Robustness of HPHC Reduction in THS 2.2 Aerosol Relative to 3R4F Reference Cigarette Smoke under Extreme Climatic Conditions

2021 ◽  
Vol 30 (3) ◽  
pp. 109-126
Author(s):  
Laurent Poget ◽  
Catherine Goujon ◽  
Samuel Kleinhans ◽  
Serge Maeder ◽  
Jean-Pierre Schaller
Keyword(s):  
Cigarette Smoke ◽  
Heating System ◽  
Tobacco Product ◽  
Climatic Conditions ◽  
Mainstream Smoke ◽  
Humid Climate ◽  
Experimental Conditions ◽  
Puff Volume ◽  
Temperature And Humidity ◽  
Health Canada

Summary In order to assess robustness for the reduction of harmful and potentially harmful constituent (HPHC) levels generated by the Tobacco Heating System 2.2 (THS 2.2), a heated tobacco product, we compared the aerosol of this product with mainstream smoke from the 3R4F reference cigarette under different conditions of temperature and humidity. The desired climatic conditions were achieved by using an air-conditioning system coupled with the smoking-machine housing. Two extreme climatic conditions were selected, representing a “Hot and Dry” climate (30 °C and 35% relative humidity RH) and a “Hot and Very Humid” climate (30 °C and 75% RH). In addition, aerosol and smoke were generated using the standard conditions recognized for smoking-machine analyses of tobacco products (22 °C and 60% RH), which were close to the climatic conditions defined for “Subtropical and Mediterranean” environments (25 °C and 60% RH). The experimental conditions were chosen to simulate the use of THS 2.2 and cigarettes under extreme conditions of temperature and humidity. HeatSticks and cigarettes taken from freshly opened packs were subjected to short-term conditioning from two to a few more days under the same experimental conditions. We analyzed 54 HPHCs in THS 2.2 aerosol and 3R4F cigarette smoke, generated in accordance with the Health Canada Intense (HCI) standard, using modified temperature and humidity conditions for sample conditioning and machine-smoking experiments. We used a volume-adjusted approach for comparing HPHC reductions across the different climatic conditions investigated. Although a single puffing regimen was used, the total puff volume recorded for the 3R4F cigarette smoke varied due to the influence of temperature and humidity on combustion rate, which justified the use of a volume-adjusted approach. Volume-adjusted yields were derived from HPHC yields expressed in mass-per-tobacco stick normalized per total puff volume. The results indicated that, regardless of the considered climatic conditions, the HPHC levels investigated in THS 2.2 aerosol were reduced by at least 90%, on average, when compared with the concentrations in 3R4F cigarette mainstream smoke. This confirmed the robustness in performance for THS 2.2 to deliver reduced levels of HPHCs under the extreme climatic conditions investigated in this study. In order to further characterize the robustness of these reductions, the lowest reduction performance achieved for individual HPHCs across all climatic conditions was used to define the threshold for a robust reduction. The majority of the 54 HPHCs investigated in THS 2.2 aerosol showed more than 90% reduction. Calculations derived from nicotine-adjusted yields also confirmed robust reductions for all investigated HPHCs. The small differences in absolute reduction between the volume- and nicotine-adjusted approaches were predominantly attributed to a combination of the differences in both nominal nicotine deliveries and total puff volumes between THS 2.2 and 3R4F cigarettes; however, this did not influence the determination of robustness. Our findings confirm the value of this approach for assessing the robustness of a product’s performance under different climatic conditions.

scholarly journals Robustness of HPHC Reduction for THS 2.2 Aerosol Compared with 3R4F Reference Cigarette Smoke Under High Intensity Puffing Conditions

2020 ◽  
Vol 29 (2) ◽  
pp. 66-83
Author(s):  
Catherine Goujon ◽  
Samuel Kleinhans ◽  
Serge Maeder ◽  
Laurent Poget ◽  
Jean-Pierre Schaller
Keyword(s):  
Cigarette Smoke ◽  
High Intensity ◽  
Large Range ◽  
Tobacco Product ◽  
Mainstream Smoke ◽  
Cigarette Filter ◽  
Puff Volume ◽  
Multiple Regimes ◽  
Present Context ◽  
Health Canada

SummaryIn the absence of standards specific for testing the reduction robustness of the levels of harmful and potentially harmful constituents (HPHCs), the aerosol from the THS 2.2, a heated tobacco product, was compared with the mainstream smoke of the 3R4F reference cigarette over a broad range of machine-smoking regimes. The average reduction and the introduced concept of threshold limits of robust reduction were derived from HPHC concentrations, in mass per tobacco-stick normalized per total puff volume, to propose an alternative for the assessment of products where nicotine-adjusted yields would be inappropriate. In addition, this study explores the influence of 3R4F reference cigarette filter ventilation, and discusses the roles of temperature and precursors in the present context of robustness of HPHC reduction. Fifty-four HPHCs were analyzed under multiple regimes in THS 2.2 aerosol and 3R4F cigarette smoke. The average reduction of HPHC concentrations compared across all regimes characterized the robustness. Threshold limits of reduction of individual HPHCs were statistically determined across all regimes. The results observed under Health Canada Intense (HCI) and more intense regimes indicated that on average the reductions in HPHCs levels investigated in THS 2.2 aerosol were more than 90% and that the majority of the 54 HPHCs investigated in THS 2.2 aerosol showed more than 90% reduction. The robustness of THS 2.2 in maintaining the levels of reduction of representative HPHCs, whatever the puffing regime, can be quantified. The mass of HPHC per tobacco-stick normalized per total puff volume is a valuable approach to compare the robustness of the performance of a product over a large range of puffing conditions. Our findings will greatly complement the assessment for robustness of current and future similar products where classical approaches would present limitations.

scholarly journals Comparison of 3R4F cigarette smoke and IQOS heated tobacco product aerosol emissions

2021 ◽  
Author(s):  
Teemu Kärkelä ◽  
Unto Tapper ◽  
Tuula Kajolinna
Keyword(s):  
Particulate Matter ◽  
Electron Microscope ◽  
Cigarette Smoke ◽  
Significant Proportion ◽  
Heating System ◽  
Tobacco Product ◽  
Average Concentration ◽  
Solid Particles ◽  
Health Canada ◽  
Aerosol Emissions

AbstractIn this study, the smoke from a 3R4F research cigarette and the aerosol generated by the Heated Tobacco Product IQOS, also referred to as the Tobacco Heating System (THS) 2.2 in the literature, were compared. The objective was to characterize the gas and suspended particulate matter compositions in the mainstream smoke from a combusted 3R4F cigarette and in the aerosol generated by IQOS during use. The results indicated that the determined aerosol emissions from IQOS were notably lower than in the cigarette smoke under a Health Canada Intense puffing regimen. As an interesting detail in this study, the maximum nicotine concentrations within a puff were practically the same in both the 3R4F smoke and the IQOS aerosol, but the average concentration was lower for the IQOS aerosol. For both products, water constituted a significant proportion of the particulate matter, although it was substantially higher in the IQOS aerosol. Furthermore, combustion-related solid particles observed in the 3R4F smoke contained elements such as carbon, oxygen, potassium, calcium, and silicon. In contrast, IQOS aerosol particulate matter was composed of semi-volatile organic constituents with some minor traces of oxygen and silicon. The particulate matter found in the IQOS aerosol was volatile, which was especially noticeable when exposed to the electron beam of the scanning electron microscope (SEM) and Transmission Electron Microscope (TEM).

scholarly journals Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach

2017 ◽  
Vol 6 (6) ◽  
pp. 930-946 ◽  
Author(s):  
Anita R. Iskandar ◽  
Yannick Martinez ◽  
Florian Martin ◽  
Walter K. Schlage ◽  
Patrice Leroy ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Heating System ◽  
Tobacco Product ◽  
Small Airway ◽  
Biological Impact ◽  
Systems Toxicology

The biological impact of a tobacco heating system 2.2 aerosol and cigarette smoke were compared.

scholarly journals Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro

2021 ◽  
Author(s):  
Carine Poussin ◽  
Marco van der Toorn ◽  
Sophie Scheuner ◽  
Romain Piault ◽  
Athanasios Kondylis ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cigarette Smoke ◽  
In Vitro Study ◽  
Aging Effect ◽  
Heating System ◽  
Tobacco Product ◽  
Premature Aging ◽  
Maximum Effect ◽  
Toxicology Study

AbstractAging and smoking are major risk factors for cardiovascular diseases (CVD). Our in vitro study compared, in the context of aging, the effects of the aerosol of Tobacco Heating System 2.2 (THS; an electrically heated tobacco product) and 3R4F reference cigarette smoke (CS) on processes that contribute to vascular pathomechanisms leading to CVD. Young and old human aortic smooth muscle cells (HAoSMC) were exposed to various concentrations of aqueous extracts (AE) from 3R4F CS [0.014–0.22 puffs/mL] or THS aerosol [0.11–1.76 puffs/mL] for 24 h. Key markers were measured by high-content imaging, transcriptomics profiling and multianalyte profiling. In our study, in vitro aging increased senescence, DNA damage, and inflammation and decreased proliferation in the HAoSMCs. At higher concentrations of 3R4F AE, young HAoSMCs behaved similarly to aged cells, while old HAoSMCs showed additional DNA damage and apoptosis effects. At 3R4F AE concentrations with the maximum effect, the THS AE showed no significant effect in young or old HAoSMCs. It required an approximately ten-fold higher concentration of THS AE to induce effects similar to those observed with 3R4F. These effects were independent of nicotine, which did not show a significant effect on HAoSMCs at any tested concentration. Our results show that 3R4F AE accelerates aging in young HAoSMCs and exacerbates the aging effect in old HAoSMCs in vitro, consistent with CS-related contributions to the risk of CVD. Relative to 3R4F AE, the THS AE showed a significantly reduced impact on HAoSMCs, suggesting its lower risk for vascular SMC-associated pathomechanisms leading to CVD.

scholarly journals Impact of 6-Month Exposure to Aerosols From Potential Modified Risk Tobacco Products Relative to Cigarette Smoke on the Rodent Gastrointestinal Tract

2021 ◽  
Vol 12 ◽  
Author(s):  
James N. D. Battey ◽  
Justyna Szostak ◽  
Blaine Phillips ◽  
Charles Teng ◽  
Ching Keong Tung ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Heating System ◽  
Smoking Initiation ◽  
Tobacco Product ◽  
Intestinal Microbiome ◽  
Disease Pathogenesis ◽  
Tobacco Products ◽  
Microbiome Composition ◽  
Adverse Health Effects ◽  
The Impact

Cigarette smoking causes adverse health effects that might occur shortly after smoking initiation and lead to the development of inflammation and cardiorespiratory disease. Emerging studies have demonstrated the role of the intestinal microbiome in disease pathogenesis. The intestinal microbiome is susceptible to the influence of environmental factors such as smoking, and recent studies have indicated microbiome changes in smokers. Candidate modified risk tobacco products (CMRTP) are being developed to provide substitute products to lower smoking-related health risks in smokers who are unable or unwilling to quit. In this study, the ApoE–/– mouse model was used to investigate the impact of cigarette smoke (CS) from the reference cigarette 3R4F and aerosols from two CMRTPs based on the heat-not-burn principle [carbon-heated tobacco product 1.2 (CHTP 1.2) and tobacco heating system 2.2 (THS 2.2)] on the intestinal microbiome over a 6-month period. The effect of cessation or switching to CHTP 1.2 after 3 months of CS exposure was also assessed. Next-generation sequencing was used to evaluate the impact of CMRTP aerosols in comparison to CS on microbiome composition and gene expression in the digestive tract of mice. Our analyses highlighted significant gene dysregulation in response to 3R4F exposure at 4 and 6 months. The findings showed an increase in the abundance of Akkermansiaceae upon CS exposure, which was reversed upon cessation. Cessation resulted in a significant decrease in Akkemansiaceae abundance, whereas switching to CHTP 1.2 resulted in an increase in Lactobacillaceae abundance. These microbial changes could be important for understanding the effect of CS on gut function and its relevance to disease pathogenesis via the microbiome.

scholarly journals Aldehyde and Volatile Organic Compound Yields in Commercial Cigarette Mainstream Smoke Are Mutually Related and Depend on the Sugar and Humectant Content in Tobacco

2019 ◽  
Vol 22 (10) ◽  
pp. 1748-1756 ◽  
Author(s):  
Jeroen L A Pennings ◽  
Johannes W J M Cremers ◽  
Mark J A Becker ◽  
Walther N M Klerx ◽  
Reinskje Talhout
Keyword(s):  
Cigarette Smoke ◽  
Tobacco Product ◽  
International Standards ◽  
World Health ◽  
Mainstream Smoke ◽  
Additional Advantage ◽  
Product Regulation ◽  
Volatile Organic ◽  
Health Organization ◽  
International Standards Organization

Abstract Introduction The World Health Organization (WHO) Framework Convention on Tobacco control recognizes the need for tobacco product regulation. In line with that, the WHO Study Group on Tobacco Product Regulation (TobReg) proposed to regulate nine toxicants in mainstream cigarette smoke, including aldehydes, volatile organic compounds (VOCs), and carbon monoxide (CO). We analyzed their relations in 50 commercially available cigarette brands, using two different smoking regimes, and their dependence on sugar and humectant concentrations in tobacco filler. Methods We measured sugar and humectant in tobacco filler and aldehydes, VOCs, and tar, nicotine, and CO (TNCO) in mainstream smoke. The general statistics, correlations between emission yields, and correlations between contents and emissions yields were determined for these data. Results For aldehydes, several significant correlations were found with precursor ingredients in unburnt tobacco when smoked with the Intense regime, most prominently for formaldehyde with sucrose, glucose, total sugars, and glycerol. For VOCs, 2,5-dimethylfuran significantly correlates with several sugars under both International Standards Organization (ISO) and Intense smoking conditions. A correlation network visualization shows connectivity between a sugar cluster, an ISO cluster, and an Intense cluster, with Intense formaldehyde as a central highest connected hub. Conclusions Our multivariate analysis showed several strong connections between the compounds determined. The toxicants proposed by WHO, in particular, formaldehyde, can be used to monitor yields of other toxicants under Intense conditions. Emissions of formaldehyde, acetaldehyde, acrolein, and 2,5-dimethylfuran may decrease when sugar and humectants contents are lowered in tobacco filler. Implications Our findings suggest that the aldehydes and VOCs proposed by TobReg are a representative selection for smoke component market monitoring purposes. In particular, formaldehyde yields may be useful to monitor emissions of other toxicants under Intense conditions. Since the most and strongest correlations were observed with the Intense regime, policymakers are advised to prescribe this regime for regulatory purposes. Policymakers should also consider sugars and humectants contents as targets for future tobacco product regulations, with the additional advantage that consumer acceptance of cigarette smoke is proportional to their concentrations in the tobacco blend.

scholarly journals IQOS: examination of Philip Morris International’s claim of reduced exposure

2018 ◽  
Vol 27 (Suppl 1) ◽  
pp. s30-s36 ◽  
Author(s):  
Gideon St.Helen ◽  
Peyton Jacob III ◽  
Natalie Nardone ◽  
Neal L Benowitz
Keyword(s):  
Cigarette Smoke ◽  
Systemic Exposure ◽  
Tobacco Product ◽  
Global Market ◽  
Mainstream Smoke ◽  
Aerosol Chemistry ◽  
Philip Morris ◽  
The Usa ◽  
Human Exposure Assessment ◽  
The Impact

BackgroundNew electronic heated tobacco products are being introduced in the global market and are gaining popularity. In 2016, Philip Morris International, Inc. (PMI) submitted a modified risk tobacco product (MRTP) application to the Food and Drug Administration (FDA) to market IQOS in the USA with claims of reduced exposure and reduced risk.MethodsWe examined PMI’s MRTP application, specifically sections on aerosol chemistry and human exposure assessment, to assess the validity of PMI’s claims of reduced exposure and risk.FindingsPMI reported levels for only 40 of 93 harmful and potentially harmful constituents (HPHCs) on FDA’s HPHC list in IQOS mainstream aerosol. All substances in PMI’s list of 58 constituents (PMI-58) were lower in IQOS emissions compared with mainstream smoke of 3R4F reference cigarettes. However, levels of 56 other constituents, which are not included in the PMI-58 list or FDA’s list of HPHCs, were higher in IQOS emissions; 22 were >200% higher and seven were >1000% higher than in 3R4F reference cigarette smoke. PMI’s studies also show significantly lower systemic exposure to some HPHCs from use of IQOS compared with smoking combustible cigarettes.ConclusionPMI’s data appear to support PMI’s claim that IQOS reduces exposure to HPHCs. However, PMI’s data also show significantly higher levels of several substances that are not recognised as HPHCs by the FDA in IQOS emissions compared with combustible cigarette smoke. The impact of these substances on the overall toxicity or harm of IQOS is not known.

The Control of Cigarette Smoke Deliveries Using Heat-Shrinkable Films

1975 ◽  
Vol 8 (2) ◽  
Author(s):  
R. A. Crellin ◽  
G. O. Brooks ◽  
H. G. Horsewell
Keyword(s):  
Particulate Matter ◽  
Cellulose Acetate ◽  
Cigarette Smoke ◽  
Total Particulate Matter ◽  
Puff Volume ◽  
Cigarette Paper ◽  
High Degree

AbstractA ventilating filter for cigarettes has been developed which reduces the delivery of smoke constituents from the final two to three puffs. Since the normaI delivery for these three puffs can account for up to half the total particulate matter and nicotine delivered by the whole cigarette, usefuI reductions per cigarette can be produced. The ventilating filter consists of cellulose acetate tow wrapped in heat-shrinkable film and attached to a tobacco rod using perforated tipping paper. When the cigarette is smoked, the perforations remain closed by contact with the impermeable film until transfer of heat to the filter is sufficient to soften the filter tow and shrink the film. Ventilating air now enters the cigarette and reduces the smoke deliveries. The effectiveness of the ventilating filter is increased by using films which have a low shrink temperature, high shrink tension and a high degree of biaxiaI shrinkage. Increases in filter plasticiser level, tipping perforation area and puff volume improve the effectiveness of the ventilating filter but increases in cigarette paper porosity and tobacco butt length reduce the effectiveness

scholarly journals Indoor Climate Performance in a Renovated School Building

Energies ◽  
2021 ◽  
Vol 14 (10) ◽  
pp. 2827
Author(s):  
Pavla Mocová ◽  
Jitka Mohelníková
Keyword(s):  
Indoor Environment ◽  
Natural Ventilation ◽  
Carbon Dioxide Concentration ◽  
Heating System ◽  
Climatic Conditions ◽  
School Building ◽  
Ventilation Strategy ◽  
Indoor Climate ◽  
Microbiological Testing ◽  
Indoor Comfort

Indoor climate comfort is important for school buildings. Nowadays, this is a topical problem, especially in renovated buildings. Poorly ventilated school classrooms create improper conditions for classrooms. A post-occupancy study was performed in a school building in temperate climatic conditions. The evaluation was based on the results of long-term monitoring of the natural ventilation strategy and measurements of the carbon dioxide concentration in the school classroom’s indoor environment. The monitoring was carried out in an old school building that was constructed in the 1970s and compared to testing carried out in the same school classroom after the building was renovated in 2016. Surprisingly, the renovated classroom had a significantly higher concentration of CO2. It was found that this was due to the regulation of the heating system and the new airtight windows. The occupants of the renovated classroom have a maintained thermal comfort, but natural ventilation is rather neglected. A controlled ventilation strategy and installation of heat recovery units are recommended to solve these problems with the classroom’s indoor environment. Microbiological testing of the surfaces in school classrooms also shows the importance of fresh air and solar radiation access for indoor comfort.

Sign in / Sign up

Export Citation Format

Share Document