Targeted nanoparticles from xyloglucan–doxorubicin conjugate loaded with doxorubicin against drug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 26137-26146 ◽  
Author(s):  
Xuan Xie ◽  
Shiying Luo ◽  
Jean Felix Mukerabigwi ◽  
Jian Mei ◽  
Yuannian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Side Effects ◽  
Tumor Cells ◽  
Cellular Uptake ◽  
Drug Delivery Systems ◽  
Drug Resistant ◽  
The Novel ◽  
Targeted Nanoparticles ◽  
Nanoparticle Drug Delivery

The novel targeted Xyloglucan–doxorubicin nanoparticle drug delivery systems (DOX nano-DDSs) exhibited improved cellular uptake, increased accumulation in tumor, higher cytotoxicity against drug resistant tumor cells and reduced side effects.

Use of Anticancer Platinum Compounds in Combination Therapies and Challenges in Drug Delivery

2020 ◽  
Vol 27 (18) ◽  
pp. 3055-3078 ◽  
Author(s):  
Xiao Xiao ◽  
James Trevor Oswald ◽  
Ting Wang ◽  
Weina Zhang ◽  
Wenliang Li
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Acquired Drug Resistance ◽  
Safe Delivery ◽  
Combinational Therapy ◽  
Solid Malignancies ◽  
Tumor Drugs

As one of the leading and most important metal-based drugs, platinum-based pharmaceuticals are widely used in the treatment of solid malignancies. Despite significant side effects and acquired drug resistance have limited their clinical applications, platinum has shown strong inhibitory effects for a wide assortment of tumors. Drug delivery systems using emerging technologies such as liposomes, dendrimers, polymers, nanotubes and other nanocompositions, all show promise for the safe delivery of platinum-based compounds. Due to the specificity of nano-formulations; unwanted side-effects and drug resistance can be largely averted. In addition, combinational therapy has been shown to be an effective way to improve the efficacy of platinum based anti-tumor drugs. This review first introduces drug delivery systems used for platinum and combinational therapeutic delivery. Then we highlight some of the recent advances in the field of drug delivery for combinational therapy; specifically progress in leveraging the cytotoxic nature of platinum-based drugs, the combinational effect of other drugs with platinum, while evaluating the drug targeting, side effect reducing and sitespecific nature of nanotechnology-based delivery platforms.

Self-organized nanoparticle drug delivery systems from a folate-targeted dextran–doxorubicin conjugate loaded with doxorubicin against multidrug resistance

RSC Advances ◽  
2015 ◽  
Vol 5 (87) ◽  
pp. 71164-71173 ◽  
Author(s):  
Yuannian Zhang ◽  
Haili Wang ◽  
Jean Felix Mukerabigwi ◽  
Min Liu ◽  
Shiying Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Multidrug Resistance ◽  
Drug Release ◽  
Cellular Uptake ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Self Organized ◽  
Nanoparticle Drug Delivery

DOX nano-DDSs with the function of both targeting tumors and controlling drug release were prepared which exhibited larger drug releases, higher cytotoxicity against HepG2/DOX cells, improved cellular uptake and decreased side toxicities.

scholarly journals Polymeric Encapsulation of a Ru(II)-based Photosensitizer for Folate Targeted Photodynamic Therapy of Drug Resistant Cancers

2020 ◽  
Author(s):  
Johannes Karges ◽  
Mickaël Tharaud ◽  
Gilles Gasser
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
High Selectivity ◽  
Drug Resistant ◽  
Multicellular Tumor Spheroids ◽  
Targeted Photodynamic Therapy ◽  
Polymeric Encapsulation ◽  
Cancerous Cells

<p>The currently used photodynamic therapy (PDT) photosensitizers (PSs) are generally associated with a poor cancer cell selectivity, which is responsible for some undesirable side effects. To overcome these problems, the use of selective drug delivery systems is currently envisioned. In this article, the encapsulation of a promising Ru(II) polypyridine complex-based PDT PS in a polymer with terminal folate groups to form nanoparticles is presented. While showing a high selectivity for cancerous cells over non-cancerous cells, the nanoparticles were found to be highly phototoxic in 2D monolayer cells as well as 3D multicellular tumor spheroids upon 480 nm or 595 nm irradiation. Promisingly, the nanoparticles were also active in drug resistant cancer cells lines, indicating that they are able to overcome drug resistances. <br></p>

scholarly journals Enhanced cellular uptake of engineered spider silk particles

2015 ◽  
Vol 3 (3) ◽  
pp. 543-551 ◽  
Author(s):  
Martina B. Elsner ◽  
Heike M. Herold ◽  
Susanne Müller-Herrmann ◽  
Hendrik Bargel ◽  
Thomas Scheibel
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cellular Uptake ◽  
Drug Delivery Systems ◽  
Spider Silk ◽  
Tissue Cell ◽  
Total Drug ◽  
Specific Targeting ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Drug delivery systems allow tissue/cell specific targeting of drugs in order to reduce total drug amounts administered to an organism and potential side effects upon systemic drug delivery.

scholarly journals Polymeric Encapsulation of a Ru(II)-based Photosensitizer for Folate Targeted Photodynamic Therapy of Drug Resistant Cancers

2020 ◽  
Author(s):  
Johannes Karges ◽  
Mickaël Tharaud ◽  
Gilles Gasser
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
High Selectivity ◽  
Drug Resistant ◽  
Multicellular Tumor Spheroids ◽  
Targeted Photodynamic Therapy ◽  
Polymeric Encapsulation ◽  
Cancerous Cells

<p>The currently used photodynamic therapy (PDT) photosensitizers (PSs) are generally associated with a poor cancer cell selectivity, which is responsible for some undesirable side effects. To overcome these problems, the use of selective drug delivery systems is currently envisioned. In this article, the encapsulation of a promising Ru(II) polypyridine complex-based PDT PS in a polymer with terminal folate groups to form nanoparticles is presented. While showing a high selectivity for cancerous cells over non-cancerous cells, the nanoparticles were found to be highly phototoxic in 2D monolayer cells as well as 3D multicellular tumor spheroids upon 480 nm or 595 nm irradiation. Promisingly, the nanoparticles were also active in drug resistant cancer cells lines, indicating that they are able to overcome drug resistances. <br></p>

Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy

2020 ◽  
Vol 27 (13) ◽  
pp. 2118-2132 ◽  
Author(s):  
Aysegul Hanikoglu ◽  
Hakan Ozben ◽  
Ferhat Hanikoglu ◽  
Tomris Ozben
Keyword(s):  
Oxidative Stress ◽  
Drug Resistance ◽  
Side Effects ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Chemotherapeutic Agents ◽  
Oxidation Reactions ◽  
Hybrid Compounds ◽  
Induced Apoptosis

: Elevated Reactive Oxygen Species (ROS) generated by the conventional cancer therapies and the endogenous production of ROS have been observed in various types of cancers. In contrast to the harmful effects of oxidative stress in different pathologies other than cancer, ROS can speed anti-tumorigenic signaling and cause apoptosis of tumor cells via oxidative stress as demonstrated in several studies. The primary actions of antioxidants in cells are to provide a redox balance between reduction-oxidation reactions. Antioxidants in tumor cells can scavenge excess ROS, causing resistance to ROS induced apoptosis. Various chemotherapeutic drugs, in their clinical use, have evoked drug resistance and serious side effects. Consequently, drugs having single-targets are not able to provide an effective cancer therapy. Recently, developed hybrid anticancer drugs promise great therapeutic advantages due to their capacity to overcome the limitations encountered with conventional chemotherapeutic agents. Hybrid compounds have advantages in comparison to the single cancer drugs which have usually low solubility, adverse side effects, and drug resistance. This review addresses two important treatments strategies in cancer therapy: oxidative stress induced apoptosis and hybrid anticancer drugs.

Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy

2020 ◽  
Vol 21 (11) ◽  
pp. 1084-1098
Author(s):  
Fengqian Chen ◽  
Yunzhen Shi ◽  
Jinming Zhang ◽  
Qi Liu
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Therapeutic Index ◽  
Delivery Systems ◽  
Epigenetic Therapy ◽  
Cancer Therapies ◽  
Therapeutic Benefits ◽  
High Therapeutic Index

This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery systems with epigenetic therapy is a promising approach to reaching a high therapeutic index and minimizing the side effects.

Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine

2014 ◽  
Vol 3 (2) ◽  
pp. 105-118 ◽  
Author(s):  
Pedro Martins ◽  
Daniela Rosa ◽  
Alexandra Fernandes ◽  
Pedro V. Baptista
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nanoparticle Drug Delivery

Nanoparticle-based drug delivery systems with platinum drugs for overcoming cancer drug resistance

2021 ◽  
Author(s):  
Peng Xie ◽  
Yushu Wang ◽  
Dengshuai Wei ◽  
Lingpu Zhang ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Platinum Drugs ◽  
Effective Strategy ◽  
Platinum Drug ◽  
Cancer Drug Resistance ◽  
Platinum Drug Resistance

The mechanisms of chemoresistance and nanoparticle-based drug delivery systems for platinum drugs were detailed summarized in this review. The current combination therapy provided an effective strategy to overcome the platinum drug resistance.

scholarly journals Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery

2019 ◽  
Vol 87 (3) ◽  
pp. 20 ◽  
Author(s):  
Miléna Lengyel ◽  
Nikolett Kállai-Szabó ◽  
Vince Antal ◽  
András József Laki ◽  
István Antal
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Freeze Drying ◽  
Delivery Systems ◽  
The Novel ◽  
Practical Applications ◽  
Inhaled Insulin ◽  
Formulation Factors ◽  
Novel Drug ◽  
Significant Production

Microparticles, microspheres, and microcapsules are widely used constituents of multiparticulate drug delivery systems, offering both therapeutic and technological advantages. Microparticles are generally in the 1–1000 µm size range, serve as multiunit drug delivery systems with well-defined physiological and pharmacokinetic benefits in order to improve the effectiveness, tolerability, and patient compliance. This paper reviews their evolution, significance, and formulation factors (excipients and procedures), as well as their most important practical applications (inhaled insulin, liposomal preparations). The article presents the most important structures of microparticles (microspheres, microcapsules, coated pellets, etc.), interpreted with microscopic images too. The most significant production processes (spray drying, extrusion, coacervation, freeze-drying, microfluidics), the drug release mechanisms, and the commonly used excipients, the characterization, and the novel drug delivery systems (microbubbles, microsponges), as well as the preparations used in therapy are discussed in detail.

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