scholarly journals Recent Developments and Aspects of Industrial Fluoroalkylation

2021 ◽  
Vol 75 (11) ◽  
pp. 923-935
Author(s):  
Matthias Beller ◽  
Florian Fischer ◽  
Andreas Locher ◽  
Helfried Neumann ◽  
Christoph Taeschler ◽  
...  
Keyword(s):  
Large Scale ◽  
Active Ingredients ◽  
Industrial Environment ◽  
Direct Activation ◽  
Fluoroalkyl Substituent ◽  
Recent Developments ◽  
Enormous Number

Fluoroalkylations have received increasing attention in the academic and industrial environment due to the particular properties of the active ingredients that are strongly influenced by fluoroalkyl substituents. The inherent difficulties of introducing a fluoroalkyl substituent into advanced intermediates has triggered the development of an enormous number of specialized reagents, which, however, are often not suitable for large scale applications. In contrast to this reagent based fluoroalkylation approach, the direct activation of industrially readily available fluoroalkyl halides could be more suitable for a large-scale process. In this way the dithionite initiated fluoroalkylation as well as newly developed catalytically activated fluoroalkylation protocols were considered for industrial large-scale applications.

Recent Developments in the Downstream Processing of Phycobiliproteins from Algae: A Review

2021 ◽  
Vol 06 ◽  
Author(s):  
Ayekpam Chandralekha Devi ◽  
G. K. Hamsavi ◽  
Simran Sahota ◽  
Rochak Mittal ◽  
Hrishikesh A. Tavanandi ◽  
...  
Keyword(s):  
Cell Wall ◽  
Large Scale ◽  
Downstream Processing ◽  
Review Article ◽  
Current Status ◽  
Wall Structure ◽  
Scale Production ◽  
Cell Wall Disruption ◽  
Recent Developments ◽  
Macro Algae

Abstract: Algae (both micro and macro) have gained huge attention in the recent past for their high commercial value products. They are the source of various biomolecules of commercial applications ranging from nutraceuticals to fuels. Phycobiliproteins are one such high value low volume compounds which are mainly obtained from micro and macro algae. In order to tap the bioresource, a significant amount of work has been carried out for large scale production of algal biomass. However, work on downstream processing aspects of phycobiliproteins (PBPs) from algae is scarce, especially in case of macroalgae. There are several difficulties in cell wall disruption of both micro and macro algae because of their cell wall structure and compositions. At the same time, there are several challenges in the purification of phycobiliproteins. The current review article focuses on the recent developments in downstream processing of phycobiliproteins (mainly phycocyanins and phycoerythrins) from micro and macroalgae. The current status, the recent advancements and potential technologies (that are under development) are summarised in this review article besides providing future directions for the present research area.

scholarly journals On the geophysical processes impacting palaeo-sea-level observations

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Yusuke Yokoyama ◽  
Anthony Purcell
Keyword(s):  
Sea Level ◽  
Large Scale ◽  
Global Climate ◽  
Sea Level Change ◽  
Sea Level Changes ◽  
Factors Affecting ◽  
Ice Volume ◽  
Level Change ◽  
Recent Developments ◽  
Geophysical Processes

AbstractPast sea-level change represents the large-scale state of global climate, reflecting the waxing and waning of global ice sheets and the corresponding effect on ocean volume. Recent developments in sampling and analytical methods enable us to more precisely reconstruct past sea-level changes using geological indicators dated by radiometric methods. However, ice-volume changes alone cannot wholly account for these observations of local, relative sea-level change because of various geophysical factors including glacio-hydro-isostatic adjustments (GIA). The mechanisms behind GIA cannot be ignored when reconstructing global ice volume, yet they remain poorly understood within the general sea-level community. In this paper, various geophysical factors affecting sea-level observations are discussed and the details and impacts of these processes on estimates of past ice volumes are introduced.

scholarly journals Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPA

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Ângela C. B. Neves ◽  
Ivanna Hrynchak ◽  
Inês Fonseca ◽  
Vítor H. P. Alves ◽  
Mariette M. Pereira ◽  
...  
Keyword(s):  
Large Scale ◽  
Neuroendocrine Tumours ◽  
Radiochemical Yield ◽  
Clinical Applications ◽  
Clinical Use ◽  
Molar Activity ◽  
Neuropsychiatric Diseases ◽  
Recent Developments ◽  
Key Issues ◽  
Improved Methods

AbstractThe neurotracer 6-[18F] FDOPA has been, for many years, a powerful tool in PET imaging of neuropsychiatric diseases, movement disorders and brain malignancies. More recently, it also demonstrated good results in the diagnosis of other malignancies such as neuroendocrine tumours, pheochromocytoma or pancreatic adenocarcinoma.The multiple clinical applications of this tracer fostered a very strong interest in the development of new and improved methods for its radiosynthesis. The no-carrier-added nucleophilic 18F-fluorination process has gained increasing attention, in recent years, due to the high molar activities obtained, when compared with the other methods although the radiochemical yield remains low (17–30%). This led to the development of several nucleophilic synthetic processes in order to obtain the product with molar activity, radiochemical yield and enantiomeric purity suitable for human PET studies.Automation of the synthetic processes is crucial for routine clinical use and compliance with GMP requirements. Nevertheless, the complexity of the synthesis makes the production challenging, increasing the chance of failure in routine production. Thus, for large-scale clinical application and wider use of this radiopharmaceutical, progress in the automation of this complex radiosynthesis is of critical importance.This review summarizes the most recent developments of 6-[18F]FDOPA radiosynthesis and discusses the key issues regarding its automation for routine clinical use.

A Review of Machine Learning and Data Mining Approaches for Business Applications in Social Networks

2013 ◽  
Vol 9 (1) ◽  
pp. 36-53
Author(s):  
Evis Trandafili ◽  
Marenglen Biba
Keyword(s):  
Machine Learning ◽  
Data Mining ◽  
Social Networks ◽  
Large Scale ◽  
Viral Marketing ◽  
Social Network Mining ◽  
Business Applications ◽  
Mining Community ◽  
Recent Developments ◽  
Analysis Of Social Networks

Social networks have an outstanding marketing value and developing data mining methods for viral marketing is a hot topic in the research community. However, most social networks remain impossible to be fully analyzed and understood due to prohibiting sizes and the incapability of traditional machine learning and data mining approaches to deal with the new dimension in the learning process related to the large-scale environment where the data are produced. On one hand, the birth and evolution of such networks has posed outstanding challenges for the learning and mining community, and on the other has opened the possibility for very powerful business applications. However, little understanding exists regarding these business applications and the potential of social network mining to boost marketing. This paper presents a review of the most important state-of-the-art approaches in the machine learning and data mining community regarding analysis of social networks and their business applications. The authors review the problems related to social networks and describe the recent developments in the area discussing important achievements in the analysis of social networks and outlining future work. The focus of the review in not only on the technical aspects of the learning and mining approaches applied to social networks but also on the business potentials of such methods.

Recent Developments in Japanese Flaw Assessment Methods of WES 2805

2008 ◽  
Author(s):  
Yukito Hagihara ◽  
Masayoshi Kurihara ◽  
Hitoshi Yoshinari ◽  
Takashi Miyata
Keyword(s):  
Welded Joints ◽  
Large Scale ◽  
Welded Joint ◽  
Estimation Method ◽  
Assessment Methods ◽  
Crack Tip Opening Displacement ◽  
Opening Displacement ◽  
Design Curve ◽  
Load Carrying ◽  
Recent Developments

The standard for the method of assessment for flaws in the welded joints of WES 2805 was first published in 1976 and was revised in 1980 and 1997. A further revision has been carried out by the technical committee of FTS in the Japan Welding Engineering Society and the revision was completed in 2007. The standard of WES 2805 is based on a CTOD (crack tip opening displacement) design curve approach for brittle fracture, and is used for the assessment of the significance of flaws in a stress concentrated region, where large scale yielding takes place. Main topics for the recent developments for flaw assessment methods are described in this paper. These are the interaction criterion of multiple flaws, fatigue crack growth laws, determination of equivalent crack length and strain due to stress concentration, estimation method of the critical CTOD from Charpy energy and proposal of partial safety factors. In order to examine the effectiveness of the standard, extensive 2-D and 3-D FE analyses are performed for various welded joints such as a load-carrying fillet welded joint, a non-load-carrying fillet welded joint and a box welded joint. Some of them are introduced in this paper. Their analytical results indicate that the present CTOD design curve method gives a reasonable evaluation.

Relative Importance of Blockchain in Cryptocurrency, Banking & Health Care

2020 ◽  
Vol 8 (12) ◽  
pp. 6-25
Author(s):  
Hari Priya Ponnakanti ◽  
Bilal Gonen
Keyword(s):  
Large Scale ◽  
Banking Sector ◽  
Trade Credit ◽  
Future Research ◽  
Large Database ◽  
High Scale ◽  
Blockchain Technology ◽  
Medical Sector ◽  
Recent Developments ◽  
Pros And Cons

This paper looks at the opportunities and challenges of implementing blockchain technology across medical, finance and banking sectors, and provides a clear view which can enable Blockchain for more extents. After going through few articles and papers related to applications of Blockchain, we gained a vivid knowledge on pros and cons on Blockchain applications from each article. Few drawbacks that we encountered are using Power of Work (POW) in medical sector which is destroying the computing ability at a stage when system is getting bigger and eventually which is wasting lots of resources. One study over conceptual proposal on blockchain is the idea of using trade credit as the value of transactions, and this trade credit is in the scope of trade secret which improves trade confidentiality and makes it more secure. Moreover, centralization systems have few risks owing to their dependence on a high scale which could tamper the data or can even block access, change the rules and might even completely shut down the system. Few more drawbacks are designing and building a secure blockchain system is much more difficult on large-scale of banking sector with large database. To address these challenges, recent developments in blockchain technology are enabling novel opportunities in every possible sector by using Trust-worthy cloud, IoT and artificial intelligence, which makes it more powerful and secure. After analyzing Blockchain implementations and identifying their limitations, we conclude with several promising directions for future research.

Strategic Ethnography and the Biography of Artefacts

2013 ◽  
pp. 347-376 ◽  
Author(s):  
Neil Pollock ◽  
Robin Williams
Keyword(s):  
Enterprise Resource Planning ◽  
Technology Implementation ◽  
Large Scale ◽  
Resource Planning ◽  
Work Organisation ◽  
Social Scientists ◽  
Knowledge Based ◽  
Enterprise Resource Planning Systems ◽  
Recent Developments

In health research and services, and in many other domains, the authors note the emergence of large-scale information systems intended for long-term use with multiple users and uses. These e-infrastructures are becoming more widespread and pervasive and, by enabling effective sharing of information and coordination of activities between diverse, dispersed groups, are expected to transform knowledge-based work. Social scientists have sought to analyse the significance of these systems and the processes by which they are created. Much current attention has been drawn to the often-problematic experience of those attempting to establish them. By contrast, this chapter is inspired by concerns about the theoretical and methodological weakness of many studies of technology and work organisation—particularly the dominance of relatively short-term, often single site studies of technology implementation. These weaknesses are particularly acute in relation to the analysis of infrastructural technologies. The authors explore the relevance to such analysis of recent developments in what they call the Biography of Artefacts (BoA) perspective—which emphasises the value of strategic ethnography: theoretically-informed, multi-site, and longitudinal studies. They seek to draw insights from a programme of empirical research into the long-term evolution of corporate e-infrastructures (reflected in current Enterprise Resource Planning systems) and review some new conceptual tools arising from recent research into e-Infrastructures (e-Is). These are particularly relevant to understanding the current and ongoing difficulties encountered in attempts to develop large-scale Health Infrastructures.

Change or Continuity in Cultures?

2019 ◽  
pp. 194-213
Author(s):  
Robert M. Fishman
Keyword(s):  
Cultural Change ◽  
Large Scale ◽  
Cultural Continuity ◽  
Continuity And Change ◽  
Contemporary Politics ◽  
Recent Developments ◽  
Theoretical Question

This chapter poses the large theoretical question of what generates cultural change or continuity, and provides examples of both patterns in the cases examined in the book. The large-scale program of commemorations of Portugal’s Carnation Revolution is treated in depth, taking it as an example of a mechanism providing for cultural continuity in that post-revolutionary polity. Obviously, revolution itself contributed earlier to cultural change in that case. In the Spanish case efforts to promote cultural change during the Zapatero years, in the 15-M movement, and more recently in contemporary politics are taken up. The analysis searches for mechanisms of cultural change but also offers observations on why it is typically difficult for efforts at cultural change to achieve success as broad as that to be found in revolutionary Portugal. Complex combinations of continuity and change are also taken up. Recent developments in both Spain and Portugal are examined.

scholarly journals Recent developments in chitosan encapsulation of various active ingredients for multifunctional applications

2020 ◽  
Vol 492 ◽  
pp. 108004 ◽  
Author(s):  
Zulfiqar Ali Raza ◽  
Shanza Khalil ◽  
Asif Ayub ◽  
Ibrahim M. Banat
Keyword(s):  
Active Ingredients ◽  
Recent Developments

scholarly journals Magnetism Science with the Square Kilometre Array

Galaxies ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 53
Author(s):  
George Heald ◽  
Sui Mao ◽  
Valentina Vacca ◽  
Takuya Akahori ◽  
Ancor Damas-Segovia ◽  
...  
Keyword(s):  
Magnetic Fields ◽  
Large Scale ◽  
Galactic Nuclei ◽  
Dark Matter Annihilation ◽  
New Techniques ◽  
Square Kilometre Array ◽  
New Radio ◽  
Recent Developments ◽  
Using Data ◽  
The Impact

The Square Kilometre Array (SKA) will answer fundamental questions about the origin, evolution, properties, and influence of magnetic fields throughout the Universe. Magnetic fields can illuminate and influence phenomena as diverse as star formation, galactic dynamics, fast radio bursts, active galactic nuclei, large-scale structure, and dark matter annihilation. Preparations for the SKA are swiftly continuing worldwide, and the community is making tremendous observational progress in the field of cosmic magnetism using data from a powerful international suite of SKA pathfinder and precursor telescopes. In this contribution, we revisit community plans for magnetism research using the SKA, in light of these recent rapid developments. We focus in particular on the impact that new radio telescope instrumentation is generating, thus advancing our understanding of key SKA magnetism science areas, as well as the new techniques that are required for processing and interpreting the data. We discuss these recent developments in the context of the ultimate scientific goals for the SKA era.

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