scholarly journals Genetic polymorphism of interleukin-12β (rs7709212) in chronic and aggressive periodontitis in a group of the Bengali population of India

2021 ◽  
Vol 4 ◽  
pp. 78-83
Author(s):  
Avishek Das ◽  
Ashit Pal ◽  
Somen Bagchi
Keyword(s):  
Statistical Significance ◽  
Strong Association ◽  
Venous Blood ◽  
Aggressive Periodontitis ◽  
Study Cohort ◽  
Chi Square ◽  
Specific Objective ◽  
Group B ◽  
Chi Square Analysis ◽  
Factor Α

Objectives: The genetic basis of periodontitis was demonstrated by formal genetic studies which were focused on a range of various candidate genes selected for their roles in the immune system like genes of the interleukins (IL). Bone proresorptive cytokines such as IL-1 and tumor necrosis factor-α are primarily regulated by a network of other T-cell derived cytokines, including IL-12 family. Specific objective of this study was to find out any association between IL-12β 3΄ untranslated region (UTR) (rs7709212) gene polymorphism and chronic as well as aggressive periodontitis (AgP) in Bengali population of West Bengal, India. Materials and Methods: A total of 88 Bengali participants of both sexes were recruited and were divided into three groups: Group A (chronic periodontitis [CP] group), Group B (AgP group), and Group C (healthy control). DNA extraction from collected peripheral venous blood was performed by phenol chloroform method and ethanol precipitation. Genotyping of extracted DNA samples was carried out for locus IL-12β 3΄UTR (rs7709212) by real time-polymerase chain reaction. Association between genotypes and cases was examined by the odds ratio with 95% confidence interval and chi-square analysis using R statistical software. Statistical significance was defined as P < 0.05. Results: On analysis of the minor allele frequencies of total periodontitis cases and control, the results were found to be statistically significant with the P = 0.03045. Conclusion: The present study suggested a strong association of single nucleotide polymorphism of IL-12β (rs7709212) with total periodontitis cases (both CP and AgP) in the present study cohort.

Public Perceptions of a Rural Emergency Medical Services System

1994 ◽  
Vol 9 (4) ◽  
pp. 257-259 ◽  
Author(s):  
Lawrence H. Brown ◽  
N. Heramba Prasad ◽  
Kirk Grimmer
Keyword(s):  
Emergency Medical Services ◽  
Statistical Significance ◽  
Public Perceptions ◽  
Medical Services ◽  
Chi Square ◽  
Telephone Directory ◽  
Emergency Medical ◽  
Chi Square Analysis ◽  
Lay Public

AbstractIntroduction:To determine the awareness of citizens and physicians concerning the capabilities of a rural emergency medical services (EMS) system.Hypothesis:Citizens and physicians are unaware of the capabilities of the EMS system.Methods:Residents were selected randomly from the local telephone directory and asked a series of structured questions about their EMS agency. A written survey was distributed to area physicians. Chi-square analysis was used to compare the proportion of respondents who knew the available interventions in their community with the proportion of those who did not. Statistical significance was inferred at p <0.01.Results:A total of 49% of the citizens were able to identify available skills, and 41.4% of the physicians were able to identify available skills. Physicians were less likely than were the citizens to be able to identify the skills performed by each provider (p <0.001).Conclusion:This study indicates that both physicians and the lay public have little understanding of the capabilities of their EMS system.

scholarly journals Associations between Modifiable Health-Risk Behaviors and Personality Types

2017 ◽  
Vol 8 (2) ◽  
Author(s):  
Jon C. Schommer ◽  
Paul D. Tieger ◽  
Anthony W. Olson ◽  
Lawrence M. Brown
Keyword(s):  
Health Risk ◽  
Risk Behaviors ◽  
Statistical Significance ◽  
Personality Type ◽  
Health Risk Behaviors ◽  
Personality Types ◽  
Chi Square ◽  
Related Stress ◽  
The Individual ◽  
Chi Square Analysis

Objectives: The first objective for this study was to explore if characteristics of personality type (using the Preferred Communication Style Questionnaire) are associated with the following modifiable health-risk behaviors: smoking, exercise, alcohol consumption, nutrition, sleep, depression-related stress, anxiety-related stress, healthcare professional usage, and self-discipline. The second objective for this study was to explore if characteristics of personality type are associated with (1) the quality of patient-physician relationships, (2) patient-physician communication, and (3) preferred method for receiving information. Methods: Data were collected from 10,500 adult individuals residing in the United States via an on-line, self-administered survey coordinated by Qualtrics Panels from March 14-30, 2016. Chi-square analysis was used for making comparisons between categories of personality types and items related to health-risk behaviors. Statistical significance was set at p < 0.05. However, chi-square analysis with large sample sizes (e.g. 10,500 in this study) readily yields statistical significance. Practical significance was set at four or more percentage points above or below the overall mean. Results: Regarding objective 1, personality type was associated with all nine health-risk behaviors studied. Personality types within the Experiencer temperament (17% of the U.S. population) accounted for 46% of the undesirable scores we computed for health-risk behaviors. The Idealist temperament (17% of population) accounted for 32% of the undesirable scores. Conceptualizers (10% of population) accounted for 17% of the undesirable scores and Traditionalists (46% of population) accounted for 5% of the undesirable scores. Regarding objective 2, the findings showed that personality type was associated with (1) the importance people place on the patient-physician relationship, (2) which characteristics of that relationship are most desirable, (3) desire for more communication with their physician, and (4) the preferred method for receiving information. Discussion and Conclusions: Precision medicine has been proposed as a way to create a new taxonomy of disease that uses individual specific data to develop accurate diagnosis, targeted treatment, and improved health outcomes. Based on the findings of this study, we propose that inclusion of personality type is an important component of these efforts so that the health care system can conform more to the individual patient in order to increase engagement and adherence, reduce errors, minimize ineffective treatment and waste, and can be cost effective. Conflict of Interest Co-author, Paul Tieger is CEO of SpeedReading People, LLC which holds copyright for the Individual Wellness Plan and Adherence Predictive Index tools that are mentioned in this manuscript.   Type: Original Research

scholarly journals Incidences of Root Microcracks Caused by Hand and Rotary File System at Different Lengths

2019 ◽  
Vol 3 (9) ◽  
pp. 283-289
Author(s):  
Shuchi Sukul ◽  
Goldy Rathee ◽  
Parimal Anand ◽  
Sakshi Kataria ◽  
Pratibha Taneja
Keyword(s):  
File System ◽  
Statistical Significance ◽  
File Systems ◽  
In Vitro Study ◽  
Root Surface ◽  
P Value ◽  
Chi Square ◽  
Chi Square Test ◽  
Group B

OBJECTIVES: The present research was conducted to assess incidences of root microcracks caused by hand and rotary file system at different lengths MATERIAL AND METHODS: This in-vitro study was undertaken to assess incidence of root microcracks caused by hand and rotary file system at different lengths In total, 100 the mandibular premolar with straight roots determined with intact, fully formed apices were taken. Samples were randomly distributed into 5 groups based on the file system used: a) Group A: Control, b) Group B: Reciproc, c) Group C: WaveOne, d) Group D: One Shape and e) Group E: ProTaper. Pearson Chi-square test was used to determine the differences between groups. The dentinal defects were expressed as percentage of samples with microcracks in each group. Level of statistical significance was set at p-value less than 0.05. RESULTS: The chi square test was used to compare the Distribution of the number of teeth in which cracks were observed on the horizontal sections. It was found to be significant with group ProTaper showing maximum cracks at 3,6,9 mm level as compared to other file systemCONCLUSION: Nickel-titanium instruments causes cracks on the apical root surface or in the root canal wall. ProTaper causes maximum dentinal cracks as compared to other file systems

scholarly journals Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal disease

2003 ◽  
Vol 17 (2) ◽  
pp. 183-188 ◽  
Author(s):  
Sheila Cavalca Cortelli ◽  
Antonio Olavo Cardoso Jorge ◽  
José Roberto Cortelli ◽  
Shawn Francis Jordan ◽  
Violet Ibyola Haraszthy
Keyword(s):  
Periodontal Disease ◽  
Strong Association ◽  
Aggressive Periodontitis ◽  
Actinobacillus Actinomycetemcomitans ◽  
Periodontal Pocket ◽  
Chain Reaction ◽  
Chi Square ◽  
Pocket Depth ◽  
Polymerase Chain ◽  
Brazilian Cohort

This study examined the prevalence of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans in patients with periodontal disease. Pooled subgingival plaque samples from 136 patients with some form of periodontal disease were examined. Subjects were between 14 and 76 years of age. Clinical examinations included periodontal pocket depth (PD), plaque index (PI) and bleeding index (BI). The obtained plaque samples were examined for the presence of highly or minimally leukotoxic A. actinomycetemcomitans strains by the polymerase chain reaction (PCR). Chi-square and logistic regression were performed to evaluate the results. Forty-seven subjects were diagnosed with gingivitis, 70 with chronic periodontitis and 19 with aggressive periodontitis. According to chi-square there was no significant correlation detected between PD (chi2 = 0.73), PI (chi2 = 0.35), BI (chi2 = 0.09) and the presence of the highly leukotoxic A. actinomycetemcomitans. The highly leukotoxic A. actinomycetemcomitans strains were correlated with subjects that were 28 years of age and younger (chi2 = 7.41). There was a significant correlation between highly leukotoxic A. actinomycetemcomitans and aggressive periodontitis (chi2 = 22.06). This study of a Brazilian cohort confirms the strong association between highly leukotoxic A. actinomycetemcomitans strains and the presence of aggressive periodontitis.

scholarly journals Autopsy Utilization in Medicolegal Defense of Anesthesiologists

2011 ◽  
Vol 115 (4) ◽  
pp. 713-717 ◽  
Author(s):  
Lorri A. Lee ◽  
Linda S. Stephens ◽  
Corinne L. Fligner ◽  
Karen L. Posner ◽  
Frederick W. Cheney ◽  
...  
Keyword(s):  
Cause Of Death ◽  
Statistical Significance ◽  
Chi Square ◽  
Autopsy Findings ◽  
New Information ◽  
Malpractice Claims ◽  
Hospital Deaths ◽  
American Society ◽  
Chi Square Analysis ◽  
Closed Claims

Background The rate of autopsy in hospital deaths has declined from more than 50% to 2.4% over the past 50 yr. To understand the role of autopsies in anesthesia malpractice claims, we examined 980 closed claims for deaths that occurred in 1990 or later in the American Society of Anesthesiologists Closed Claims Project Database. Methods Deaths with autopsy were compared with deaths without autopsy. Deaths with autopsy were evaluated to answer the following four questions: Did autopsy findings establish a cause of death? Did autopsy provide new information? Did autopsy identify a significant nonanesthetic contribution to death? Did autopsy help or hurt the defense of the anesthesiologist? Reliability was assessed by κ scores. Differences between groups were compared with chi-square analysis and Kolmogorov-Smirnov test with P &lt; 0.05 for statistical significance. Results Autopsies were performed in 551 (56%) of 980 claims for death. Evaluable autopsy information was available in 288 (52%) of 551 claims with autopsy. Patients in these 288 claims were younger and healthier than those in claims for death without autopsy (P &lt; 0.01). Autopsy provided pathologic diagnoses and an unequivocal cause of death in 21% of these 288 claims (κ= 0.71). An unexpected pathologic diagnosis was found in 50% of claims with evaluable autopsy information (κ = 0.59). Autopsy identified a significant nonanesthetic contribution in 61% (κ = 0.64) of these 288 claims. Autopsy helped in the defense of the anesthesiologist in 55% of claims and harmed the defense in 27% (κ = 0.58) of claims with evaluable autopsy information. Conclusions Autopsy findings were more often helpful than harmful in the medicolegal defense of anesthesiologists. Autopsy identified a significant nonanesthetic contribution to death in two thirds of claims with evaluable autopsy information.

The Predictive Value of Micrometastasis in Nonsentinel Lymph Nodes

2012 ◽  
Vol 78 (6) ◽  
pp. 669-674 ◽  
Author(s):  
Patrick D. Glasgow ◽  
Nikhil Satchidanand ◽  
Gopal Chandru Kowdley
Keyword(s):  
Breast Cancer ◽  
Logistic Regression ◽  
Lymph Nodes ◽  
Axillary Dissection ◽  
Statistical Significance ◽  
Chi Square ◽  
Logistic Regression Models ◽  
Node Positive Disease ◽  
Completion Axillary Dissection ◽  
Chi Square Analysis

The rate of micrometastatic disease (MMD) to nonsentinel lymph nodes (NSLNs) has been shown to vary considerably in the literature. We identified patients with breast cancer with MMD (N1mi) and measured the incidence of NSLN involvement. We then compared these patients with those who had no metastasis to the SLN (N0) and those who had macrometastasis to the SLN (N2) in an attempt to better understand the behavior of patients with N1mi positivity. A retrospective analysis was conducted on 574 patients with invasive breast cancer between January 2000 and December 2007. Patients were stratified into three groups: no metastasis (N0), MMD (N1mi), and macrometastasis (N2). Chi square analysis and logistic regression models using SPSS software were applied to determine significance between groups. MMD rate was 7.7 per cent (44 of 574). Of this subset of patients, 33 underwent completion axillary dissection, and only two were found to have NSLN-positive disease. Statistical significance was achieved for NSLN positivity when comparing all three nodal groups against one another (χ22,572 = 337.084, P = 0.000). Logistic regression showed multifocality and lymphovascular invasion to be significant predictors of NSLN metastasis. NSLN positivity in patients with MMD acts similarly to node-positive disease and therefore cannot completely exclude axillary dissection from therapeutic algorithm.

scholarly journals In Vivo Bonding of Orthodontic Brackets to Fluorosed Enamel using an Adhesion Promotor

2008 ◽  
Vol 78 (2) ◽  
pp. 357-360 ◽  
Author(s):  
James Noble ◽  
Nicholas E. Karaiskos ◽  
William A. Wiltshire
Keyword(s):  
Dental Fluorosis ◽  
Statistical Significance ◽  
High Volume ◽  
Aluminum Silicate ◽  
Control Group ◽  
Adhesion Promoter ◽  
Bond Failure ◽  
Chi Square ◽  
Chi Square Analysis

Abstract Objectives: To determine the success of bracket retention using an adhesion promoter with and without the additional microabrasion of enamel. Materials and Methods: Fifty-two teeth with severe dental fluorosis were bonded in vivo using a split-mouth design where the enamel surfaces of 26 teeth were microabraded with 50 μm of aluminum silicate for 5 seconds under rubber dam and high volume suction. Thirty-seven percent phosphoric acid was then applied to the enamel, washed and dried, and followed by placement of Scotchbond Multipurpose Plus Bonding Adhesive. Finally, precoated 3M Unitek Victory brackets were placed and light cured. The remaining teeth were bonded using the same protocol but without microabrasion. Results: After 9 months of intraoral service, only one bond failure occurred in the control group where microabrasion was used. Chi-square analysis revealed P = .31, indicating no statistical significance between the two groups. Conclusions: Bonding orthodontic attachments to fluorosed enamel using an adhesion promoter is a viable clinical procedure that does not require the additional micro-mechanical abrasion step.

scholarly journals ACL Injuries Aren’t Just for Girls: The Role of Age in Predicting Pediatric ACL Injury

2020 ◽  
Vol 12 (6) ◽  
pp. 559-563
Author(s):  
David A. Bloom ◽  
Adam J. Wolfert ◽  
Andrew Michalowitz ◽  
Laith M. Jazrawi ◽  
Cordelia W. Carter
Keyword(s):  
Female Athletes ◽  
Statistical Significance ◽  
Acl Injury ◽  
Childhood And Adolescence ◽  
Chi Square ◽  
Acl Injuries ◽  
Acl Tear ◽  
Chi Square Analysis ◽  
Age And Sex

Background: Female athletes have a higher rate of anterior cruciate ligament (ACL) injuries than male athletes; however, the role of age in mediating this injury risk has not been explored. The purpose of this study was to characterize the relationship between age and sex in predicting ACL injury in the pediatric population. Hypothesis: Prepubescent boys are more likely to sustain an ACL injury than prepubescent girls. Study Design: Descriptive epidemiological study. Level of Evidence: Level 4. Methods: Data were collected from the Statewide Planning and Research Cooperative System database for the state of New York from 1996 to 2016. The database was queried for patients aged ≤19 years who had been diagnosed with an ACL tear using the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) code 844.2 or the ICD-10 (10th Revision) codes S83.512A/S83.511A/S83.519A. Patient age and sex at time of ACL injury diagnosis were recorded. Chi-square analysis was used to compare the frequency of ACL injury between groups, with statistical significance set at P < 0.05. Results: A total of 20,128 patients aged ≤19 years were diagnosed with an ACL tear (10,830 males, 9298 females; male:female, 1.16:1). In all, 129 patients aged <12 years sustained an ACL tear (85 boys, 44 girls; male:female, 1.93:1), and 19,999 of those patients were aged 12 to 19 years (10,745 males, 9254 females; male:female, 1.16:1). Chi-square analysis demonstrated a significant relationship between sex and age group ( P < 0.006). Additional analysis revealed that female athletes were most at risk for ACL injury from ages 12 to 16 years, with 4025 male and 5095 female athletes sustaining ACL injuries in this group (male:female, 1:1.27; P < 0.0001). Conclusion: Prepubescent boys (aged <12 years) are more likely to sustain an ACL injury than same-aged female peers. Clinical Relevance: This study demonstrates that the risk of ACL injury varies with age and sex throughout childhood and adolescence, further guiding treatment and prevention for these pediatric athletes.

scholarly journals ANTHROPOMETRY OF THE EXTERNAL EAR AMONG ADULT IJAWS IN BAYELSA STATE OF NIGERIA

2019 ◽  
Vol 5 (1) ◽  
pp. 75-83
Author(s):  
E. I. Edibamode ◽  
K. Mordi ◽  
L. K. David ◽  
A. M. Eghoi
Keyword(s):  
Sexual Dimorphism ◽  
Statistical Significance ◽  
External Ear ◽  
Chi Square ◽  
Mean Values ◽  
Chi Square Test ◽  
Males And Females ◽  
And Gender ◽  
The Right ◽  
Chi Square Analysis

Background. External ear measurement is of utmost importance in reconstructive surgeries. Objectives. The present study is aimed at ascertaining sexual dimorphism in external ear anthropometry and ear lobe attachments among adults Ijaws in Bayelsa, Nigeria. Methods. A total of 112 adults within the age range of 18-50 yrs, who met the inclusion criteria, were involved in the study. Four linear dimensions of the ear, which are ear length (EL), ear width (EW), lobular length (LL) and lobular width (LW), were measured for both genders. The lobular attachment for both ears for males and females were also examined and results recorded. These data were subjected to Student t-test, Chi-square test, and Pearson’s correlation using SPSS version 20.0. Results. The mean values for EL, EW, LL, and LW for the left auricle in the males and females were 58.14±0.60, 27.41±0.37, 14.47±0.27, 13.50±0.34 and 57.90±0.16, 27.45±0.65, 15.41±0.31, 13.43±0.38 respectively. However, for the right auricle in the males and females, the values were 58.40±0.45, 28.21±0.68, 14.32±0.31, 13.04±0.32, and 56.66±1.10, 27.51±0.65, 15.58±0.29, 13.28±0.34 respectively. The left and right lobular length were the only parameters that proved statistical significance (p<0.05) in females compare to males. Pearson’s correlations between right and left sides for each of the parameters were positive and significant. Chi-square analysis revealed no significant relationship (p>0.05) between earlobe attachments and gender. Conclusions. Sexual dimorphism was thus established in the Ijaw population as regards lobular length dimensions. It is believed that the results of this study would be very useful for ear morphology and reconstructive surgeries.

scholarly journals Evaluation of genetic polymorphism of interleukin-1β (rs16944) in chronic and aggressive periodontitis in a group of the Bengali population of West Bengal, India

2021 ◽  
Vol 4 ◽  
pp. 27-32
Author(s):  
Avishek Das ◽  
Ritam Kundu ◽  
Ashit Kumar Pal ◽  
Somen Bagchi
Keyword(s):  
Genetic Polymorphism ◽  
Dna Extraction ◽  
Chronic Periodontitis ◽  
Odds Ratio ◽  
West Bengal ◽  
Aggressive Periodontitis ◽  
Minor Allele ◽  
Study Cohort ◽  
Single Nucleotide ◽  
Chi Square Analysis

Objectives: The genetic basis of periodontitis was demonstrated by formal genetic studies which were focused on a range of various candidate genes selected for their roles in the immune system like genes of the interleukins (ILs) which regulate the intensity of host immunity-inflammatory response. This regulation of host response may be associated with the genetic polymorphisms, specific single-nucleotide polymorphisms of the genes of various ILs. Interleukin-1 (IL-1) is a principal mediator of inflammatory responses acting on many cell types and is itself produced by many different cells, including macrophages, endothelial cells, B cells, fibroblasts, epithelial cells, astrocytes, and osteoblasts in response to microorganisms, bacterial toxins, and complement components. In the present study, an attempt has been made to explore the role of IL-1β-511 (rs16944) genetic polymorphism in chronic as well as aggressive periodontitis in a group of the Bengali population of West Bengal, India. Materials and Methods: A total of 88 Bengali patients of both sexes were recruited in this study and they were divided into three groups: Group A (chronic periodontitis group), Group B (aggressive periodontitis group), and Group C (healthy control). The clinical parameters taken into consideration in the assessment of chronic and aggressive periodontitis were plaque index, calculus index, gingival index, probing pocket depth (PPD), and clinical attachment loss (CAL). A 3 ml of peripheral venous blood was collected from each selected participant and transferred to 3% EDTA containing serum vial and stored at −20°C for DNA extraction. DNA extraction was performed by the phenol chloroform method and ethanol precipitation. Genotyping of extracting DNA samples was carried out for locus IL-1β-511 (rs16944) by real-time polymerase chain reaction. Hardy–Weinberg equilibrium was tested for the gene polymorphism and association between genotypes and cases was examined by odds ratio with 95% confidence interval (CI) and Chi-square analysis using R programming software. Allelic frequencies were calculated according to the number of different alleles observed and the total number of alleles examined. Statistical significance was defined as P < 0.05. Results: On analysis of minor allele frequencies of total periodontitis cases and control, the results were found to be statistically insignificant with P = 0.9799. Minor allele frequency of overall periodontitis cases and controls was 0.405 and 0.403, respectively; the odds ratio was 1.008 and 95% CI ranges from 0.53 to 1.88. Conclusion: The present study suggested no association of single-nucleotide polymorphism of IL-1β-511 (rs16944) with total periodontitis cases (both chronic periodontitis and aggressive periodontitis) in the present study cohort.

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