scholarly journals Synthesis and antimicrobial properties of camphorsulfonic acid derived imidazolium salts

2014 ◽  
Vol 61 (2) ◽  
pp. 42-48 ◽  
Author(s):  
R. Mikláš ◽  
N. Miklášová ◽  
M. Bukovský ◽  
F. Devínsky
Keyword(s):  
Minimal Inhibitory Concentration ◽  
Antifungal Agents ◽  
Functional Group ◽  
Inhibitory Concentration ◽  
Antimicrobial Properties ◽  
The Novel ◽  
Good Activity ◽  
Imidazolium Salts ◽  
Amide Derivatives ◽  
Benzalkonium Bromide

Abstract A group of homochiral imidazolium salts bearing hydrophobic camphor derived moiety and ester or amide functional group were synthesized and characterized. The novel imidazolium bromides were tested as antimicrobial and antifungal agents and their minimal inhibitory concentration (MIC) was evaluated and compared to clinically used benzalkonium bromide (BAB) and carbethopendecinium bromide. The MIC values of amide derivatives 2a and 2b were slightly smaller than those for BAB, indicating their good activity. None of the prepared salts was more effective than carbethopendecinium bromide. The biocidal efficacy of amide derivatives was much higher compared to the ester analogues.

scholarly journals Synthesis and Correlation of Aggregation and Antimicrobial Properties of Homochiral Quaternary Ammonium Bromides Derived from Camphoric Acid

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
R. Mikláš ◽  
N. Miklášová ◽  
M. Bukovský
Keyword(s):  
Quaternary Ammonium ◽  
Cationic Surfactants ◽  
Antifungal Agents ◽  
Inhibitory Concentration ◽  
Antimicrobial Properties ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
The Novel ◽  
Benzalkonium Bromide ◽  
Camphoric Acid

Abstract A group of homochiral quaternary ammonium salts bearing hydrophobic camphoric acid-derived moiety was synthesized and characterized. The aggregation properties of the prepared compounds were evaluated by surface tension measurements, and the critical micelle concentration (CMC) was calculated. The novel quaternary ammonium bromides were tested as antimicrobial and antifungal agents, and their minimal inhibitory concentration (MIC) was evaluated and compared to clinically used benzalkonium bromide (BAB). Correlation of MIC with CMC reveals that monomers of prepared cationic surfactants, instead of micelles, are primarily responsible for antimicrobial activity.

scholarly journals Antifungal agents in non-neonatologic pediatrics

2013 ◽  
Vol 4 (1S) ◽  
pp. 45-50
Author(s):  
Elio Castagnola
Keyword(s):  
Minimal Inhibitory Concentration ◽  
Amphotericin B ◽  
Antifungal Agent ◽  
Antifungal Agents ◽  
Inhibitory Concentration ◽  
Time Dependent ◽  
Combination Therapies ◽  
Agent Interactions

The spectrum of action of antifungal agents helps driving the choice of the treatment, basing on the activity against the fungus of interest. Pharmacokinetics should also be taken into account, considering the time-dependent and the concentration-dependent drugs. Triazoles belong to the first group, while amphotericin B and echinocandins belong to the second one. The effectiveness of time-dependent drugs hangs on the time spent above the Minimal Inhibitory Concentration (MIC), whereas that of concentration-dependent drugs is related to the peak of concentration achieved. Thetissue penetration is another important factor that should be taken into account while prescribing an antifungal agent. Interactions with other drugs, above all with those used to treat underlying pathologies, should also be considered. Fungicidal drugs are generally preferred to fungistatic agents, therefore echinocandins and amphotericin B are more prescribed than azoles. Combination therapies are not recommended.

scholarly journals Antimicrobial efficacy of Novel Ethanolic Extract of Morinda Citrifolia Against Enterococcus Feacalis by Agar Well Diffusion Method and Minimal Inhibitory Concentration- An Invitro Study.

2019 ◽  
Vol 22 (3) ◽  
pp. 365-370
Author(s):  
Sriram Gummuluri ◽  
Venkata Teja Kavalipurapu ◽  
Apoorva Vasundhara Kaligotla
Keyword(s):  
Antimicrobial Activity ◽  
Minimal Inhibitory Concentration ◽  
Root Canal ◽  
Inhibitory Concentration ◽  
Ethanolic Extract ◽  
Morinda Citrifolia ◽  
Antimicrobial Efficacy ◽  
Diffusion Method ◽  
The Novel ◽  
Agar Well Diffusion Assay

Introduction: the long term success of root canal treatment is ultimately related to the effective debridement and disinfection of the root canal system. Hence, the irrigants play an important role in achieving the good penetrability and bactericidal activity. The present study was mainly aimed at evaluating the invitro antimicrobial efficacy of Novel Ethanolic Extract of Morinda Citrifolia by agar well diffusion and minimal inhibitory concentration. Materials and Methods:the antimicrobial efficacy of the Novel Ethanolic Extract of Morinda Citrifolia was tested using agar well diffusion and minimal inhibitory concentration was assessed. The zone of inhibitions were determined at 10 mg/ml concentration of Ethanolic Extract of Morinda Citrifolia on agar well plate and Minimal Inhibitory Concentration (MIC) against tested microorganism. Results: results obtained in the present study by both qualitative and quantitative experiments revieled that the tested Ethanolic Extract of Morinda Citrifolia possesses potential antibacterial activity against Enterococcus Feacalis when compared with standard antibiotic tetracycline. the highest zone of inhibition of 15mm was showed at 1000micrograms by agar well diffusion assay. The optimal antimicrobial activity was seen at 250micrograms for Morinda Citrifolia against Enterococcus Feacalis.Conclusion: novel Ethanolic extract of Morinda Citrifolia has shown an optimal antimicrobial activity against E.Feaclais. But still, future studies are still needed.

Chemical Characterization of Lavandula dentata Essential Oil Cultivated in Chile and Its Antibiofilm Effect against Candida albicans

Planta Medica ◽  
2020 ◽  
Vol 86 (16) ◽  
pp. 1225-1234
Author(s):  
Andrea Müller-Sepúlveda ◽  
Camila Cid Chevecich ◽  
José A. Jara ◽  
Carolina Belmar ◽  
Pablo Sandoval ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Essential Oil ◽  
Minimal Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Antimicrobial Properties ◽  
Chemical Characterization ◽  
Gas Chromatography Mass Spectrometry ◽  
Minimal Inhibitory Concentrations ◽  
Adhesion Ability ◽  
Viability Assay

Abstract Candida albicans is the most common human fungal pathogen, and with the increase in resistance rates worldwide, it is necessary to search for new pharmacological alternatives. Lavandula dentata L. essential oil is recognized as having antimicrobial properties. However, its effect against fungal biofilms has been poorly described. C. albicans-related infections involve the development of biofilms, which are highly resistant to conventional antifungals. In this work, we evaluated the antibiofilm effect of L. dentata L. essential oil against C. albicans. First, we characterized the essential oil by gas chromatography-mass spectrometry. The antifungal effect on C. albicans reference strains was evaluated by a disk diffusion assay and the minimal inhibitory concentration was obtained through a microdilution assay. The effect of the essential oil on the adhesion ability of C. albicans was determined through a crystal violet assay, and morphogenesis inhibition was assessed by light microscopy. The effect of the essential oil on the microarchitecture of biofilms was evaluated through scanning electron microscopy. Finally, the antibiofilm effect was evaluated through an adapted biofilm scratch assay and XTT viability assay. The main constituent of the essential oil was the monoterpenoid eucalyptol (60%). The essential oil presented minimal inhibitory concentrations of 156 and 130 µg/mL against two strains assayed. This minimal inhibitory concentration inhibited adhesion, morphogenesis, biofilm formation, altered microarchitecture, and decreased the viability of established biofilms formed on abiotic surfaces for both strains assayed. This study demonstrates that the essential oil from L. dentata could be a promising treatment against C. albicans biofilms.

scholarly journals Minimal inhibitory concentration distributions and epidemiological cutoff values of five antifungal agents against Sporothrix brasiliensis

2017 ◽  
Vol 112 (5) ◽  
pp. 376-381 ◽  
Author(s):  
Rodrigo Almeida-Paes ◽  
Fábio Brito-Santos ◽  
Maria Helena Galdino Figueiredo-Carvalho ◽  
Ana Caroline Sá Machado ◽  
Manoel Marques Evangelista Oliveira ◽  
...  
Keyword(s):  
Minimal Inhibitory Concentration ◽  
Antifungal Agents ◽  
Inhibitory Concentration ◽  
Sporothrix Brasiliensis ◽  
Cutoff Values

scholarly journals Synthesis and Biological Evaluation of Benzo[b]thiophene Acylhydrazones as Antimicrobial Agents against Multidrug-Resistant Staphylococcus aureus

Biomolecules ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 131
Author(s):  
Thibaut Barbier ◽  
Alexia Barbry ◽  
Jérémy Magand ◽  
Cédric Badiou ◽  
Floriane Davy ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Minimal Inhibitory Concentration ◽  
Aromatic Ring ◽  
Antimicrobial Agents ◽  
Functional Group ◽  
Inhibitory Concentration ◽  
Multidrug Resistant ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation ◽  
Structural Diversification

The benzo[b]thiophene nucleus and the acylhydrazone functional group were combined to prepare three new series of compounds for screening against Staphylococcus aureus. The reaction of substituted benzo[b]thiophene-2-carboxylic hydrazide and various aromatic or heteroaromatic aldehydes led to a collection of 26 final products with extensive structural diversification on the aromatic ring and on position 6 of the benzo[b]thiophene nucleus. The screening lead to the identification of eight hits, including (E)-6-chloro-N’-(pyridin-2-ylmethylene)benzo[b]thiophene-2-carbohydrazide (II.b), a non-cytotoxic derivative showing a minimal inhibitory concentration of 4 µg/mL on three S. aureus strains, among which were a reference classical strain and two clinically isolated strains resistant to methicillin and daptomycin, respectively.

Nồng độ ức chế tối thiểu (Minimal Inhibitory Concentration - MIC) của một số loại kháng sinh đến vi khuẩn phân lập được từ cá dìa thương phẩm mắc bệnh lở loét (Siganus guttatus, Bloch, 1787)

2015 ◽  
Vol 104 (5) ◽  
Author(s):  
Lê Văn Bảo Duy ◽  
Dương Thị Thủy ◽  
Nguyễn Ngọc Phước ◽  
Trương Thị Hoa ◽  
Nguyễn Đức Quỳnh Anh
Keyword(s):  
Minimal Inhibitory Concentration ◽  
Vibrio Parahaemolyticus ◽  
Inhibitory Concentration ◽  
Vibrio Tubiashii

Nghiên cứu được tiến hành nhằm xác định nồng độ ức chế tối thiểu (Minimal Inhibitory Concentration - MIC) của một số loại kháng sinh đến vi khuẩn phân lập được từ cá dìa thương phẩm mắc bệnh lở loét (Siganus guttatus). Từ kết quả phân lập định danh cho thấy 2 chủng Vibrio parahaemolyticus VPMP22 và Vibrio tubiashii ATCC 19109 có mặt trên các vết lở loét ở cá dìa thương phẩm. Kết quả thử nghiệm MIC cho thấy các loại kháng sinh Cefuroxim, Cefotaxim, Tetracycline, Erythromicin, Rifamicin có nồng độ ức chế vi khuẩn Vibrio parahaemolyticus VPMP22 tốt nhất dưới 0.21 µg/ml. Các kháng sinh có Cefuroxim, Cefotaxim, Oxytetraciline, Erythromicin, Trimethoprim nồng độ ức chế vi khuẩn Vibrio tubiashii ATCC 19109 tốt nhất dưới 1.25 µg/ml. Penicillin có nồng độ ức chế tối thiểu cao nhất đối với cả 2 chủng vi khuẩn trên (80 µg/ml), cho thấy 2 chủng vi khuẩn trên đã có sự kháng thuốc đối với loại kháng sinh này. Do đó, trong phòng trị bệnh lở loét trên cá dìa nên sử dụng Cefuroxim và Cefotaxim để có hiệu quả cao nhất trong phòng trị bệnh.

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