Facets of the problem of infiltrative endometriosis: from pathogenesis to effective therapy

GYNECOLOGY ◽  
2021 ◽  
Vol 23 (2) ◽  
pp. 117-124
Author(s):  
Viktor E. Radzinskii ◽  
Mekan R. Orazov ◽  
Ljudmila M. Mihaleva ◽  
Madina A. Bekulova
Keyword(s):  
Pelvic Pain ◽  
Economic Burden ◽  
Clinical Manifestations ◽  
Effective Therapy ◽  
Reproductive Age ◽  
Personal Life ◽  
Depression And Anxiety ◽  
Women Of Reproductive Age ◽  
Unresolved Problem ◽  
High Prevalence

Endometriosis remains an unresolved problem in gynecology. The urgency of the fight against this disease is due to its high prevalence among women of reproductive age. Endometriosis, especially its infiltration forms, affects all aspects of the patients life, its clinical manifestations pelvic pain, dyspareunia, dysmenorrhea, dyschezia, lead to social disadaptation, problems in personal life, depression and anxiety. The socio-economic burden of the disease motivates researchers to further study the pathogenesis of endometriosis and search for pathogenetically justified pharmacological solutions.

Evaluation of the effectiveness of adjuvant anti-progestogen therapy after conservative myomectomy in women of reproductive age

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (4) ◽  
pp. 19-23
Author(s):  
Yanina A Lebedeva ◽  
Inna I Kovalenko ◽  
Oleg L Molchanov ◽  
Dmitrii V Baibuz ◽  
Natalia V Kulikova
Keyword(s):  
Reproductive Potential ◽  
Clinical Manifestations ◽  
Uterine Fibroids ◽  
Pain Syndrome ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Results Of Treatment ◽  
High Prevalence ◽  
Group 2 ◽  
Group 1

Relevance. Due to the high prevalence of uterine fibroids in young women and the possible effect on reproductive potential, the development, implementation and application of the most benign treatment methods are a priority. Aim. To evaluate the effectiveness of adjuvant anti-progestogen therapy after conservative myomectomy in women of reproductive age. Materials and methods. A comparative analysis of the results of treatment of patients of reproductive age with uterine myoma has been carried out. Group 1 (n=38) included patients who underwent conservative myomectomy and/or hysteroresectoscopy without subsequent anti-relapse drug therapy. The average age is 31.5 years (4.6). Group 2 (n=43) included patients after conservative myomectomy who received mifepristone as anti-relapse therapy after surgery. The average age is 31.9 years (4.5). Results. Mifepristone therapy, as an adjuvant treatment after conservative myomectomy, can significantly reduce the risk of recurrence, stabilize the size of the uterus, reduce the severity of clinical manifestations in the form of pain syndrome and heavy menstruation associated with relapse, thereby improving the reproductive health of women. Conclusions. The use of adjuvant anti-progestogen therapy after conservative myomectomy in women of reproductive age is a very effective method for treating uterine fibroids and can be considered as a therapy of choice in such patients.

Clinical and anamnestic characteristics of patients with adenomyosis, accompanied by pelvic pain syndrome

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (6) ◽  
pp. 77-80
Author(s):  
M R Orazov ◽  
V E Radzinsky ◽  
M B Khamoshina ◽  
A O Dukhin ◽  
L R Toktar ◽  
...  
Keyword(s):  
Pelvic Pain ◽  
Chronic Pelvic Pain Syndrome ◽  
Pain Syndrome ◽  
Reproductive Age ◽  
Pelvic Pain Syndrome ◽  
Common Disease ◽  
Contributing Factors ◽  
High Prevalence ◽  
Inflammatory Processes ◽  
History Of

Pelvic pain syndrome associated with adenomyosis is a common disease in women of reproductive age. Frequency of detection in the population varies from 10 to 53%. The aim - to study the clinical and anamnestic risk factors of pelvic pain, with adenomiose. Materials and methods. The study included 120 (n=120) patients with diffuse adenomyosis with pain and painless form of the disease who underwent examination and treatment in the gynecological Department of the Central clinical hospital №6 of Russian Railways in Moscow. Each patient was provided with an individual card, which was encrypted 171 sign. The studied parameters reflected the passport and anthropometric data, information about education, social status, presence of occupational hazards, complaints, illness. Results. Burdened gynecological and somatic histories, manifested a low health index, a more pronounced hereditary a family history of neoplastic diseases are contributing factors, and high prevalence of postponed surgeries, chronic, long-term ongoing inflammatory processes of the pelvic organs to create a favorable background for the further progression of chronic pelvic pain syndrome in adenomiose.

The Importance of Dermoscopy In Umbilical Tumor

2020 ◽  
Vol 2 (2) ◽  
pp. 01-02
Author(s):  
Patrícia Couto
Keyword(s):  
Pelvic Pain ◽  
Surgical Procedures ◽  
Reproductive Age ◽  
Pelvic Endometriosis ◽  
Women Of Reproductive Age ◽  
Menstrual Flow

The pelvic endometriosis is considered a relatively common, benign, estrogen-dependent disease associated with complaints of pelvic pain and infertility, affecting 6% to 10% of women of reproductive age. The etiopathogenesis of the disease is based on some theories and hypotheses. Classical theories include the hypothesis of migratory pathogenesis by retrograde menstrual flow, the theory of celomic metaplasia, the theory of embryonic rest or even iatrogenic deposition during abdominal surgical procedures

THE NATURE OF REPRODUCTIVE DISORDERS IN WOMEN WITH HYPERANDROGENISM SYNDROMEq

2021 ◽  
Vol 2 (4) ◽  
pp. 13-16
Author(s):  
M. M Asatova ◽  
◽  
S. M. Safoeva
Keyword(s):  
Laboratory Data ◽  
Clinical Manifestations ◽  
Reproductive Age ◽  
Reproductive Disorders ◽  
Menstrual Disorders ◽  
Women Of Reproductive Age ◽  
Perinatal Center ◽  
Androgen Secretion ◽  
The City ◽  
Anovulatory Infertility

PCOS occupies a leading place in the population of women with clinical manifestations of excessive androgen secretion and is detected in 72.1-82% of cases, while among women with anovulatory infertility-in 55-91% of cases (Lizneva D. (2016). The criteria, prevalence and phenotypes of PCOS. Fertil.Steril., 106 (1), 6-15). The article discusses the results of a study conducted based on the City Perinatal Center of Tashkent to study the frequency and nature of reproductive disorders in women with symptoms of hyperandrogenism. The study involved women of reproductive age with various menstrual disorders and infertility. The analysis of anamnestic, subjective and objective, clinical and laboratory data of patients was carried out

scholarly journals Adolescent endometriosis

2017 ◽  
Vol 6 (8) ◽  
pp. 3213
Author(s):  
Meenu P. Nanthakumar ◽  
Sendhil C. Arumugam
Keyword(s):  
Adverse Effects ◽  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Reproductive Age ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
Surgical Options ◽  
Reproductive Age Group

Endometriosis is predominantly a disease of women of reproductive age group. Endometriosis is not uncommon in adolescents. Presentation tends to focus on pain, especially intractable dysmenorrhea and chronic pelvic pain. In around 60% of patients with endometriosis symptoms start in adolscence. Pain unresponsive to treatment is the usual indication for a Laproscopy. The appearance of endometriotic lesions is different from that of adults. Medical and surgical options for treatment are available. Endometriosis may be progressive and adverse effects may go beyond pain and cause infertility.

scholarly journals Prevalence, Wellbeing, and Symptoms of Dysmenorrhea among University Nursing Students in Greece

Diseases ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. 5 ◽  
Author(s):  
Eugenia Vlachou ◽  
Dimitra Anna Owens ◽  
Maria Lavdaniti ◽  
John Kalemikerakis ◽  
Eleni Evagelou ◽  
...  
Keyword(s):  
Nursing Students ◽  
Severe Pain ◽  
Cross Sectional Study ◽  
Academic Functioning ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
High Prevalence ◽  
Severe Intensity ◽  
Inflammatory Drugs

Dysmenorrhea (pain during menstruation) is one of the most common medical conditions among women of reproductive age. Dysmenorrhea has been studied around the world but not yet in Greece. The aim of the present study was to investigate the prevalence, characteristics, and impact of dysmenorrhea on the wellbeing (exercising, and social and academic functioning) among nursing students in Greece. A cross-sectional study of 637 nursing students was conducted by administering a questionnaire at a university in Athens. The prevalence of dysmenorrhea was 89.2% and the rate of severe intensity was 52.5%. Factors that were associated with severe dysmenorrhea were family history (p = 0.02), early menarche (p = 0.05) and menstruation duration (p = 0.05). Women with moderate and severe pain reported using pain relievers (non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol etc., p < 0.0005). Finally, activities affected by severe pain were class attendance (p = 0.01), personal studying (p < 0.0005), exercising (p < 0.0005), and socializing (p < 0.0005). Exam attendance (p = 0.27) and clinical placement attendance (p = 0.48) were not affected by severe dysmenorrhea. Dysmenorrhea has a high prevalence among nursing students and seems to affect important aspects of wellbeing and academic performance when the pain intensity is severe. The present findings lay the foundation for further investigation of dysmenorrhea both in the Greek population and cross-culturally.

Clinical manifestations of neurosyphilis in women of reproductive age

2016 ◽  
Vol 7 (2) ◽  
pp. 57-62
Author(s):  
Maria L Chuhlovina ◽  
Denis V Zaslavsky ◽  
Ekaterina A Bichun
Keyword(s):  
Rating Scale ◽  
Congenital Syphilis ◽  
Clinical Manifestations ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Clinical Dementia Rating ◽  
Clock Drawing Test ◽  
Mattis Dementia Rating Scale ◽  
Moderate Dementia ◽  
Dementia Rating Scale

The research objective is investigation of clinical manifestations of neurosyphilis in women of reproductive age. The diagnoses were based on complaints, anamnestic information, neurological examinations, dermatovenerology consultations, serological blood and liquor tests. All the patients underwent psychometric tests. The following methods were used: mini-mental state examination (MMSE), “Frontal Assessment Battery”, Clinical Dementia Rating scale, Clock drawing test, “Information-Memory-Consideration Concentration” test, Mattis Dementia Rating Scale. Nine patients with early neurosyphilis (between the ages of 18 to 40) and eight patients with late neurosyphilis (between the ages of 28 to 43) were surveyed. Syphilitic meningitis (six cases), meningovascular neurosyphilis (three cases) were found in patients with early neurosyphilis. As for the patients with late neurosyphilis, two of them were diagnosed to have syphilitic meningitis, two patients had meningovascular neurosyphilis, two had progressive paralysis, tabes dorsalis was identified in one patient, one had taboparalysis. Only three patients showed specific skin and mucic manifestations. The patients at all the stages of neurosyphilis demonstrated mild cognitive impairments. Moderate dementia was found in one patient with early meningovascular neurosyphilis and one patient with progressive paralysis. This article considers a clinical case of a female patient with early syphilitic meningitis who had a baby with congenital syphilis.

scholarly journals Bleeding

2020 ◽  
Author(s):  
Kizito Omona
Keyword(s):  
Quality Of Life ◽  
At Risk ◽  
Abdominal Pain ◽  
Sexual Intercourse ◽  
Pelvic Pain ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Abnormal Bleeding ◽  
Monthly Period

Fibroid, also called leiomyomas, is common tumor of the uterus. Usually, women of reproductive age are at risk of getting it. However, majority of these women develop fibroid (s) by the age of 50 years. This condition usually causes painful and unpleasant symptoms such as; heavy bleeding, prolonged periods, inter-menstrual bleeding, abdominal pain and cramps, anemia, pelvic pain and pain during sexual intercourse, among others. Abnormal bleeding, such as bleeding that occurs with fibroids and heavy periods, often lasts more than 10 days per month. This fibroid symptom involves persistent bleeding between cycles, which can severely impact one’s quality of life. Abnormal bleeding, especially in fibroids, can be taken as missing three or more periods in a woman who had been having regular monthly period, or periods that last less than 21 days or more than 35 days apart from each other. Another indication of an abnormal period is bleeding through multiple pads and tampons in a short amount of time.

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