scholarly journals Characterization and stability study of some pharmaceutical ointments

2012 ◽  
Vol 23 (1) ◽  
pp. 87-91
Author(s):  
Viorica Popescu ◽  
Alina Soceanu ◽  
Simona Dobrinas ◽  
Gabriela Stanciu
Keyword(s):  
Stability Study ◽  
Fatty Matter ◽  
Volatile Substances ◽  
Ph Values ◽  
Acidity Index ◽  
Anti Inflammatory ◽  
Type Water ◽  
Total Fatty Matter ◽  
Antibiotic Ointment

Abstract In the present study we have determined some characteristics (aspect, odor, solubility, emulsion type, water and volatile substances content, total fatty matter, saponification index, ester index) for three pharmaceutical ointments belonging to the group of non-steroidal anti-inflammatory: Diclac, Ketonal, Indometacin and one antibiotic ointment for ophthalmic use: Ophtagram. In order to achieve stability study of studied ointments, the pH, the acidity index, the peroxide index and the iodine index were determined over a year every three months. After 9 months from the opening of the tubes, analytical determinations have shown that pH values, acidity, peroxide and iodine indexes no longer fit to the values recommended for medical use, which confirms the directions available on the package.

scholarly journals Quality Analysis of Selected Toilet Soaps in Saudi Arabia Markets

2020 ◽  
pp. 7-14
Author(s):  
E. E. Shehata
Keyword(s):  
Saudi Arabia ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Limited Range ◽  
Quality Analysis ◽  
Fatty Matter ◽  
Caustic Alkali ◽  
Ph Values ◽  
Free Caustic Alkali ◽  
Total Fatty Matter

Soap is sodium or potassium salt of fatty acid produced by saponification reaction. The physicochemical properties of soaps determine their quality and hence determine their efficiency. Four toilet soaps from local markets in Saudi Arabia were analyzed for moisture, pH, free caustic alkali or free fatty acid, total fatty matter and insoluble matter in alcohol. The percentage of the moisture ranged between (3.0534±0.1782 -5.1235±0.4891 %), total fatty matter (79.6907± 0.0534 - 94.8253 ± 0.0622), insoluble matter in alcohol (0.7939± 0.0134 - 1.0368± 0.0234% (and there is no excess free caustic alkali. However, the pH values between (8.715±0.0219 - 9.745±0.0212). This study showed that the percent of moisture, free caustic alkali, insoluble matter, total fatty matter and pH values for different samples found to be in limited range. Finally, the percentage of free fatty acid are (1.0433±0.0813 -1.4107±0.1731%). The soaps analyzed proved to be of high quality and meet the standard values.

scholarly journals Formulation and Evaluation of a Moisturizing Cream using Almond Butter

2017 ◽  
Vol 9 (3) ◽  
Author(s):  
M. N. Karemore ◽  
Hemendra Shah ◽  
P. Dharmadhikari ◽  
S. M. Bhise
Keyword(s):  
Thermal Stability ◽  
Specific Gravity ◽  
Subjective Evaluation ◽  
Stability Study ◽  
Chemical Parameters ◽  
Fatty Matter ◽  
Accelerated Stability ◽  
Globule Size ◽  
Total Fatty Matter ◽  
Physical And Chemical

Almond butter is one of the moisturizing agents, which has good emollient and moisturizing properties and hence can be well utilized to design a moisturizing cream, which can provide a good moisturizing property and help to maintain the healthy skin. The aim of the present study is to formulate moisturizing cream using Almond Butter and to evaluate its moisturizing property. In the present study, proper cream base was formulated by taking different trials and evaluated. The cream base showing the best results with respect to pH, thermal stability, total fatty matter and specific gravity was used for the incorporation of the active ingredient in different concentration and was evaluated for physical and chemical parameters. The subjective evaluation of the final product was carried out on volunteers of age 20 - 25 years with dry skin and moisturizing capacity was studied using corneometer. The values for pH, thermal stability, total fatty matter and specific gravity of the selected cream base were found to be within the standard limits. From the results of accelerated stability study of cream, it was found that the cream containing 3% Almond Butter was stable and effective with respect to color, odor, pH, viscosity, globule size and centrifugation. This cream was used for subjective evaluation and it was found that all the candidates experienced desired effect without any irritation. Hence it can be concluded that Almond Butter is having excellent moisturizing effect and can be used as moisturizing agent in different cosmetic products.

scholarly journals Laundry Soap Production from the Respective Tallows of Goat, Sheep and Cow: Evaluation of Physicochemical Properties for the Best

2021 ◽  
pp. 22-33
Author(s):  
Abdullahi Nwaha Isah ◽  
Umi Aisah Asli ◽  
Nasiru Audu ◽  
Sadiku Itopa Bello ◽  
Jibrin Waziri ◽  
...  
Keyword(s):  
Moisture Content ◽  
Physicochemical Properties ◽  
Foam Height ◽  
Acid Value ◽  
Deep Penetration ◽  
Free Acidity ◽  
Fatty Matter ◽  
National Agency ◽  
Laundry Soap ◽  
Total Fatty Matter

Tallow mainly consists of triglycerides, whose major constituents are derived from stearic, palmitic and oleic acids, and its usage reduces production cost of soap, adds lather stability and hardness to soap. Laundry soaps were produced with variation on amount of tallow (sourced from cow, sheep and goat) and labelled as A, B, C, D and E formulations. The respective tallows were characterized in terms of saponification value and acid value and determined to be 192.14 and 2.24mg KOH/g (cow tallow); 200.56 and 2.38mgKOH/g (sheep tallow) and 197.75 and 1.96 mgKOH/g (goat tallow). The physicochemical properties of soap which determine its area of usage and cleansing properties were determined. The properties considered in this work were hardness, moisture content, foam capacity, pH, free acidity content, and total fatty matter. The hardness, moisture content, foam capacity, pH, free acidity content and total fatty matter of the produced soaps were determined and ranged between mild-deep penetration level; 11-21%; 1-9cm; 8-10.5; 0.16-0.82% and 40-86% respectively. From the comparative analysis, soap made from sheep tallow has the lowest penetration level (with formulations B and E), lowest free acidity content of 0.16% (with formulation A), highest total fatty matter of 86% (using formulation E), highest foam height of 9cm (with formulation A), lowest moisture content of 11% (with formulation A) and mild alkalinity of 8 (with formulations A, B and E). These results showed that the soaps produced from sheep tallow are the best in terms of hardness, lather and skin friendliness, due to its high degree of longer carbon chain lengths of fatty acids. These values satisfy the standard limit set for good quality laundry soap by National Agency for Food and Drug Administration and Control and Encyclopaedia of Industrial Chemical Analysis, respectively.

scholarly journals STANDARDIZATION AND STABILITY EVALUATION OF DRY EXTRACTS OF MYRACRODRUON URUNDEUVA ALLEMÃO OBTAINED BY SPRAY DRIER

2017 ◽  
Vol 9 (2) ◽  
pp. 154 ◽  
Author(s):  
Renata Da Silva Leite ◽  
Valmir Gomes De Souza ◽  
Agna HÉlia De Oliveira ◽  
JosÉ VenÂncio Chaves JÚnior ◽  
Islaine De Souza Salvador ◽  
...  
Keyword(s):  
Silicon Dioxide ◽  
Feed Rate ◽  
Stability Study ◽  
Inflammatory Activity ◽  
Inlet Temperature ◽  
Dry Extract ◽  
Anti Inflammatory ◽  
The Stability ◽  
Drying Conditions ◽  
Quercetin Concentration

<p><strong>Objective</strong>:<strong> </strong>This study aimed to obtain standardised dry extracts of <em>Miracrodruon urundeuva </em>Allemão using spray-dryer and evaluate the stability of the extracts.</p><p><strong>Methods</strong>:<strong> </strong>It evaluated the drying parameters: Proportion of colloidal silicon dioxide (CSD) (10, 15 and 20%), inlet temperature (160, 170 and 180 °C) and feed rate (4, 6 and 8 ml/min). The study of the accelerated stability of dry extract occurred in temperature of 40 °C (±2 °C) and relative humidity of 75% (±5%) for 6 mo. The anti-inflammatory activity of the dry extract was evaluated in Swiss mice by the paw edema method.</p><p><strong>Results</strong>:<strong> </strong>Variations in drying conditions did not represent significant variations in yields of the process. The drying temperature and feed rate significantly influenced the concentration of quercetin (p≤0.05). The increase in inlet temperature and feed flow promoted the increase of quercetin concentration in the extracts. The stability study showed that the concentration of quercetin in dry extract was stable over a period of 6 mo. The dry extract showed anti-inflammatory activity in mice orally.</p><p><strong>Conclusion</strong>:<strong> </strong>A condition of 10% of colloidal silicon dioxide with an 180 °C inlet temperature and a feed rate of 8 ml/min was considered the most adequate for obtaining the extracts and the drying process resulted in stable dry extracts and the quercetin was a suitable biomarker for monitoring the process.</p>

Topical antiedematogenic and anti-inflammatory effect of Scutia buxifolia Reissek gel and stability study

2017 ◽  
Vol 167 ◽  
pp. 29-35 ◽  
Author(s):  
Aline Augusti Boligon ◽  
Laís da Rosa Moreira ◽  
Mariana Piana ◽  
Marli Matiko Anraku de Campos ◽  
Sara Marchesan Oliveira
Keyword(s):  
Stability Study ◽  
Anti Inflammatory ◽  
Inflammatory Effect

A Simple Rapid Method for Direct Determination of Total Fatty Matter in Soaps

1977 ◽  
Vol 79 (7) ◽  
pp. 285-288 ◽  
Author(s):  
M. K. Kundu ◽  
A. T. Deb ◽  
S. P. Gupta
Keyword(s):  
Rapid Method ◽  
Direct Determination ◽  
Fatty Matter ◽  
Total Fatty Matter

scholarly journals The estimation of moisture and total fatty matter in “acid oils” and soap stocks

The Analyst ◽  
1918 ◽  
Vol 43 (506) ◽  
pp. 158-161
Author(s):  
E. Richards Bolton ◽  
Cecil Revis
Keyword(s):  
Fatty Matter ◽  
Total Fatty Matter

Ibuprofen loaded nano-ethanolic liposomes carbopol gel system: in vitro characterization and anti-inflammatory efficacy assessment in Wistar rats

2018 ◽  
Vol 38 (3) ◽  
pp. 291-298 ◽  
Author(s):  
Atefeh Afshar Moghaddam ◽  
Abdul Ahad ◽  
Mohd. Aqil ◽  
Farhan J. Ahmad ◽  
Yasmin Sultana ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Wistar Rats ◽  
Entrapment Efficiency ◽  
Stability Study ◽  
In Vitro Characterization ◽  
Rat Paw Edema ◽  
Anti Inflammatory ◽  
The Stability

AbstractThe objective of the present study was to develop and characterize nano-ethanolic liposomes (NEL) for transdermal delivery of ibuprofen (IBU). The NEL for transdermal delivery of IBU were prepared by thin film hydration technique and evaluated for vesicle size, shape, entrapment efficiency, transdermal flux, andin vivoanti-inflammatory activity in Wistar rats. The NEL optimized formulation (NEL-Opt) presented vesicle sizes of 32.85±1.98 nm and entrapment efficiency of 86.40±0.55% with improved transdermal flux. The presence of ethanol and flexibility of NEL could be the reasons for better permeation enhancement of IBU via rat’s skin.In vivoanti-inflammatory study of IBU-loaded NEL-Opt gel showed significant reduction (41.18%) of edema in carrageenan-induced rat paw edema as compared to conventional gel of IBU, where reduction of edema was found to be 12.50%. Our results suggest that developed NEL formulations are efficient systems for transdermal IBU delivery against inflammation. The stability study confirmed that the NEL-Opt gel formulation was considerably stable at refrigerator temperature. Our results concluded that NEL are an efficient carrier for transdermal delivery of IBU.

scholarly journals Essential mint oil-based emulsions: preparation and characterization

2019 ◽  
Vol 70 (01) ◽  
pp. 83-87 ◽  
Author(s):  
DĂNILĂ ANGELA ◽  
ZAHARIA CARMEN ◽  
ŞUTEU DANIELA ◽  
EMIL IOAN MUREŞAN ◽  
LISĂ GABRIELA ◽  
...  
Keyword(s):  
Chemical Properties ◽  
Quality Characteristics ◽  
Matter Content ◽  
Mentha Piperita ◽  
Stable Emulsion ◽  
Time Stability ◽  
Fatty Matter ◽  
Physical Chemical ◽  
Acidity Index

The aim of this work is to present briefly the preparation methodology of four emulsions (named M2, M3, M6, and M7) based on extracted mint oil (Mentha Piperita) and their physical-chemical properties and quality characteristics (pH, density, acidity index, peroxide index, diene and triene content, in-time stability, humidity and fatty matter content), in order to select the most recommendable emulsion to be used in textile field. This work also underlines that the most stable emulsion is M6 emulsion followed by M3 emulsion.

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