Synthesis, characterization and antioxidant activity of 2-(4-Phenyl-6-p-Tolylpyrimidin-2-ylthio)-N-(4-substituted Phenyl)acetamides
A series of 2-(4-phenyl-6-p-tolylpyrimidin-2-ylthio)-N- (4-substituted phenyl)acetamide(4a-o) has been synthesized. Compounds have been characterized and tested for their antioxidant activity. The titled compounds (4a-o) have been synthesized by the reaction between 4-phenyl-6-p-tolylpyrimidine-2-thiol (2) with 2-chloro-N-substituted phenylacetamide (3ao) refluxed in acetone using catalytic amount of K2CO3. Compound (2) has been synthesized from (E)-1-phenyl- 3-p-tolylprop-2-en-1-one (1) with equimolar amount thiourea refluxed in alcoholic KOH to get compound (2). Starting compound chalcone was synthesized by Claisen-Schmidt condensation. All synthesized compounds have been characterized using spectroscopic techniques such as FT-IR, 1H NMR, 13C NMR, Mass Spectrometry and elemental analysis. Antioxidant assay has been performed by using DPPH radical scavenging method. Compounds 4-h and 4-o have shown good antioxidant activity.