Effectiveness of complex treatment of «dry eye» syndrome on the background of chronic peripheral uveitis

2021 ◽  
pp. 45-48
Author(s):  
E.B. Tatarnikova ◽  
◽  
O.I. Krivosheina ◽  
Keyword(s):  
Dry Eye ◽  
Comparison Group ◽  
Combined Treatment ◽  
Treatment Method ◽  
Main Group ◽  
Dry Eye Syndrome ◽  
Laser Coagulation ◽  
Complex Method ◽  
Comprehensive Method ◽  
Tear Production

Purpose to evaluate the effectiveness of a comprehensive method of treating dry eye syndrome against the background of chronic peripheral uveitis. Material and methods. The study was performed among 98 patients (196 eyes), who made up 2 observation groups: the main group (78 people) and comparison group (20 people). The main group was treated with a new method, the comparison group was prescribed local anti-inflammatory and tear replacement therapy. Results. Application of the combined treatment showed a significant decrease in OSDI and occurrence of changes in ocular surface (up to 100%), characteristic for the syndrome of «dry eye». The indicators of total tear production became higher up to 2 times from the initial level after the therapy. Conclusion: The use of a new complex method of treatment significantly reduces the subjective and objective manifestations of the "dry eye" syndrome, contributes to an increase in total tear production against the background of relief of inflammation on the extreme periphery of the fundus compared to traditional pharmacotherapy. Key words: dry eye syndrome, chronic peripheral uveitis, combined treatment method, laser coagulation of the extreme periphery of the retina.

A new approach to the treatment of dry eye syndrome against the background of chronic peripheral uveitis

2021 ◽  
pp. 154-157
Author(s):  
E.B. Tatarnikova ◽  
◽  
O.I. Krivosheina ◽  
Keyword(s):  
Conservative Treatment ◽  
Dry Eye ◽  
Comparison Group ◽  
Anterior Segment ◽  
Main Group ◽  
Dry Eye Syndrome ◽  
Laser Coagulation ◽  
Complex Method ◽  
Anti Inflammatory

Aim. To study the clinical and functional effectiveness of a complex method of treatment of dry eye syndrome against the background of chronic peripheral uveitis, including local tear-replacement and anti-inflammatory therapy in combination with laser retinal coagulation on the extreme periphery of the fundus. Materials and methods. The study was performed among 98 patients who made up 2 follow-up groups: the main group (78 people) and the comparison group (20 people). All patients underwent OSDI questionnaires, visometry, pneumotonometry, biomicroscopy of the anterior segment of both eyes, binocular ophthalmoscopy with sclerocompression, and the Schirmer I test. In the main group, along with conservative treatment, laser coagulation of the extreme periphery of the retina was performed, in the comparison group - conservative treatment. The follow-up period was 3 months. Results and discussion. The use of a complex method of treatment of «dry eye» syndrome against the background of chronic peripheral uveitis significantly reduces the number of complaints according to the OSDI questionnaire, improves the condition of the eye surface (reducing the overhang of the conjunctival fold, the severity of «sluggish» hyperemia of the conjunctiva of the eyelids and transitional folds, reducing the amount of conjunctival discharge). The indicator of total tear production in the main group after 3 months. it increases by 1,5 times in comparison with the initial data, and in 100% of cases, stable relief of inflammation of the chorioretinal structures on the extreme periphery of the fundus is provided. Conclusion. A new effective method for the treatment of dry eye syndrome against the background of chronic peripheral uveitis, including local tear-replacement and anti-inflammatory therapy in combination with laser retinal coagulation on the extreme periphery of the fundus, has been developed and introduced into clinical practice. The use of this method provides stable clinical and functional results in the long-term period and can be recommended for the treatment of «dry eye» syndrome of mild to moderate severity against the background of chronic peripheral uveitis. Key words: dry eye syndrome, chronic peripheral uveitis, laser coagulation of the extreme periphery of the retina.

scholarly journals Therapy of Dry Eye Syndrome after Inflammatory Diseases of Cornea

2020 ◽  
Vol 17 (1) ◽  
pp. 124-132
Author(s):  
I. A. Gndoyan ◽  
A. V. Petrayevsky
Keyword(s):  
Visual Acuity ◽  
Dry Eye ◽  
Comparison Group ◽  
Inflammatory Diseases ◽  
Dry Eye Syndrome ◽  
Corneal Tissue ◽  
Observation Group ◽  
Group 14 ◽  
Basic Therapy ◽  
Tear Production

Purpose: evaluation of the efficacy of the drug Tealose® in the therapy of cornea inflammatory diseases consequences such as dry eye syndrome.Patients and methods: 34 patients (34 eyes) with dry eye syndrome after inflammatory diseases of the cornea, aged 28–56 years old were included in the study. Two clinical groups were formed: observation group — 20 subjects (20 eye) and comparison group — 14 subjects (14 eyes). The dynamics of such indicators were estimated under therapy: visual acuity with maximal correction, corneal epithelium entity according fluoresceine dye test, tear production according Schirmer and Norn tests, the grade of dry eye syndrome severity according index of OSDI — Questionnarie. The patients in observation group in addition to the basic therapy, which included instillation antiseptics и 4 % taurine solution, were treated with 3 % solution of tregalose (Tealose®, “Laboratuar Thea”, France) by such mode: using of 4 times daily instillations during 1 month, 1 month break, than continuation of the same regimen instillations during 1 month was performed. The patients in comparison group in addition to the same basic therapy were treated with Visomitin® (“Mitotech”, Russia) by the mode, which was used for tregalose.Results. The improvement of cornea’s epithelization (p < 0,05), increasing of visual acuity with maximal correction (p < 0,05), improvement of tear production (p < 0,05), as well as the OSDI-index (p < 0,05) were revealed in the patients of the observation group. In the patients of the comparison group positive dynamics of these indicators was insignificant and unreliable.Conclusions. Using of 3 % tregalose solution in patients with consequences of inflammatory diseases of the cornea — keratitis leads to effective treatment of “dry eye” syndrome, reduces the severity of epithelization disorders and tendency to scarring in the corneal tissue.

Relationship between duration of antihypertensive regimen and incidence of dry eye syndrome in patients with primary open-angle glaucoma

2021 ◽  
pp. 75-78
Author(s):  
A.D. Pilipenko ◽  
◽  
R.A. Burya ◽  
A.V. Romanova ◽  
◽  
...  
Keyword(s):  
Antihypertensive Therapy ◽  
Dry Eye ◽  
Primary Open Angle Glaucoma ◽  
Comparison Group ◽  
Open Angle Glaucoma ◽  
Main Group ◽  
Dry Eye Syndrome ◽  
Open Angle ◽  
Antihypertensive Regimen ◽  
Initial Symptoms

Purpose. To study the incidence of dry eye syndrome (DES) in patients with primary open-angle glaucoma (POAG), depending on the duration of the use of local antihypertensive therapy. Material and methods. The material for the study was patients who were examined in the treatment and diagnostic department of the Khabarovsk branch the S. Fyodorov Eye Microsurgery Federal State Institution with a confirmed clinical diagnosis of POAG. The main group included 45 patients with a duration of antihypertensive therapy of 1 month or more. The comparison group consisted of 15 patients with newly diagnosed POAG. The period of use of antihypertensive therapy in them did not exceed one month. Depending on the experience of using antihypertensive therapy, the patients of the main group were divided into 3 subgroups. All were questioned using the DEQ-5 dry eye questionnaire, Schirmer I, II and Norn's tests, objective examination of the anterior segment of the eyes. The analysis of the detection and severity of DES among patients with POAG was carried out, taking into account the experience of using the antihypertensive regimen. Results. According to the questionnaire, 26 patients (58%) of the main group presented complaints typical of DES, while in the comparison group only 3 patients (20%) presented them (p<0.05). There was also a tendency towards a decrease in the total and main type of tear production in the main group according to the results of Schirmer's tests I and II – 10.9±1.04 mm and 7.7±0.48 mm versus 13.9±2.5 mm and 10, 2±2.1 mm in the comparison group (p>0.05). The stability of the tear film, according to Norn's test, also differed: 8.2±0.35 sec. and 9.5±1.8 sec. in the main and comparison group, respectively (p> 0.05). Conclusion. The initial symptoms of xerosis of the ocular surface are recorded in the period from 1 to 3 years from the beginning of the use of antihypertensive drugs and increase in proportion to the increase in the length of the disease. Key words: dry eye syndrome, glaucoma, antihypertensive therapy.

Experience of Optimization of Medical Care for Women in Menopause with Dry Eye Syndrome

2021 ◽  
pp. 31-35
Author(s):  
A.S. Obrubov ◽  
◽  
Keyword(s):  
Medical Care ◽  
Dry Eye ◽  
Combined Therapy ◽  
Combined Treatment ◽  
Low Frequency ◽  
Main Group ◽  
Dry Eye Syndrome ◽  
Control Group ◽  
Treatment Technology ◽  
Complex Preparation

Purpose. Optimization of medical care for women in menopause with dry eye syndrome from the standpoint of experimental and clinical substantiation of combined technologies. Material and methods. The studies were carried out on a group of 72 patients (144 eyes) in the postmenopausal period with dry eye syndrome. The average age of women was 54.4±3.3 years. All patients, depending on the therapy, were divided into two groups. The first group (control) consisted of 34 women (68 eyes) who received only local daily monotherapy for 20 days – instillation of low-viscosity «artificial tear» preparations HyloComod. Patients of the main group were divided into 2 subgroups and used a combined treatment technology. The first subgroup consisted of 21 patients (42 eyes), who, in addition to local daily therapy of the above drug, received a suis-organ complex preparation of estrogen-like orientation Ovarium compositum once every 3 months. The second subgroup included 17 patients (34 eyes) who received a treatment technology that included local daily therapy with artificial tears in combination with courses (once every 3 months) of exposure to the head area by a pulsed low-frequency electromagnetic field in combination with suis-organ complex preparation of estrogen-like orientation Ovarium compositum. Results. The combined treatment technology was well tolerated in all examined women. There were no complications or side effects. A significant increase in the main tear production in women of the main group made it possible to achieve a significantly more pronounced decrease in symptoms of subjective discomfort than in women in the control group. The achieved results of treatment of women in the main group persisted for 2.5–3 months, which determined the frequency of the courses of combination therapy with a frequency of twice every 6 months during the subsequent observation period. Conclusion. The course of combined therapy makes it possible to achieve significant relief of subjective manifestations of dry eye syndrome in postmenopausal women. The implementation of the therapeutic effect occurs, apparently, due to the synergism of the natural factors used, which makes it possible to significantly activate the compensatory and adaptive processes in the meibomian glands. Key words: dry eye syndrome of climacteric origin, combined treatment technology, estrogen deficiency, sex hormones.

scholarly journals APPLICATION OF VACUUM THERAPY IN CONDITIONS OF COMPLEX TREATMENT OF COMPLEX FORMS OF DIABETIC SYNDROME

2019 ◽  
pp. 83-87
Author(s):  
I. M. Kozlovskaya ◽  
A. G. Iftodiy ◽  
J. V. Kulachek ◽  
V. I. Grebenyuk ◽  
N. I. Kovtiuk
Keyword(s):  
Blood Flow ◽  
Comparison Group ◽  
Main Group ◽  
Vacuum Therapy ◽  
Complex Method ◽  
Results Of Treatment ◽  
Comprehensive Method ◽  
Complex Forms ◽  
Diabetic Syndrome ◽  
Inflammatory Effect

Summary. The aim of the study was to improve the results of treatment of patients with diabetic foot syndrome by applying a complex method of VAC-associated therapy. After 5 days of this treatment we enhanced the local blood flow of wounds from 27-31 to 52-54 mm Hg. (p<0.01), while in the comparison group the blood flow was 29-34 mm Hg, granulation tissue in the wound developed on average 4.93±0.64 days, which was significantly faster than in the control – 9,42±0.81 (p<0,05). Contamination of the wound of the main group before treatment was 8,4±0.14 Lg CFU/g of tissue, for 5 days – 2,8±0.21 Lg CFU/g of tissue, and the regenerative-inflammatory type of cytograms dominated. For 10 days the pathological microflora in the wound was absent, regional epithelialization appeared, the cytogram was of the regenerative type. In the comparison group, contamination before treatment was 8,1±0,17 Lg CFU/g (p<0.05), on the 5th and 10th day the indices were significantly higher than main group– 6,2±0.18 Lg CFU/g (p<0,01) and 3,8±0.19 Lg CFU/g (p<0,01), respectively and the cytograms were still of inflammatory type. The proposed comprehensive method of VAC-therapy provides an effective antibacterial, anti-inflammatory effect, promotes better regeneration and significantly improves the wound healing.

Dry eye syndrome in patients with gout

2021 ◽  
pp. 6-11
Author(s):  
K.N. Odinaeva ◽  
◽  
N.S. Al Khateeb ◽  
M.A. Frolov ◽  
◽  
...  
Keyword(s):  
Uric Acid ◽  
Correlation Coefficient ◽  
Dry Eye ◽  
Strong Correlation ◽  
Strong Dependence ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Film Rupture ◽  
High Tendency ◽  
Tear Production

Purpose. To determine and study the features of the development of dry eye syndrome (DES) in gout, depending on urate-lowering therapy, the duration of the gout disease and the concentration of uric acid in the tear. Material and methods. The study involved 149 male patients (261 eyes) aged 35 to 75 years (mean age 60.63 ± 11.00 years). Among them, 110 people (202 eyes) with an established diagnosis: "Cataract with concomitant gout disease" and 39 people (59 eyes) with cataracts without clinical and laboratory signs of gout. All patients underwent both standard ophthalmological examinations and special ones. The concentration of uric acid in tears was determined by high performance liquid chromatography (HPLC). The diagnosis of gout was confirmed according to the criteria recommended by ACR / EULAR (2016). Results. In patients with gout who do not take a urate-lowering drug, DES occurs more often (82.1%) than in patients without gout (23.1%). With an increase in the concentration of uric acid in the tear, there is a high tendency to a shortening of the tear film rupture time (strong correlation coefficient r=-0.51, p<0.001) and to a decrease in tear production (Schirmer I test) (strong correlation coefficient r=-0.59, p<0.001). Conclusion. The data obtained indicate clear changes in the functional parameters of total tear production (Schirmer I's test) and the stability of the pre-corneal tear film (Norn's test) in patients with gout. This can be considered as a fact of the predisposition of this category of patients to the development of DES. A strong dependence of changes in tear production and HRVP on the concentration of uric acid in the tear was established. There is an obvious need for additional examination of this category of patients and an adequate choice of therapy, as well as the timely appointment of "artificial tear" drugs. Key words: dry eye syndrome, uric acid, gout.

scholarly journals Profilo farmacologico clinico e farmacoeconomico di un gel oftalmico a base di carbomero 974P e PVA (Siccafluid®) nella terapia della cheratocongiuntivite secca

2005 ◽  
Vol 6 (3) ◽  
pp. 185-196
Author(s):  
Lorenzo Pradelli ◽  
Letizia Vacchini
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Lubricating Film ◽  
Tear Production ◽  
Ocular Discomfort ◽  
Ophthalmic Solutions

BACKGROUND: The dry eye sindrome refers to a group of disorders of the tear film due to reduced tear production or excessive tear evaporation that is associated with symptoms of ocular discomfort and may cause disease of the ocular surface. Dry eye syndrome varies in severity, duration and etiology. The cornerstone of dry eye syndrome therapies includes the intraocular gel or ophthalmic solutions instillation, reaching correct artificial lubrication. Molecules that can produce a stable lubricating film are the carbomers. METHODS: In the first step of our work we reviewed the data from literature reporting about carbomers’ characteristics in respect to other lacrimal substitutes. Then, a pharmacoeconomical analysis has been performed on ophtalmic gels derived from carbomers 974P and PVA. RESULTS: Dry eye sindrome, if not adequately treated, determines a deterioration of the patient’s quality of life, other than high secondary costs. CONCLUSION: The high therapeutical index of carbomers 974P and PVA-based gels, in addition to the their limited cost (totally free for Sjögren patients in Italy), suggests that this product is characterized by one of the best benefits-to-costs ratios in the treatment of dry eye sindrome.

scholarly journals Stimulation of Basal Secretion in the Treatment of Dry Eye Syndrome

2019 ◽  
Vol 16 (1) ◽  
pp. 70-75
Author(s):  
L. I. Uchakova ◽  
S. V. Balalin ◽  
V. L. Zagrebin
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Goblet Cells ◽  
Dry Eye Syndrome ◽  
Ophthalmological Examination ◽  
Basal Secretion ◽  
Tear Production ◽  
Before And After ◽  
The Stability ◽  
Conjunctival Goblet Cells

The aim is to evaluate the effectiveness of Stillavit in the treatment of dry eye syndrome (DES) and its effect on the density of conjunctival goblet cells and the functional parameters of tear production. Methods. There were analyzed treatment results of 18 patients (36 eyes) with DES at the age of 48 to 80 years (average 60.6 ± 1.3 years) including 17 women and 1 male before and after 1 and 3 months after Stillavit prescription. In all patients in addition to a standard ophthalmological examination the results of Schirmer I, Norn, as well as the LIPCOF test were evaluated and the density of conjunctival goblet cells was examined. Results. After 1 and 3 months there was a significant improvement in the results of the Norn test: from 5.17 ± 0.22 seconds to 7.18 ± 0.17 seconds which indicated an increase in the stability of the tear film. After 3 months there was a significant increase in the density of conjunctival goblet cells, improvement in the Schirmer sample: from 9.26 ± 0.89 to 11.7 ± 0.6 mm (t = 2.28, p < 0.05) and LIPCOF test (t = 2.18, p < 0.05) which indicated an increase in tear production and a significant decrease in the inflammatory process and edema of the conjunctiva. Conclusion. Treatment of DES with the use of Stillavit leads after 3 months to a significant increase in the density of conjunctival goblet cells, increases tear production and stability of the tear film.

scholarly journals Influence of Personal Respiratory and Visual Protective Equipment on the Development and Progression of Dry Eye Syndrome

2020 ◽  
Vol 17 (3) ◽  
pp. 519-526
Author(s):  
A. V. Kuroyedov ◽  
P. Ch. Zavadski ◽  
A. Yu. Brezhnev ◽  
V. V. Gorodnichii ◽  
I. R. Gazizova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dry Eye ◽  
Respiratory System ◽  
Dry Eye Syndrome ◽  
Protective Equipment ◽  
Artificial Tears ◽  
Tear Production ◽  
Prophylactic Measures ◽  
Working Day ◽  
Schirmer I Test

Purpose. To study the influence of personal protective equipment (PPE) of the respiratory and visual systems on the development and progression of dry eye syndrome (DES) and its relationship with other risk factors for medical workers.Patients and methods. The data of 243 people (male — 22.2 %, female — 77.8 %) were analyzed as part of a multi-center analytical scientific one-step study. Total tear production (Schirmer I test) was studied at the beginning and the end of the working day in persons used PPE of respiratory system (disposable medical face mask, gauze masks or different types of respirators), as well as PPE of the eyes (protective half-closed/closed glasses or protective screens). Risk factors for the development and progression of DES were registered (age, smoking, systemic hormones intake, soft contact lenses), as well as the use of artificial tears.Results. A decrease in the Schirmer I test score at the end of a 7–8 hour work shift was found by an average of 3 mm (from 13 (9; 16) mm to 10 (6; 15) mm, p < 0.001). Statistically significant changes were typical mainly for medical personnel (p < 0.001) with the maximum severity in persons working in outpatient sector. The presence of at least one DES risk factor was found in 30.5 % of patients, two factors — in 3.0 %, and three or more — in 7.0 %. There was no influence of risk factors on the degree of changes in total tear production. Reduced tear production is typical for some PPE of respiratory system (disposable masks and respirators) and the eye (screens and half-closed glasses) (p < 0.001). In people who do not use PPE of the eye, significant changes were detected only in the presence of risk factors.Conclusion. The negative influence of various PPE of the respiratory system and eye on the total tear production was established. The decrease in the results of the Schirmer I test by the end of the working day was 20–25 % of the basic level, regardless of the presence of traditional risk factors for DES. The severity of changes depended on the type of PPE used. The data obtained are particularly relevant during the new COVID-19 coronavirus pandemic and justify the need to establish specific prophylactic measures. One of the possible methods is the preventive use of artificial tears. 

scholarly journals The Use of Radiofrequency Thermal Ablation in Combine Treatment of Patients with Liver Bilobar Metastases from Colorectal Cancer

2018 ◽  
Vol 3 (2) ◽  
pp. 49-53
Author(s):  
OI I Kaganov ◽  
SV V Kozlov ◽  
AE E Orlov ◽  
NV V Blinov
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Combined Treatment ◽  
Treatment Method ◽  
Main Group ◽  
Rank Test ◽  
Control Group ◽  
Metastatic Process ◽  
Oncology Centre

Aim - determination of RFTA place in the combined treatment of bilobar liver metastatic process of colorectal cancer. Materials and methods. 176 patients with colorectal cancer with multiple (more than 4) bilobar liver metastases were included in the study after primary tumor removal. The research was held in Samara Regional Oncology Centre from 2001 to 2014. According to the treatment method patients were divided into two groups. Main group got the combined (chemotherapy + RFTA) treatment (98 patients). In control group only chemotherapy was applied to 78 patients. Results. One-, two- and three-year OS were 73.5%, 25.1%, 7.2% in the main group and 39.6%, 6.3%, 2.1% in the control group. With RFTA application we reached the 1.8% index of four-year survival in the main group, while three-year survival in the control group was only 2.1%. The OS median reached 18 months in the main group and 11 months in the control group, OS curves in two comparing groups were significantly different( log-rank test 3.77, р=0,000). Conclusion. Combination of RFTA with chemotherapy as the treatment of bilobar liver metastases of colorectal cancer, significantly improves the DFS and overall survival indexes, comparing to the group of patients who received only chemotherapy.

Sign in / Sign up

Export Citation Format

Share Document