Comparative Evaluation of BGR-34 and Sitagliptin in Diabetic Subjects-Open Labelled Randomised Parallel Clinical Study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ravinder Singh ◽  
Harbir Kaur Rao ◽  
Anil Sharma ◽  
Thakur Gurjeet Singh ◽  
Abhimanyu Parashar ◽  
...  
Keyword(s):  
Clinical Study ◽  
Blood Sugar ◽  
Glycated Haemoglobin ◽  
Postprandial Glucose ◽  
Size Analysis ◽  
Random Blood Sugar ◽  
Treatment Of Diabetes ◽  
The Mean ◽  
Sugar Levels

Abstract This article is mainly concerned with the simultaneous open model clinical study of the drug named sitagliptin, a potent hyperglycaemic drug against a novel entity of the natural origin BGR- 34 in diabetic subjects. This was a 3-month randomized, parallel, comparative study. One hundred subjects were planned to be included in the study. The patients were randomly divided into two groups and according to the appropriate sample size analysis, both groups consisted of 100 patients, following the inclusion and exclusion criteria. A total of 90 patients (both male and female) of the mean patient age 30-65 years with the type 2 diabetes were enrolled in the phase 4 of this study and then the data were analyzed on the basis of the different test which included HbA1c (glycated haemoglobin), RBS (random blood sugar), FBS (fasting blood sugar) and PPG (postprandial glucose) values. After completion of the data calibration, the results were analyzed and as a result 10-20% decreased values of HBA1C values accompanied with the RBS, FBS and PPG values were seen in the patients undergoing a 12-week course with BGR-34. Based on the results obtained in the present study, it can be concluded that BGR-34 is effective in reducing high blood sugar levels and this reflects that the BGR-34 therapy is more effective drug in the treatment of diabetes suggesting that it is better in efficacy, and reliability with little or no adverse effects.

scholarly journals Complementary treatment to reduce blood sugar levels of type 2 diabetes mellitus patients

2020 ◽  
Vol 9 (3) ◽  
pp. 267
Author(s):  
Jujuk Proboningsih ◽  
Anita Joeliantina ◽  
Aida Novitasari ◽  
Dewi Purnamawati
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Medical Treatment ◽  
Blood Sugar ◽  
Control Group ◽  
Research Subjects ◽  
Random Blood Sugar ◽  
Sugar Levels

Diabetes mellitus is a chronic disease that requires long-term management. There is a tendency in type 2 diabetes mellitus patients to use herbs as a complement to medical treatment. The purpose of this study was to analyze the use of herbs as a complement to medical treatment in reducing blood sugar levels of T2DM patients. This type of research is quasi-experimental, with 40 research subjects divided into 4 groups. Determination of research subjects by purposive sampling in accordance with established inclusion criteria. Data analysis using paired T test. The majority of respondents was women (77.5%) and had no genetic history (75%). The duration of type 2 diabetes mellitus  majority was &gt;5 years 72.5%). Data on random blood sugar levels before (p=0.098) and after (p=0.113) intervention were normally distributed and homogeneous p&gt;0.05 (0.839). The treatment group (groups 2, 3, and 4) showed a significant decrease in random blood sugar levels as the control group (1) with a significance value &lt;0.05. Giving herbs has a tendency to reduce random blood sugar levels when used as a complement to medical treatment. Bitter melon shows the effect of decreasing random blood sugar levels greater than the provision of bay leaves and cinnamon.<br /><br />

scholarly journals Overview of Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients at Royal Prima Hospital Medan Indonesia

2021 ◽  
Vol 3 (1) ◽  
pp. 224-228
Author(s):  
Riski N. Situmeang ◽  
Erwin Sopacua
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Mean Value ◽  
Total Data ◽  
The Mean ◽  
Sugar Levels

Diabetes Mellitus (DM) is a chronic disease characterized by blood glucose (blood sugar) levels exceeding normal. Diabetic nephropathy is a chronic microvascular complication that often occurs in diabetics. This study presents a picture of diabetic nephropathy in type 2 DM patients at the Royal Prima Hospital in Medan. This research is a type of descriptive research. The sample from this study was the total data of patients suffering from diabetic nephropathy who met the inclusion and exclusion criteria at Royal Prima Hospital from January 1, 2020 – to December 31, 2020. The inclusion criteria for the subjects of this study were complete patient medical records, type 2 diabetes patients, urinalysis tests. (proteinuria ≥ +2), renal function examination exceeds normal values, blood urea, and creatinine. The mean age of diabetic nephropathy patients was 57.52 years and the majority were 62 men (50.8%). The average picture of urea levels in diabetic nephropathy patients is 51.8 and the average creatinine level is 1.48. The majority of patients with diabetic nephropathy do not have proteinuria. And the average blood sugar level is 267 mg/dL. In conclusion, the incidence of diabetic nephropathy is highest in patients aged 57 years. The mean value of urea level is 51.80 mg/dl, creatinine value is 1.48 mg/dl, and the average blood sugar level is 267 mg/dl. Most proteinuria was in the negative category of as many as 107 people (87%).

Gula Darah Sewaktu Tidak Dapat Memperkirakan Kejadian TB pada Pasien DM Tipe 2

2021 ◽  
Vol 3 (1) ◽  
pp. 33-37
Author(s):  
Siti Salma Nurhaliza Fitriadi ◽  
Ratna Damailia ◽  
Wida Purbaningsih
Keyword(s):  
Blood Sugar ◽  
Secondary Data ◽  
Control Group ◽  
P Value ◽  
Random Blood Sugar ◽  
Pulmonary Tb ◽  
Type 2 Dm ◽  
Sugar Levels ◽  
Dm Type 2

Tuberkulosis (TB) merupakan penyakit infeksi yang menempati peringkat utama penyebab kematian di dunia. Indonesia berada pada peringkat ke-3 dari 30 negara yang memiliki kasus TB terbanyak. Diabetes melitus (DM) tipe 2 merupakan salah satu faktor risiko terjadi TB. Paparan hiperglikemi pada pasien DM tipe 2 dapat memengaruhi sistem imun hingga lebih rentan menderita TB. Penelitian ini bertujuan menganalisis hubungan gula darah sewaktu pada saat pertama didiagnosis  DM tipe 2 dengan kejadian TB paru pada pasien DM tipe 2 di RSUD Al-Ihsan Bandung. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan kasus kontrol. Kelompok kasus berjumlah 34 orang pasien DM tipe 2 yang mengalami TB, sedangkan kelompok kontrol berjumlah 59 pasien DM tipe 2 tanpa TB. Data penelitian merupakan data sekunder yang berasal dari rekam medis pasien. Pengumpulan dan pengolahan data diambil sesuai dengan kriteria inklusi dan eksklusi. Hasil penelitian terhadap 93 orang subjek di RSUD Al-Ihsan menunjuk bahwa pasien yang memiliki hiperglikemia berjumlah 19 pasien (56%) pada kelompok kasus dan 35 pasien (59%) pada kelompok kontrol. Hasil uji chi square didapatkan bahwa nilai p adalah 0,746 (p > 0,05) dengan alpha 5% (0,05), odd ratio sebesar 0,868.  Berdasar atas hasil uji analitik terhadap data penelitian dapat disimpulkan bahwa gula darah sewaktu pada pasien DM tipe 2 belum dapat menilai kemungkinan terjadi kejadian TB. Random Blood Sugar Unable to Predict the Incidence of TB in Type 2 DM PatientsTuberculosis (TB) the world’s leading cause of death from a single infectious disease. Indonesia is ranked 3rd out of the 30 countries with the most TB cases. Hyperglycemic exposure in type 2 DM patients can affect the immune system, making it more susceptible to TB. This study aims to look at the relationship of random blood sugar levels at the first time patient diagnosed as type 2 DM in pulmonary TB patients with type 2 DM at Al-Ihsan Hospital Bandung. During this study used an analytic observasional method in case control study. The sample of this study was a group of 34 dm type 2 patients experienced TB, while the control group were 59 Type 2 DM patients without TB.. The research was obtained from secondary data from medical record. This collection and processing data were taken in the inclusion criteria. The results of the study conducted on 93 people showed that in Al-Ihsan Hospital there was 54 patients (15%) had hyperglycemia and 39 patients (42%) had normoglycemia. Type 2 DM patients who experienced TB were 34 patients (37%), the results of analytical tests obtained that type 2 DM patients who had Pulmonary TB percentage was more common in patients with normal random blood sugar at 38.5% (15 patients). From the results of this study known p value > 0.746 with alpha 5% (0.05) with odd ratio 0.868. Based on this study shows that there is no relationship between blood sugar levels of dm type 2 patients and the incidence of pulmonary TB.

scholarly journals Comparison of Random Blood Sugar and pH of Blood- A Clinicopathological Study

2021 ◽  
pp. 302-309
Author(s):  
P. Titus Lalith Antony ◽  
Palati Sinduja ◽  
R. Priyadharshini
Keyword(s):  
Blood Sugar ◽  
Ph Value ◽  
Mean Value ◽  
Age Group ◽  
Periodontal Health ◽  
Random Blood Sugar ◽  
The Mean ◽  
Spss Software ◽  
And Gender ◽  
Sugar Levels

Aim: This study aims to compare the random blood sugar pH of the blood. Introduction: Hyperglycemia is a risk factor for the impairment of periodontal health while periodontal disease, in turn, is responsible for the adverse effects on glycemic control and the pathophysiology of diabetes-related complications. An increase in blood sugar levels has a direct effect on pH with respect to age. Hence this study deals with the association of random blood sugar levels and pH with age, gender, and dental complaints. Materials and Methods: 20 random blood samples were collected from the patients in Saveetha Dental College. The random blood sugar level was analyzed by the semi-quantitative method and the pH was analyzed by using a multi reagent strip. And the results were statistically analyzed using SPSS software and represented as pie charts and bar graphs. Results and Discussion: The overall mean value of RBS and blood pH was found to be 138.4 mg/dl and 7.06 respectively. The mean RBS value is higher in the 41-50 years age group of people than in other age categories and the mean pH value is same for all age categories. In the present study, samples with periodontic complaints have higher mean value of RBS values (193) than other dental complaints and the mean pH value is same for all dental complaints. Conclusion: Within the limits of the study, it can be observed that there is a significant association between the age group, gender, and dental complaints with RBS and pH of the patients. However, further studies must be conducted to have more accurate results and elicit the association between pH and RBS with age and gender.

PLASMA FREE FATTY ACID AND BLOOD SUGAR LEVELS IN NEWBORN INFANTS AND THEIR MOTHERS

PEDIATRICS ◽  
1966 ◽  
Vol 37 (4) ◽  
pp. 597-604
Author(s):  
Doman K. Keele ◽  
Jacob L. Kay
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Newborn Infants ◽  
Plasma Free Fatty Acid ◽  
Significant Negative Correlation ◽  
The Mean ◽  
Sugar Levels ◽  
Diabetic Mothers

Simultaneous plasma free fatty acid (FFA) and blood sugar levels were determined for fasting newborn infants during the first 24 hours of life, for their cord bloods, and for their mothers at delivery. The following observations were made. In control infants the mean FFA level rose about three times the cord level after birth and was accompanied by a 25% drop in the mean blood sugar level. Thereafter, the mean blood sugar level remained relatively constant, but the mean FFA level varied from 2½ to 3 times the cord level. There was no significant correlation between the length of maternal fasting prior to delivery and the infant FFA level; there was, however a significant negative correlation between the length of maternal fasting prior to delivery and the infant blood sugar level at 24 hours of age. High FFA levels occurred in the infants of obese mothers and low levels were observed in infants with delayed respirations, in infants of preeclamptic mothers, and in infants of diabetic mothers.

scholarly journals Korelasi asupan makronutrien dengan indeks massa tubuh, kadar gula darah, dan protein total darah pada pengguna narkoba

2021 ◽  
Vol 17 (3) ◽  
pp. 147
Author(s):  
Ginta Siahaan ◽  
Tiarlince Bakara ◽  
Yusnita Yusnita ◽  
Kasmiyeti Kasmiyeti
Keyword(s):  
Body Mass Index ◽  
Blood Sugar ◽  
Body Mass ◽  
Drug Users ◽  
Blood Sugar Level ◽  
Blood Protein ◽  
Macronutrient Intake ◽  
Total Blood ◽  
Random Blood Sugar ◽  
Sugar Levels

Correlation of macronutrient intake with body mass index, blood sugar levels, and total blood protein in drug usersBackground: Random blood sugar level and total blood protein need to be measured among drug users because their macronutrient intakes (carbohydrates, fat, protein, and energy) are not appropriate to the pattern of daily habits before uses drugs. Drug users had decreased appetite during the influence and withdrawal symptoms of drugs with the impacts on their body mass index (BMI). Objective: To analyze the correlation of macronutrient intakes between the random blood sugar level, total blood protein, and BMI drug users.Methods: This research was conducted with a cross-sectional design and observational study. 73 drug users were included in the study with the screening by inclusion criteria. 24-hour food recall was used to collect the macronutrient intakes, random blood sugar levels and total blood protein were monitored by the GOD-PAP method, and BMI was measured by weight and height. Data analysis used Pearson’s correlation test in bivariate and multivariate was carried out by multiple linear regressions. Results: Pearson’s correlation analysis showed that there was a significant correlation between macronutrient intakes (energy, carbohydrate, fat) with random blood sugar level, total blood protein, and BMI. BMI was the most affected by energy (β=0.531), random blood sugar level was the most affected by carbohydrates (β=0.073), and total blood protein was the most affected by protein (β=0.837).Conclusions: Macronutrient intake is significantly related to BMI, random blood sugar levels, and total blood protein in drug users. Community collaboration with related parties such as the public health service and National Narcotics Agency will very quickly detect drug side effects early on eating disorders that will affect the nutritional status of its users.

scholarly journals Pengaruh Pelayanan Kefarmasian di Rumah pada Pasien Diabetes Melitus Tipe 2 di Puskesmas Wilayah Kota Yogyakarta

2020 ◽  
Vol 10 (2) ◽  
pp. 126
Author(s):  
Nur Rasdianah ◽  
Suwaldi Martodiharjo ◽  
Tri Murti Andayani ◽  
Lukman Hakim
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Medication Adherence ◽  
Glycemic Control ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Level Of Knowledge ◽  
Sugar Levels

The increasing prevalence of diabetes mellitus (DM) in Indonesia requires participation of all parties including pharmacists. This study aims to determine the impact of the implementation of home pharmacy service guidelines for patients with type 2 diabetes mellitus on the level of knowledge, medication adherence, therapeurical satisfaction and glycemic control. This study used a quasi-experimental design with one group pre-test and post-test design involving 37 patients with type 2 diabetes mellitus who met the requirements of inclusion and exclusion criterias. The Diabetes Knowledge Questionnaire (DKQ-24) and the Diabetes Medication Satisfaction Tool (DMSAT) were used for collecting the data. Patient adherence was measured using a pillcount method and fasting blood sugar levels (FSB) data were obtained from the laboratory results. The study was conducted in two community health centers and patient’s home in the Yogyakarta Municipality area. The data were analysed using Wilcoxon and Spearman test. The results showed the change of the level of knowledge, medication adherence, therapeutic satisfaction and glycemic control before and after intervention of pharmacy services at home. The average decreasing of fasting blood sugar levels 17.09 mg/dL ± 1.43

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