To study the effect of taurine on the effects of vital bones and regulate the level of glucose in type II diabetes

Taurine is sulfur containing semi-essential amino acid that has important roles in many biological processes, but its effect on glucose homeostasis, weight, growth and bone mineralization weren’t well defined. Objectives: the evaluation of oral Taurine effects has used for 3 months on bone mineralization biomarker, glycemic control and body weight in type ll diabetic patients. Methods: the interventional double-blind placebo-controlled study in which 80 patients with type 2 diabetes mellitus (age range 45-55) assigned in either control (n=40), or study group the (n=40) group. The last group has received a 1000mg capsule of Taurine once a day for three months. Parameters measured were serum calcium, 25(OH) vitamin D and osteocalcin, NTX-1 HbA1C% with fasting blood glucose before and after 3 months. Results: taurine led to significant (p<0.05) rise in osteocalcin, significant lowering in body weight, BMI and there were no significant changes in serum calcium, NTX-1, Vitamin D, HbA1C and fasting blood glucose, all as compared with the control value. Conclusions: the 3 months of oral Taurine are used in type II diabetic patients may modulate bone mineralization represented by elevation of osteocalcin and reduction of body weight, but has no significant effect on glycemic control and did not reduce HbA1C%.

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Utilizing Technology-Enabled Intervention to Improve Blood Glucose Self-Management Outcome in Type 2 Diabetic Patients Initiated on Insulin Therapy: A Retrospective Real-World Study

International Journal of Endocrinology ◽

10.1155/2020/7249782 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Jian Lin ◽

Xia Li ◽

Shan Jiang ◽

Xiao Ma ◽

Yuxin Yang ◽

...

Keyword(s):

Blood Glucose ◽

Glycemic Control ◽

Insulin Therapy ◽

Fasting Blood Glucose ◽

Blood Glucose Control ◽

Diabetic Patients ◽

Premixed Insulin ◽

Type 2 Diabetic Patients ◽

Self Monitoring

Background. The aim of this study was to assess the benefits of a mobile-enabled app through Lilly Connected Care Program (LCCP) in achieving blood glucose control and adhering to self-monitoring of blood glucose in patients with type 2 diabetes mellitus (T2DM). Methods. This retrospective study included T2DM patients who were initiated on insulin therapy (mostly premixed insulin) after failure to respond to oral antidiabetic drugs. Patients were provided with glucometers enabled with synchronous data transmission to healthcare providers and family members. The primary objective was to assess the benefits of LCCP based on changes in fasting blood glucose (FBG) and postprandial glucose (PPG) levels from baseline to 12 weeks. Paired t-test was used to assess the change in blood glucose (BG) from baseline to week 12. Results. In total, 14,085 T2DM patients were recruited. Compared with baseline, significant reductions in FBG and PPG were evident at week 12 (FBG: -0.39 mmol/L; PPG: −0.79 mmol/L; both P < 0.001 ). Furthermore, at week 12, the proportion of patients attaining a target glucose level of FBG <7.0 mmol/L and PPG <10.0 mmol/L was 25.37% and 59.68%, respectively, with a statistically significant increase compared with that at baseline (6.74% and 45.59%, respectively, both P < 0.001 ). The frequent monitoring of patients could gain a higher target achievement of FBG (28.1% vs 24.2%) and PPG (64.4% vs 55.1%) than the occasional monitoring patients. Additionally, the incidence of hypoglycemia gradually decreased and was significantly lower than the baseline level. Conclusions. In T2DM patients with poor glycemic control, the application of mobile enabled intervention (LCCP) along with insulin significantly reduced the hypoglycemia while improving glycemic control during period of naïve initiating insulin therapy. Additionally, the high frequency of BG self-monitoring was associated with better glycemic control.

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Egg consumption may improve factors associated with glycemic control and insulin sensitivity in adults with pre- and type II diabetes

Food & Function ◽

10.1039/c8fo00194d ◽

2018 ◽

Vol 9 (8) ◽

pp. 4469-4479 ◽

Cited By ~ 8

Author(s):

Shirin Pourafshar ◽

Neda S. Akhavan ◽

Kelli S. George ◽

Elizabeth M. Foley ◽

Sarah A. Johnson ◽

...

Keyword(s):

Blood Glucose ◽

Insulin Sensitivity ◽

Glycemic Control ◽

Type Ii Diabetes ◽

Fasting Blood Glucose ◽

Apolipoprotein A1 ◽

Type Ii ◽

Daily Consumption ◽

Factors Associated ◽

Egg Consumption

Daily consumption of one large egg for 12 weeks improves fasting blood glucose, ATP-binding cassette protein family A1, and apolipoprotein A1 in overweight or obese individuals with pre- and type II diabetes.

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The Effect of Biochanin A as PPAR γ agonist on LDL Particles Diameter and Type 2 Diabetic Dyslipidemia

International Journal of Medical Laboratory ◽

10.18502/ijml.v6i2.1028 ◽

2019 ◽

Author(s):

Darya Ghadimi ◽

Mohammad Taghi Taghi Goodarzi ◽

Mahdi Bahmani ◽

Zohre Khajehahmadi

Keyword(s):

Diabetes Mellitus ◽

Body Weight ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Male Rats ◽

Biochanin A ◽

Diabetic Patients ◽

Low Density ◽

Diabetic Dyslipidemia ◽

Ldl Particles

Background and Aims: Small dense low-density lipoproteins (sd-LDL) particles are smaller and heavier than typical LDL ones. They can penetrate into the endothelium of coronary arteries more easily because of their small size. Diabetes mellitus is accompanied by dyslipidemia such as increasing concentration of plasma very low density lipoprotein and sd-LDL. Peroxisome proliferator activated receptor γ (PPARγ ) can decrease the level of sd-LDL in plasma. Biochanin A (BCA), a natural compound, is a PPARγ agonist. The present study was designed to investigate the effect of BCA on sd-LDL-Clolesterol level in diabetic animals. Materials and Methods: Adult male rats (Wistar strain) were used as the animal models in this study. Animals were made diabetic by single intraperitoneal injection of Streptozotocin- Nicotinamide and then treated by 1 and 5 mg/kg of BCA for 28 days. Body weight and fasting blood glucose were also tested before and at the end of treatment. Furthermore, the size of LDL particles were measured by nondenaturing polyacrylamide gradient gel electrophoresis assay. Results: Results of the present study indicated that BCA administration at dose of 5mg/kg decreased fasting blood glucose level and increased body weight and diameter of LDL particles in diabetic animals significantly. Conclusions: BCA seems to be an appropriate agent in diabetes mellitus, because it improves the diabetic dyslipidemia, which is the most important complication in diabetic patients.

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Frequency of impaired fasting glucose in first degree relatives of Type-II diabetic patients and its association with Body Mass Index

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.3.57 ◽

2020 ◽

Vol 36 (3) ◽

Author(s):

Alia Ali Muhammed ◽

Azeem Taj ◽

Muhammed Uthman Ahmed ◽

Elsa Tabrez

Keyword(s):

Body Mass Index ◽

Blood Glucose ◽

Impaired Fasting Glucose ◽

Type Ii Diabetes ◽

Fasting Glucose ◽

Fasting Blood Glucose ◽

Diabetic Patients ◽

Type Ii ◽

Glucose Levels ◽

First Degree Relatives

Objectives: To determine the frequency of impaired fasting glucose in first degree relatives of people with Type-II diabetes and its association with BMI. Methods: This cross-sectional study was conducted in Diabetic clinic of Shaikh Zayed Hospital, Lahore from July to December 2017. Individuals aged ≥35 years, first degree relatives of people with Type-II diabetes, were selected and their fasting blood glucose levels were checked twice a week apart. Study participants were divided into 3 groups. Group-I were those with normal fasting blood glucose (FBS: <100mg/dl), Group-II were those with impaired fasting glucose (100-125mg/dl), considered as high risk and Group-III included those who turned out to be having frank diabetes (FBS: ≥126mg/dl). Exclusion criteria were known diabetes and pregnancy. Proportions of impaired fasting glucose levels versus BMI were compared using Chi-square test. Significance was considered at P <0.001. Results: A total of hundred subjects were included in the study with the mean age of 44.27 years. Sixty percent participants had normal FBS, 31% showed impaired FBS and 09% had frank diabetes (P <0.001). Significant association was found between impaired fasting glucose and BMI, as with increasing BMI the frequency of impaired fasting glucose increases. Conclusion: First-degree relatives of people with Type-II diabetes showed higher frequency of impaired fasting glucose and obesity was an important risk factor. doi: https://doi.org/10.12669/pjms.36.3.57 How to cite this:Ali A, Taj A, Ahmed MU, Tabrez E. Frequency of impaired fasting glucose in first degree relatives of Type-II diabetic patients and its association with Body Mass Index. Pak J Med Sci. 2020;36(3):407-411. doi: https://doi.org/10.12669/pjms.36.3.57 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The Relation between Diabetes-Related Distress and Glycemic Control

QJM ◽

10.1093/qjmed/hcaa052.036 ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

M S Hamed ◽

N A Ibrahim ◽

H M Ali ◽

C G Kheir

Keyword(s):

Blood Glucose ◽

Glycemic Control ◽

Significant Relationship ◽

Positive Relationship ◽

Fasting Blood Glucose ◽

Diabetes Distress ◽

Diabetic Patients ◽

Significant Relation ◽

Emotional Burden ◽

Significant Positive Relationship

Abstract Background Diabetes Distress is the understandable sense of burden or defeat that may occasionally punctuate the diabetic patient life. Also, Diabetes distress (DD) refers to the unique, often hidden emotional burdens and worries that are part of the spectrum of patient experience when man-aging a severe demanding chronic disease like diabetes. Objectives is to assess the relationship between Diabetes-related distress (using a Diabetes Distress Screening Scale) and the glycemic control (using A1C) and inflammation (using hs-CRP) in diabetic patients. Patients and Methods This study is a cross sectional study which had been carried out in outpatient clinic of endocrinology department of El Agouza Police Hospital during the period between June 2017 to June 2018.The study was done on 350 Type2 Diabetic patients.BMI,Wist/Hip Ratio, Fasting blood glucose,Post prandial blood glucose,HbA1c,hs-CRP,Creatinin,BUN,SGPT and SGPT were done to the patients, also Diabetes Distress Screening Scale Quastionnaire was completed by the patients. Results In this study we found that there is a highly significant positive relationship between HbA1c and both Fasting Blood Glucose and Post Prandial Blood Glucose. Also,there was a highly significant positive relationship between CRP and Fasting Blood Glucose while there was a non significant relationship between CRP and Post Prandial Blood Glucose.Fasting blood glucose and Post Prandial Blood Glucose showed a highly significant positive relationship with Total DDS score, Emotional burden and Physician realted distress, and showed non significant relationship with Regimen related distress and interpersonal distress.As regard the relation between HbA1c and Total DDS score, there was a highly significant positive relationship between them and also highly significant positive relationship between HbA1c and Emotional burden and physician related distress, but there was non significant relation between HbA1c and Regimen related distress and interpersonal distress. There was highly significant positive relationship between CRP and Total DDS score and also emotional burden, and there was significant positive relationship between CRP and Regimen related distress, and non significant relation between CRP and physician related distress and interpersonal distress. Conclusion In this study 350 type 2 diabetic patients were included. 55 diabetic patients show moderate distress with a highly significant relationship with the glycemic control (HbA1c) and significant relationship with CRP. In this age and sex were non significant factors while duration of diabetes, BMI and Wist-hip ratio show significant relation with HbA1c which reflect the glycemic control.

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The effect of glycemic control on CEA, CA 19-9, amylase and lipase levels

Open Medicine ◽

10.1515/med-2015-0002 ◽

2014 ◽

Vol 10 (1) ◽

Cited By ~ 1

Author(s):

Naim Ata ◽

Kürşat Dal ◽

Metin Kucukazman ◽

Abdullah Ö. Yeniova ◽

Serdar Karakaya ◽

...

Keyword(s):

Blood Glucose ◽

Glycemic Control ◽

Pancreas Cancer ◽

Fasting Blood Glucose ◽

Exocrine Function ◽

Control Group ◽

Diabetic Patients ◽

Short Period ◽

Before And After ◽

Pancreatic Exocrine

AbstractBackground: Diabetes mellitus is closely related to pancreas cancer. In this study we aimed to investigate the effect of hyperglycemia on tumor and inflammation markers, as well as pancreatic exocrine functions.Methods: A total of 98 consecutive diabetic patients with poor glycemic control, and 50 healthy controls were included in the study. We measured hsCRP, erythrocyte sedimentation rate (ESR), CA19-9, CEA, amylase and lipase in addition to routine biochemistry tests, before and after euglycemia was achieved.Results: Fasting blood glucose, HbA1c, CA19-9,CEA, hsCRP, ESR, triglycerides, AST, ALT, GGT, ALP, total cholesterol and LDL-C levels decreased significantly with the regulation of glycemic control. Amylase and lipase levels increased with the regulation of glycemic control. After glycemic control, CA19-9 and CEA levels were still higher, whereas amylase and lipase levels were still lower in the diabetic group compared with the control group. Basal HbA1c showed significant correlation with CA19-9, CEA, amylaseand lipase.Conclusions: We propose to repeat observations of tumor markers after hyperglycemia is resolved, in order to avoid unnecessary invasive tests. Our data also suggest that pancreatic exocrine function was improved with lowering blood glucose in a short period of time.

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The blood glucose lowering effect of Malaysian Tinospora crispa in rats

Jurnal Natural ◽

10.24815/jn.v20i1.15907 ◽

2020 ◽

Vol 20 (1) ◽

pp. 20-23

Author(s):

SARAH FIRDAUSA ◽

MAUNG MAUNG CHO ◽

KHIN MAUNG MAUNG ◽

NILAR AUNG ◽

NORSIDAH KUZAIFAH ◽

...

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Diabetic Rats ◽

The Body ◽

Hypoglycemic Agents ◽

Diabetic Patients ◽

Chronic Hyperglycemia ◽

Reduce Blood Glucose ◽

Maintain Body Weight

Diabetes is defined as a chronic hyperglycemia which should be countered by the effective, safe and readily available hypoglycemic agents. Herbal is among alternatives that has been used by society for years but lacks of documented evidences. Tinospora crispa (TC) is enriched by phytochemicals which potentially reduce blood glucose thus is useful for diabetic patients. This study aimed to investigate the potency of TC inreducing blood sugar and body weight. It involved 30 healthy rats divided into 5 groups namely: normal control, normal fed with TC extract, diabetic, TC-treated diabetic (dose 500 mg/kg w/w), and vitamin E-traeted diabetic rats (60 IU). The body weight and fasting blood glucose were measured each week for 1 month. The administration of TC extract 500 mg/kg (w/w) helps to maintain body weight in diabetic rats and reduce the fasting blood glucose. TC is highly potent as hypoglycemic agents therefore needed to be explored further.

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Medication Adherence to Oral Hypoglycemic Agents Among Type II Diabetic Patients and Their Clinical Outcomes with Special Reference to Fasting Blood Glucose and Glycosylated Hemoglobin Levels

Kathmandu University Medical Journal ◽

10.3126/kumj.v11i3.12510 ◽

2015 ◽

Vol 11 (3) ◽

pp. 226-232 ◽

Cited By ~ 3

Author(s):

SS Shrestha ◽

R Shakya ◽

BM Karmacharya ◽

P Thapa

Keyword(s):

Blood Glucose ◽

Glycemic Control ◽

Special Reference ◽

Clinical Outcomes ◽

Glycosylated Hemoglobin ◽

Fasting Blood Glucose ◽

Hypoglycemic Agents ◽

Diabetic Patients ◽

Age Group ◽

Oral Hypoglycemic Agents

Background Oral hypoglycemic agents (OHAs) are the major treatment for people with type 2 diabetes mellitus (DM2). However, non-adherence to OHAs remains as one of the main reasons for poor glycemic control. Objectives To assess the adherence pattern to OHAs and clinical outcomes with special reference to fasting blood glucose (FBG) level and glycosylated hemoglobin (HbA1c) levels. Methods Informed consent was obtained from patients fulfilling the criteria and from the patient party in case of incapacitated patients. Information was obtained by interviewing them and filled in the appropriate questionnaire. All the medical information of the patients was obtained from the medical case records and laboratory reports. Results OHAs had been discontinued by 25% of patients. Overall 38% had ever discontinued and/ or often missed OHAs. Intentional discontinuation of OHAs attributed for 72% of the patients, followed by forgetfulness (42.9%), carelessness (30.6%), and hypoglycemia, (24%). There were 50.50% patients who had uncontrolled FBG (>130 mg/dl) level and 39% had uncontrolled HbA1c (≥ 7%) level. Taking reference age group 51-60 years, control of FBG level was found to be statistically associated with the decreasing age group (p = 0.006, OR = 4.8) as well as increasing age group (p = 0.008, OR = 4.034). There was significant association between controlled HbA1c level and patients’ knowledge about the precautions to be taken while using OHAs (p = 0.044, OR = 4). However, there was no significant association between glycemic control and OHAs adherence. Conclusion Majority of the patients who had missed OHAs attributed it to forgetfulness. Hypoglycemia may also be one of the contributing factors for poor adherence to OHAs. However no association was found between adherence and various other factors like age groups, treatment complexity, health literacy and social or family support. DOI: http://dx.doi.org/10.3126/kumj.v11i3.12508 Kathmandu Univ Med J 2013; 43(3):226-232

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Anti-dyslipidemic properties of green gold nanoparticle: improvement in oxidative antioxidative balance and associated atherogenicity and insulin resistance

Clinical Phytoscience ◽

10.1186/s40816-020-00224-6 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Reyhane Javanshir ◽

Moones Honarmand ◽

Mehran Hosseini ◽

Mina Hemmati

Keyword(s):

Vitamin D ◽

Body Weight ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Thiol Group ◽

Diabetic Rats ◽

Antidiabetic Activity ◽

Stress Markers ◽

Total Antioxidant

Abstract Background Nowadays, the green synthesis of AuNPs in the presence of plants has been attracted a lot of attention. Herein, in vivo antidiabetic activity of AuNPs synthesized using Ziziphus jujuba in streptozotocin-induced diabetic rats has been evaluated. Methods Formation of AuNPs was confirmed by UV-vis, HR-TEM and XRD. Different doses of jujube gold nanoparticles (0.5 and 1 mg/kg) were used to treat streptozotocin-induced diabetic rats in different groups. At the end of experiment (21 days), serum level of fasting blood glucose (FBG), insulin, Body weight, HOMA-IR, vitamin D, ALT, AST, urea, creatinine, lipid profile, prooxidant-antioxidant balance (PAB) and liver oxidative stress markers were determined. Results results showed a significant decrease in the level of liver MDA (P = 0.001), fasting blood glucose (P = 0.0001), HOMA-IR (P = 0.0001), ALT (P = 0.0001), AST (P = 0.0001), urea (P = 0.02), Triglycerides (P = 0.002), Total cholesterol (P = 0.0001), PAB (P = 0.0001) and AIP (P = 0.001) and in contrast a significant increase total antioxidant capacity (P = 0.02), insulin (P = 0.03), Body weight (P = 0.0001) and vitamin D (P = 0.0001) in the AuNPs-treated diabetic group compared to the diabetic rats. No significant change was observed in the total thiol group (P = 0.18), LDL-C (P = 0.43), creatinine (P = 0.09) and HDL-C (P = 0.71) level in diabetic rats treated with AuNPs compared to diabetic rats. Conclusion The results of this study proves that green AuNPs exerted promising antidiabetic and anti-oxidant properties.

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The Potential Anti-Obesity, Anti-Diabetic and Anti-Oxidant Effects of Vitamin a in Streptozotocin-Induced Diabetic Mice

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i631189 ◽

2021 ◽

pp. 50-64

Author(s):

Yosra Alhindi ◽

Anwar Bafaraj ◽

Abeer Barasain ◽

Massarah Hadidi ◽

Norah Bajandooh ◽

...

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Vitamin A ◽

Lipid Profile ◽

Fat Mass ◽

Serum Insulin ◽

Fasting Blood Glucose ◽

Diabetic Patients ◽

Diabetic Mice ◽

Water Control

Background: Evidence suggests that there is a link between diabetes mellitus and Vitamin A. Moreover, it has been reported that diabetes induces oxidative stress. Lately, a wide attention has been developed to the protective biochemical function of natural antioxidants contained vitamins, which can reduce the oxidative damage caused by free radical species. Objective: To investigate the anti-obesity, anti-diabetic and anti-oxidative effects of vitamin A in streptozotocin (STZ)-induced diabetic mice. Methods: Male mice were randomly divided into three groups: Control- nondiabetic, received a normal diet and water; Control-diabetic, received STZ 45mg/kg once intraperitoneally; and Treated-diabetic, received both STZ as before plus Vitamin A (4-IU/day) orally daily for 16 weeks. Food intake, body weight, fat mass, fasting blood glucose, serum insulin, and lipid profile were estimated. Also, superoxide dismutase (SOD), glutathione peroxidase (GPO), catalase (CAT), and malonaldehyde (MDA) were measured. Results: Treated diabetic mice with Vitamin A showed a significant improvement in their body weight, fat mass, lipid profile as well as SOD, GPO and CAT compared to Control-diabetic mice. However, Vitamin A caused no significant change on fasting blood glucose and insulin levels. Furthermore, plasma level of MDA was significantly elevated in diabetic mice compared to normal mice. Diabetic mice treated with vitamin A had a significantly reduced level of MDA, suggesting that vitamin A might have a vital role in the protection of tissues from damage by free radicals. Conclusion: Supplementation with vitamin A may be a useful treatment strategy for diabetic patients to reduce/prevent the pathological complications of diabetes.

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