Criteria positive and criteria negative anaphylaxis, with a focus on undifferentiated somatoform idiopathic anaphylaxis: A review and case series

2020 ◽  
Vol 41 (6) ◽  
pp. 436-441 ◽  
Author(s):  
Daniel A. Rosloff ◽  
Kunal Patel ◽  
Paul J. Feustel ◽  
Jocelyn Celestin
Keyword(s):  
Diagnostic Criteria ◽  
Statistical Significance ◽  
Case Series ◽  
Poor Response ◽  
Response To Treatment ◽  
Fisher Exact Test ◽  
Subjective Symptoms ◽  
Significant Difference ◽  
Physical Findings ◽  
Idiopathic Anaphylaxis

Background: Undifferentiated somatoform (US) idiopathic anaphylaxis (IA) is considered a psychogenic disorder characterized by a lack of observable physical findings and poor response to treatment. Although failure to diagnose true anaphylaxis can have disastrous consequences, identification of US-IA is crucial to limit unnecessary expenses and use of health care resources. Objective: To better define the presentation and understand the potential relationship between US-IA and underlying psychiatric comorbidities. Methods: We retrospectively reviewed 110 visits by 107 patients to our institution for evaluation and management of anaphylaxis over a 1-year period. The patients were classified as having either criteria positive (CP) or criteria negative (CN) anaphylaxis based on whether they met Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium criteria for the clinical diagnosis of anaphylaxis. Patient characteristics, including objective and subjective signs and symptoms, and the presence of psychiatric diagnoses were collected and analyzed. Statistical significance was assessed by using the Fisher exact test. A literature review of US-IA and other psychogenic forms of anaphylaxis was performed. Results: Patients with CP anaphylaxis were more likely to present with hypotension, wheezing, urticaria, and vomiting than were patients with CN anaphylaxis. The patients with CN anaphylaxis were more likely to present with subjective symptoms of sensory throat tightness or swelling compared with patients with CP anaphylaxis. No significant difference was detected in the prevalence of psychiatric conditions between the two groups. Conclusion: Patients who met previously established diagnostic criteria for anaphylaxis were more likely to present with objective physical findings than those who did not meet criteria for true anaphylaxis. CN patients who presented for treatment of anaphylaxis were more likely to present with subjective symptoms. Formal diagnostic criteria should be used by clinicians when evaluating patients with suspected anaphylaxis.

scholarly journals Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project

2021 ◽  
Vol 28 ◽  
pp. 107327482110384
Author(s):  
Mohammad A. J. Abdulla ◽  
Prem Chandra ◽  
Susanna El Akiki ◽  
Mahmood B. Aldapt ◽  
Sundus Sardar ◽  
...  
Keyword(s):  
Body Weight ◽  
Survival Curve ◽  
Statistical Significance ◽  
Response Assessment ◽  
Test Methods ◽  
Response To Treatment ◽  
Molecular Response ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Transcript Type

Objective It is debatable whether BCR-ABL1 transcript type has an impact on outcome of treatment of patients with CML, and it is not widely studied whether body weight influences response to treatment. In this study, we tried to find out if any of these factors has an impact on response to treatment and outcome. Methodology We conducted a retrospective analysis of the files of 79 patients being treated in our center for CML with known BCR-ABL1 breakpoints, and patients’ management and response assessment was done based on ELN 2013 guidelines. The analysis was performed based on two main groups, obese vs. normal BMI, and then based on BCR-ABL1 transcripts: e13a2 vs. e14a2. Cumulative incidence of MMR, CCyR, and DMR were estimated using the Kaplan–Meier survival curve method, and comparisons between groups were performed by the Log-rank/Gray test methods. Results/conclusion In the patient-cohort studied, there was no statistically significant difference in molecular response between patients with CML based on body weight or transcript type although patients in the obesity group achieved higher and faster MMR with no statistical significance.

INADVERTANT PENETRATION OF BLOOD VESSELS DURING INFERIOR ALVEOLAR NERVE BLOCK TECHNIQUES

2013 ◽  
Vol 5 (2) ◽  
pp. 21-25
Author(s):  
Manjunath. Shankariah ◽  
Malapati Sudhakar Rao ◽  
Kalappa T Muthanna
Keyword(s):  
Nerve Block ◽  
Statistical Significance ◽  
Inferior Alveolar Nerve ◽  
The Other ◽  
Fisher Exact Test ◽  
Inferior Alveolar Nerve Block ◽  
Systemic Complications ◽  
Exact Test ◽  
Group I ◽  
Significant Difference

ABSTRACT Background The blood aspiration technique before the injection of local anesthetic solution is an essential procedure, because it prevents possible systemic’ complications. The purpose of this study is to evaluate the incidence of intravascular injection in different techniques of inferior alveolar nerve block and to know the technique which has very low incidence of vascular penetration. Methods Fifty patients in the ages of 17-70 years irrespective of sex, who were indicated for bilateral extractions of mandibular teeth were selected for this study. Patients were randomly divided into two divisions consisting of 25 patients requiring bilateral extraction procedures. In first division classical technique of inferior alveolar nerve block was administered on one side and on 2nd appointment Angelo Sargenti technique was administered on the other side. In the second division of 25 patients, indirect technique was administered on one side in 1st appointment and Clark and Holmes technique was administered on the other side in next appointment. Incidence of positive aspiration due to inadvertent penetration of inferior alveolar vessels was recorded. Results In group I positive aspiration rate was 8%, group II it was 4%, group III it was 4% and group IV it was 8%. Chi-square and fisher exact test was used and statistically there was no significant difference in the incidence of positive aspiration in all four groups. We found an overall aspiration rate of 6% in all four groups. Conclusion The incidence of positive aspiration was evaluated in all the 4 groups. There was no statistical significance in the rate of positive aspiration in all the groups included in our study.

Correlation between hemodynamic parameters and response to high-dose interleukin-2 in metastatic melanoma

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 18012-18012
Author(s):  
J. P. Dutcher ◽  
C. Dasanu ◽  
I. Codreanu ◽  
M. Yeddu ◽  
H. Muniswamy ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Statistical Significance ◽  
Interleukin 2 ◽  
Mean Difference ◽  
Mean Blood Pressure ◽  
Response To Treatment ◽  
High Dose ◽  
Separate Analysis ◽  
Significant Drop ◽  
Significant Difference

18012 Background: A direct correlation between the levels of hypotension during IL-2 treatment and response in melanoma has not yet been demonstrated, although both have been correlated with higher IL-2 doses and production of nitric oxide. Methods: A retrospective study analyzed the association between response to IL-2 and systolic, diastolic, mean blood pressure (BP), and heart rate (HR) at baseline and during treatment, by using the t-test. Further, same comparison was performed after BP was corrected for the amount of neosynephrine (neo) utilized during IL-2 treatment (subtracting the raise in BP produced by neo using individual patient coefficients). 22 patients (13 females, 9 males) with a median age of 54 years (range 36–71) received a total of 26 courses of IL-2 (between 2001–2005). Median number of prior treatments was 2.5 (range 0–5). Outcomes were divided in (A) responders (1CR, 3PRs and 4SDs), and (B) non-responders (18PD). Results: When adjusting for the effects of neo, the corrected mean BP during treatment was significantly lower in (A) compared to (B) (52.17 vs 64.34 mmHg, P = 0.018; mean difference −12.17, 95% CI −22.06 to −2.27). Similarly, the decrease in corrected mean blood pressure from baseline was greater in (A) (−34.89 vs −20.67 mmHg, P = 0.003; mean difference −14.22, 95% CI −23.09 to −5.37). A trend towards statistical significance was recorded for the variation in uncorrected mean BP (17.86 vs. 23.22 mmHg, P = 0.085; mean difference −5.36, 95% CI −11.53 to 0.80). Separate analysis demonstrated a significant drop in both systolic (−17.85 mmHg, P = 0.009; 95% −30.77 to −4.91) and diastolic (−12.05 mmHg, P = 0.01; 95% CI −21.02 to −3.07) corrected BP in (A) vs. (B), but no significant difference for either uncorrected parameters. No correlation between response and the HR, number of IL-2 doses or total quantity of neo was observed. Conclusions: Uncorrected variation in mean BP shows a trend towards significance in predicting response to IL-2. However, corrected mean, systolic and diastolic BP correlate closely with response to treatment. Implications of this association may reside in better outcomes for an intensive IL-2 treatment, with aggressive pressor support. A common pathogenetic basis for response to IL-2 and induction of hypotension is possible. No significant financial relationships to disclose.

Levetiracetam monotherapy for treatment of structural epilepsy in dogs: 19 cases (2010–2015)

2017 ◽  
Vol 181 (15) ◽  
pp. 401-401 ◽  
Author(s):  
Darren Kelly ◽  
Francesca Raimondi ◽  
Nadia Shihab
Keyword(s):  
Side Effects ◽  
Seizure Control ◽  
Case Series ◽  
Poor Response ◽  
Response To Treatment ◽  
Seizure Freedom ◽  
Retrospective Case ◽  
Cluster Seizures ◽  
Structural Epilepsy

To evaluate the efficacy and tolerability of levetiracetam monotherapy in dogs with structural epilepsy. Retrospective case series. Nineteen client-owned dogs with structural epilepsy. Seizure frequencies after initiation of treatment were used to evaluate the efficacy of levetiracetam monotherapy. Seizure control was considered good if no seizures occurred within three months of starting treatment or poor if seizures returned within one month of starting treatment. Tolerability was evaluated by considering the occurrence and severity of any reported side effects. Ten of the 19 dogs were considered to have a good response to treatment with 7 achieving complete seizure freedom. Nine dogs were considered to have poor response to treatment. There was a statistically significant reduction in the percentage of patients experiencing cluster seizures from 68.4% to 15.8% (p=0.002). Side effects were noted in 8 of the 19 dogs but were considered mild in all cases. Follow-up times ranged from 12 days to 426 days. When used in conjunction with other appropriate therapies, levetiracetam may be an efficacious option for monotherapy in dogs with structural epilepsy. Its tolerability makes it a suitable option for use in a wide variety of patients.

scholarly journals Cranial Nerve Injuries and the Retrojugular Approach in Carotid Endarterectomy

2008 ◽  
Vol 90 (8) ◽  
pp. 685-688 ◽  
Author(s):  
William D Beasley ◽  
Christopher P Gibbons
Keyword(s):  
Carotid Endarterectomy ◽  
Cranial Nerve ◽  
Statistical Significance ◽  
Cranial Nerves ◽  
Case Series ◽  
Surgical Approaches ◽  
Nerve Injuries ◽  
Retrospective Case ◽  
Significant Difference ◽  
Cranial Nerve Injuries

INTRODUCTION This is a retrospective case series analysis to compare the incidence of cranial nerve injuries in carotid endarterectomy by the retrojugular and anteromedial approaches. PATIENTS AND METHODS Data were extracted from a prospectively collected database. Ninety-one retrojugular carotid endarterectomies were compared with 145 anteromedial carotid endarterectomies. All were performed under local anaesthesia and used the eversion technique. Data were analysed using the chi-squared test. RESULTS Nine (3.8%) cases were complicated by cranial nerve injuries. In four cases, multiple nerves were involved. In total, 13 (5.5%) cranial nerves were injured. The affected nerves were: two (0.8%) marginal mandibular, two (0.8%) laryngeal, three (1.2%) accessory and six (2.5%) hypoglossal. There was no statistically significant difference in total or specific cranial nerve injuries between the two surgical approaches. CONCLUSIONS The risk of cranial nerve injuries was similar following either the retrojugular or anteromedial approach. Accessory nerve injuries were only seen in the retrojugular approach but this did not reach statistical significance.

Disease Knowledge In Chronic Myeloid Leukemia (CML) Patients as a Predictor of Compliance to Treatment.

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4481-4481
Author(s):  
Courtney Nicole Johnson ◽  
Lisa Cowan ◽  
Gerry Lising Gorospe ◽  
Sikander Ailawadhi
Keyword(s):  
Patient Compliance ◽  
Conflicts Of Interest ◽  
Healthcare Providers ◽  
Treatment Compliance ◽  
Response To Treatment ◽  
Healthcare Personnel ◽  
Fisher Exact Test ◽  
Cell Transplant ◽  
Significant Difference ◽  
Compliance To Treatment

Abstract Abstract 4481 Background: Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL fusion protein have greatly improved outcome of patients with CML. Despite this, some patients fail to respond or lose their initial response on continued treatment. Reasons for this are not completely understood and may include poor patient compliance. We developed a questionnaire (CML-Q) to explore patient knowledge of CML and its predictive value in compliance and response to treatment. Relationship of compliance with serum drug levels was also studied. Methods: Patients enrolled in the CML program at LAC+USC Medical Center were eligible. CML-Q included 42 questions addressing patient demographics (14%), prior knowledge of CML (7%), specifics about cause and pathogenesis of CML (5%), self-perceived compliance (5%), satisfaction regarding treatment and healthcare providers (19%) and quality of life (50%). Physician assessed patient compliance was determined separately. In patients currently on imatinib, serum drug trough levels were determined using commercially available laboratory testing. T-test and Fisher Exact test were used for statistical analysis with a 0.05 nominal significance level. Results: The CML-Q was administered to 80 patients. Of these, 39 responded while the rest either declined or were lost to follow up. Amongst the 39 evaluable patients (18 females; 46%, 21 males; 55%) median age was 47.5 yr (range 25–78) and median time since diagnosis was 34.1 mth (range 9–230). Majority of these (n=33; 84.6%) were on TKIs at the time of analysis. Four (11%) patients had received previous stem cell transplant for CML. Amongst the patients 19 (49%) were on first, 7 (18%) on second, 5 (13%) on third, 5 (13%) on fourth, 2 (5%) on fifth and 1 (2%) on seventh line treatment. Twenty-six patients (66%) responded to the Spanish version of CML-Q, while 13 (34%) responded in English. Responses to CML-Q were complete in 49% cases, while others had some skipped or erroneous responses. In such cases, the skipped or erroneous answers were withdrawn from final analysis while questions with complete and unambiguous responses were included. Patient compliance was classified as patient-perceived or physician-perceived. A kappa statistic between these two groups was 0.13, suggesting only slight agreement between the patient's own and the physician's assessment of compliance to treatment. Thus, for compliance-related analysis, patients were divided into true-compliant (TC) (patient-perceived and physician-perceived compliant) (42%) and non-compliant (NC) (reported non-compliant by the patient or physician or both) (58%) groups. There was a significant difference between TC and NC responses to the CML-Q regarding time since CML diagnosis (< or >3 yr, respectively) (p=0.04), specific questions addressing compliance to medications (p=0.002) and those addressing treatment staff's explanation of the effects of treatment (p=0.01). In a subset of patients taking imatinib (n=20; TC=10, NC=10), serum trough imatinib levels were evaluated. There was no statistically significant difference between the mean serum imatinib trough level of TC (1448 ng/ml) and NC (1321 ng/ml) groups (p=0.99). Response to treatment for all patients was classified as optimal or suboptimal based on established CML response milestones. In the TC group 94% patients had optimal responses while 76% patients had optimal responses within the NC group. This was not statistically significant (p=0.19). Conclusions: There is limited data on factors that may affect treatment compliance in CML patients, and ultimately may dictate efficacy of therapeutic interventions. Using an extensive CML questionnaire, we observed that compliance may be perceived differently by patients and healthcare providers. Specific questions regarding treatment adherence were able to differentiate TC and NC groups. Patients were more likely to comply if they were aware of the treatment effects, as explained by healthcare personnel. There was no significant association between compliance and serum imatinib levels. NC patients were more likely to have a CML diagnosis for >3 yrs, suggesting that patient education should be reinforced with continued treatment. Although not statistically significant, compliant patients more often had optimal response to treatment. Our results suggest that patient compliance to treatment in CML should be further evaluated in larger cohorts prospectively. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Comparison of Propofol Vs Thiopentone in Post Operative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy

2019 ◽  
Vol 18 (1) ◽  
pp. 23-29
Author(s):  
Bhuwan Raj Kunwar ◽  
Thaneshowr Rijal ◽  
Puja Thapa ◽  
Mallika Rayamajhi ◽  
Biswo Ram Amatya
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Statistical Significance ◽  
Postoperative Nausea And Vomiting ◽  
Nausea And Vomiting ◽  
P Value ◽  
Fisher Exact Test ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Post Operative Nausea

Introduction: Postoperative Nausea and Vomiting (PONV) is one of the commonest causes of significant morbidity in the patients after laparoscopic cholecystectomy. The purpose of this study was to compare the incidence of PONV when propofol and thiopentone were used as induction agents during laparoscopic cholecystectomy. Methods: A prospective, randomised comparative study was conducted in operation theatre at a tertiary level referral hospital of Nepal. A sample size of 100 ASA I - II patients aged between 18 and 70 years were included and scheduled for elective laparoscopic cholecystectomy. The study population were divided into two groups: Group A (Propofol), n = 50 and Group B (Thiopentone), n = 50. These patients were followed up for the first 24 hours postoperatively for any PONV at 0-6 hrs, 6-12 hrs, 12-24 hrs. Results: Out of the 100 patients, PONV was observed almost similar in both groups. i.e. group A (Propofol) n = 31, (62%) and group B (Thiopentone) n = 26 (52%) with no statistical significance (p value = 0.1998) within the first 24 hours postoperatively in both groups; and no significant difference was observed at the different time intervals viz. at 0-6 hrs (p value 0.262): Group A = 45%; Group B = 40%; 6-12 hrs (p value 0.781): Group A = 17.5%, Group B = 22.5%; 12-24 hrs (p value 1.000) Group A = 0%; Group B = 2.5% when using the Fisher exact test. The mean ages for development of PONV in these two groups were: Group A = 40 years and Group B = 38 years. The p-value was 0.5125 which showed no statistical significance. In our study 76% (n = 38) were females and 24% (n = 12) were males in Group A; while 70% (n = 35) were females and 30% (n = 15) males in Group B. However, there was no statistical difference between the two groups in terms of PONV. Conclusions: The study showed that there was a high incidence of PONV during laparoscopic cholecystectomy. However, there was no significant difference in the incidence of PONV when propofol or thiopentone was used.  

Abstract T P298: Impact of Accurate Weight Based Dosing of IV tPA in Acute Ischemic Stroke Patients

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Vishal B Jani ◽  
Sopan Lahewala ◽  
Shilpkumar Arora ◽  
Erin Shell ◽  
Anmar Razak ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Statistical Significance ◽  
Categorical Variables ◽  
Stroke Severity ◽  
Fisher Exact Test ◽  
Weight Estimation ◽  
Stroke Patients ◽  
Significant Difference ◽  
Iv Tpa

Background: Accurate weight-based dosing is essential for efficacy and safety of thrombolysis in acute ischemic stroke (AIS). Stroke patients may be unable to communicate correct body weight (BW). Dosing may be estimated which can lead to error. Objective: To assess accuracy of weight estimation and the effect of weight and dosing discrepancy on outcome of patients with AIS Methods: 94 patients receiving IV tpa for AIS in a CSC registry between Feb, 2013 and Jul, 2014 were reviewed. All were given estimated weight based tPA- per patient input or agreement of 2 providers in ER. Accurate weights were obtained and recorded later. Actual weight was used to calculate the ideal TPA doses and compared to the weights and doses used. The cohort was separated into two groups based on weight discrepancy to those 10 kg (non forgiven) discrepancy. Rate of hemorrhage, NIHSS and hospice/mortality were assessed. Difference between categorical variables was tested using the chi-square and Fisher’ Exact Test. Differences between continuous variables were tested using Wilcoxon Rank Sum test and presented with median and IQ range. Results: 86.1% (forgiven cohort) were given the optimal tPA dose despite estimation. There was a significant difference in stroke severity based on admission NIHSS between the cohorts (33.3% in forgiven vs. 69.2% non-forgiven. P=0.04). Stroke severity based on discharge NIHSS did not reach statistical significance (mild: 71.8% vs 63.6%, moderate: 16.9% vs 9.1% and severe: 11.3% vs 27.3%, p = 0.32). 30 days modified Rankin Scale (mRS) was available for 52 pts without any significant difference (good outcome 44.4% vs 57.1%, poor outcome 35.6 % vs 28.6 %, p = 0.82). Statistically non significance toward higher rate of hemorrhagic conversion (6.4% vs 7.7%, p = 0.41), and higher mortality in non-forgiven group (7.41% vs 15.38%, p= 0.33). Conclusion: Accurate BW measurement prior tPA still remains challenging. In this study, weight estimation by 2 providers is fairly accurate. 14 % of the patients with discrepancy of > 10 kg had higher rate of mortality and hemorrhage although this was not statistically significant. Further studies with larger sample sizes are needed to examine the safety of weight estimation in AIS patients who receive IV tpa

scholarly journals Effectiveness of Injection of Trigger Points with Platelet Rich Plasma as A Pain Management Method in Rotator Cuff Syndrome: إدارة الآلام المزمنة في متلازمة الكفة المدورة بواسطة زرق نقاط التوتر بالبلازما الغنية بالصفائح الدموية

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Hayder Ghali Algawwam, Abdullah Ahmed Mohammad
Keyword(s):  
Chronic Pain ◽  
Pain Management ◽  
Rotator Cuff ◽  
Platelet Rich Plasma ◽  
Poor Response ◽  
Trigger Points ◽  
Response To Therapy ◽  
Response To Treatment ◽  
Significant Difference ◽  
Management Method

Objective The aim of the current study is to evaluate the effectiveness of the injection of trigger points with platelet-rich plasma as a pain management method in chronic pain resulting from rotator cuff syndrome. Methodology A retrospective study was designed for the period from August 1, 2016, until July 31, 2019, 36 patients (21 females and 15 males) visited our private clinic in Kirkuk, Iraq because of chronic shoulder pain, they received trigger points PRP injections. The PRP was prepared by centrifuging the patient's own blood. The response to therapy was graded: excellent, good, fair and poor. Results The mean age was 52.3± 1.9 years. Most of the patients (n: 33, 92%) had either overweight or obesity and (n: 16, 44.6%) had hypertension either alone or in combination with diabetes mellitus. Most of the patients (n: 30, 83.3%) received three sessions while (n: 6, 16.7%) received one session of PRP injections. Most of the patients (n: 28, 77.8%) yielded either good or excellent response to treatment, while (n: 8, 22.2%) from the patient had an either fair or poor response to treatment, there was a statistically significant difference (p˂0.01) between the 2 groups. Conclusion PRP injections of trigger points in patients complaining from chronic pain as a result of rotator cuff syndrome seem to be an effective, safe and cheap pain management method.

scholarly journals Varicella Infection During Pregnancy- Maternal and Fetal Outcome; Case Series and Analysis in a Tertiary Centre in South India!

2021 ◽  
Vol 5 (04) ◽  
pp. 01-05
Author(s):  
Nina Navakumar ◽  
Madhuri Sambangi ◽  
Vidyalekshmy Ranganayaki
Keyword(s):  
South India ◽  
Statistical Significance ◽  
Tertiary Care ◽  
Case Series ◽  
Fetal Outcome ◽  
Care Hospital ◽  
Varicella Infection ◽  
Study Results ◽  
Significant Difference ◽  
Obstetric Population

Background: This is a retrospective study undertaken to analyse the maternal and fetal outcome of varicella infection during pregnancy. Methods: This is a retrospective observational study done in Kerala Institute of Medical Sciences, Trivandrum, a tertiary care hospital in South India. Sixty nine women infected with chickenpox during pregnancy from January 2009 to February 2018 (9 years) were taken for the study. Results: The incidence of chickenpox during pregnancy in our study was 33.7 in 10000 pregnancies. There were no spontaneous miscarriages. The incidence of congenital anomalies was 7.2% and when compared to the overall obstetric population of the nine year study period in which the incidence was 6.5 %, there was no statistical significance (p- 0.99). The incidence of preterm labour was 4.7% and when compared to the overall obstetric population in which the incidence was 15 %, there was a statistically significant less incidence (p- 0.035). The incidence of polyhydramnios was 4.7% and when compared to the overall obstetric population in which the incidence was 1%, there was a statistically significant increased incidence (p - 0.018). The incidence of fetal growth restriction was 13% and when compared to the overall obstetric population in which the incidence was 12.4%, there was no statistically significant difference (p- 0.963) Conclusions: The maternal and fetal complications with chickenpox infection during pregnancy were more when infected in the first trimester. Early treatment, screening and followup will reduce the maternal and fetal morbidity

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