Amphiphilic Ionic Liquid Induced Fusion of Phospholipid Liposomes

2020 ◽  
Author(s):  
Sandeep Kumar ◽  
Navleen Kaur ◽  
Venus Singh Mithu
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Membrane Fusion ◽  
Solid State Nmr ◽  
Structural Integrity ◽  
Cellular Membrane ◽  
Phospholipid Membrane ◽  
Imidazolium Cations ◽  
Phospholipid Liposomes ◽  
Potential Applications

Membrane fusion is a key biological phenomenon with potential applications in biotechnology. In this work, we provide biophysical and structural evidence that liposomes composed of POPC/POPG phospholipids undergo fusion in the presence of ionic liquids containing 1-alkyl-3-methyl-imidazolium cations. The fusion phenomenon is confirmed using dynamic light scattering based size measurements, and Fluorescence based dye leakage and lipid mixing assays. <sup>1</sup>H-<sup>1</sup>H NOESY measurements using solid-state NMR spectroscopy were performed to obtain insights into fusion mechanism. It is found that ionic liquid induced splaying of phospholipid chains is crucial for overcoming the hydration barrier between the merging bilayers. Also, transiently lived fusion-holes are formed at the initial stages of bilayer mixing resulting in a leaky fusion phenomenon. <br><br>Although considered as “green” alternatives to conventional solvents, ionic liquids can exhibit cytotoxicity by altering the structural integrity of cellular membrane. Our study provides mechanistic details of the evolution of phospholipid membrane structure resulting in membrane fusion when subjected to increasing ionic liquid concentrations. We believe that findings of this study will further our understanding of ionic liquids induced cytotoxicity and non-protein assisted membrane fusion. <br><br>

scholarly journals Amphiphilic Ionic Liquid Induced Fusion of Phospholipid Liposomes

2020 ◽  
Author(s):  
Sandeep Kumar ◽  
Navleen Kaur ◽  
Venus Singh Mithu
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Membrane Fusion ◽  
Solid State Nmr ◽  
Structural Integrity ◽  
Cellular Membrane ◽  
Phospholipid Membrane ◽  
Imidazolium Cations ◽  
Phospholipid Liposomes ◽  
Potential Applications

Membrane fusion is a key biological phenomenon with potential applications in biotechnology. In this work, we provide biophysical and structural evidence that liposomes composed of POPC/POPG phospholipids undergo fusion in the presence of ionic liquids containing 1-alkyl-3-methyl-imidazolium cations. The fusion phenomenon is confirmed using dynamic light scattering based size measurements, and Fluorescence based dye leakage and lipid mixing assays. <sup>1</sup>H-<sup>1</sup>H NOESY measurements using solid-state NMR spectroscopy were performed to obtain insights into fusion mechanism. It is found that ionic liquid induced splaying of phospholipid chains is crucial for overcoming the hydration barrier between the merging bilayers. Also, transiently lived fusion-holes are formed at the initial stages of bilayer mixing resulting in a leaky fusion phenomenon. <br><br>Although considered as “green” alternatives to conventional solvents, ionic liquids can exhibit cytotoxicity by altering the structural integrity of cellular membrane. Our study provides mechanistic details of the evolution of phospholipid membrane structure resulting in membrane fusion when subjected to increasing ionic liquid concentrations. We believe that findings of this study will further our understanding of ionic liquids induced cytotoxicity and non-protein assisted membrane fusion. <br><br>

scholarly journals Amphiphilic ionic liquid induced fusion of phospholipid liposomes

2020 ◽  
Vol 22 (43) ◽  
pp. 25255-25263
Author(s):  
Sandeep Kumar ◽  
Navleen Kaur ◽  
Venus Singh Mithu
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Structural Integrity ◽  
Unilamellar Vesicles ◽  
Phospholipid Liposomes ◽  
Large Unilamellar Vesicles ◽  
The Impact

The impact of increasing concentration of imidazolium-based ionic liquids ([CnMIM]+[Br]−) on the structural integrity of large unilamellar vesicles (LUVs) made of pure phosphatidylcholine (PC) and phosphatidylglycerol (PG) lipids.

Tetracarboxyl-Functionalized Ionic Liquid: Synthesis and Catalytic Properties

2015 ◽  
Vol 68 (10) ◽  
pp. 1513 ◽  
Author(s):  
Miaona Feng ◽  
Guoying Zhao ◽  
Hongling Gao ◽  
Suojiang Zhang
Keyword(s):  
Ionic Liquid ◽  
Catalytic Activity ◽  
Ionic Liquids ◽  
Propionic Acid ◽  
Propylene Carbonate ◽  
Propylene Oxide ◽  
High Stability ◽  
Ammonium Acetate ◽  
Catalytic Properties ◽  
Potential Applications

Novel tetracarboxyl-functionalized 2,2′-biimidazolium-based ionic liquids (ILs) with different anions were synthesized in two steps from readily available and sustainable starting materials including ammonium acetate, glyoxal, and halogenated propionic acid. The functionalized IL exhibited higher catalytic activity towards the cycloaddition of CO2 to terminal epoxides. With propylene oxide as a substrate, the optimum yield of propylene carbonate reached 82.7 % at an initial CO2 pressure of 2.0 MPa for 4 h at 140°C. Moreover, the functionalized IL catalyst displayed a high stability and can be reused for at least five cycles without obvious loss of catalytic activity. The results provide a simple and economical way to synthesize multi-functionalized imidazolium-based ILs with versatile potential applications.

Ionic Liquids in Surface Protection of Aluminum and Its Alloys

2019 ◽  
Author(s):  
Joaquin Arias-Pardilla ◽  
Tulia Espinosa ◽  
José Sanes ◽  
Ana Eva Jiménez ◽  
Ginés Martínez-Nicolás ◽  
...  
Keyword(s):  
Wear Resistance ◽  
Corrosion Resistance ◽  
Ionic Liquid ◽  
Ionic Liquids ◽  
Industrial Applications ◽  
Energy Storage Devices ◽  
New Techniques ◽  
Surface Protection ◽  
Storage Devices ◽  
Potential Applications

Aluminum and its alloys are used in an increasing number of applications but the development of surface coatings and new techniques for corrosion resistance enhancement and for increasing wear resistance will be determinant for applications under aggressive environments. Ionic liquids have already found many industrial applications, including their use in surface protection. The present article will focus on the use of ionic liquids in aluminum and its alloys surface protection applications, including corrosion protection and inhibition, anodization and passivation processes, wear resistance, and potential applications of ionic liquid electrolytes in energy storage devices.

scholarly journals Ionic Liquid Crystals in Tribology

Lubricants ◽  
2019 ◽  
Vol 7 (9) ◽  
pp. 72 ◽  
Author(s):  
M.D. Avilés ◽  
C. Sánchez ◽  
R. Pamies ◽  
J. Sanes ◽  
M.D. Bermúdez
Keyword(s):  
Molecular Structure ◽  
Ionic Liquid ◽  
Ionic Liquids ◽  
Liquid Crystals ◽  
Tribological Performance ◽  
Wear Rates ◽  
Fatty Acid Derivatives ◽  
Potential Applications ◽  
Ionic Liquid Crystals ◽  
Definition Of

The present work intends to provide a brief account of the most recent advances in the use of ionic liquid crystals (ILCs) in the field of tribology, that is, the development of new lubricants with the ability to reduce the coefficients of friction and the wear rates of materials under sliding conditions. After a definition of ILCs and their relationship with neutral liquid crystals (LCs) and ionic liquids (ILs), the review will be focused on the influence of molecular structure and composition on the tribological performance, the combination with base oils, surfactants or water, and the different sliding configuration and potential applications. The main mechanisms proposed in order to justify the lubricating ability of ILCs will be analyzed. Special emphasis will be made for recent results obtained for fatty acid derivatives due to their renewable and environmentally friendly nature.

scholarly journals Adjusting the cation and anion nature in ionic liquids used for the growth control of nanoparticles of organic conductors

2016 ◽  
Vol 4 (1) ◽  
pp. 65-75 ◽  
Author(s):  
Dominique de Caro ◽  
Christophe Faulmann ◽  
Lydie Valade ◽  
Kane Jacob ◽  
Benoit Cormary
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Supporting Electrolyte ◽  
Electronic Devices ◽  
Growth Control ◽  
Organic Conductors ◽  
Organic Conductor ◽  
Valuable Characteristic ◽  
Potential Applications

Ionic liquids are used for controlling the growth of organic conductors as nanoparticles. We review the conditions of preparation of nanoparticles of conductors derived from tetrathiafulvalene (TTF), tetramethyltetraselenafulvalene (TMTSF) and bis-ethylenedithiotetrathiafulvalene (BEDT-TTF). They are prepared by electrocrystallization using an ionic liquid supporting electrolyte in which the cation plays the role of growth controller and the anion enters the composition of the expected organic conductor. Stable suspensions of nanoparticles are obtained in one case, a valuable characteristic for potential applications in electronic devices.

scholarly journals Properties of Dicationic Disiloxane Ionic Liquids

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2949
Author(s):  
Vladimir G. Krasovskiy ◽  
Gennady I. Kapustin ◽  
Olga B. Gorbatsevich ◽  
Lev M. Glukhov ◽  
Elena A. Chernikova ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Hydrolytic Stability ◽  
Melting Points ◽  
Imidazolium Cations ◽  
Dicationic Ionic Liquids

A number of dicationic ionic liquids with a disiloxane linker between imidazolium cations and bis(trifluoromethylsulfonyl)imide anion were synthesized and characterized. Melting points, viscosity, and volatility in a vacuum were measured; the thermal and hydrolytic stability of ionic liquids were also studied. The dependence of the properties on the structure of substituents in the cation of the ionic liquid was demonstrated.

scholarly journals Low temperature glass/crystal transition in ionic liquids determined by H-bond vs. coulombic strength

2020 ◽  
Vol 22 (36) ◽  
pp. 20524-20530
Author(s):  
Carlos López-Bueno ◽  
Marius R. Bittermann ◽  
Bruno Dacuña-Mariño ◽  
Antonio Luis Llamas-Saiz ◽  
María del Carmen Giménez-López ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Solar Cells ◽  
Liquid Crystals ◽  
Low Temperature ◽  
Ionic Conductors ◽  
Potential Applications ◽  
Crystal Transition ◽  
Ionic Liquid Crystals ◽  
Glass Crystal

Self-assembled ionic liquid crystals are anisotropic ionic conductors, with potential applications in areas as important as solar cells, battery electrolytes and catalysis. We show that the type of crystal formed depend on the strength of H-bonds.

scholarly journals Mechanism of charge accumulation of poly(heptazine imide) gel

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Goichiro Seo ◽  
Yuki Saito ◽  
Miyu Nakamichi ◽  
Kyohei Nakano ◽  
Keisuke Tajima ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Charge Accumulation ◽  
First Report ◽  
New Concepts ◽  
Proposed Model ◽  
Theoretical Investigations ◽  
Potential Applications ◽  
Stimuli Response ◽  
Induced Charge

AbstractPhoto-stimuli response in materials is a fascinating feature with many potential applications. A photoresponsive gel of poly(heptazine imide), PHI, termed PHIG, exhibits photochromism, photoconductivity, and photo-induced charge accumulation, and is generated using ionic liquids and PHI. Although there are several examples of ionic liquid gels that exhibit photochromism and photoconductivity, this is the first report of an ionic liquid gel that exhibits both these properties as well as charge accumulation. We conducted experimental and theoretical investigations to understand the mechanism of the photostimulus response of PHIG, especially charge accumulation. The proposed model explains both the mechanism of charge accumulation and dark photocatalysis by PHI and provides new concepts in the field of photofunctional materials.

scholarly journals PROPERTIES OF 1-BUTYL-3-METHYLIMIDAZOLIUM BROMIDE IONIC LIQUID AND ITS BLENDS WITH WATER AND BROMIDES OF SILVER, COPPER AND TANTALUM

2018 ◽  
Vol 59 (6) ◽  
pp. 89
Author(s):  
Elena P. Grishina ◽  
Ludmila M. Ramenskaya
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Intramolecular Interactions ◽  
Crystalline Hydrate ◽  
Potential Range ◽  
Phase System ◽  
Glass Temperature ◽  
Green Solvents ◽  
Imidazolium Cations ◽  
Electrochemical Window

Ionic liquids with N,N¢-dialkylimidazolium cation characterized now as "green" solvents are investigated intensively to find their practical application. In this research the physical-chemical, electrochemical and corrosion properties of 1-butyl-3-methylimidazolium bromide (BMImBr) and its blends with water and bromides of silver (I), cupper (II) and tantalum (V) were studied. BMImBr is a hygroscopic ionic liquid and in depending on a water content can exists as a solid, liquid, metastable supercooled melt, and two-phase system – liquid and crystalline hydrate of BМImBr´0.5Н2О composition. At 1:1 components ratio the structural transformation of the melt (СН2О<50 mol%) « the solution (СН2О>50 мол.%) was observed. The BMImBr ionic liquid is a good solvent towards bromides of silver (I), cupper (II) and tantalum (V). These salts destroy the inter- and intramolecular interactions of BMImBr and generate the complex metal-containing ions with Br- anion of ionic liquid. As a result the glass temperature and the density increased, the melting point decreased and on isotherms of dynamic viscosity and specific electro conductivity a distinct minimum was observed at the low concentration range of the salt. Electrochemical window of BMImBr is 1.9 V and it is limited by bromide ions oxidation in the anodic potential range and by imidazolium cations reduction in the cathodic potential range. Additions of the water and the metals salt are an electrochemical active. In their presence the redox processes proceeds inside of the electrochemical window and the discharge-ionization process is the limiting steps. From IL studied the thin films of silver and copper can be deposited with good adhesion on metal substrates including tantalum and titanium. Investigated ionic liquids are a corrosive fluid, and corrosion of the metal increases dramatically in the presence of the same cations.

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