scholarly journals PENGARUH KOMBINASI EKSTRAK PETROLEUM ETER BAWANG PUTIH (Allium sativum Linn) DENGAN VITAMIN C TERHADAP AKTIVITAS Candida albicans

2016 ◽  
Vol 16 (1) ◽  
pp. 37-42
Author(s):  
Nurul Khaira ◽  
Misrahanum Misrahanum ◽  
Rinaldi Idroes ◽  
Muhammad Bahi ◽  
Khairan Khairan
Keyword(s):  
Candida Albicans ◽  
Vitamin C ◽  
Petroleum Ether ◽  
Allium Sativum ◽  
Organosulfur Compound ◽  
Inhibition Zone ◽  
Garlic Extract ◽  
Antibacterial And Antifungal Activities ◽  
Vitamine C ◽  
Antibacterial And Antifungal

Garlic (Allium sativum) contains organosulfur compound that plays an important role as an antibacterial and antifungal activities. Ascorbic acid or vitamine C also has been show has a good activity as an antioxidant and as an antifungal. The aims of the research is to determine the effect of the combination of petroleum ether garlic extract with vitamin C against Candida albicans. Zone of inhibition testing done by Kirby-Bauer method. The results showed that the combination of petroleum ether garlic extract with vitamin C in concentration of 50% did not show an activity significantly. Meanwhile, the activity of petroleum ether garlic extract alone at concentration of 50 and 75% showed activities towards Candida albicans with a diameter of inhibition zone are 19.46 and 27.46 mm respectively. 

Substituted 4-Formyl-2H-chromen-2-ones: Their Reaction with N-(2,3,4,6-Tetra-Oacetyl- β-D-galactopyranosyl)thiosemicarbazide, Antibacterial and Antifungal Activity of Their Thiosemicarbazone Products

2020 ◽  
Vol 24 (19) ◽  
pp. 2272-2282
Author(s):  
Vu Ngoc Toan ◽  
Nguyen Minh Tri ◽  
Nguyen Dinh Thanh
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Candida Albicans ◽  
Selenium Dioxide ◽  
Antibacterial And Antifungal Activity ◽  
E Coli ◽  
Antibacterial And Antifungal Activities ◽  
Alkyl Ethers ◽  
Antibacterial And Antifungal

Several 6- and 7-alkoxy-2-oxo-2H-chromene-4-carbaldehydes were prepared from corresponding alkyl ethers of 6- and 7-hydroxy-4-methyl-2-oxo-2H-chromen-2-ones by oxidation using selenium dioxide. 6- and 7-Alkoxy-4-methyl-2H-chromenes were obtained with yields of 57-85%. Corresponding 4-carbaldehyde derivatives were prepared with yields of 41-67%. Thiosemicarbazones of these aldehydes with D-galactose moiety were synthesized by reaction of these aldehydes with N-(2,3,4,6-tetra-O-acetyl-β-Dgalactopyranosyl) thiosemicarbazide with yields of 62-74%. These thiosemicarbazones were screened for their antibacterial and antifungal activities in vitro against bacteria, such as Staphylococcus aureus, Escherichia coli, and fungi, such as Aspergillus niger, Candida albicans. Several compounds exhibited strong inhibitory activity with MIC values of 0.78- 1.56 μM, including 8a (against S. aureus, E. coli, and C. albicans), 8d (against E. coli and A. niger), 9a (against S. aureus), and 9c (against S. aureus and C. albicans).

Synthesis and investigation of 3,5-bis-linear and macrocyclic tripeptidopyridine candidates by using l-valine, N,N′-(3,5-pyridinediyldicarbonyl)bis-dimethyl ester as synthon

2019 ◽  
Vol 74 (6) ◽  
pp. 473-478 ◽  
Author(s):  
Abd El-Galil E. Amr ◽  
Ahmed M. Naglah ◽  
Nermien M. Sabry ◽  
Alhussein A. Ibrahim ◽  
Elsayed A. Elsayed ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Candida Albicans ◽  
Organic Molecules ◽  
Biological Activities ◽  
Dimethyl Ester ◽  
Antimicrobial Activities ◽  
Current Work ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

AbstractInterest in the synthesis of heterocyclic organic molecules with peptide moieties has gained attention due to their potential biological activities. The current work aimed at synthesizing new macrocyclic tripeptide imides and evaluating their possible antimicrobial activities. A series of 11 derivatives were prepared from dimethyl 3,5-pyridinevalinyl ester either by NaOH or NH2NH2 treatment, followed by cyclization and further reaction with NaOH or NH2NH2. The majority of synthesized derivatives showed promising antibacterial and antifungal activities in comparison to standard known antibiotics. Compounds 5a and 7b showed the most potential antibacterial against Staphylococcus aureus and antifungal activities against Candida albicans, respectively.

scholarly journals Synthesis of Biogenic Silver Nanoparticles (AgCl-NPs) Using a Pulicaria vulgaris Gaertn. Aerial Part Extract and Their Application as Antibacterial, Antifungal and Antioxidant Agents

Nanomaterials ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 638 ◽  
Author(s):  
Majid Sharifi-Rad ◽  
Pawel Pohl
Keyword(s):  
Antioxidant Activity ◽  
Candida Albicans ◽  
Aerial Part ◽  
Silver Chloride ◽  
Radical Scavenging ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antioxidant Agents ◽  
Vis Spectroscopy ◽  
Antibacterial And Antifungal

In this study, very simple and fast one-step synthesis of biogenic silver chloride nanoparticles (AgCl-NPs) using a Pulicaria vulgaris Gaertn. aerial part extract from an aqueous solution of silver nitrate at room temperature is proposed. The proceedings of the reaction were investigated by UV–Vis spectroscopy. AgCl-NPs were characterized using X-ray diffraction spectroscopy (XRD), Fourier-transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). Antibacterial and antifungal activities of these nanoparticles were evaluated by disk diffusion and microdilution methods against Staphylococcus aureus, Escherichia coli, Candida albicans, and C. glabrata. In addition, the antioxidant activity of the synthesized AgCl-NPs was determined by the DPPH radical scavenging assay. The antimicrobial test confirmed the bactericidal activity of biosynthesized AgCl-NPs against Gram-positive and Gram-negative bacteria. They also exhibited good antifungal activities with minimum inhibitory concentration (MIC) values ranging from 40 to 60 µg/mL against Candida glabrata and Candida albicans, respectively. In addition, biosynthesized AgCl-NPs were established to have remarkable antioxidant activity. All this pointed out that the proposed new biosynthesis approach resulted in production of AgCl-NPs with convenient biomedical applications.

scholarly journals Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Ghazala Yaqub ◽  
Abdul Hannan ◽  
Erum Akbar ◽  
Muhammad Usman ◽  
Almas Hamid ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Functional Groups ◽  
Antibacterial Activities ◽  
Positive Control ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Strategy to synthesize novel carbazole, that is, 2,3-dihydro-2-phenyl-6H-pyridazino[4, 5-b]carbazole-1,4-dione (2), is developed as key reaction. This novel compound showed ideal reactivity toward different functional groups like methyl, carboxylic, nitro, piperazine, and amine; thus series of its derivatives are synthesized sequentially with the aim to fuel up the carbazole compounds with new versatile derivatives. All compounds were investigated for their activity against bacteria (MRSA andS. typhi) and fungi (Candida albicans). Among tested compounds3,6, and8exhibited pronounced antibacterial activities while2,5, and9also showed moderate activities.2,3,5,7, and9showed stronger antifungal activity againstCandida albicanscomparable to positive control.

Antibacterial, antifungal and cytotoxic effects of a sea cucumberHolothuria leucospilota, from the north coast of the Persian Gulf

2013 ◽  
Vol 93 (5) ◽  
pp. 1401-1405 ◽  
Author(s):  
Flora Mohammadizadeh ◽  
Maryam Ehsanpor ◽  
Majid Afkhami ◽  
Amin Mokhlesi ◽  
Aida Khazaali ◽  
...  
Keyword(s):  
Persian Gulf ◽  
Inhibition Zone ◽  
North Coast ◽  
Cytotoxic Activities ◽  
Extract Concentration ◽  
The North ◽  
Antibacterial And Antifungal Activities ◽  
Brine Shrimp Lethality Assay ◽  
The Persian Gulf ◽  
Antibacterial And Antifungal

Bioactive compounds of gonad, respiration tree, cuvierian organ, and body wall of the sea cucumberHolothuria leucospilotacollected from the north coast of the Persian Gulf were extracted using ethyl acetate, methanol and water–methanol solvents. Extracts were evaluated for their antibacterial and antifungal activities againstAspergillus niger,Candida albicans,Staphylococcus aureus,Pseudomonas aeruginosaandEscherichia coli. The activity was determined using the disc diffusion test. Cytotoxic activities of the extracts were determined by brine shrimp lethality assay. Results demonstrated that theA. nigerwas shown to be the most sensitive microorganism followed byC. albicans. The inhibition zone againstA. nigerandC. albicanshad minimum inhibitory concentrations ranging from 3 to 7 μg/ml. The highest antifungal activity was found in G (water–methanol) with an inhibition zone of 50 mm againstA. nigerat 18 μg/ml extract concentration continuing with CT (methanol) with 46 mm inhibition zone againstA. nigerat 18 μg/ml extract concentration. The highest cytotoxic effect of methanol extract was found with LC50values of about 40.31 μg/ml in the gonad organ fromH. leucospilotacontinuing with the respiration tree organ with LC50values of about 72.49 μg/ml.

SYNTHSIS, CHARACTERISATION AND ANTI MICROBIAL EVALUATION OF NOVEL 2-SUBSTITUTED QUINOXALINE DERIVATIVES

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (05) ◽  
pp. 5-10
Author(s):  
G. R Kamala ◽  
◽  
A. K. Velagaleti
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Bacillus Subtilis ◽  
Candida Albicans ◽  
Bacillus Pumilus ◽  
Biological Activities ◽  
Significant Activity ◽  
Antibacterial And Antifungal Activities ◽  
Quinoxaline Derivatives ◽  
Weak Activity ◽  
Antibacterial And Antifungal

literature survey indicates that 2-substituted quinoxaline derivatives possess different pharmacological and biological activities, of which most potent activities are anti-bacterial, anti-fungal, anti-inflammatory, and analgesic activity. In view of above literature, we planned to synthesize novel 2-Substituted quinoxaline derivatives. The final synthesised were characterized by physical (M.P, TLC) and spectral analysis (1HNMR, IR). The 2-substituted quinoxaline nucleus was constructed by condensation of o-phenylene diamine and diethy loxalate in equimolar quantities which upon heating yielded quinoxaline -2, 3-diol moiety. The quinoxaline -2,3-diol was treated with POCl3 to furnish 2,3-di chloro quinoxaline (2). Further the 2-chloro-3-hydrazinoquinoxaline (3) was synthesized by the reaction of 2,3- dichloroquinoxaline (2) and hydrazine hydrate in methanolic medium upon refluxing for 60 min. different Schiff’s bases of 2-chloro-3- hydrazine quinoxaline were obtained by refluxing the appropriate substituted benzaldehyde and 2-chloro-3-hydrazinoquinoxaline (3) in acetic medium for 3 h. All the synthesized compounds were screened for their antibacterial and antifungal activities by using cup plate method against Bacillus subtilis, Bacillus pumilus, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger and Candida albicans at 100, 50 μg/mL concentration using ciprofloxacin and clotrimazole as reference standard drugs respectively. Compounds 4e and 4f showed significant activity against Pseudomonas aeruginosa, 4a and 4d showed significant activity against Bacillus subtilis, the compound 4c showed good activity against the organism Bacillus pumilus, whereas the compound 4a shown moderate antifungal activity against Candida albicans. The rest of the compounds showed weak activity when compared to the standard ciprofloxacin and clotrimazole.

Design and Synthesis of Novel Antimicrobial Benzimidazolium Compounds

2012 ◽  
Vol 554-556 ◽  
pp. 1686-1689 ◽  
Author(s):  
Jiang Ping Meng
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Bacillus Subtilis ◽  
Candida Albicans ◽  
Mass Spectrum ◽  
Significant Activity ◽  
Design And Synthesis ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

In this research, a series of novel benzimidazolium compounds were designed, synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Bacillus proteus, and two fungi, Candida albicans and Aspergillus fumigatus. All of the synthesized compounds exhibited significant activity against the evaluated bacteria. The structures of these novel compounds were measured by 1H NMR, IR and mass spectrum.

scholarly journals Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one

2010 ◽  
Vol 7 (s1) ◽  
pp. S400-S404 ◽  
Author(s):  
B. Lakshminarayanan ◽  
V. Rajamanickam ◽  
T. Subburaju ◽  
L. A. Pradeep Rajkumar ◽  
H. Revathi
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Spectral Data ◽  
Aromatic Aldehyde ◽  
E Coli ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Derivatives Of

Some new 3-(substituted)-chromen-2-one have been synthesized by condensation of 3-acetylchromen-2-one with various aromatic aldehyde in presence of ethanol and alkali. The synthesized compounds were identified by spectral data and screened for their antibacterial activity againstB. pumilis, B. substilisandE. coliand antifungal activity againstA. nigerandCandida albicans. Among the synthesized compounds, some compounds of aryl chromen, which are having electron releasing substituent such as methoxy and hydroxyl at various positions, showed moderate to considerable antibacterial and antifungal activities.

scholarly journals Formula Optimization of Feminine Liquid Soap from Garlic (Allium sativum Linn) Extract

2021 ◽  
Vol 1 (2) ◽  
Author(s):  
Ingenida Hadning ◽  
Astri Yunika
Keyword(s):  
Candida Albicans ◽  
Sodium Lauryl Sulfate ◽  
Allium Sativum ◽  
Lauryl Sulfate ◽  
Liquid Soap ◽  
Fungus Infection ◽  
Severe Problem ◽  
Physical Quality ◽  
Test Requirements ◽  
Antibacterial And Antifungal

Leucorrhoea is a condition frequently experienced by women. If it is not appropriately treated, it can become a more severe problem. Leucorrhoea is caused by “Candida albicans” fungus infection. Garlic (Allium sativum Linn) has antibacterial and antifungal activity, where garlic can inhibit the growth of the Candida albicans. This study aims to determine the optimal formulation of feminine liquid soap from garlic extract (Allium sativum Linn) with good physical quality; thus, garlic in treating Leucorrhoea can be practically easier. Optimization of liquid soap formulation used carbopol and sodium lauryl sulfate with various concentration variations. The method included organoleptic observation, pH, and specific gravity for one-month storage to obtain a good physical quality of liquid soap. The result showed that the formula with 10% sodium lauryl sulfate met the physical quality test requirements of feminine liquid soap; thus, the formulation of feminine liquid soap with 10% sodium lauryl sulfate was optimal.

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