Retrospective Study of Blood Transfusion Complications in the Capital Region of Denmark from 1999-2017: Characteristics of Potentially “Dangerous” Blood Donors?s

Objectives: We hypothesized that the blood donors most frequently involved in complications would induce more and severe immunologic transfusion complications compared to other donors, i.e. potentially “dangerous”. Secondary aims were differences in demographic variables. Background: Donor-related mechanisms may contribute to allogeneic blood transfusion complications and may represent a dangerous treatment adverse event. Materials and Methods: By analyzing transfusion data from the Capital Region of Denmark from January 1, 1999 to December 31, 2017; 2,574,646 blood transfusions and 9,779 transfusion complications from 194,432 blood donors were included in our dataset. We divided donors into three groups based on the number of complications and complication frequency (potentially “dangerous” vs. two differently defined control groups i.e. control 1 and control 2), and compared the nature of transfusion complications and demographic variables by statistical analysis. Results: There were no differences in the proportion of complication types between the potentially “dangerous” donors and control donors, and no difference in the proportion of complications from RBCs, plasma or platelets according to ABO and RhD blood types. However, more potentially “dangerous” donors were female and had ABO blood type B compared to control donors (p<0.001 and p<0.01, respectively). The potentially “dangerous” donors were younger compared to control donors (40.36 years vs. 45.24 years and 42.84 years, p<0.001). Conclusion: The potentially “dangerous” did not display more/severe immunologic transfusion complications compared to control donors. However, they differed in regards to gender, age and blood type. Further research regarding the differences in complication frequency per donor and demographic variety is warranted.

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Signalment and Blood Types in Cats Being Evaluated as Blood Donors at Two Italian University Blood Banks

Veterinary Medicine International ◽

10.1155/2014/704836 ◽

2014 ◽

Vol 2014 ◽

pp. 1-3 ◽

Cited By ~ 7

Author(s):

Eva Spada ◽

Arianna Miglio ◽

Daniela Proverbio ◽

Maria Teresa Antognoni ◽

Giada Bagnagatti De Giorgi ◽

...

Keyword(s):

Blood Donors ◽

Type A ◽

Blood Type ◽

Transfusion Reaction ◽

Type B ◽

Blood Typing ◽

Blood Types ◽

Blood Banks ◽

Type Ab ◽

Transfusion Reactions

Data from potential feline blood donors presented at two university blood banks in Italy were recorded. Blood typing was performed using an immunochromatographic method. Over the three years of the study 357 cats representing 15 breeds, 45.3% female and 54.7% male, with a mean age of 3.8 years were evaluated. Of these 90.5% were blood type A, 5.6% type B, and 3.9% type AB. The majority of the cats (54.6%) were European DSH (92.3% were type A, 5.1% type B, and 2.6% type AB), and 21% were Maine Coon (MCO) cats (100% blood type A). The estimated frequencies of transfusion reactions following an unmatched transfusion between DSH (donors and recipients), MCO (donor and recipients), DSH donors and MCO recipients, and MCO donors and DSH recipients were 4.8%, 0%, 0%, and 5.1% for major reactions and 7.2%, 0%, 7.7%, and 0% for minor transfusions reactions, respectively. In a population of blood donors that includes DSH and MCO the risk of transfusion reaction is between 5% and 8% if typing is not performed on donor and recipient blood. Blood typing should therefore be performed before transfusion to remove the risk of transfusion reactions due to blood type incompatibilities.

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ABO blood type and risk of porcine bioprosthetic aortic valve degeneration: SWEDEHEART observational cohort study

BMJ Open ◽

10.1136/bmjopen-2019-029109 ◽

2019 ◽

Vol 9 (5) ◽

pp. e029109 ◽

Cited By ~ 1

Author(s):

Michael Persson ◽

Gustaf Edgren ◽

Magnus Dalén ◽

Natalie Glaser ◽

Martin L Olsson ◽

...

Keyword(s):

Heart Failure ◽

Cohort Study ◽

Aortic Valve ◽

Aortic Valve Replacement ◽

Valve Replacement ◽

Type A ◽

Blood Type ◽

Type B ◽

Structural Valve Deterioration ◽

Abo Blood Type

ObjectiveBlood type A antigen on porcine aortic bioprostheses might initiate an immune reaction leading to an increased frequency of structural valve deterioration in patients with blood type B or O. The aim was to analyse the association between ABO blood type and porcine bioprosthetic aortic valve degeneration.DesignObservational nationwide cohort study.SettingSwedish population-based study.ParticipantsAdult patients (n=3417) who underwent surgical aortic valve replacement and received porcine bioprosthetic aortic valves between 1995 and 2012 from the Swedish Web system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies register. The study database was enriched with information from other national registers.ExposureThe patients were categorised into type A/AB and type B/O blood groups.Primary and secondary outcome measuresPrimary outcome measure was aortic valve reoperation, and secondary outcomes were heart failure and all-cause mortality. We report risk estimates that account for the competing risk of death.ResultsIn total, 3417 patients were identified: 1724 (50.5%) with blood type A/AB and 1693 (49.5%) with blood type B/O. Both groups had similar baseline characteristics. The cumulative incidence of aortic valve reoperation was 3.4% (95% CI 2.5% to 4.4%) and 3.6% (95% CI 2.6% to 4.6%) in the type B/O and the A/AB group, respectively, at 15 years of follow-up (absolute risk difference: −0.2% (95% CI −1.5% to 1.2%)). There was no significantly increased risk for aortic valve reoperation in patients with blood type B/O compared with type A/AB (HR 0.95, 95% CI 0.62 to 1.45). There was no significant difference in absolute or relative risk of heart failure or death between the groups.ConclusionsWe found no significant association between patient blood type and clinical manifestations of structural valve deterioration following porcine aortic valve replacement. Our findings suggest that it is safe to use porcine bioprosthetic valves without consideration of ABO blood type in the recipient.Trial registration numberNCT02276950

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TP9.2.24Is preoperative ABO blood typing required in emergency appendicectomies?

British Journal of Surgery ◽

10.1093/bjs/znab362.123 ◽

2021 ◽

Vol 108 (Supplement_7) ◽

Author(s):

Ricardo Rodrigues ◽

Ieuan Reece ◽

Nabil El-Masry

Keyword(s):

Blood Transfusion ◽

Primary Outcome ◽

Outcome Measure ◽

Primary Outcome Measure ◽

Blood Type ◽

Single Centre ◽

Blood Typing ◽

Suspected Appendicitis ◽

Chronic Anaemia ◽

Abo Blood Type

Abstract Aims Intra-operative bleeding is very rarely a complication of laparoscopic appendicectomy. Despite this, it is often mandatory for any patient undergoing an emergency appendicectomy to have pre-operative ABO blood type sampling. This could be an unnecessary expense and may lead to patients being delayed for theatre. The aim of this study was to see how many patients who underwent an appendicectomy required a blood transfusion intra-operatively or within 30 days of their operation. Methods Data were collected retrospectively for patients of all ages who underwent an appendicectomy for suspected appendicitis at a single centre from March 2018 to May 2020. The primary outcome measure was intra-operative and post-operative blood transfusion up until 30 days after the operation. Results Over 26 months, 698 appendicectomies were performed. Preoperative ABO blood typing was performed in 95% (n = 663) of patients. Collectively, 1,305 blood samples were obtained at a combined total cost of £13,703 to the hospital. None of the patients required blood transfusion intra- or post-operatively. Pre-operative blood transfusion was performed in only three patients, all due to chronic anaemia. 21 (3%) patients were delayed in going to theatre whilst awaiting two valid ABO blood typing results. Conclusions Emergency appendicectomies very rarely experience complications associated with bleeding or requiring blood transfusion. Clinical guidelines should reflect this by avoiding recommendation of such tests in emergency appendicectomies, reducing delays to surgery and resulting in a more efficient allocation of financial and staff resources.

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Effect of Ambulation during First Stage of Labor on Labor Pain and Outcome of Labor among the Primigravida Mothers in a Selected Hospital, Mangalore

Journal of SAFOG with DVD ◽

10.5005/jp-journals-10006-1207 ◽

2013 ◽

Vol 5 (1) ◽

pp. 1-3

Author(s):

V Savitha ◽

Sabitha Nayak ◽

Shynee Paul

Keyword(s):

Demographic Variables ◽

Labor Pain ◽

Normal Vaginal Delivery ◽

Control Group ◽

Control Groups ◽

Significant Difference ◽

The Mean ◽

And Control ◽

Experimental Group ◽

First Stage Of Labor

ABSTRACT Objectives • To assess the intensity of labor pain and outcome of labor among the control group. • To assess the effectiveness of ambulation on intensity of labor pain and outcome of labor among the experimental group. • To assess the usefulness of ambulation by opinionnaire among experimental group. • To compare the effectiveness of ambulation on the intensity of labor pain and outcome of labor among experimental and control groups. • To find an association between the intensity of labor pain with selected demographic variables. Materials and methods An experimental research approach was used for the study. Random sampling technique was used to allocate the subjects into experimental and control groups. Visual analog scale was used to assess the intensity of pain and observational check list was used to assess the outcome of labor. The study comprised of 40 primigravida mothers and they were grouped as experimental and control through randomization. One group received ambulation treatment, the other did not. The researcher then observed the groups to determine the effect of the treatment. Results The collected data was analyzed by descriptive and inferential statistics. The intensity of pain revealed that 40% in the experimental and 55% in the control groups experienced severe pain. The labor augmentation revealed that both oxytocin and cerviprime gel was used for 30% in the experimental and 35% in the control groups. On the mode of delivery, majority of mothers (60%) had normal vaginal delivery both in experimental and control groups. On the duration of the first stage of labor revealed that 50% in the experimental and 20% in the control groups were between 10 to 12 hours. Second stage of labor revealed that majority were between 1 and 2 hours in both the control and experimental groups. The opinion of experimental group mothers on ambulation revealed that half of the mothers (50%) agreed for recommending the ambulation for their neighbors and friends and less than half (35%) of them have agreed for comfort during first stage of labor and 40% of them have agreed for ambulation should be made as a routine in labor room. In the experimental group, mean pain score (6.8) is less than the control group (7.5). The calculated Mann-Whitney Z-value (2.045) is greater than the Z α-value of 1.960 at 0.05 level of significance. In the experimental group, the mean duration of first stage of labor score (3.95) is significantly higher than the control group mean score (3.00). The mean outcome of labor in experimental group (13.95) is greater than the control group. Conclusion There was a significant difference in the duration of first stage of labor between the experimental and control groups. But, there was no significant difference in the overall outcome of labor between experimental and control groups. There was no significant association between intensity of labor pain with selected demographic variables. This may be because of small sample size. How to cite this article Savitha V, Nayak S, Paul S. Effect of Ambulation during First Stage of Labor on Labor Pain and Outcome of Labor among the Primigravida Mothers in a Selected Hospital, Mangalore. J South Asian Feder Obst Gynae 2013;5(1):1-3.

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6. Blood transfusion

Blood: A Very Short Introduction ◽

10.1093/actrade/9780199581450.003.0006 ◽

2016 ◽

pp. 103-123

Author(s):

Chris Cooper

Keyword(s):

Blood Transfusion ◽

20Th Century ◽

Human Blood ◽

Blood Type ◽

Early 20Th Century ◽

Animal Blood ◽

Blood Banks ◽

History Of ◽

Abo Blood Type ◽

The 19Th Century

‘Blood transfusion’ outlines the history of transfusing animal blood dating back to the 17th century. The 19th century saw the first successful human blood transfusion, but two major issues remained: the problems of clotting and blood group incompatibility. Albert Hustin and Luis Agote resolved the first issue in 1914 by using sodium citrate in transfusions to work as an anticoagulant. Richard Lewisohn calculated the correct levels of citrate needed to avoid poisoning the blood. Karl Landsteiner’s work in early 20th-century Vienna revealed the ABO blood type distinctions, solving the latter problem. The creation of blood banks and the potential for viral contamination of blood and blood products are also discussed.

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Frequencies of feline blood types in Hungary

Acta Veterinaria Hungarica ◽

10.1556/004.49.2001.4.1 ◽

2001 ◽

Vol 49 (4) ◽

pp. 369-375 ◽

Cited By ~ 13

Author(s):

Nóra Bagdi ◽

Melinda Magdus ◽

E. Leidinger ◽

Judith Leidinger ◽

K. Vörös

Keyword(s):

Blood Transfusion ◽

Blood Group ◽

Diagnostic Method ◽

Type A ◽

Blood Groups ◽

Blood Type ◽

Type B ◽

Blood Types ◽

Type Ab ◽

Transfusion Reactions

Feline blood group determination is done as a routine diagnostic method in numerous countries. Blood transfusion reactions and feline neonatal isoerythrolysis (FNI) can be avoided with the identification of different feline blood groups. The present study is the first investigation in Hungary during which 100 cats have been examined from all over the country. These cats were out of six breeds: European domestic shorthair, Persian mix, Persian, Abyssinian, Siamese and British shorthair. In the Hungarian feline population European domestic shorthair are most common but other breeds also occur. European domestic shorthair, Persian mix, Abyssinian, Siamese and British shorthair individuals all belonged to blood type A (100%). Blood type B was found very rarely and only in Persian cats. One-third of the Persian cats were categorised into blood type B, whilst type AB was not found during the study.

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Associations of ABO blood type and galactose-deficient immunoglobulin A1 with adverse outcomes in patients with IgA nephropathy

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfz171 ◽

2019 ◽

Cited By ~ 1

Author(s):

Manliu Wang ◽

Jicheng Lv ◽

Pei Chen ◽

Guizhen Yu ◽

Sufang Shi ◽

...

Keyword(s):

Iga Nephropathy ◽

Cox Regression ◽

Type A ◽

Adverse Outcomes ◽

Blood Type ◽

Blood Group Antigens ◽

Type B ◽

Progression Of Kidney Disease ◽

Abo Blood Type

Abstract Background Both ABO blood group antigens and pathogenic immunoglobulin A1 (IgA1) in patients with IgA nephropathy (IgAN) are influenced by modifications of N-acetylgalactosamine and galactose. The purpose of this study was to assess whether ABO blood type is associated with galactose-deficient IgA1 (Gd-IgA1) in the progression of kidney disease in patients with IgAN. Methods We enrolled 1313 IgAN patients with a median of 44 months follow-up and measured the plasma Gd-IgA1 levels. Multivariate Cox regression models were used to estimate the association between all variables and adverse outcomes. Using the propensity score matching method, 718 IgAN patients with blood type either A or B were selected, and their data were used to assess the association of blood type and Gd-IgA1/serum complement 3 (sC3) with outcomes. Results We found that the risk of adverse outcomes was significantly higher in patients with blood type A than in those with type B (hazard ratio = 1.82, 95% confidence interval 1.23–2.71; P = 0.003) after multivariate adjustment. The Gd-IgA1 levels showed trends similar to the multivariate-adjusted event-free curves for the blood types. However, this higher risk of adverse outcomes in type A than in type B patients was no longer significant after the addition of Gd-IgA1/sC3 to the model. Conclusions IgAN patients with blood type A had a higher risk of adverse outcomes than those with type B, and this risk was associated with Gd-IgA1/sC3. Thus, the ABO blood type may provide a reference for the prognostic factors for individuals with IgAN.

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Effects of Tranexamic Acid on Mortality and Blood Transfusion in Trauma Patients with Significant Hemorrhage: A Clinical Trial

Advances in Bioscience and Clinical Medicine ◽

10.7575/aiac.abcmed.17.05.04.04 ◽

2017 ◽

Vol 5 (4) ◽

pp. 24

Author(s):

Farzad Kakaei ◽

Peyman Virani ◽

Shahriar Hashemzadeh ◽

Sina Zarrintan ◽

Samad Beheshtirouy ◽

...

Keyword(s):

Blood Transfusion ◽

Tranexamic Acid ◽

Study Groups ◽

Control Group ◽

Case Group ◽

Trauma Patients ◽

Transfusion Rate ◽

Control Groups ◽

Significant Difference ◽

And Control

Extensive hemorrhage is a significant cause of mortality in trauma patients. Tranexamic acid has been used for controlling bleeding in cardiovascular surgeries and dental manipulations in patients with hemophilia. However, in traumatic patients with bleeding, its use dates back to more recent years. This study aims to examine the effects of this drug on reducing mortality and blood transfusion rate in trauma patients with significant hemorrhage. A total of 60 patients with significant trauma-related hemorrhage (systolic blood pressure < 90 mmHg/heart rate > 110/min) from the emergency department of Imam Reza Hospital (Tabriz, Iran), were randomized in two groups. The case group received intravenous Tranexamic acid (1 g in 10 min and then 1 g over 8 h). The control group received placebo. Rate of transfusion and rate of one-month mortality were compared between the study groups. The mean ICU stay and overall hospitalization times did not have significant difference between two groups (p<0.05). Transfusion of packed cells was 6.03±1.50 and 6.03±1.22 units in case and control groups respectively. Transfusion of fresh frozen plasma (FFP) was 2.50±1.36 and 3.03±0.96 units in case and control groups respectively (p=0.09). Transfusion of platelets was 0.40±0.20 1.33±0.31 units in case and control groups respectively (p=0.01). Three patients (10%) in the case group and 4 patients (13.3%) in the control group were expired (p=0.50). Tranexamic acid is safe and effective in reducing platelet transfusion rate in patients with trauma-related significant hemorrhage. However, transfusion need and mortality would not reduce by its use in trauma patients.

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