Application Value of Blood Types Gene Detection in Blood Transfusion of Patients with ABO Blood Type Identification Difficulty

Abstract ABO blood type has been reported to be a predictor of poor prognosis in critically ill patients. Here, we aim to correlate different blood types with clinical outcomes in patients with severe burns. We conducted a single-center retrospective cohort study by enrolling patients with severe burn injuries (≥40% TBSA) between January 2012 and December 2017. Baseline characteristics and clinical outcomes were compared between disparate ABO blood types (type O vs non-O type). Multivariate logistic and linear regression analyses were performed to identify an association between ABO blood type and clinical outcomes, including in-hospital mortality, the development of acute kidney injury (AKI), and hospital or ICU length of stay. A total of 141 patients were finally enrolled in the current study. Mortality was significantly higher in patients with type O blood compared with those of other blood types. The development of AKI was significantly higher in patients with blood type O vs non-O blood type (P = .001). Multivariate analysis demonstrated that blood type O was independently associated with in-hospital mortality and AKI occurrence after adjusting for other potential confounders. Our findings indicated the blood type O was an independent risk factor of both increased mortality and the development of AKI postburn. More prudent and specific treatments are required in treating these patients to avoid poor prognosis.

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Race, ABO Blood Type, Gender, Age and Venous Thromboembolism Risk: Not Black and White

Blood ◽

10.1182/blood.v116.21.568.568 ◽

2010 ◽

Vol 116 (21) ◽

pp. 568-568 ◽

Cited By ~ 1

Author(s):

Chunhui Fang ◽

Henny Heisler Billett

Keyword(s):

Venous Thromboembolism ◽

Gender Difference ◽

Prognostic Score ◽

Male Gender ◽

Adult Patients ◽

Blood Type ◽

Lower Prevalence ◽

Blood Types ◽

Multiple Variables ◽

Abo Blood Type

Abstract Abstract 568 Venous thromboembolism (VTE) prevalence has been noted to be different for different racial groups: Non-Hispanic blacks tend to have a higher risk compared with non-Hispanic whites. Different ABO blood types have also been previously shown to be associated with different risk of VTE, with individuals with O blood type carry the lowest VTE risk. Given that blacks have a higher percentage of O blood type, one would expect to see a lower prevalence of VTE. In order to explain this paradoxical finding, we utilized the Clinical Looking Glass (CLG) system to study the relative influence of race, gender, age, and ABO blood type on the VTE risk. A total of 61,077 adult patients admitted to our large diverse urban hospital between 2000 and 2009 who had blood typing performed were included in the study. Four cohorts were established according to ABO blood group and the prevalence of VTE among each cohort was examined. We confirmed the higher prevalence of VTE in blacks (7.05% vs. 6.75%, p<0.001). While it has been previously shown that male gender is associated with higher VTE risk, we found this to be true only for the younger patient population: in adult patients less than 45yrs, male carried a higher prevalence of VTE (5.97% vs. 3.06%, p<0.001); in patients aged between 45 and 64yrs, no gender difference in the prevalence of VTE could be determined (8.40% vs. 8.33%, p=0.86). For patients aged between 65 and 84yrs, male gender was actually associated with lower prevalence of VTE (10.11% vs. 12.07%, p=0.009). No gender difference was seen in patients older than 80 (11.11% vs. 11.99%, p=0.356). When the prevalence of VTE was examined within each blood type, we confirmed that O blood type in general carries a lower VTE risk compared with other non-O blood types (6.9% vs. 8.4%, p<0.001); this held true for both genders (See Figure). To better analyze this complex interaction between race, ABO blood type, gender, age and VTE risk, we used logistic regression analysis. Race appeared to be the strongest determinant (black vs. white OR 1.43; 95% CI: 1.33, 1.52), followed by ABO blood type (Type A 1.2, 95% CI: 1.13–1.3; Type AB 1.2, 95% CI: 1.05, 1.40; Type B 1.33, 95% CI 1.23, 1.44), then gender (male vs. female OR 1.11; 95% CI: 1.04, 1.18) and finally, age (OR 1.03; 95% CI 1.03 – 1.03).). In conclusion, VTE risk for any individual is a composite of multiple variables. Our study suggests that race, gender, ABO blood type and age might allow us, in combination with other known risk factors, to develop a prognostic score for VTE risk stratification for each patient. Disclosures: No relevant conflicts of interest to declare.

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ABO and RHD blood types distribution of the patients treated in the Federal Center of Cardiovascular Surgery of Krasnoyarsk

Clinical Medicine (Russian Journal) ◽

10.18821/0023-2149-2016-94-5-353-355 ◽

2016 ◽

Vol 94 (5) ◽

pp. 353-355

Author(s):

Aleksnder A. Makovskiy ◽

A. A. Popov ◽

S. D. Gysev ◽

L. I. Barhatova

Keyword(s):

Cardiovascular Surgery ◽

Type A ◽

Blood Type ◽

Transfusion Therapy ◽

Blood Types ◽

The People ◽

Hospital Patients ◽

Abo Blood Type ◽

The Mean ◽

Group B

The knowledge of blood types frequency in hospital patients helps to plan and perform transfusion therapy at blood donor centers. The distribution of patients’ blood by ABO groups and RhD allows to more efficiently organize and use donor blood banks. The risk of a disease is related to genome composition and is inherited with an ABO blood type. Every person should know his (her) ABO blood type and RhD to enable early identification of the first symptoms of an illness. Materials and methods. This work is based on the study of 4831 blood samples from patients treated at the Center of Cardiovascular Surgery in 2013 (2885 (59,7%) men of the mean age 55 years and 1946 (40,3 %) women of the mean age 57 years). Results. Type A blood occurred most frequently (1787 or 37,0% samples) followed by group O (1625 or 33,6% samples). Samples of group B made up 1025 of the total (21,2%), AB blood group was found in 394 samples (8,2%). Conclusion. The blood types distribution of the ABO system in the patients treated at the Center of Cardiovascular Surgery was characterized by the following pattern: A > O > B > AB. Group A was identified in 37,0% of the patients. Its frequency is similar to that in the population of the western part of Russia and Moscow but different from that in the people living in nearby regions. The frequency of RhD system antigens is comparable in all regions of Russia. CcDEe, ccDEe, CcDee, CCDee are considered to be the most widespread phenotypes. The residents of the Krasnoyarsk region and some nearby regions having blood type A apply to the Center of Cardiovascular Surgery with cardiovascular disorders more frequently than those with others ABO blood types.

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Effect of Intraoperative Blood Transfusion On Treg And Foxp3 In Patients With Digestive Tract Malignancies And Different Abo Blood Types

10.21203/rs.3.rs-34071/v1 ◽

2020 ◽

Author(s):

Yajun Liu ◽

Junzhi Sun ◽

Yun Xia ◽

Michael R. Lyaker ◽

Jianshe Yu

Keyword(s):

Blood Transfusion ◽

Digestive Tract ◽

Blood Group ◽

Radical Resection ◽

Foxp3 Expression ◽

Blood Type ◽

Foxp3 Mrna ◽

Blood Types ◽

Significant Difference ◽

Group A

Abstract Background Blood transfusion can cause immunosuppression and lead to worse outcomes in patients with digestive tract malignancies; however, the specific mechanism behind this is not completely understood. One theory is that increased numbers of regulatory CD3 + CD4 + CD25 + FOXP3 + T cells (Tregs) and forkhead box protein-3 mRNA (FOXP3) expression in the blood after transfusion contribute to these outcomes. The effect of blood transfusion on immune function in patients with different ABO blood types is variable. This study investigates the effect of intraoperative blood transfusion on the number of Tregs and the expression of FOXP3 in the blood of patients with different ABO blood types and digestive tract malignancies. Methods Patients with digestive tract malignancies who underwent radical resection and received intraoperative blood transfusion were divided into four groups according to their blood types:blood group A, B, O and AB (n=20 ). Blood was collected before surgery, immediately after transfusion, 1 day after transfusion, and 5 days after transfusion. The number of Tregs was measured by flow cytometry. The expression of FOXP3 was detected by real time reverse transcription polymerase chain reaction (RT-PCR). Results There was no significant difference in the number of Tregs or expression of FOXP3 mRNA among patients with different blood types before surgery. However, the number of Tregs and the expression of FOXP3 increased after blood transfusion in all blood type groups. This increase was especially evident and statistically significant on the first day after blood transfusion when compared with measures obtained before the surgery. Measures returned to the preoperative level five days after surgery. There were significant differences in the increase of Tregs and expression of FOXP3 among patients with different blood types. The greatest increase was seen in patients with blood group B and the least in blood group A. Conclusions Intraoperative blood transfusion can lead to an increase in blood Tregs and FOXP3 expression in patients with digestive tract malignancies. Increases were greatest on the first day after surgery and differed among patients with different blood types. Increases were greatest in blood type B and least in blood type A.

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TP9.2.24Is preoperative ABO blood typing required in emergency appendicectomies?

British Journal of Surgery ◽

10.1093/bjs/znab362.123 ◽

2021 ◽

Vol 108 (Supplement_7) ◽

Author(s):

Ricardo Rodrigues ◽

Ieuan Reece ◽

Nabil El-Masry

Keyword(s):

Blood Transfusion ◽

Primary Outcome ◽

Outcome Measure ◽

Primary Outcome Measure ◽

Blood Type ◽

Single Centre ◽

Blood Typing ◽

Suspected Appendicitis ◽

Chronic Anaemia ◽

Abo Blood Type

Abstract Aims Intra-operative bleeding is very rarely a complication of laparoscopic appendicectomy. Despite this, it is often mandatory for any patient undergoing an emergency appendicectomy to have pre-operative ABO blood type sampling. This could be an unnecessary expense and may lead to patients being delayed for theatre. The aim of this study was to see how many patients who underwent an appendicectomy required a blood transfusion intra-operatively or within 30 days of their operation. Methods Data were collected retrospectively for patients of all ages who underwent an appendicectomy for suspected appendicitis at a single centre from March 2018 to May 2020. The primary outcome measure was intra-operative and post-operative blood transfusion up until 30 days after the operation. Results Over 26 months, 698 appendicectomies were performed. Preoperative ABO blood typing was performed in 95% (n = 663) of patients. Collectively, 1,305 blood samples were obtained at a combined total cost of £13,703 to the hospital. None of the patients required blood transfusion intra- or post-operatively. Pre-operative blood transfusion was performed in only three patients, all due to chronic anaemia. 21 (3%) patients were delayed in going to theatre whilst awaiting two valid ABO blood typing results. Conclusions Emergency appendicectomies very rarely experience complications associated with bleeding or requiring blood transfusion. Clinical guidelines should reflect this by avoiding recommendation of such tests in emergency appendicectomies, reducing delays to surgery and resulting in a more efficient allocation of financial and staff resources.

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ABO blood group and the risk of breast cancer: Multicenter, case-control, observational study.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.1572 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 1572-1572

Author(s):

Yuksel Urun ◽

Tulay Koru-Sengul ◽

Kadri Altundag ◽

Gungor Utkan ◽

Handan Onur ◽

...

Keyword(s):

Breast Cancer ◽

Prognostic Factors ◽

Blood Group ◽

Blood Groups ◽

Blood Type ◽

Abo Blood Group ◽

Abo Blood Groups ◽

Blood Types ◽

Abo Blood Type

1572 Background: The role of genetic factors in the development of cancer is widely accepted. ABO blood type is an inherited characteristic and previous studies have observed an association between ABO blood group and risk of certain malignancies, including pancreatic and gastric cancer. The data on the role of ABO blood group and Rh factor in breast cancer is inconclusive. Methods: All patients who had breast cancer (BC) and treated between 2000-2010 at the Departments of Medical Oncology of both Ankara and Hacettepe Universities (Ankara, Turkey) with defined ABO blood type and Rh factor were included in our retrospective reviews of tumor registry records. A group of volunteer healthy women donors of Turkish Red Crescent between 2004-2011 were identified as a control group, without any matching factors. The relationship of ABO blood types and Rh factor with various prognostic factors such as age at diagnosis, menopausal status, family history of breast cancer, and ER/PR/HER2 status were evaluated from 1740 BC patients. We compared the distributions of ABO blood types, Rh factors among 1740 patients and 204,553 healthy controls. Among BC patients, differences between each of aforementioned ABO blood groups and Rh factors with respect to various prognostic factors were explored, respectively. Results: Overall distributions of ABO blood groups as well as Rh factor were comparable between patients (44% A, 8% AB, 16% B, 32% O, 88% Rh+) and controls (41% A, 8% AB, 16% B, 35% O, 87% Rh+). However, there were statistically significant differences between patients and controls with respect to A vs. nonA (p=0.019) and marginal significance (p=0.051) for O vs. nonO. Among patients, there were statistically significant differences between A and nonA with respect to HER2 (p=0.0421), M stage (p=0.0447), T stage (p=0.0020). Only T stage (p=0.0337) were significantly different between O vs nonO. Grade (p=0.0227) and M stage (p=0.0107) were significantly different between Rh factors. Conclusions: In our study sample, ABO blood type was statistically significantly associated with breast cancer. Additional studies are necessary to determine the mechanisms by which ABO blood type may influence the risk of breast cancer.

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6. Blood transfusion

Blood: A Very Short Introduction ◽

10.1093/actrade/9780199581450.003.0006 ◽

2016 ◽

pp. 103-123

Author(s):

Chris Cooper

Keyword(s):

Blood Transfusion ◽

20Th Century ◽

Human Blood ◽

Blood Type ◽

Early 20Th Century ◽

Animal Blood ◽

Blood Banks ◽

History Of ◽

Abo Blood Type ◽

The 19Th Century

‘Blood transfusion’ outlines the history of transfusing animal blood dating back to the 17th century. The 19th century saw the first successful human blood transfusion, but two major issues remained: the problems of clotting and blood group incompatibility. Albert Hustin and Luis Agote resolved the first issue in 1914 by using sodium citrate in transfusions to work as an anticoagulant. Richard Lewisohn calculated the correct levels of citrate needed to avoid poisoning the blood. Karl Landsteiner’s work in early 20th-century Vienna revealed the ABO blood type distinctions, solving the latter problem. The creation of blood banks and the potential for viral contamination of blood and blood products are also discussed.

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Frequencies of feline blood types in Hungary

Acta Veterinaria Hungarica ◽

10.1556/004.49.2001.4.1 ◽

2001 ◽

Vol 49 (4) ◽

pp. 369-375 ◽

Cited By ~ 13

Author(s):

Nóra Bagdi ◽

Melinda Magdus ◽

E. Leidinger ◽

Judith Leidinger ◽

K. Vörös

Keyword(s):

Blood Transfusion ◽

Blood Group ◽

Diagnostic Method ◽

Type A ◽

Blood Groups ◽

Blood Type ◽

Type B ◽

Blood Types ◽

Type Ab ◽

Transfusion Reactions

Feline blood group determination is done as a routine diagnostic method in numerous countries. Blood transfusion reactions and feline neonatal isoerythrolysis (FNI) can be avoided with the identification of different feline blood groups. The present study is the first investigation in Hungary during which 100 cats have been examined from all over the country. These cats were out of six breeds: European domestic shorthair, Persian mix, Persian, Abyssinian, Siamese and British shorthair. In the Hungarian feline population European domestic shorthair are most common but other breeds also occur. European domestic shorthair, Persian mix, Abyssinian, Siamese and British shorthair individuals all belonged to blood type A (100%). Blood type B was found very rarely and only in Persian cats. One-third of the Persian cats were categorised into blood type B, whilst type AB was not found during the study.

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ABO blood type analysis in patients with chronic obstructive pulmonary disease

Genetika ◽

10.2298/gensr2102457p ◽

2021 ◽

Vol 53 (2) ◽

pp. 457-471

Author(s):

Blazenka Petricevic ◽

Dragica Pesut

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Lung Function ◽

General Population ◽

Pulmonary Disease ◽

Tobacco Smoking ◽

Blood Type ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Blood Types ◽

Abo Blood Type

Tobacco smoking is major risk factor for development of chronic obstructive pulmonary disease (COPD), which appears in 15-20% of smokers. Apart from smoking, exposure to polluted air and various noxae, and several genetic factors influence its development as well. The ABO blood type distribution varies among populations in the world, but also within subpopulations. A large number of studies have shown a correlation between blood types and the pathology of various diseases. These markers, used in population genetic research, have mainly shown deviations in the representation of blood groups in different diseases, compared to the general population. The aim of this study was to determine the ABO blood types distribution in patients with COPD compared to the general population, and their possible association with COPD stage, patients? nutritional status and lung function impairment. This observational, prospective study included 150 patients (68.7% men and 31.3% women), average age 64.80 ? 8.38 years, diagnosed with COPD. Data were collected at the Clinical Center of Montenegro in Podgorica and at the Special Hospital for Lung Diseases Brezovik in Niksic. Determination of blood types of the ABO system and Rh factors for all subjects was performed at the Blood Transfusion Center in Podgorica. Apart from patients? tobacco smoking status (duration of smoking and the number of cigarettes smoked per day expressed in pack/years for current smokers and former smokers), we also analyzed their exposure to various other noxae, their body mass index, and lung function in correlation to ABO blood type and Rh factor, and performed statistical analysis. We found a significant difference in the distribution of ABO blood types in patients with COPD compared to the general population. The highest frequency of blood type A was found in patients with COPD. We also found the lowest average values of spirometry parameters in that group, which represented majority of those patients with respiratory insufficiency having the most severe stage of the disease. Combined blood types A, B and were significantly more common in patients with COPD in comparison to blood type O, which is the least represented (23.3%). The least obstructive disturbance of pulmonary ventilation was found in the patients with B type. Respiratory insufficiency showed differences in gender representation, found in 40.4% of women, and in 25.2% of men with terminal phase of COPD. The prevalence of AB, higher than expected, decreases with the severity of the disease.

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ABO Blood Type and Personality Traits: Evidence from Large-scale Surveys in Japan

10.31124/advance.12410228.v1 ◽

2020 ◽

Author(s):

Masayuki Kanazawa

Keyword(s):

Personality Traits ◽

Significant Relationship ◽

Large Scale ◽

The Other ◽

Blood Type ◽

Blood Types ◽

Abo Blood Type ◽

The Relationship

The relationship between blood type and personality has long been one of the more challenging issues of scientific studies. Several large-scale surveys were conducted to address the issue, and some of them had shown statistically significant associations. This study analyzed data from two large-scale surveys (Survey 1: N = 1,000, Survey 2: N = 1,859) to examine the relationship between blood type and personality. ANOVA results indicated that 17 of the total 20 respondents’ own blood type characteristic question items scored higher as “fit to my personality” than the averages of the other blood types. In both Survey 1 and 2, the same differences in scores were found in the groups who reported no blood type personality knowledge, although the values were smaller. Thus, we observed a clear and significant relationship between blood type and personality in large-scale surveys.

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