Uraria picta: A comprehensive review on evidences of utilization and strategies of conservation

Uraria picta (Jacq.) DC. (Prishnaparni) is one of the most important medicinal plants used in different traditional systems of medicines including the Ayurveda and Traditional Chinese medicine. The major use of this plant was found in the most popular Ayurvedic formulation “Dashmula” and in several many other important Ayurvedic formulations. IUCN placed this woody herb in the least concern category as per version 3.1. It has extensive therapeutic uses and pharmacological activities. Though this plant is a source of many phytochemicals, the uses are uncertain because the raw plant parts or crude extracts are being used in all formulations. Therefore, extensive investigations are necessary to focus on the identification of these phytochemicals. It is an urgent need to give special attention to collecting various aspects and more efforts are required in all areas for utilization and conservation of this valuable medicinal herb. Herein, a compilation of all information with various aspects has been presented, including the authors published work on Uraria picta. This review pursues attention towards biological activity, phytochemical profile, utilization, propagation and conservation of Uraria picta.

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Phytochemistry, Pharmacological Activities, Toxicity and Clinical Application of Momordica cochinchinensis

Current Pharmaceutical Design ◽

10.2174/1381612825666190329123436 ◽

2019 ◽

Vol 25 (6) ◽

pp. 715-728 ◽

Cited By ~ 3

Author(s):

Hai-Yue Lan ◽

Bin Zhao ◽

Yu-Li Shen ◽

Xiao-Qin Li ◽

Su-Juan Wang ◽

...

Keyword(s):

Clinical Practice ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Southeast Asia ◽

Clinical Application ◽

Chemical Constituents ◽

Folk Medicine ◽

Pharmacological Activities ◽

Pharmacological Studies ◽

Momordica Cochinchinensis

Momordica cochinchinensis (Lour.) Spreng (M. cochinchinensis) is a deciduous vine that grows in Southeast Asia. It is known as gac in Vietnam and as Red Melon in English. Gac is reputed to be extremely benificial for health and has been widely used as food and folk medicine in Southeast Asia. In China, the seed of M. cochinchinensis (Chinese name: Mu biezi) is used as traditional Chinese medicine (TCM) for the treatment of various diseases. More than 60 chemical constituents have been isolated from M. cochinchinensis. Modern pharmacological studies and clinical practice demonstrate that some chemical constituents of M. cochinchinensis possess wide pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammatory, etc. This paper reviews the phytochemistry, pharmacological activities, toxicity, and clinical application of M. cochinchinensis, aiming to bring new insights into further research and application of this ancient herb.

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Cardiovascular Modulating Effects of Magnolol and Honokiol, Two Polyphenolic Compounds from Traditional Chinese Medicine-Magnolia Officinalis

Current Drug Targets ◽

10.2174/1389450120666191024175727 ◽

2020 ◽

Vol 21 (6) ◽

pp. 559-572 ◽

Cited By ~ 1

Author(s):

Yuan Yuan ◽

Xiaocui Zhou ◽

Yuanyuan Wang ◽

Yan Wang ◽

Xiangyan Teng ◽

...

Keyword(s):

Phenolic Compounds ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Cardiac Hypertrophy ◽

Therapeutic Potential ◽

Current Data ◽

Polyphenolic Compounds ◽

Comprehensive Review ◽

Magnolia Officinalis

Honokiol and its isomer magnolol are poly-phenolic compounds isolated from the Magnolia officinalis that exert cardiovascular modulating effects via a variety of mechanisms. They are used as blood-quickening and stasis-dispelling agents in Traditional Chinese Medicine and confirmed to have therapeutic potential in atherosclerosis, thrombosis, hypertension, and cardiac hypertrophy. This comprehensive review summarizes the current data regarding the cardioprotective mechanisms of those compounds and identifies areas for further research.

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Traditional Medicinal Systems

Advanced Pharmacological Uses of Medicinal Plants and Natural Products - Advances in Medical Diagnosis, Treatment, and Care ◽

10.4018/978-1-7998-2094-9.ch001 ◽

2020 ◽

pp. 1-24

Author(s):

Aashaq Hussain Bhat ◽

Shahla Nigar

Keyword(s):

Chinese Medicine ◽

Side Effects ◽

Herbal Medicine ◽

Traditional Chinese Medicine ◽

Medicinal Plants ◽

Secondary Metabolites ◽

Modern Science ◽

Blood Purification ◽

Traditional Use ◽

Korean Medicine

Medicinal plants are a great source of medicine for treating various human ailments. Traditional use of herbal medicine, which was developed within an ethnic group before the development and spread of modern science, is the very basis and an integral part of various cultures. Different medicinal systems throughout the globe are still operational and use natural herbs for treating diseases. Traditional Chinese Medicine (TCM), Ayurveda, Kampo, Traditional Korean Medicine (TKM), and Unani are some commonly found traditional medicinal systems in use today. They are used directly, or their secondary metabolites are used as anti-bacterial, antifungal, immunomodulators, anti-hair fall, and multiple other purposes. However, their blood purification properties prevent blood from toxicity. Hundreds of medicinal plants are used in Ayurveda for blood purification, particularly plants which are astringent or bitter (pungent or sharp tastes). In addition, medicinal herbs do not have side effects.

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Saussurea lappa: A Comprehensive Review on its Pharmacological Activity and Phytochemistry

Current Traditional Medicine ◽

10.2174/2215083805666190626144909 ◽

2020 ◽

Vol 6 (1) ◽

pp. 13-23

Author(s):

Reyaz Hassan ◽

Mubashir Hussain Masoodi

Keyword(s):

Biological Activity ◽

Adverse Effects ◽

Chemical Constituents ◽

Literature Survey ◽

Perennial Herb ◽

Comprehensive Review ◽

Saussurea Lappa ◽

Therapeutic Uses ◽

Wide Range ◽

Anti Inflammatory

Around 3000 species of Saussurea are known, however Saussurea lappa Clarke which is perennial herb and has been traditionally used as anticancer, anti-inflammatory, antiviral, medicine without many adverse effects. Phytochemistry of Saussurea lappa after thorough literature survey revealed various varied and copious metabolites such as sesquiterpenes, flavonoids, phytosterols, lignans, terpenes. Many of these compounds have been found to possess a wide range of biological activity such as anticancer, anti-inflammatory, anti-hepatotoxic, anti-viral, etc. Among sesquiterpenes particularly Dehydrocostuslactone, dihydrocostunolide, costunolide Lappadilactone, have been isolated as the main chemical constituents. This review aims to cover published work from public databases (e.g. PubMed, Google Scholar, ResearchGate) and Non-English, Ph.D./MS thesis databases (e.g. CKNIChina, Jairo-Japan, Myto-Malaysia, Shodhganga-India) with a particular focus on phytochemistry and therapeutic uses of different fractions as well as isolated compounds from Saussurea lappa.

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Study on Transformation of Ginsenosides in Different Methods

BioMed Research International ◽

10.1155/2017/8601027 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 14

Author(s):

Meng-meng Zheng ◽

Fang-xue Xu ◽

Yu-juan Li ◽

Xiao-zhi Xi ◽

Xiao-wei Cui ◽

...

Keyword(s):

Biological Activity ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Pharmacological Activity ◽

Theoretical Foundation ◽

Major Constituent ◽

Chemical Methods ◽

Physical Methods ◽

Medicinal Value

Ginseng is a traditional Chinese medicine and has the extensive pharmacological activity. Ginsenosides are the major constituent in ginseng and have the unique biological activity and medicinal value. Ginsenosides have the good effects on antitumor, anti-inflammatory, antioxidative and inhibition of the cell apoptosis. Studies have showed that the major ginsenosides could be converted into rare ginsenosides, which played a significant role in exerting pharmacological activity. However, the contents of some rare ginsenosides are very little. So it is very important to find the effective way to translate the main ginsenosides to rare ginsenosides. In order to provide the theoretical foundation for the transformation of ginsenoside in vitro, in this paper, many methods of the transformation of ginsenoside were summarized, mainly including physical methods, chemical methods, and biotransformation methods.

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Nature as a Treasure Trove for Anti-COVID-19: Luteolin and Naringenin from Indonesian Traditional Herbal Medicine Reveal Potential SARS-CoV-2 Mpro Inhibitors Insight from in Silico Studies

10.26434/chemrxiv.13356842.v1 ◽

2020 ◽

Author(s):

Wahyu Prasetyo ◽

Triana Kusumaningsih ◽

Maulidan Firdaus

Keyword(s):

Chinese Medicine ◽

Herbal Medicine ◽

Traditional Chinese Medicine ◽

Medicinal Plants ◽

Small Molecule ◽

In Silico ◽

Dft Studies ◽

Traditional Herbal Medicine ◽

In Silico Studies ◽

Bioactive Phytochemicals

<div>Since the worldwide is currently facing the COVID-19 pandemic, there are no drugs or vaccines have been approved</div><div>for the treatment of SARS-CoV-2 infection. Therefore, there is an urgent need for in-depth research on emerging</div><div>human infectious coronaviruses. As part of our endeavour in combating this COVID-19 pandemic, in this paper, we</div><div>report on the discovery of an active antiviral small-molecule from Indonesian traditional herbal medicine used in Jamu</div><div>to inhibit 3CLpro of SARS-CoV-2 using in-silico approaches. As one of the mega biodiversity countries, Indonesia has</div><div>more than 1,180 species that can be prospected for medicine plants. Jamu, the Indonesian traditional herbal medicine,</div><div>is supposed to have similar potentials as those of traditional Chinese medicine (TCM). However, due to the lack of</div><div>scientific proof, Jamu is not recognised in the Guideline of COVID-19 Patients, particularly in Indonesia. Thus, in</div><div>this study, we performed virtual docking screening along with pharmacokinetic and DFT studies of selected 49</div><div>bioactive phytochemicals from several medicinal plants used in Jamu against the 3CLpro enzyme of SARS-CoV-2.</div><div>From the result, it was noted that from a set of 49 phytochemicals of medicinal plants used in Jamu, 2 phytochemicals,</div><div>i.e., Luteolin and Naringenin were identified as potential druggable inhibitors candidates of 3CLpro of SARS CoV-2.</div>

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Bioactive Compounds of Polygonatum Sibiricum - Therapeutic Effect and Biological Activity

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530321666210208221158 ◽

2021 ◽

Vol 21 ◽

Author(s):

Xin Zhao ◽

Suryaji Patil ◽

Qian Airong ◽

Caihong Zhao

Keyword(s):

Biological Activity ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Therapeutic Effect ◽

Bioactive Compounds ◽

Antimalarial Drug ◽

Biological Activities ◽

Modern Medicine ◽

Triterpenoid Saponins ◽

Immense Potential

Abstract: Plants serves as an important source of medicinal compounds and their use in various diseases dates back to hundreds of years. One such plant-based compound and the discovery of the antimalarial drug, artemisinin, have significantly brought phytomedicines into the spotlight and have enhanced the understanding and consequently, the application of formulations derived from plants. Traditional Chinese Medicine (TCM), which is based primarily on plants, holds immense potential and is an unexplored source for modern medicine. Many herbs including Polygonatum sibiricum (PS) are used in Chinese medicine as a treatment for various diseases. Polygonatum sibiricum (PS) belongs to the Liliaceae family and is used not only as a medicinal but also dietary supplement. PS has a highly diverse composition of bioactive compounds such as flavones, homoisoflavanone, alkaloids, lignins, steroid saponins, triterpenoid saponins, polysaccharides, etc. Because of such diverse composition, PS has been used as an anti-aging, anti-inflammatory, anti-osteoporotic, as well as an immunity booster, sleep enhancer, etc. Therefore, in his article, we review the therapeutic effect of bioactive compounds such as polysaccharides, saponins, and PS extract in various diseases and their biological activities in fatigue, immunity, sleep, anti-aging, etc.

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Indigenous Uses and Pharmacological Activity of Traditional Medicinal Plants in Mount Taibai, China

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2017/8329817 ◽

2017 ◽

Vol 2017 ◽

pp. 1-11 ◽

Cited By ~ 5

Author(s):

Na Chang ◽

Ziwen Luo ◽

Dengwu Li ◽

Huiying Song

Keyword(s):

Economic Development ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Medicinal Plants ◽

Medicinal Plant ◽

Plant Species ◽

Pharmacological Activity ◽

Traditional Medicinal Plants ◽

Pharmacological Data ◽

Indigenous Uses

This study was carried out to investigate the indigenous use and pharmacological activity of traditional medicinal plants of Mount Taibai, China. Pharmacological data were collected by conducting informal interviews with local experienced doctors practicing traditional Chinese medicine and via open-ended questionnaires on villagers. We conclude that the residents of Mt. Taibai possess rich pharmacological knowledge. This study may help identify high-value traditional medicinal plant species, promote economic development associated with local medicinal plants, and increase awareness from government departments.

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Chrysanthemum indicum L.: A Comprehensive Review of its Botany, Phytochemistry and Pharmacology

The American Journal of Chinese Medicine ◽

10.1142/s0192415x20500421 ◽

2020 ◽

Vol 48 (04) ◽

pp. 871-897 ◽

Cited By ~ 1

Author(s):

Yanhao Shao ◽

Yunda Sun ◽

Ding Li ◽

Yiping Chen

Keyword(s):

Quality Control ◽

Chinese Medicine ◽

Resource Availability ◽

Immune Regulation ◽

Chemical Constituents ◽

Pharmacological Activities ◽

Comprehensive Review ◽

Perennial Plant ◽

Chrysanthemum Indicum ◽

Hepatoprotective Effects

Chrysanthemum indicum L. (C. indicum L.), a member of the Compositae family, is a perennial plant that has been used as a traditional medicine for more than 2000 years in China and is widely used for the treatment of Pemphigus, swelling, pain, and scrofula. To date, more than 190 chemical constituents have been isolated and identified from this plant, including flavonoids, terpenoids, phenylpropanoids, and phenolic acids. Numerous modern studies have shown that extracts or monomeric compounds from C. indicum L. have several pharmacological activities, such as anti-inflammatory anti-oxidation, antipathogenic microorganism, anticancer, immune regulation, and hepatoprotective effects. However, resource availability, the research on the mechanism, and quality control are still insufficient, which deserves further efforts. In this paper, the advances in botany, phytochemistry, and pharmacology of C. indicum L were reviewed. We hope that this review can provide important information for traditional Chinese medicine, phytochemistry, synthetic and medicinal chemistry researchers for making full use of C. indicum L. resource.

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