scholarly journals ENDOCRINE FUNCTION OF ADIPOSE TISSUE (LITERATURE REVIEW)

2021 ◽  
Vol 28 (2) ◽  
pp. 18-25
Author(s):  
Vladimir Georgievich Solovyov ◽  
◽  
Svetlana Petrovna Kalashnikova ◽  
Lyubov Gennadievna Nikonova ◽  
Margarita Albertovna Gagaro
Keyword(s):  
Adipose Tissue ◽  
Metabolic Disorders ◽  
Physiological Role ◽  
Biologically Active ◽  
Endocrine Function ◽  
Systemic Level ◽  
Tissue Sensitivity ◽  
And Storage ◽  
Active Substances

Adipose tissue serves not only as a place for the accumulation and storage of triacylglycerides as energy substrates, but also produces many hormone-like substances, mediators, cytokines, chemokines that act at the local and systemic level and aff ect metabolism, regulate tissue sensitivity to insulin, reproductive and the immune system. The review presents the current results of scientifi c research on the problem of the physiological role of biologically active substances produced by adipose tissue and their participation in the development of metabolic disorders.

scholarly journals UP-TO-DATE VIEW AT THE ROLE OF ASEPTIC INFLAMMATION OF ADIPOSE TISSUE IN THE GENESIS OF OBESITY AND METABOLIC SYNDROME

2013 ◽  
Vol 19 (4) ◽  
pp. 305-310 ◽  
Author(s):  
N. N. Kryukov ◽  
M. M. Ginzburg ◽  
E. V,. Kiseleva
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Biologically Active ◽  
Aseptic Inflammation ◽  
Systemic Level ◽  
Tissue Sensitivity ◽  
The Relationship ◽  
Insight Into ◽  
Active Substances

Over the past two decades the views at the role of adipose tissue in the metabolic and energy metabolism have radically changed. There have appeared more and more evidence on the production of biologically active substances by adipose tissue, the so-called adipocytokines that are involved in the regulation of metabolic processes at the local or systemic level, of the tissue sensitivity to insulin, as well as pro-inlammatory or anti-inlammatory effect. By analysing the relationship and interaction of abdominal obesity, aseptic inlammation of adipose tissue and insulin resistance, it should be emphasized that these processes operate on the principle of mutual reinforcement, forming a vicious circle. Further understanding of adipokines and cytokines participation in the development of obesity and metabolic syndrome may contribute to a deeper insight into their biological role.

scholarly journals Metabolic disorders in adipocytokine imbalance and gestational complications

2017 ◽  
Vol 14 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Natalya B. Chabanova ◽  
Sergey I. Mataev ◽  
Tatiana N. Vasilkova ◽  
Irina A. Troshina
Keyword(s):  
Adipose Tissue ◽  
Metabolic Disorders ◽  
Maternal Obesity ◽  
Experimental Studies ◽  
Vascular Wall ◽  
Biologically Active ◽  
Endocrine Organ ◽  
Close Relationship ◽  
Tissue Sensitivity ◽  
Active Substances

Adipose tissue as an endocrine organ synthesizes a large number of biologically active substances, adipocytokines, which have both local and systemic effects influencing the vascular wall, tissue sensitivity to insulin, glucose metabolism, and systemic inflammation. The data obtained from clinical and experimental studies demonstrate the close relationship between the imbalance of adipocytokines and pregnancy complications such as insulin resistance, gestational diabetes, and preeclampsia. In this connection, close attention of obstetrician-gynecologists and endocrinologists is focused on etiopathogenic aspects of the formation of gestational complications with metabolic disorders caused by an imbalance of adipocytokines with maternal obesity and to the search for markers of these disorders. The review presents the current literature data on adipose tissue hormones and their influence on the course of a gestational process.

scholarly journals Comorbidity of chronic pancreatitis and metabolic syndrome: mechanisms of development

2019 ◽  
Vol 43 (2) ◽  
pp. 15-19
Author(s):  
T. N. Hristich ◽  
D. O. Hontsariuk
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Pancreatitis ◽  
Intestinal Microbiota ◽  
Metabolic Disorders ◽  
Subsequent Development ◽  
Healthy Person ◽  
Biologically Active ◽  
Endocrine Function ◽  
Intestinal Microbiome

In this article, the authors analyze a number of known and probable mechanisms involved in the formation of metabolic disorders upon chronic pancreatitis in comorbidity with metabolic syndrome. The issue of involvement of pancreatic endocrine apparatus in development of insulin resistance upon chronic pancreatitis, namely, the role of such a hormone as insulin, is highlighted. The role of this hormone in development of disorders of fat metabolism, obesity and arterial hypertension is presented. The authors emphasize the role of adrenal hormones, estrogen in the pathogenesis of both diseases. The issue of effect of endocrine function disorders on the state of external pancreatic secretion with subsequent development of disorders in the microbiota composition is considered (which also contributes to the progression of both diseases). The data on presence of a possible relationship between the composition, functional activity of the intestinal microbiota and development of metabolic syndrome, chronic pancreatitis are given. The significance of intestinal microbiota in the maintenance of various vital processes of a healthy person, food digestion, as well as synthesis, metabolism, recycling, utilization of various biologically active substances (vitamins, hormones, steroids, immunoglobulins) and elimination of toxins is revealed. The role of microorganisms in the formation of feeding behavior via axis “intestinal microbiome — intestine — brain” is analyzed. Modern ideas on the ability of microorganisms to provoke formation of metabolic disorders upon chronic pancreatitis are presented. The data confirming connection of certain dysbiotic changes (increased ratio of Firmicutes/Bacteroidetes, reduced number of Bacteroidetes and increased number of Firmicutes) with development of obesity, overweight, type 2 diabetes mellitus (known risk factors of metabolic syndrome) is given. It is suggested to prevent formation of metabolic syndrome in chronic pancreatitis by increasing the number of specimens of Bifidobacterium genus and Faecalibacteriumprausnitzii strains in the intestine.

scholarly journals Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ

2001 ◽  
Vol 60 (3) ◽  
pp. 329-339 ◽  
Author(s):  
Paul Trayhurn ◽  
John H. Beattie
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Physiological Role ◽  
Retinol Binding Protein ◽  
Endocrine Function ◽  
Specific Factor ◽  
Secretory Proteins ◽  
Metabolic Role ◽  
White Fat

The traditional role attributed to white adipose tissue is energy storage, fatty acids being released when fuel is required. The metabolic role of white fat is, however, complex. For example, the tissue is needed for normal glucose homeostasis and a role in inflammatory processes has been proposed. A radical change in perspective followed the discovery of leptin; this critical hormone in energy balance is produced principally by white fat, giving the tissue an endocrine function. Leptin is one of a number of proteins secreted from white adipocytes, which include angiotensinogen, adipsin, acylation-stimulating protein, adiponectin, retinol-binding protein, tumour neorosis factor a, interleukin 6, plasminogen activator inhibitor-1 and tissue factor. Some of these proteins are inflammatory cytokines, some play a role in lipid metabolism, while others are involved in vascular haemostasis or the complement system. The effects of specific proteins may be autocrine or paracrine, or the site of action may be distant from adipose tissue. The most recently described adipocyte secretory proteins are fasting-induced adipose factor, a fibrinogen–angiopoietin-related protein, metallothionein and resistin. Resistin is an adipose tissue-specific factor which is reported to induce insulin resistance, linking diabetes to obesity. Metallothionein is a metal-binding and stress-response protein which may have an antioxidant role. The key challenges in establishing the secretory functions of white fat are to identify the complement of secreted proteins, to establish the role of each secreted protein, and to assess the pathophysiological consequences of changes in adipocyte protein production with alterations in adiposity (obesity, fasting, cachexia). There is already considerable evidence of links between increased production of some adipocyte factors and the metabolic and cardiovascular complications of obesity. In essence, white adipose tissue is a major secretory and endocrine organ involved in a range of functions beyond simple fat storage.

scholarly journals Adipose-Derived Exosomes as Possible Players in the Development of Insulin Resistance

2021 ◽  
Vol 22 (14) ◽  
pp. 7427
Author(s):  
Arkadiusz Żbikowski ◽  
Agnieszka Błachnio-Zabielska ◽  
Mauro Galli ◽  
Piotr Zabielski
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Metabolic Disorders ◽  
Biologically Active ◽  
Whole Body ◽  
Secretory Function ◽  
Endocrine Organ ◽  
Actual Knowledge ◽  
Whole Body Metabolism

Adipose tissue (AT) is an endocrine organ involved in the management of energy metabolism via secretion of adipokines, hormones, and recently described secretory microvesicles, i.e., exosomes. Exosomes are rich in possible biologically active factors such as proteins, lipids, and RNA. The secretory function of adipose tissue is affected by pathological processes. One of the most important of these is obesity, which triggers adipose tissue inflammation and adversely affects the release of beneficial adipokines. Both processes may lead to further AT dysfunction, contributing to changes in whole-body metabolism and, subsequently, to insulin resistance. According to recent data, changes within the production, release, and content of exosomes produced by AT may be essential to understand the role of adipose tissue in the development of metabolic disorders. In this review, we summarize actual knowledge about the possible role of AT-derived exosomes in the development of insulin resistance, highlighting methodological challenges and potential gains resulting from exosome studies.

scholarly journals Metabolic role of visceral adipose tissue and main methods of its diagnosis at the present stage

2020 ◽  
Vol 82 (1) ◽  
Author(s):  
G.D. Fadieienko ◽  
Ya.V. Nikiforova
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Biologically Active ◽  
Inflammatory Infiltration ◽  
Endocrine Organ ◽  
Metabolic Functions ◽  
Metabolic Role ◽  
Visceral Adipose ◽  
Active Substances

A review of the literature on the metabolic role of visceral adipose tissue and the main methods for its diagnosis is presented. Visceral adipose tissue is an active endocrine organ what secretes a number of biologically active substances. With an increase in the proportion of visceral adipose tissue, moderate inflammation is observed with a chronic systemic increase in the activity of adipokines. Adipokines carry out several immune or metabolic functions associated with inflammatory infiltration. Active substances such as leptin, adiponectin, resistin, etc., the source of which is visceral adipose tissue, have peripheral, central and local effects on the metabolism of glucose and lipids, glycolysis processes in the liver, etc. It is the activity of visceral adipose tissue that should be considered among the main pathophysiological development factors obesity and its potential metabolic cardiovascular and/or liver complications.

scholarly journals Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity

Children ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 554
Author(s):  
Stefania Croce ◽  
Maria Antonietta Avanzini ◽  
Corrado Regalbuto ◽  
Erika Cordaro ◽  
Federica Vinci ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Metabolism ◽  
Th17 Cells ◽  
Metabolic Disorders ◽  
Potential Role ◽  
Immune Monitoring ◽  
Metabolic Dysfunction ◽  
Impaired Glucose Metabolism ◽  
T Cell Infiltration

In the last few decades, obesity has increased dramatically in pediatric patients. Obesity is a chronic disease correlated with systemic inflammation, characterized by the presence of CD4 and CD8 T cell infiltration and modified immune response, which contributes to the development of obesity related diseases and metabolic disorders, including impaired glucose metabolism. In particular, Treg and Th17 cells are dynamically balanced under healthy conditions, but imbalance occurs in inflammatory and pathological states, such as obesity. Some studies demonstrated that peripheral Treg and Th17 cells exhibit increased imbalance with worsening of glucose metabolic dysfunction, already in children with obesity. In this review, we considered the role of adipose tissue immunomodulation and the potential role played by Treg/T17 imbalance on the impaired glucose metabolism in pediatric obesity. In the patient care, immune monitoring could play an important role to define preventive strategies of pediatric metabolic disease treatments.

scholarly journals Influence of drying methods on preservation of biologically active substances of garden strawberries being raw material for food enrichment

2021 ◽  
Vol 845 (1) ◽  
pp. 012094
Author(s):  
I M Novikova ◽  
O M Blinnikova ◽  
L G Eliseeva ◽  
D A Blinnikova
Keyword(s):  
Shelf Life ◽  
Storage Period ◽  
Storage Conditions ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Raw Material ◽  
Drying Methods ◽  
Urgent Problem ◽  
And Storage ◽  
Active Substances

Abstract At present, the preservation of the consumer properties of berry products is an urgent problem. Use of fresh garden strawberries is limited by a short storage period and seasonality. Under optimal storage conditions in a normal atmosphere, the average shelf life of strawberries is from 2 to 9 days depending on the variety. To meet the needs of the population in garden strawberries and meet the physiological needs in a unique complex of biologically active substances, strawberries are subjected to different processing methods. Drying being a type of fruit and berry products processing has the following advantages: a significant increase in the shelf life of products, a decrease in the mass and storage volumes of dried berries, preservation of minerals, carbohydrates, dietary fiber, antioxidants, bioflavonoids and many biologically active compounds in berries. Modern drying technologies allow preserving the content of essential vitamins to its full extent. Comparison of two technologies for drying garden strawberries has established that vitamins and other biologically active substances are well preserved in berries. Berries dried by convective vacuum-impulse method (CVI) are recommended to be used for food enrichment.

TRENDS IN THE USE OF PACKAGING MATERIALS AND PACKAGING METHODS FOR PRODUCTS CONTAINING LABILE BIOLOGICALLY ACTIVE SUBSTANCES

2020 ◽  
Author(s):  
Е.П. ВИКТОРОВА ◽  
А.Д. АЧМИЗ ◽  
М.В. ЛУКЬЯНЕНКО ◽  
С.О. СЕМЕНИХИН
Keyword(s):  
Biologically Active Substances ◽  
Biologically Active ◽  
Packaging Materials ◽  
High Quality ◽  
Advantages And Disadvantages ◽  
Concentrate Polymer ◽  
Oxidative Processes ◽  
Livestock Products ◽  
And Storage ◽  
Active Substances

При производстве качественной пищевой продукции особое внимание необходимо уделять ее упаковыванию и хранению. Витаминно-минеральные концентраты, используемые для приготовления пищевых продуктов и получения качественной безопасной продукции животноводства, содержат комплекс лабильных биологически активных веществ, для сохранности которых необходимо минимизировать окислительные процессы. Это обусловливает повышенные требования к упаковке таких продуктов. С целью выбора упаковочного материала и способа упаковки витаминно-минерального концентрата проведен тематический обзор публикаций отечественных и зарубежных ученых. Рассмотрены тенденции в области применения упаковочных материалов, указаны преимущества и недостатки биополимеров. На основе проведенного анализа установлено, что для упаковывания витаминно-минерального концентрата целесообразно в качестве материала упаковки использовать полимерные пленки, обладающие высокой свето- и газонепроницаемостью, позволяющей снизить скорость протекания окислительных процессов и, следовательно, сократить потери содержащихся в продукте лабильных биологически активных веществ. В качестве способа упаковки можно рекомендовать применять вакуумирование, обеспечивающее отсутствие кислорода воздуха в упаковке. When producing high-quality food products, special attention should be paid to their packaging and storage. Vitamin and mineral concentrates used for food preparation and production of high-quality safe livestock products contain a complex of labile biologically active substances, for the safety of which it is necessary to minimize oxidative processes. This leads to increased requirements for the packaging of such products. In order to select the material and method of packaging of vitamin and mineral concentrates, a thematic review of publications of domestic and foreign scientists was conducted. Trends in the use of packaging materials are considered, advantages and disadvantages of biopolymers are indicated. It was found that for packaging vitamin and mineral concentrate, polymer pellicle with high light and gas tightness, which allows reducing the rate of oxidative processes and, consequently, reducing the loss of labile biologically active substances contained in the product, should be used as a packaging material. Vacuuming, which ensures the absence of oxygen in the air in the package, can be recommended as a method of packaging.

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