scholarly journals Risk Factors for Stroke in Patients with Chronic Kidney Disease

2020 ◽  
Vol 17 (1) ◽  
pp. 35-44
Author(s):  
Delia Timofte ◽  
Dorin Dragoș ◽  
Adina Măndiţă ◽  
Andra-Elena Balcangiu-Stroescu ◽  
Maria-Daniela Tănăsescu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Diseases ◽  
Public Health Problem ◽  
Developed Countries ◽  
Cardiovascular Complications ◽  
Replacement Treatment ◽  
High Incidence ◽  
Main Culprit

AbstractStroke is a public health problem especially in developed countries, being an important cause of death and disability. The prevalence of chronic kidney disease (CKD) in the general population varies from country to country. The percentage of afflicted patients is on the rise, mainly due to the high incidence of diabetes mellitus (DM) complicated with diabetic nephropathy (DN) and of the kidney vascular diseases (hypertensive nephroangiosclerosis and ischemic nephropathy). In patients with CKD, strokes are relatively frequent, especially hemorrhagic ones, due to a host of risk factors, both modifiable and unmodifiable.Cardiovascular complications (which may be prevented by risk factors control) are the main culprit for the relatively high mortality rate of CKD patients, frequently leading to their death before the initiation of renal replacement treatment (dialysis, kidney transplant).

scholarly journals THU0300 RISK FACTORS FOR COMPLICATIONS AND REFRACTORY COURSE IN PATIENTS WITH ANCA-ASSOCIATED SYSTEMIC VASCULITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 378.2-378
Author(s):  
A. Chudinov ◽  
I. Belyaeva ◽  
M. Pervakova ◽  
V. Mazurov ◽  
O. Inamova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Induction Therapy ◽  
Granulomatosis With Polyangiitis ◽  
Disease Risk ◽  
Systemic Vasculitis ◽  
Cardiovascular Complications ◽  
Infectious Complications ◽  
Eosinophilic Granulomatosis With Polyangiitis

Background:ANCA-associated systemic vasculitis (AAV) is characterized by a high incidence of complications and high mortality. The most significant complications during the first 3 years of the disease are infectious and cardiovascular. Development of chronic kidney disease also impairs the prognosis of AAV. Refractory to induction therapy can significantly increase the severity of organ lesions in patients with AAV.Objectives:The aim of this study was to determine risk factors for complications and refractory course in patients with AAV.Methods:Patients with granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA) were observed during the first 3 years of the disease and included in this study between 2010 and 2018. Most common infectious complications requiring inpatient treatment were pneumonia, mycosis, sepsis, purulent arthritis, purulent otitis media. Cardiovascular complications included pulmonary thromboembolism, myocardial infarction, ischemic stroke, venous thrombosis.Results:In total 209 (165 [79%] female and mean age 51.8 ± 13.2 years) AAV patients (94 GPA; 46 MPA; and 69 EGPA) were included in the analysis. Risk factors for infectious complications were BVAS level at the beginning of induction therapy > 25 (OR – 2.92, 95% CI (1.53;5.45) p<0.001), usage of prednisone in doses more than 60 mg / day at the induction of remission (OR – 2.76, 95% CI (1.45;5.29) p=0.003), usage of prednisone in doses ≥ 10 mg / day after 6 months of induction therapy (OR – 2.60, 95% CI (1.38;4.93) p=0.003), ANCA-PR3 positivity (OR – 2.25, 95% CI (1.13;4.46) p=0.017) and presence of diabetes mellitus in the AAV onset (OR – 1.77, 95% CI (1.14;3.45) p=0.038). Patients with AAV had following risk factors for cardiovascular complications: male (OR – 2.28, 95% CI (1.33;3.88) p=0.002), BVAS level > 25 (OR – 2.1, 95% CI (1.11;3.16) p=0.008) and presence of coronary artery disease in the AAV onset (OR – 2.2, 95% CI (1.18;4.10) p=0.015). ANCA positivity (OR – 5.62, 95% CI (2.1;14.9) p<0.001), presence of rapidly progressive glomerulonephritis in the first 3 months from onset AAV (OR – 5.02, 95% CI (3.42;7.35) p<0.001) and over 60 years of age (OR – 2.17, 95% CI (1.38;3.44) p=0.001) were risk factors of development of chronic kidney disease. Risk factors for refractory to induction therapy in patients with AAV were ANCA-PR3 positivity (OR – 3.13, 95% CI (1.63;6.02) p<0.001), BVAS level > 25 (OR – 2.63, 95% CI (1.74;4.34) p<0.001), initiation of therapy after 4 months from the onset of clinical manifestations (OR – 2.17, 95% CI (1.26;3.91) p=0.005). We additionally defined that identification of pathological phenotypes of alpha-1-antitrypsin was risk factors for refractory course in patients with GPA manifestations (OR – 2.66, 95% CI (1.12;6.33) p=0.048).Conclusion:Our study has shown that high disease activity, ANCA positivity and comorbid pathology increase risk of serious complications. Early administration of immunosuppressive therapy, adequate steroid dosing and use of risk factors for complications and refractory course in clinical practice can significantly improve the prognosis of AAV.Disclosure of Interests:None declared

Risk Factors for Chronic Kidney Disease

2019 ◽  
pp. 29-38
Author(s):  
Hania Kassem ◽  
Bernard G. Jaar
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Stones ◽  
Developed Countries ◽  
Modifiable Risk Factors ◽  
Public Health Burden ◽  
Obstructive Sleep ◽  
Significant Public Health ◽  
Common Risk Factors

Chronic kidney disease (CKD) represents a significant public health burden worldwide and several risk factors have been identified over the years; these have been well-described in the medical literature. Common risk factors such as diabetes mellitus and hypertension will be described in other chapters. While this chapter will focus mainly on CKD risk factors observed in developed countries, several of these are also observed in developing countries. It is now well-established that some risk factors are modifiable while others are non-modifiable. In this chapter, we will explore several of these non-modifiable risk factors in more detail, such as age, gender, race, family history, and low birth weight. But we will also discuss some of the modifiable risk factors such as kidney stones, obstructive sleep apnea, smoking, drugs (excluding NSAIDs), diet, obesity, metabolic syndrome, and hyperuricemia. We will provide a balanced and up to date review of the evidence linking these risk factors with CKD.

scholarly journals Association of Serum Phosphate and Related Factors in ESRD-Related Vascular Calcification

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Cai-Mei Zheng ◽  
Kuo-Cheng Lu ◽  
Chia-Chao Wu ◽  
Yung-Ho Hsu ◽  
Yuh-Feng Lin
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Calcification ◽  
Cardiovascular Complications ◽  
Serum Phosphate ◽  
Related Factors ◽  
Therapeutic Prevention ◽  
Esrd Patients

Vascular calcification is common in ESRD patients and is important in increasing mortality from cardiovascular complications in these patients. Hyperphosphatemia related to chronic kidney disease is increasingly known as major stimulus for vascular calcification. Hyperphosphatemia and vascular calcification become popular discussion among nephrologist environment more than five decades, and many researches have been evolved. Risk factors for calcification are nowadays focused for the therapeutic prevention of vascular calcification with the hope of reducing cardiovascular complications.

scholarly journals Predictors Of The Development Of Chronic Kidney Disease In Patients With Chronic Obstructive Pulmonary Disease

2021 ◽  
Vol 03 (04) ◽  
pp. 178-183
Author(s):  
Kayumova Gulnoz Karimovna ◽  
◽  
Akhmedova Nilufar Sharipovna ◽  
Keyword(s):  
Risk Factors ◽  
Chronic Obstructive Pulmonary Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Pulmonary Disease ◽  
Right Atrial ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
High Incidence

The aim of the study was to identify predictors of decreased glomerular filtration in patients with chronic obstructive pulmonary disease (COPD). Materials and methods. We analyzed 145 case histories of patients diagnosed with COPD. The majority (84.1%, n = 122) of them are males (the average age of men is 60.7 ± 0.9 years, the average age of women is 62.0 ± 2.7 years). A comparative analysis of the prevalence of risk factors for chronic kidney disease (CKD) in patients with COPD: age, gender, smoking, arterial hypertension, overweight, etc. The glomerular filtration rate (GFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD – EPI) formula, according to which the patients were divided into 6 groups: group 1 - hyperfiltration, group 2 - GFR CKD – EPI ≥ 90 ml / min / 1 , 73 m2, 3rd - GFR CKD – EPI 60–89 ml / min / 1.73 m2, 4th - GFR CKD – EPI 45–59 ml / min / 1.73 m2, 5th - GFR CKD – EPI 30 - 44 ml / min / 1.73 m2 and 6th-GFR CKD-EPI <30 ml / min / 1.73 m2. Results. Patients with COPD have a high incidence of CKD risk factors. A correlation was found between the prevalence of CKD risk factors and the severity of COPD. The main predictors of the development of CKD in patients with COPD: duration of COPD> 9 years, body mass index> 26.5 kg / m2, smoking index> 51.3, albumin> 44.0 g / l, total protein> 70.0 g / L, forced expiratory volume in the first second ≤ 1.6 L, right atrial size> 35.5 mm, systolic pressure in the pulmonary artery> 36.6 mm Hg. Art., the thickness of the posterior wall of the left ventricle> 10.5 mm, Tiffno's index ≤ 62%. Conclusion. It was found that patients with COPD have a high incidence of both traditional and nonspecific risk factors for a decrease in GFR.

scholarly journals Assessment of Risk Factors for Cardiovascular Complications in Patients with Chronic Kidney Disease (CKD) Stage III-V before Dialysis

2014 ◽  
Vol 9 (1) ◽  
pp. 25-32
Author(s):  
MK Khan ◽  
HU Rashid ◽  
S Yesmine ◽  
IH Mahmoo ◽  
SMA Habib ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Cardiovascular Complications ◽  
Left Ventricular ◽  
Small Sample ◽  
Stage Iii ◽  
Ckd Stage

Background: Chronic Kidney Disease is a major public health and clinical problem throughout the world including Bangladesh. The prevalence of cardiovascular complications is much higher in patients with CKD regardless of stages than normal population. Considering this view, a cross sectional study was conducted in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, with an aim to assessing the cardiovascular complications & associated risk factors among the patients with chronic kidney disease (CKD) stage III-V before dialysis. Methods: A total of 109 patients were selected consecutively who had a diagnosis of CKD and an estimated GFR of less than 60 ml/min/1.73m2 of stages III to V and who had not received any form of renal replacement therapy, during a period of June 2006 to July 2007. Results: The study included 63 males and 46 females with age ranging from 18 to 65 years having a mean age 45.5±12.2 years. Left ventricular failure, left ventricular hypertrophy (by ECG and echocardiography), cardiomegally by X-ray were identified as significant cardiovascular complications among the patients of CKD stage V (p<0.05). However , logistic regression analysis revealed that hypertension and CKD stages appeared to be the important predictors of cardiovascular complications p<0.05). Data analysis found that hypertension, smoking and anemia appeared to be important risk factors for cardiovascular complications in CKD patients (p<0.05) by bi-variate analysis. Conclusion: Though the study findings did not generalize the CKD patients in Bangladesh due to small sample size, however, heart failure and left ventricular hypertrophy significantly appeared to be the main cardiovascular complications in CKD stage V compared to other two stages (stage III and IV)(p<0.05). Anemia, hypertension were identified as important risk factors (p<0.05). DOI: http://dx.doi.org/10.3329/uhj.v9i1.19508 University Heart Journal Vol. 9, No. 1, January 2013; 25-32

scholarly journals Risk factors for chronic kidney disease: a hospital based cross sectional study from Visakhapatnam

2018 ◽  
Vol 5 (9) ◽  
pp. 3909
Author(s):  
Sindhura Moparthi ◽  
Madhavi Seepana ◽  
Devi Madhavi Bhimarasetty
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Data Entry ◽  
Public Health Problem ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dialysis Unit

Background: Chronic kidney disease (CKD) is being increasingly recognised as a leading public health problem. In India, given its population >1 billion, the rising incidence of CKD is likely to pose major problems for both healthcare and the economy in future years. Diabetes and hypertension are strong predictors for development and progression of chronic kidney disease. The objective of the study was to assess risk factors for chronic kidney disease among patients undergoing dialysis in King George Hospital (KGH), Visakhapatnam.Methods: This is an observational descriptive cross sectional study done in dialysis unit in KGH. A total of 100 patients were selected out of 141 registered CKD patients by simple random sampling technique. Study is done in the month of October- November 2015. A pretested semi structured schedule was administered. Informed written consent was taken from the patients. MS excel 2007 was used for data entry. Data was analysed by SPSS trial version 20. Categorical data was analysed by Chi square test.Results: Among 100 study subjects 72 were females and 28 were males. 91% of the CKD patients were Hypertensive, among whom 73.6% were males and 26.4% were females. This difference was not found to be statistically significant (p=0.446). 22% of the CKD patients were Diabetic, among whom 81.8% were males and 18.2% were females.Conclusions: Better understanding of the role of risk factors in CKD is needed. Large community based cross sectional studies are needed to study in detail about CKD risk factors. 

scholarly journals Prevalence and risk factors of chronic kidney disease in a populated area with highly moving populations

2020 ◽  
Author(s):  
Mohammad Khajedaluee ◽  
Sanaz Ahmadi Ghezeldasht ◽  
Arman Mosavat ◽  
Reza Hekmat ◽  
Seyed Abdolrahim Rezaee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Drug Abuse ◽  
Kidney Disease ◽  
Strong Association ◽  
Public Health Problem ◽  
Clinical History ◽  
Major Public Health Problem ◽  
Hematologic Tests ◽  
Associated Risk Factors

AbstractBackgroundChronic kidney disease (CKD) is a major public health problem worldwide. Prevalence and associated risk factors of CKD was evaluated in the greater Mashhad, a highly populated pilgrimage city, in 2018 on 2,976 subjects.MethodsThis study was carried out in the greater Mashhad, a highly populated pilgrimage city, in 2018 on 2,976 subjects. For each participant a standard questionnaire, a physical examination and clinical history were completed. Then biochemical and hematologic tests for kidney function were performed.ResultsObesity was observed more frequently in subjects with CKD, thus BMI was positively correlated with the prevalence of CKD (p<0.001). Moderately reduced GFR was found in 17.6% and 7.1%, and severely reduce GFR at 0.7% and 0.5%, of males and females, respectively (p<0.001).Drug abuse also showed a strong association with CKD (p=0.004), but smoking did not. Using univariate and multivariate logistic regression of decreased estimated GFR<60 showed that age (OR=1.06), gender (OR=2.14), diabetes (OR=1.07), hypertension (OR=1.39) and drug usage (OR=3.29) were risk factors for CKD; BMI was not. The same statistics showed that only age (OR=1.02), diabetes (OR=2.61) and hypertension (OR=1.16) were risk factors for albuminuria. The prevalence of hypertension (22.1%) was a risk factor for CKD, and vice versa. BMI and drug abuse were also risk factors for hypertension, but not smoking.ConclusionThese findings demonstrated that progression of CKD and hypertension in any population should be considered in the context of changes in human behaviours, etiology, disease severity, co-occurring diseases, addiction and priority of therapy over prevention.

scholarly journals МОДИФІКАЦІЯ ФАКТОРІВ РИЗИКУ СЕРЦЕВО-СУДИННИХ УСКЛАДНЕНЬ В ПЛАНІ ОПТИМІЗАЦІЇ ЛІКУВАННЯ ХВОРИХ ІЗ ХРОНІЧНОЮ ХВОРОБОЮ НИРОК СЕАНСАМИ ПРОГРАМНОГО ГЕМОДІАЛІЗУ

2014 ◽  
Author(s):  
I. L. Kuchma
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiovascular Complications ◽  
National Registry ◽  
Treatment Programs ◽  
Number Of Patients ◽  
Class 1 ◽  
Therapy Sessions

<p class="1">The number of patients with chronic kidney disease (CKD) in substitution therapy sessions dialysis program in Ukraine is growing. Improvement of methods of renal replacement therapy (RRT), chronic kidney disease, in particular, the use of modern dialysis technology has led to a significant increase in the life expectancy of patients. However, the mortality of the disease remains high. In its structure heavily reliant on cardiovascular disease, according to the National registry of patients with chronic kidney disease in 2011 it was 72 %. In this regard, there is actual determination of risk factors for these complications and the search for new methods to ensure their prevention. The author studied the effect of individually tailored and standard hemodialysis treatment programs on the risk factors of cardiovascular complications in patients with CKD. It is concluded that the custom-fitted options at the time of hemodialysis and ultrafiltration properties klirensovyh dialyzer electrolyte composition of the dialysate can achieve better results in the management of risk factors in patients with CKD.</p>

scholarly journals Prevalence and Associated Risk Factors of Chronic Kidney Disease in an Elderly Population from Eastern China

2019 ◽  
Vol 16 (22) ◽  
pp. 4383 ◽  
Author(s):  
Andong Ji ◽  
Chunlei Pan ◽  
Hongxia Wang ◽  
Zhezhen Jin ◽  
Joseph H. Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Eastern China ◽  
Public Health Problem ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Major Public Health Problem ◽  
Cross Sectional ◽  
Associated Risk Factors

Chronic kidney disease (CKD) is a global major public health problem. Almost all of previous studies evaluating the prevalence of CKD focused on adults, while studies among the elderly were relatively rare, especially in China. The aim of this study was to investigate the prevalence and associated risk factors of CKD among the elderly in Qingdao, China. This was a cross-sectional study with 38,038 inhabitants (aged 60–109) randomly recruited in Qingdao, China. All participants were required to complete a questionnaire for their demographic characteristics. Blood and urine samples of participants were collected, and the albumin and creatinine levels were measured for albuminuria and estimated glomerular filtration rate (eGFR) assessment. The associations between risk factors and indicators of kidney damage were analyzed by logistic regression. A total of 34,588 inhabitants completed the survey. The overall prevalence of CKD was 11.41% (95% confidence interval (CI): 11.07–11.74%) in the elders from Qingdao in 2016. The prevalence of albuminuria and low eGFR (<60 mL/min per 1·73 m²) were 8.47% (95% CI: 8.17–8.76%) and 3.98% (95% CI: 3.78–4.19%), respectively. Older age, hypertension, diabetes, anemia, hyperuricemia, hyperhomocysteinemia, hypertriglyceridemia, obesity, and LDL-C ≥ 4.1 mmol/L were independently associated with the presence of CKD. In conclusion, common chronic non-communicable diseases, including hypertension, diabetes, obesity, hyperhomocysteinemia, hyperuricemia, and hypertriglyceridemia, were associated with greater prevalence of CKD.

scholarly journals Rationale and design of a multicenter Chronic Kidney Disease (CKD) and at-risk for CKD electronic health records-based registry: CURE-CKD

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Keith C. Norris ◽  
◽  
O. Kenrik Duru ◽  
Radica Z. Alicic ◽  
Kenn B. Daratha ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
At Risk ◽  
Kidney Disease ◽  
Primary Care Physicians ◽  
Public Health Problem ◽  
Healthcare Systems ◽  
Electronic Health Record Data ◽  
Increased Risk ◽  
Electronic Health

Abstract Background Chronic kidney disease (CKD) is a global public health problem, exhibiting sharp increases in incidence, prevalence, and attributable morbidity and mortality. There is a critical need to better understand the demographics, clinical characteristics, and key risk factors for CKD; and to develop platforms for testing novel interventions to improve modifiable risk factors, particularly for the CKD patients with a rapid decline in kidney function. Methods We describe a novel collaboration between two large healthcare systems (Providence St. Joseph Health and University of California, Los Angeles Health) supported by leadership from both institutions, which was created to develop harmonized cohorts of patients with CKD or those at increased risk for CKD (hypertension/HTN, diabetes/DM, pre-diabetes) from electronic health record data. Results The combined repository of candidate records included more than 3.3 million patients with at least a single qualifying measure for CKD and/or at-risk for CKD. The CURE-CKD registry includes over 2.6 million patients with and/or at-risk for CKD identified by stricter guide-line based criteria using a combination of administrative encounter codes, physical examinations, laboratory values and medication use. Notably, data based on race/ethnicity and geography in part, will enable robust analyses to study traditionally disadvantaged or marginalized patients not typically included in clinical trials. Discussion CURE-CKD project is a unique multidisciplinary collaboration between nephrologists, endocrinologists, primary care physicians with health services research skills, health economists, and those with expertise in statistics, bio-informatics and machine learning. The CURE-CKD registry uses curated observations from real-world settings across two large healthcare systems and has great potential to provide important contributions for healthcare and for improving clinical outcomes in patients with and at-risk for CKD.

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