Invivo Activity of Polyherbal Gels Prepared Using Carbopol

2020 ◽  
Vol 10 (3) ◽  
pp. 63-66
Author(s):  
Parasakthi N ◽  
Deepika R ◽  
Sivanathan C ◽  
Abubackkar Sithiq PD ◽  
Venkateshan N
Keyword(s):  
Physiological Stress ◽  
Defense Responses ◽  
The Body ◽  
Peptic Ulcers ◽  
Onset Of Action ◽  
Standard Drug ◽  
Root Extracts ◽  
Carbopol 940 ◽  
Anti Inflammatory ◽  
Rich Countries

Pain and inflammation are the basic defense responses of the body that the result of the injury and any other damage to the body. During the years the concerns were raised towards the inflammation that is caused to the oxidative damage that is resulted in the physiological stress due to oxidation. There are a lot of drugs that are used to treat the condition effectively and the typical examples are NSAID’s and SAID’s which have a noted mechanism to show the anti-inflammatory activity. They have serious problems with the side effects like Gastrointestinal irritation, Gastric pain, Gastric perforations and peptic ulcers. Herbs have been used as better alternatives that are used to treat diseases. The significance of the medicinal plants had been emphasized significantly in tradition rich countries like India and all over the world. The research proof of those herbs for their activities and their traditional claims were proven. Poly Herbal Gels were prepared using the root extracts of the plant Corchorus olitorius. The gels were prepared using the Carbopol 940 and the prepared gels were investigated for their anti-inflammatory property and the gels showed a significantly better activity compared to the plant extract and the standard drug too. The addition of other drugs in to the gels added and advantage to the increase in the activity and faster onset of action as the gel was applied directly in the place of the inflammation.

Antipyretic Activity of the Root Extracts of Xylocarpus

2019 ◽  
Vol 9 (3) ◽  
pp. 35-38
Author(s):  
Ganesh Kumar Y ◽  
Pranitha D ◽  
Phaneendra D ◽  
Madhava Reddy Ch
Keyword(s):  
Mechanisms Of Action ◽  
Prostaglandin Synthesis ◽  
The Body ◽  
Human Race ◽  
Pharmacological Activities ◽  
Standard Drug ◽  
Root Extracts ◽  
Antipyretic Activity ◽  
Inhibition Of Prostaglandin Synthesis ◽  
Elevated Body Temperature

Various types of conditions exist in the body that causes fever and pain. Drugs that are used to treat fever are called antipyretics, and those are usually prescribed to treat elevated body temperature. But those drugs result in many other side effects like ulcers, perforations, bleedings and obstructions, which make their use questionable and limiting. Medicinal plants are used in the treatment of diseases from the starting of the human race and the process; they had been subjected to rigorous investigations and tests to establish a scientific proof and validation of the various pharmacological activities and their respective mechanisms of action in treating the herbs. Considering the anti-inflammatory properties of the plant, Xylocarpus mekongesis was investigated for its antipyretic activity in yeast method and 3doses out of which 00mg/kg body weight showed a better activity compared to the standard drug and other extracts too. The mechanism of action was similar to the paracetamol action that is inhibition of prostaglandin synthesis.

scholarly journals Investigations of the prepared polyherbal ointment for its anti-inflammatory activity

2018 ◽  
Vol 8 (1) ◽  
pp. 1-4
Author(s):  
Purushothaman M ◽  
Soujanya H ◽  
Jagadeeshwari S ◽  
Shiva Kumar K
Keyword(s):  
Physiological Stress ◽  
Scientific Evidence ◽  
Prostaglandin Synthesis ◽  
The Body ◽  
Stress And Strain ◽  
Paw Edema ◽  
Medical Systems ◽  
Standard Drug ◽  
External Agent ◽  
Treatment Alternatives

Inflammation is the defence response of the body to any injury or any other external agent that causes damage to the human body. Over many years there had been a rising concern for the inflammation that is caused due to the physiological stress and strain in the body due to the oxidative free radicals and oxidative damage. Medicinal plants have been used as the best treatment alternatives for the diseases in various medical systems in India and around the world. The scientific proof and validation are not authentic to that desired level. In this regard, herbs have been investigated for their pharmacological properties based on the medicinal claims and folklore claims. They had been worked by numerous amounts of research where the claims had been proven correct and published with scientific evidence. The ointment was prepared using the extracts of the plant Salvia and the activity was attributed to the phytosterols, and by inhibiting the prostaglandin synthesis. The activity was comparable to the standard drug and the extracts and showed better activity. The activity exhibited by the ointment was very rapid and enhanced the healing of the paw edema, which was induced by carrageenan.

Ethanol-induced gastric ulcer in rats and intervention of tert-butylhydroquinone: Involvement of Nrf2/HO-1 signalling pathway

2019 ◽  
Vol 39 (4) ◽  
pp. 547-562 ◽  
Author(s):  
Z Rahman ◽  
DK Dwivedi ◽  
GB Jena
Keyword(s):  
Gastric Ulcer ◽  
Physiological Stress ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Health Concern ◽  
Related Factor ◽  
Gastric Mucosal Lesion ◽  
Nuclear Factor ◽  
Standard Drug ◽  
Anti Inflammatory

Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Ethanol-induced GU in animal model resembles the pathophysiology of human ulcer. The present study was designed to investigate the cytoprotective and anti-inflammatory properties of tert-butylhydroquinone (tBHQ), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator, against gastric mucosal damage induced by acute exposure of ethanol (5 ml/kg). The intervention of tBHQ (25 and 50 mg/kg, per os (po)) and omeprazole (20 mg/kg, po) was done for 10 consecutive days. Omeprazole was chosen as a standard drug because it is prescribed for the treatment of GU. Pretreatment of tBHQ decreased gastric mucosal lesion, ulcer index, apoptotic cells and lipid peroxidation level induced by ethanol. Furthermore, the intervention of tBHQ increased gastric mucosa integrity, pH, reduced glutathione, collagen and mucus-producing goblet cells. Intervention of tBHQ increased the expression of antioxidant markers such as Nrf2, haeme oxygenase-1 and catalase and decreased the expressions of inflammatory markers such as nuclear factor kappa-light-chain-enhancer of activated B cells and cyclooxygenase-2. The cytoprotective potential of tBHQ against gastric mucosal damage might be due to its ability to enhance cellular antioxidants and anti-inflammatory responses.

Comparison of anti-inflammatory activity of various species of lamiaceae

2021 ◽  
Vol 6 (1) ◽  
pp. 10-13
Author(s):  
Deepa N ◽  
Madhivadhani K ◽  
Hari M ◽  
Prakash N ◽  
Lohith S ◽  
...  
Keyword(s):  
Free Radicals ◽  
The Body ◽  
Inflammatory Activity ◽  
Medical Applications ◽  
Preventive Action ◽  
Standard Drug ◽  
Synthetic Drugs ◽  
Nepeta Cataria ◽  
External Agents ◽  
Anti Inflammatory

The process of inflammation is often triggered by the stimulus from outside sources that usally cause harm to human skin and tissues. It is a response of the body that protects itself from external agents but when it is excess and built up in the body it causes some worsening symptoms. Synthetic drugs usually cause side effects and adverse effects. Herbs are normally known to combat inflammations and fight free radicals. The antioxidants present in the herbs causes the preventive action of the oxidation and causes lowering of the inflammation. There were also investigations performed on the plant to prove the above activities. Among all the plants that are available in nature lamiaceae members, plants like Molucella laevis, Nepeta cataria, Vitex agnus, Origanum dictamnus and Mentha piperata were considered as major medicinal plants with a lot of medical applications. 5 members of lamiaceae were selected to study and compare the anti-inflammatory activity and the data suggests all the plants have better activity and out of all the Mentha extract showed a significantly better activity compared to the standard drug.

Evaluation of anti-pyretic activity of Dracaena sanderiana by Brewer’s yeast method

2020 ◽  
Vol 9 (2) ◽  
pp. 32-34
Author(s):  
Pavani C H
Keyword(s):  
Herbal Remedies ◽  
Standard Drug ◽  
Chemical Substances ◽  
Beneficial Effects ◽  
Potential Value ◽  
Plant Effects ◽  
Therapeutic Properties ◽  
Dracaena Sanderiana ◽  
Anti Inflammatory ◽  
Inflammatory Action

These medicinal plants are used to develop a therapy for the disease. To improve the science, investigate the scientific proof and activities validation, therefore the use of various herbal remedies for their pain-relieving and anti-inflammatory action in these current days. includes influence, anti-inflammatory, anti effect, analgesia, effects and some beneficial effects on the GI system. show the potential value of pain relief, cancer prevention and weight loss. According to these plant effects, consider that this present study was mainly based on to investigate and likely to reduce the fever caused by the outdoor and indoor. potential of is evidenced in leave studies. The medicinal plant produces a variety of chemical substances which shows significant therapeutic properties with the standard drug paracetamol.

In-vivo evaluation of lipid lowering ability of Chloris paraguaiensis extracts

2020 ◽  
Vol 7 (2) ◽  
pp. 21-24
Author(s):  
Pavani C H
Keyword(s):  
Medicinal Plants ◽  
Chemical Constituents ◽  
The Body ◽  
Lipid Lowering ◽  
Medical Systems ◽  
In Vivo Evaluation ◽  
Standard Drug ◽  
Anti Oxidant ◽  
And Control

Hyperlipidemia is the immediate results of the excessive fat intake in food. This results in the elevated levels of cholesterol and triglycerides in the blood. This leads to heart conditions like CAD, hypertension, congestive heart failure as risk factors which can be lethal. There are many drugs to treat and control the lipids levels in the body. These drugs are either designed to prevent LDL accumulation and VLDL synthesis. Some drugs also lower the elevated levels of saturated lipids in the body. But many drugs are known to cause side effects and adverse effects; therefore, alternatives to the drugs are the subjects for current investigations. Herbs and medicinal plants are used as treatment sources for many years. They have been used in the Indian medical systems like Ayurveda, Siddha etc. As the application of herbs in the treatment is growing, there is an urgent need for the establishment of Pharmacological reasoning and standardization of the activity of the medicinal plants. Chloris paraguaiensis Steud. is Poyaceae member that is called locally as Uppugaddi. Traditionally it is used to treat Rheumatism, Diabetes, fever and diarrhoea. The chemical constituents are known to have anti-oxidant properties and most of the anti-oxidants have anti-hyperlipidemic activity too. Since the plant has abundant flavonoid and phenol content, the current research focusses on the investigation of the anti-hyperlipidemic activity of the plant Chloris extracts. Extracts of Chloris at 200mg/kg showed a comparably similar anti hyperlipidemia activity to that of the standard drug. The extracts showed a dose based increase in the activity at 100 and 200mg/kg body weight.

Antipyretic activity of the root extracts of Desmodium Gangeticum

2018 ◽  
Vol 8 (2) ◽  
pp. 20-23
Author(s):  
Raja Sheker K ◽  
Naveen B ◽  
Anil kumar A ◽  
Abhilash G
Keyword(s):  
Gastric Ulcers ◽  
Plant Leaves ◽  
Medical Systems ◽  
Human Race ◽  
Standard Drug ◽  
Root Extracts ◽  
Antipyretic Activity ◽  
Scientific Investigations ◽  
And Control ◽  
Effective Drugs

Fevers are considered as the most important parameters to evaluate and diagnose most of the disease conditions like inflammations, wounds and other infections. There are effective drugs that treat and control the fevers out of which NSAID's are most important ones. They cause notable side effects like gastric ulcers, gastric mucosal perforations etc. which make the use of those drugs limited. Herbs are used to treat various diseases, starting from the evolution of the human race. During this, herbs had been introduced to many types of tests and scientific investigations to prove the activities that herbs possess. The diseases that the herbs are used for are notable in the medical systems like Ayurveda and other systems. The need for the validation of the activities of the herbs and medicinal plants is utmost important these days. The extracts of the plant leaves of Desmodium gangeticum were extracted with ethanol and then investigated for the antipyretic activity in yeast induced pyretic method. The extract was tested in two doses 200 and 400mg/kg. This was found significant when compared to the standard drug.

ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF ACETYLSALICYLIC ACID: PHYSIOLOGICAL MECHANISMS

2020 ◽  
Vol 6(72) (1) ◽  
pp. 197-219
Author(s):  
I. V. Cheretaev ◽  
D. R. Khusainov ◽  
E. N. Chuyan ◽  
M. Yu. Ravaeva ◽  
A. N. Gusev ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Physiological Mechanism ◽  
The Body ◽  
Physiological Mechanisms ◽  
Scientific Publications ◽  
Thermal Pain ◽  
Order Of Magnitude ◽  
Anti Inflammatory ◽  
Number Of Publications ◽  
Electrical Stimuli

The purpose of the review is to summarize current literature data and the results of our own research on the analgesic and anti-inflammatory effects of acetylsalicylic acid, as well as the physiological mechanisms underlying them. This acid is the most studied reference representative of salicylates, which is convenient to consider the physiological effects characteristic in general for this group of chemical and medicinal products. Acetylsalicylic acid has analgesic properties against thermal pain and pain caused by electrical stimuli, as well as a pronounced anti-inflammatory effect. The realization of these properties depends on the peculiarities of aspirin metabolism in the body, ion and synaptic mechanisms for controlling the functional state of the cell, neurotransmitter systems of the сentral nervous system, and mechanisms of peripheral and сentral analgesia. Analgesic properties of acetylsalicylic acid founded not only in normal, but also in ultra-small doses. Various physical and especially chemical factors significantly change their effects. This increases the interest in studying the analgesic activity of salicylates and their physiological mechanisms, since such studies can serve as a basis for creating new non-steroidal anti-inflammatory drugs with low toxicity and high safety for patients, and improve the strategy of their practical use. Currently, the most detailed study of the physiological mechanism of analgesic and anti-inflammatory action of aspirin and its main metabolite – salicylic acid. However, it should be note that despite the abundance of existing data obtained in scientific studies of the effects of aspirin and its practical use, there are a number of unexplained aspects of the action of this drug, the mechanism of which has not yet been deciphered. The continuing interest in the effects and mechanisms of action of this drug and in connection with the expansion of its use evidenced by a consistently high number of scientific publications on aspirin in the most famous foreign and domestic publications. At the same time, the number of publications about aspirin is an order of magnitude higher than about any other drug known to humanity.

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