significantly lower in group III compared to groups I (P = 0.039) and II (P = 0.044). Blood transfusion was indicated in 9 cases among group III, while only one case needed blood transfusion in group II, and no cases in group I.Conclusions: The use of local intra-myometrial OA is an option for reducing blood loss during myomectomy, but still efficacy is less than local vasopressin. This may be attributed to the low concentrations used, and to the less potency of OA as a vasoconstrictor agent.


2005 ◽  
Vol 71 (9) ◽  
pp. 786-790
Author(s):  
Carlos Donayre ◽  
Uzoamaka Adimora ◽  
Tae Song ◽  
George Kopchok ◽  
Maurice Lippmann ◽  
...  

Endoluminal repair of abdominal aortic aneurysms (AAA) is associated with decreased blood loss and transfusion requirements when compared to open AAA repair. We evaluated the use of an intraoperative autotransfusion system during endoluminal exclusion of AAAs. Fifty endoluminal AAA procedures selected at random were reviewed retrospectively. Patients were divided into 4 groups according to their estimated blood loss: Group I, 20 patients (0–500 cc); Group II, 18 patients (501–1,000 cc); Group III, 7 patients (1,001–1,500 cc); and Group IV, 5 patients (1,501–3,400 cc). The average blood loss was 327 cc for Group I, 728 cc for Group II, 1,217 for Group III, and 2,125, for Group IV. The overall blood loss was 834 cc, but 75 per cent was recovered. Hematuria was always present when greater than 1,000 cc of blood was retransfused, but renal function was not affected even with the concomitant administration of radiographic contrast. Only one patient required an autologous blood transfusion. The use of an autotransfusion device is safe, efficacious, and appears to further limit the need for homologous blood transfusion in patients undergoing endoluminal AAA repair.


1972 ◽  
Vol 12 (137) ◽  
pp. 429-431 ◽  

The International Federation of Blood Donors held its seventh Congress in Monaco in October 1971, and the report of its work has now been published. This reproduces various technical communications on, inter alia, “The Importance of Blood Donation for Organ Transplants” and current blood transfusion problems. It contains also a report by the Belgian Red Cross Society's constantly developing blood donor service, for the number of donors has unceasingly increased from 131,000 in 1969 to 147,000 in 1971.


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