scholarly journals Wound Healing properties of OPAL A (patented Carica papaya fruit extract)

2017 ◽  
Author(s):  
REDDY SREEKANTH VOOTUKURI
Keyword(s):  
Wound Healing ◽  
Carica Papaya ◽  
Fruit Extract

scholarly journals 679 Wound Healing properties of OPAL A (patented Carica papaya fruit extract)

2017 ◽  
Vol 137 (10) ◽  
pp. S309
Author(s):  
R. Vootukuri ◽  
G. Trigiante ◽  
M. Philpott
Keyword(s):  
Wound Healing ◽  
Carica Papaya ◽  
Fruit Extract

scholarly journals Effect of Carica papaya Extract toward Incised Wound Healing Process in Mice (Mus musculus) Clinically and Histologically

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Rachmi Fanani Hakim ◽  
Fakhrurrazi ◽  
Dinni
Keyword(s):  
Wound Healing ◽  
Mus Musculus ◽  
Carica Papaya ◽  
Healing Process ◽  
Antibacterial Properties ◽  
The Body ◽  
Wound Healing Process ◽  
Protective Function ◽  
Incised Wound ◽  
Anterior Teeth

Wound healing entails a sequence of complex biological processes, which is a protective function of the body that focuses on a quick recovery. Reducing wound healing time is crucial in a wound as it lowers the chance of infection and decreases complications and costs. Papaya extract was obtained by a maceration method. It contains papain enzyme, flavonoid, saponin, and alkaloid, which act as an anti-inflammatory, astringent substance, vasodilator, antioxidant, analgesic, with antifungal, and antibacterial properties, and increase the collagen synthesis. This study aimed to assess the effect of Carica papaya extract application toward incised wound healing process in mice (Mus musculus) clinically and histologically. This experimental laboratory study was performed using 24 mice weighing between 30 and 40 grams and 12 and 14 weeks of age as experimental animals. Each group was incised along 5 mm at the labial gingiva under both of mandible anterior teeth with a depth reaching alveolar bone. Papaya extract was applied topically in the morning and evening for 14 days. The clinical result was obtained by assessing the length of wound closure measured every day for 14 days. Based on the statistic test result, it showed that the papaya extract has a significant effect (p≤0.05) toward the healing process of an incised oral wound in mice. Histologically at day 14, 75% concentration papaya extract showed perfect epithelial layer and fibrillation.

scholarly journals The Effect of Carica Pubescens Lenne and K. Koch Fruit Extract from Dieng Plateau and Cangar to the Amount of Fibroblasts Cells on the Healing of Oral Mucosal Inflammation

2016 ◽  
Vol 1 (1) ◽  
pp. 20
Author(s):  
Risma Aprinda Kristanti
Keyword(s):  
Wound Healing ◽  
Mucosal Inflammation ◽  
Gingival Tissue ◽  
Control Group ◽  
Apical Region ◽  
Gingival Fibroblasts ◽  
Fruit Extract ◽  
Significant Difference ◽  
Gingival Mucosa ◽  
Mucosal Wound

<p>The purposes of this research are to know the effect of <em>C.pubescens</em> fruit extract on the amount of gingival fibroblasts in wound healing of <em>Rattus </em><em>norvegicus</em> mouth cavity’s mucosal and to know the effect of <em>C.pubescens</em> comes from two different areas (Dieng and Cangar) on the amount of gingival fibroblasts in wound healing of <em>Rattus</em><em> norvegicus</em> oral mucosa. Twenty eight rats are divided to be four groups (K1, K2, K3, and K4), each rat is wounded 1 cm on the gingival mucosa of lower jaw (specifically on the apical region of incisive teeth). K1 is the control group with aquadest treatment on the wound. The wound in the K2 is treated with <em>C.pubescens </em>fruit extract from Dieng. The wound in the K3 is treated with <em>C.pubescens </em>fruit extract from Cangar. And the treatment for K4 is medicated by policresulen (common medicine for oral mucosal wound). On the fifth day of the treatment, all rats are sacrificed, and the gingival tissue is taken up for the next step. Gingival tissue is smeared by Haematoxylin Eosin (HE) to analyze the amount of gingival fibroblasts histologically. The result of this research shows that the highest average amount of gingival fibroblasts comes from K4 (policresulen treatment). And there is no significant difference on the number of <em>Rattus norvegicus</em> gingival fibroblasts from all of the groups (K1, K2, K3, and K4).</p><p> </p><p><strong>Keywords</strong>: <em>fibroblast, gingival, wound, mucosa, mouth, C.pubescens</em></p>

scholarly journals The Effectiveness of the Antiinfamation Combination Gel of Okra Fruit (Abelmoschus esculentus) Extracts and Shallots Extract (Allium cepa L.)

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Sara Nurmala ◽  
Moerfia Moerfia ◽  
Santi Novianti
Keyword(s):  
Wound Healing ◽  
Allium Cepa ◽  
The United States ◽  
Abelmoschus Esculentus ◽  
Male Rats ◽  
Cell Multiplication ◽  
Fruit Extract ◽  
White Rats ◽  
Allium Cepa L ◽  
Anti Inflammatory

Wound is a condition that is the destruction of the unity or network components, which are specifically found the substance of tissue damaged or lost, either damage the continuity of the skin, mucous membranes and bones or other organs. Wound healing is a very complex process involving many cells. The process of wound healing is portrayed as occurs in biological surgical wound occurred. Several phases of wound healing are: the process of inflammation (inflammatory), the process of cell multiplication (proliferation) and cell maturation process (maturase). Okra is a plant that allegedly came from Southeast Asia. Okra has grown in many countries in almost all over the world. In the UK okra known as the Lady's Finger, in India it is called by the name of Bhindi while the United States called Gumbo. In Indonesia, this plant also has a local name that is Rabamea (Bima), Coffee Java (Java), Arabian Coffee (Sulawesi), Hoinu (Southeast Sulawesi), but better known by the name of okra. This study aims to determine the effective concentration and determine the length of time of wound healing using a combination gel okra fruit extract (Abelmoschus esculentus) And shallots (Allium cepa L.) as an anti-inflammatory against cuts in male white rats (Sprague -Dawley) with a length of observation for 9 days. This study uses Betadine® ointment as a positive control. The results showed the combination of fruit extract gel okra 6% and shallots 2% contained in the formula 3 most effective as an anti-inflammatory against cuts in male rats by administration for 6 days.

Wound healing activity of Terminalia bellerica Roxb. and gallic acid in experimentally induced diabetic animals

2019 ◽  
Vol 17 (2) ◽  
Author(s):  
Manish Pal Singh ◽  
Avneet Gupta ◽  
Siddhraj Singh Sisodia
Keyword(s):  
Wound Healing ◽  
Gallic Acid ◽  
Dead Space ◽  
Diabetic Rats ◽  
Fruit Extract ◽  
Standard Drug ◽  
Terminalia Bellerica ◽  
Wound Model ◽  
Wound Healing Activity ◽  
Experimentally Induced

AbstractBackgroundDiabetic wound are the major problem of society because of its delay healing of wound in hyperglycemia patient. The target of this study need to know the gallic acid compelling synergistically wound healing in diabetic animals as it is available in fruit extract or is more effective in given pure form in diabetic animals.MethodsThe wound healing effects of fruit extract Terminalia bellerica Roxb. and gallic acid were evaluated in experimentally induced hyperglycemic animals. In this investigation, excision and dead space wound models were used. The contraction wound %, re-epithelialization days, area of scar, histopathological examination of tissue, hydroxyproline level and weight of tissue granuloma were evaluated in this study.ResultsTerminalia bellerica fruit extract (400 mg/Kg) and gallic acid (200 mg/Kg) have been ingested by orally in streptozotocin induced diabetic rats. They were founded significantly (p<0.05) improved percentage wound contraction and decreased the size of scar area and days of re-epithelialization in excision wound model. Also, they were improved the level of hydroxyproline level in diabetic rats as compared to diabetic control group in dead space wound model. Standard drug vitamin C was also founded significantly improved wound healing activity in rats. These results suggested that treated groups accelerated wound healing activity in diabetic rat.ConclusionsThe observations and results obtained in the present study indicated the wound healing efficacy of fruit ethanolic extract and gallic acid in diabetic animals. Yet, the wound healing effect was increasingly reported with gallic acid.

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