Effect of endurance exercise on attention and depression in Parkinson’s disease patients - A new approach

Aim of the study is to determine the effects of endurance exercise on depression and attention deficiency in people with Parkinson’s disease patients. The methodology of the study is,15 participants with Parkinson's disease were selected both male and female from the neurological rehabilitation centre, Chennai. The purpose and procedure of the study were completely explained to the participants, and informed consent was obtained from all the participants. Depression scale and the digit-symbol task was evaluated before starting the exercise program and participants were randomized into two groups (Group A and Group B). This study compared the effect of endurance exercise to stretch-balance training. The exercise program was given for a duration of 12 weeks. After 12 weeks, Hospital anxiety & depression scale and digit-symbol task were used to check for the progress. The result we determine from the statistical analysis, it has been revealed that depression symptoms decreased with endurance exercise and stretch-balance training but didn't show any significant improvement on attention with endurance exercise while with stretch-balance training it shows minimal improvement. Hence, we conclude that endurance exercise is a viable intervention in PD that can be used as a protective technique against depression symptoms and can also be used for improving attention in people with Parkinson’s.

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Instrumental or Physical-Exercise Rehabilitation of Balance Improves Both Balance and Gait in Parkinson’s Disease

Neural Plasticity ◽

10.1155/2018/5614242 ◽

2018 ◽

Vol 2018 ◽

pp. 1-17 ◽

Cited By ~ 16

Author(s):

Marica Giardini ◽

Antonio Nardone ◽

Marco Godi ◽

Simone Guglielmetti ◽

Ilaria Arcolin ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Balance Control ◽

Balance Training ◽

Exercise Program ◽

Gait Training ◽

Timed Up And Go ◽

Balance Exercises ◽

Marginal Improvement ◽

Balance Rehabilitation

We hypothesised that rehabilitation specifically addressing balance in Parkinson’s disease patients might improve not only balance but locomotion as well. Two balance-training protocols (standing on a moving platform and traditional balance exercises) were assessed by assigning patients to two groups (Platform,n=15, and Exercises,n=17). The platform moved periodically in the anteroposterior, laterolateral, and oblique direction, with and without vision in different trials. Balance exercises were based on the Otago Exercise Program. Both platform and exercise sessions were administered from easy to difficult. Outcome measures were (a) balancing behaviour, assessed by both Index of Stability (IS) on platform and Mini-BESTest, and (b) gait, assessed by both baropodometry and Timed Up and Go (TUG) test. Falls Efficacy Scale-International (FES-I) and Parkinson’s Disease Questionnaire (PDQ-8) were administered. Both groups exhibited better balance control, as assessed both by IS and by Mini-BESTest. Gait speed at baropodometry also improved in both groups, while TUG was less sensitive to improvement. Scores of FES-I and PDQ-8 showed a marginal improvement. A four-week treatment featuring no gait training but focused on challenging balance tasks produces considerable gait enhancement in mildly to moderately affected patients. Walking problems in PD depend on postural instability and are successfully relieved by appropriate balance rehabilitation. This trial is registered with ClinicalTrials.govNCT03314597.

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Relationship between Gait Parameters and Postural Stability in Early and Late Parkinson's Disease and Visual Feedback-Based Balance Training Effects

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2017.051 ◽

2017 ◽

Vol 5 (2) ◽

pp. 207-214 ◽

Cited By ~ 1

Author(s):

Mohieldin M. Ahmed ◽

Douaa M. Mosalem ◽

Aziz K. Alfeeli ◽

Ayyoub B. Baqer ◽

Doaa Youssry Soliman

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Gait Analysis ◽

Postural Stability ◽

Walking Speed ◽

Balance Training ◽

Assessment Tools ◽

Dynamic Posturography ◽

Gait Parameters ◽

Group B

BACKGROUND: Gait disorders or postural instability has been done before. However, lack of reviews has addressed the relation between gait and postural stability in Parkinson's disease (PD).AIM: The aim was to evaluate the relation between gait parameters and postural stability in early and late stages of PD.MATERIALS AND METHODS: The forty-one idiopathic PD patients were divided into two groups into a group (A) considered as early PD and group (B) considered as late ambulant PD. They were evaluated for postural stability by computerised dynamic posturography (CDP) device and gait analysis using an 8 m-camera Vicon 612 data capturing system set.RESULTS: There was a statistically significant improvement of composite equilibrium score, the composite latency of motor response, walking speed and cadence after treatment as compared to before training (p < 0.05) in early PD. However, in the late PD, there was a non-significant change of previous parameters after treatment as compared to before training (p > 0.05).There was a significant correlation between UPDRS motor part score, walking speed and composite equilibrium score after training in early PD (p > 0.05).CONCLUSIONS: Both gait analysis and CDP are important quantitative assessment tools of gait and posture instability.

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Impact of endurance exercise on levodopa associated cortisol release and force increase in patients with Parkinson's disease

Aktuelle Neurologie ◽

10.1055/s-2007-987895 ◽

2007 ◽

Vol 34 (S 2) ◽

Author(s):

T Müller ◽

S Muhlack

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Endurance Exercise ◽

Force Increase ◽

Cortisol Release

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Is Depression or Apathy Playing a Key Role in Predicting Financial Capacity in Parkinson’s Disease with Dementia and Frontotemporal Dementia?

Brain Sciences ◽

10.3390/brainsci11060785 ◽

2021 ◽

Vol 11 (6) ◽

pp. 785

Author(s):

Vaitsa Giannouli ◽

Magda Tsolaki

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Frontotemporal Dementia ◽

Cognitive Abilities ◽

Short Form ◽

Geriatric Depression Scale ◽

Depression Scale ◽

Decisive Role ◽

Financial Capacity ◽

Capacity Performance

(1) Background: Depression and apathy both affect cognitive abilities, such as thinking, concentration and making decisions in young and old individuals. Although apathy is claimed to be a “core” feature of Parkinson’s disease (PD) and frontotemporal dementia (FTD), it may occur in the absence of depression and vice versa. Thus, the aim of this study is to explore whether depression or apathy better predict financial capacity performance in PD and FTD as well as in nondemented participants. (2) Methods: Eighty-eight participants divided into three groups (PD, FTD and non-demented participants) were examined with the Mini-Mental State Examination (MMSE) and the Legal Capacity for Property Law Transactions Assessment Scale (LCPLTAS)—Full and short form. The Geriatric Depression Scale informant version (GDS-15) and the Irritability-Apathy Scale (IAS) we completed by caregivers. (3) Results: The results indicated that both PD and FTD patients’ general cognitive functioning and financial capacity performance is negatively influenced by apathy and not by depression. (4) Conclusions: Differences in financial capacity performance indicate that apathy should not be disregarded in clinical assessments. Further studies on larger PD and FTD populations are necessary in order to investigate the decisive role of mood factors on financial capacity impairment.

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A Comparison of Pain between Parkinson’s Disease and Multiple System Atrophy: A Clinical Cross-Sectional Survey

Pain Research and Management ◽

10.1155/2019/3150306 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6

Author(s):

He-Yang You ◽

Lei Wu ◽

Hai-Ting Yang ◽

Chen Yang ◽

Xiao-Ling Ding

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Multiple System Atrophy ◽

Rating Scale ◽

Depression Scale ◽

Healthy Controls ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Disease Rating ◽

Vas Scores

Background. Pain is frequent in Parkinson’s disease (PD) and Parkinson-plus syndrome. This study aimed to assess the prevalence, characteristics, therapy (especially the effect of dopaminergic therapy), and associated symptoms of pain in Parkinson's disease and multiple system atrophy (MSA) patients. Methods. Seventy-one PD patients, sixty-five MSA patients, and forty age-matched healthy controls were enrolled and evaluated by using the German pain questionnaire and visual analogue scale (VAS). In addition, the influence of pain in PD patients on anxiety, depression, and the quality of life was assessed with the Hospital Anxiety and Depression Scale (HADS) and Parkinson’s Disease Questionnaire (PDQ-39). Results. Compared to that of the healthy controls, the PD and MSA patients had a significantly higher presence of pain (P<0.01, P<0.01). PD patients had a higher presence of pain than MSA patients (P=0.007). No difference in VAS scores was observed between the PD and MSA patients (P=0.148). A total of 21 PD patients (42.85%) with pain and 13 MSA patients (43.33%) with pain received treatment. A total of 13 PD patients with pain and 6 MSA patients with pain had an improved pain intensity after using dopaminergic medication. The differences in the disease duration, Hoehn and Yahr stages, and scores on the Unified Parkinson’s Disease Rating Scale motor score, HAD-D, HAD-A, and PDQ-39 were significant between the PD patients with and without pain. Conclusion. PD and MSA patients are prone to pain with insufficient treatment. Pain interventions should be provided as soon as possible to improve the patient’s life.

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P1.041 Factor structure of the Geriatric Depression Scale in Turkish Parkinson's disease patients

Parkinsonism & Related Disorders ◽

10.1016/s1353-8020(09)70163-4 ◽

2009 ◽

Vol 15 ◽

pp. S39

Author(s):

T. Ertan ◽

S. Ertan ◽

M.E. Tavşanli ◽

G. Kiziltan ◽

S. Ozekmekci

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Factor Structure ◽

Geriatric Depression Scale ◽

Depression Scale ◽

Geriatric Depression

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P2.177 Effects of a multi-mode exercise program on quality of life and overall physical activity level in people with Parkinson's disease

Parkinsonism & Related Disorders ◽

10.1016/s1353-8020(09)70528-0 ◽

2009 ◽

Vol 15 ◽

pp. S138

Author(s):

R. Gobbi ◽

L. Gobbi ◽

M. Oliveira-Ferreira ◽

A. Salles ◽

C. Teixeira-Arroyo ◽

...

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Physical Activity Level ◽

Exercise Program ◽

Activity Level ◽

Multi Mode

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Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients With Parkinson’s Disease

Neurorehabilitation and Neural Repair ◽

10.1177/1545968315600272 ◽

2015 ◽

Vol 30 (5) ◽

pp. 411-418 ◽

Cited By ~ 26

Author(s):

Cecilia Fontanesi ◽

Svetlana Kvint ◽

Giuseppe Frazzitta ◽

Rossana Bera ◽

Davide Ferrazzoli ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Motor Function ◽

Rating Scale ◽

Cortical Plasticity ◽

Day Treatment ◽

Human Study ◽

Exercise Program ◽

Peripheral Lymphocytes ◽

Intensive Rehabilitation

Background. In a combined animal and human study, we have previously found that a 5-day treatment that enhances cortical plasticity also facilitates brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signaling and increases activated TrkB and N-methyl-d-aspartate receptor (NMDAR) association in both the cortex and the peripheral lymphocytes. Patients with Parkinson’s disease (PD), in general, show decreased cortical plasticity, as demonstrated by electrophysiological and behavioral studies. Here, we test the hypothesis that an exercise program that improves motor function and seems to slow down symptom progression can enhance BDNF-TrkB signaling in lymphocytes. Methods. A total of 16 patients with PD underwent a 4-week multidisciplinary intensive rehabilitation treatment (MIRT), which included aerobic training and physical and occupational therapy. Blood was collected before and after 2 and 4 weeks of MIRT. Lymphocytes were isolated to examine BDNF-TrkB signaling induced by incubation with recombinant human BDNF. TrkB signaling complexes, extracellular-signal-regulated kinase-2 and protein-kinase-B were immunoprecipitated; the content of immunocomplexes was determined by Western blotting. Results. After MIRT, all patients showed improvement in motor function. TrkB interaction with NMDAR and BDNF-TrkB signaling increased in peripheral lymphocytes at receptor, intracellular mediator, and downstream levels. The decrements in Unified Parkinson’s Disease Rating Scale II (UPDRSII) and total scores were significantly correlated with the increases in TrkB signaling at receptor, intracellular mediator, and NMDAR interaction levels. Conclusions. The significant correlation between reduced UPDRS scores and the changes in lymphocyte activity suggest that enhanced BDNF-TrkB signaling in lymphocyte and reduced severity of PD symptoms may be related.

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