The Relation between Diabetes-Related Distress and Glycemic Control

Abstract Background Diabetes Distress is the understandable sense of burden or defeat that may occasionally punctuate the diabetic patient life. Also, Diabetes distress (DD) refers to the unique, often hidden emotional burdens and worries that are part of the spectrum of patient experience when man-aging a severe demanding chronic disease like diabetes. Objectives is to assess the relationship between Diabetes-related distress (using a Diabetes Distress Screening Scale) and the glycemic control (using A1C) and inflammation (using hs-CRP) in diabetic patients. Patients and Methods This study is a cross sectional study which had been carried out in outpatient clinic of endocrinology department of El Agouza Police Hospital during the period between June 2017 to June 2018.The study was done on 350 Type2 Diabetic patients.BMI,Wist/Hip Ratio, Fasting blood glucose,Post prandial blood glucose,HbA1c,hs-CRP,Creatinin,BUN,SGPT and SGPT were done to the patients, also Diabetes Distress Screening Scale Quastionnaire was completed by the patients. Results In this study we found that there is a highly significant positive relationship between HbA1c and both Fasting Blood Glucose and Post Prandial Blood Glucose. Also,there was a highly significant positive relationship between CRP and Fasting Blood Glucose while there was a non significant relationship between CRP and Post Prandial Blood Glucose.Fasting blood glucose and Post Prandial Blood Glucose showed a highly significant positive relationship with Total DDS score, Emotional burden and Physician realted distress, and showed non significant relationship with Regimen related distress and interpersonal distress.As regard the relation between HbA1c and Total DDS score, there was a highly significant positive relationship between them and also highly significant positive relationship between HbA1c and Emotional burden and physician related distress, but there was non significant relation between HbA1c and Regimen related distress and interpersonal distress. There was highly significant positive relationship between CRP and Total DDS score and also emotional burden, and there was significant positive relationship between CRP and Regimen related distress, and non significant relation between CRP and physician related distress and interpersonal distress. Conclusion In this study 350 type 2 diabetic patients were included. 55 diabetic patients show moderate distress with a highly significant relationship with the glycemic control (HbA1c) and significant relationship with CRP. In this age and sex were non significant factors while duration of diabetes, BMI and Wist-hip ratio show significant relation with HbA1c which reflect the glycemic control.

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Utilizing Technology-Enabled Intervention to Improve Blood Glucose Self-Management Outcome in Type 2 Diabetic Patients Initiated on Insulin Therapy: A Retrospective Real-World Study

International Journal of Endocrinology ◽

10.1155/2020/7249782 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Jian Lin ◽

Xia Li ◽

Shan Jiang ◽

Xiao Ma ◽

Yuxin Yang ◽

...

Keyword(s):

Blood Glucose ◽

Glycemic Control ◽

Insulin Therapy ◽

Fasting Blood Glucose ◽

Blood Glucose Control ◽

Diabetic Patients ◽

Premixed Insulin ◽

Type 2 Diabetic Patients ◽

Self Monitoring

Background. The aim of this study was to assess the benefits of a mobile-enabled app through Lilly Connected Care Program (LCCP) in achieving blood glucose control and adhering to self-monitoring of blood glucose in patients with type 2 diabetes mellitus (T2DM). Methods. This retrospective study included T2DM patients who were initiated on insulin therapy (mostly premixed insulin) after failure to respond to oral antidiabetic drugs. Patients were provided with glucometers enabled with synchronous data transmission to healthcare providers and family members. The primary objective was to assess the benefits of LCCP based on changes in fasting blood glucose (FBG) and postprandial glucose (PPG) levels from baseline to 12 weeks. Paired t-test was used to assess the change in blood glucose (BG) from baseline to week 12. Results. In total, 14,085 T2DM patients were recruited. Compared with baseline, significant reductions in FBG and PPG were evident at week 12 (FBG: -0.39 mmol/L; PPG: −0.79 mmol/L; both P < 0.001 ). Furthermore, at week 12, the proportion of patients attaining a target glucose level of FBG <7.0 mmol/L and PPG <10.0 mmol/L was 25.37% and 59.68%, respectively, with a statistically significant increase compared with that at baseline (6.74% and 45.59%, respectively, both P < 0.001 ). The frequent monitoring of patients could gain a higher target achievement of FBG (28.1% vs 24.2%) and PPG (64.4% vs 55.1%) than the occasional monitoring patients. Additionally, the incidence of hypoglycemia gradually decreased and was significantly lower than the baseline level. Conclusions. In T2DM patients with poor glycemic control, the application of mobile enabled intervention (LCCP) along with insulin significantly reduced the hypoglycemia while improving glycemic control during period of naïve initiating insulin therapy. Additionally, the high frequency of BG self-monitoring was associated with better glycemic control.

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The effect of glycemic control on CEA, CA 19-9, amylase and lipase levels

Open Medicine ◽

10.1515/med-2015-0002 ◽

2014 ◽

Vol 10 (1) ◽

Cited By ~ 1

Author(s):

Naim Ata ◽

Kürşat Dal ◽

Metin Kucukazman ◽

Abdullah Ö. Yeniova ◽

Serdar Karakaya ◽

...

Keyword(s):

Blood Glucose ◽

Glycemic Control ◽

Pancreas Cancer ◽

Fasting Blood Glucose ◽

Exocrine Function ◽

Control Group ◽

Diabetic Patients ◽

Short Period ◽

Before And After ◽

Pancreatic Exocrine

AbstractBackground: Diabetes mellitus is closely related to pancreas cancer. In this study we aimed to investigate the effect of hyperglycemia on tumor and inflammation markers, as well as pancreatic exocrine functions.Methods: A total of 98 consecutive diabetic patients with poor glycemic control, and 50 healthy controls were included in the study. We measured hsCRP, erythrocyte sedimentation rate (ESR), CA19-9, CEA, amylase and lipase in addition to routine biochemistry tests, before and after euglycemia was achieved.Results: Fasting blood glucose, HbA1c, CA19-9,CEA, hsCRP, ESR, triglycerides, AST, ALT, GGT, ALP, total cholesterol and LDL-C levels decreased significantly with the regulation of glycemic control. Amylase and lipase levels increased with the regulation of glycemic control. After glycemic control, CA19-9 and CEA levels were still higher, whereas amylase and lipase levels were still lower in the diabetic group compared with the control group. Basal HbA1c showed significant correlation with CA19-9, CEA, amylaseand lipase.Conclusions: We propose to repeat observations of tumor markers after hyperglycemia is resolved, in order to avoid unnecessary invasive tests. Our data also suggest that pancreatic exocrine function was improved with lowering blood glucose in a short period of time.

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Medication Adherence to Oral Hypoglycemic Agents Among Type II Diabetic Patients and Their Clinical Outcomes with Special Reference to Fasting Blood Glucose and Glycosylated Hemoglobin Levels

Kathmandu University Medical Journal ◽

10.3126/kumj.v11i3.12510 ◽

2015 ◽

Vol 11 (3) ◽

pp. 226-232 ◽

Cited By ~ 3

Author(s):

SS Shrestha ◽

R Shakya ◽

BM Karmacharya ◽

P Thapa

Keyword(s):

Blood Glucose ◽

Glycemic Control ◽

Special Reference ◽

Clinical Outcomes ◽

Glycosylated Hemoglobin ◽

Fasting Blood Glucose ◽

Hypoglycemic Agents ◽

Diabetic Patients ◽

Age Group ◽

Oral Hypoglycemic Agents

Background Oral hypoglycemic agents (OHAs) are the major treatment for people with type 2 diabetes mellitus (DM2). However, non-adherence to OHAs remains as one of the main reasons for poor glycemic control. Objectives To assess the adherence pattern to OHAs and clinical outcomes with special reference to fasting blood glucose (FBG) level and glycosylated hemoglobin (HbA1c) levels. Methods Informed consent was obtained from patients fulfilling the criteria and from the patient party in case of incapacitated patients. Information was obtained by interviewing them and filled in the appropriate questionnaire. All the medical information of the patients was obtained from the medical case records and laboratory reports. Results OHAs had been discontinued by 25% of patients. Overall 38% had ever discontinued and/ or often missed OHAs. Intentional discontinuation of OHAs attributed for 72% of the patients, followed by forgetfulness (42.9%), carelessness (30.6%), and hypoglycemia, (24%). There were 50.50% patients who had uncontrolled FBG (>130 mg/dl) level and 39% had uncontrolled HbA1c (≥ 7%) level. Taking reference age group 51-60 years, control of FBG level was found to be statistically associated with the decreasing age group (p = 0.006, OR = 4.8) as well as increasing age group (p = 0.008, OR = 4.034). There was significant association between controlled HbA1c level and patients’ knowledge about the precautions to be taken while using OHAs (p = 0.044, OR = 4). However, there was no significant association between glycemic control and OHAs adherence. Conclusion Majority of the patients who had missed OHAs attributed it to forgetfulness. Hypoglycemia may also be one of the contributing factors for poor adherence to OHAs. However no association was found between adherence and various other factors like age groups, treatment complexity, health literacy and social or family support. DOI: http://dx.doi.org/10.3126/kumj.v11i3.12508 Kathmandu Univ Med J 2013; 43(3):226-232

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To study the effect of taurine on the effects of vital bones and regulate the level of glucose in type II diabetes

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v10i3.1508 ◽

2019 ◽

Vol 10 (3) ◽

pp. 2545-2551 ◽

Cited By ~ 2

Author(s):

Falah Hassan Shari ◽

Hiba Dawood ◽

Jubran K. Hassan ◽

Qais A. ALJazeari ◽

Mazin A.A. Najm ◽

...

Keyword(s):

Vitamin D ◽

Body Weight ◽

Blood Glucose ◽

Glycemic Control ◽

Serum Calcium ◽

Bone Mineralization ◽

Fasting Blood Glucose ◽

Controlled Study ◽

Diabetic Patients ◽

Type Ii

Taurine is sulfur containing semi-essential amino acid that has important roles in many biological processes, but its effect on glucose homeostasis, weight, growth and bone mineralization weren’t well defined. Objectives: the evaluation of oral Taurine effects has used for 3 months on bone mineralization biomarker, glycemic control and body weight in type ll diabetic patients. Methods: the interventional double-blind placebo-controlled study in which 80 patients with type 2 diabetes mellitus (age range 45-55) assigned in either control (n=40), or study group the (n=40) group. The last group has received a 1000mg capsule of Taurine once a day for three months. Parameters measured were serum calcium, 25(OH) vitamin D and osteocalcin, NTX-1 HbA1C% with fasting blood glucose before and after 3 months. Results: taurine led to significant (p<0.05) rise in osteocalcin, significant lowering in body weight, BMI and there were no significant changes in serum calcium, NTX-1, Vitamin D, HbA1C and fasting blood glucose, all as compared with the control value. Conclusions: the 3 months of oral Taurine are used in type II diabetic patients may modulate bone mineralization represented by elevation of osteocalcin and reduction of body weight, but has no significant effect on glycemic control and did not reduce HbA1C%.

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Characteristics of monitored diabetic patients by glycated haemoglobin (HbA1c)

International Journal of Bioassays ◽

10.21746/ijbio.2016.05.006 ◽

2016 ◽

Vol 5 (05) ◽

pp. 4563

Author(s):

Tariq A. Zafar

Keyword(s):

Blood Glucose ◽

Glycemic Control ◽

Glycated Haemoglobin ◽

Poor Glycemic Control ◽

Diabetic Patients ◽

Age Group ◽

Hba1c Test ◽

Significant Difference ◽

Tract Infections ◽

The Impact

Glycated haemoglobin (HbA1c) test indicates the blood glucose levels for the previous two to three months. Using HbA1c test may overcome many of the practical issues and prevent infections such as urinary tract infections (UTIs). The study aimed to evaluate the impact of glycemic control using HbA1c test to understand patient characteristics and UTIs prevalence. Glycemic control was evaluated by measuring HbA1c for a total of 208 diabetes patients who were regularly attending diabetes center in Al-Noor specialist hospital in Makkah. The results showed that good and moderate glycemic controlled patients were 14.9% and 16.9% respectively while the poor glycemic patients were 68.3%. Among the good improved glycemic control, 83.9% were females, 48.4% were from age group (15-44y). Among the moderately improved glycemic control, 68.4% were females, 54.3% were from age group (45-64 y) with no significant difference. The total number of the patients with positive UTIs was 55 (26.4%) while the total number of patients with negative was UTIs 153 (73.6%). Among the positive UTIs, 76.3% were with poor glycemic control while only 12.3% and 11% were moderate and good improved glycemic control respectively. Among the negative UTIs, 65.3% were with poor glycemic control while only 19% and 15.7% were with moderate and good improved glycemic control respectively. Prevalence of UTIs among diabetic patients was not significant (p > 0.05). It was concluded that HbA1c was useful monitoring tool for diabetes mellitus and may lead to improved outcomes. Using a HbA1c test may overcome many of the practical issues that affect the blood glucose tests.

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Factors Associated with Poor Glycemic Control Amongst Rural Residents with Diabetes in Korea

Healthcare ◽

10.3390/healthcare9040391 ◽

2021 ◽

Vol 9 (4) ◽

pp. 391

Author(s):

Junhee Ahn ◽

Youngran Yang

Keyword(s):

Physical Activity ◽

Blood Glucose ◽

Glycemic Control ◽

Fasting Blood Glucose ◽

Regular Physical Activity ◽

Poor Glycemic Control ◽

Rural Residents ◽

Factors Associated ◽

The Poor ◽

Positive Urine

(1) Background: Glycemic control is an effective way to reduce the cardiovascular complications of diabetes. The purpose of this study was to identify the factors associated with poor glycemic control amongst rural residents with diabetes in Korea. (2) Methods: This cross-sectional analysis was conducted amongst a total of 522 participants who had completed baseline health examinations for the Korean Genome and Epidemiology Study (KoGES) Rural Cohort from 2005 to 2011. The subjects were divided into two groups: the good glycemic control group (GCG) (glycosylated hemoglobin (HbA1C) < 7%) and the poor GCG (HbA1C ≥ 7%). Logistic regression was used to examine the role of sociodemographics, health-related behavior, comorbidity and diabetes-related and clinical factors in poor glycemic control amongst rural residents with diabetes. (3) Results: In total, 48.1% of participants were in the poor GCG. Poor GCG was significantly associated with drinking (odds ratio (OR) = 0.42, 95% CI = 0.24–0.71), lack of regular physical activity (OR = 1.68, 95% CI = 1.03–2.76), fasting blood glucose (FBG) > 130 mg/dL (OR = 7.80, 95% CI = 4.35–13.98), diabetes for > 7 years (OR = 1.79, 95% CI = 1.08–2.98), cholesterol ≥ 200 mg/dL (OR = 1.73, 95% CI = 1.05–2.84) and positive urine glucose (OR = 6.24, 95% CI = 1.32–29.44). (4) Conclusion: Intensive glucose control interventions should target individuals amongst rural residents with diabetes who do not engage in regular physical activity, have been diagnosed with diabetes for more than seven years and who have high fasting-blood glucose, high cholesterol levels and glucose-positive urine.

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Total Dissolved Solids as a Predictor of Lake Biomass and Productivity

Canadian Journal of Fisheries and Aquatic Sciences ◽

10.1139/f83-015 ◽

1983 ◽

Vol 40 (1) ◽

pp. 92-95 ◽

Cited By ~ 13

Author(s):

E. E. Prepas

Keyword(s):

Chlorophyll A ◽

Significant Relationship ◽

Positive Relationship ◽

Biomass Productivity ◽

Total Dissolved Solids ◽

Fish Production ◽

Dissolved Solids ◽

Significant Positive Relationship ◽

Morphoedaphic Index ◽

Shield Lakes

Total dissolved solids (TDS) and chlorophyll a were not related in 25 lakes which were all off the Precambrian Shield. Both on-shield and off-shield lakes were included in the previous reports which showed a significant relationship between TDS and productivity. When data from on-shield and off-shield lakes were analyzed separately, there was no significant positive relationship between TDS and lake biomass or productivity. It was also shown that mean depth ([Formula: see text]) was as good a predictor of fish production as the TDS: [Formula: see text] ratio, the morphoedaphic index.Key words: TDS, biomass, productivity, morphoedaphic index, chlorophyll a, lakes

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Daily Fasting Blood Glucose Rhythm in Male Mice: A Role of the Circadian Clock in the Liver

Endocrinology ◽

10.1210/en.2015-1376 ◽

2015 ◽

Vol 157 (2) ◽

pp. 463-469 ◽

Cited By ~ 15

Author(s):

Hitoshi Ando ◽

Kentaro Ushijima ◽

Shigeki Shimba ◽

Akio Fujimura

Keyword(s):

Blood Glucose ◽

Circadian Clock ◽

Mrna Expression ◽

Hepatic Glucose Production ◽

Critical Role ◽

Fasting Blood Glucose ◽

Glucose Production ◽

Diabetic Patients ◽

Dark Phase ◽

Dawn Phenomenon

Abstract Fasting blood glucose (FBG) and hepatic glucose production are regulated according to a circadian rhythm. An early morning increase in FBG levels, which is pronounced among diabetic patients, is known as the dawn phenomenon. Although the intracellular circadian clock generates various molecular rhythms, whether the hepatic clock is involved in FBG rhythm remains unclear. To address this issue, we investigated the effects of phase shift and disruption of the hepatic clock on the FBG rhythm. In both C57BL/6J and diabetic ob/ob mice, FBG exhibited significant daily rhythms with a peak at the beginning of the dark phase. Light-phase restricted feeding altered the phase of FBG rhythm mildly in C57BL/6J mice and greatly in ob/ob mice, in concert with the phase shifts of mRNA expression rhythms of the clock and glucose production–related genes in the liver. Moreover, the rhythmicity of FBG and Glut2 expression was not detected in liver-specific Bmal1-deficient mice. Furthermore, treatment with octreotide suppressed the plasma growth hormone concentration but did not affect the hepatic mRNA expression of the clock genes or the rise in FBG during the latter half of the resting phase in C57BL/6J mice. These results suggest that the hepatic circadian clock plays a critical role in regulating the daily FBG rhythm, including the dawn phenomenon.

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Factores clave en el éxito de las empresas agrarias: El caso de las cooperativas hortofrutícolas en España

Tendencias ◽

10.22267/rtend.151602.26 ◽

2015 ◽

Vol 16 (2) ◽

pp. 164 ◽

Cited By ~ 2

Author(s):

Vanessa Campos-Climent ◽

Joan Ramon Sanchis-Palacio

Keyword(s):

Regression Analysis ◽

Empirical Study ◽

Significant Relationship ◽

Positive Relationship ◽

Financial Information ◽

Fruit And Vegetables ◽

Organizational Size ◽

Significant Positive Relationship ◽

And Performance

El tamaño es una variable contingente que puede influir en los resultados de las empresas. En este trabajo se pretende contrastar la existencia o no de una relación significativa entre tamaño y resultados empresariales de las empresas agrarias, en particular de las cooperativas hortofrutícolas españolas. Para ello, se realiza un estudio empírico en base a la información económica y financiera obtenida de los registros oficiales de las cooperativas agrarias dedicadas a la comercialización de frutas y hortalizas sobre el cual se ha aplicado un análisis de regresión. El estudio demuestra que no existe una relación significativa positiva entre los resultados empresariales y el tamaño de este tipo de entidades, por lo que se puede afirmar que la capacidad competitiva de una empresa agraria depende de su propia capacidad de gestión y no de un factor de contingencia como el tamaño. ABSTRACTSize is a contingency variable that can influence firms’ performance. This study aims to contrast whether exists or not a significant relationship between organizational size and performance in agrifood firms, particularly in the case of Fruit and Vegetables Cooperatives in Spain. Therefore, an applied empirical study using regression analysis is carried out from economic and financial information of such companies obtained from official registers. The study shows that there is not a significant positive relationship between performance and size for such type of firms. RESUMOO tamanho da cota é uma variável que pode influenciar os resultados das empresas. Este trabalho tem como objetivo contrastar a existência de uma relação significativa entre tamanho e desempenho dos negócios das empresas agrícolas, em especial as cooperativas hortícolas espanhóis. Para fazer isso, um estudo empírico é realizado com base em informações obtidas dos registros oficiais das cooperativas agrícolas que se dedicam à comercialização de frutas e legumes de informação económica e financeira sobre a qual foi aplicada uma análise de regressão. O estudo mostra que há uma relação positiva e significativa entre o desempenho da empresa e do tamanho de tais instituições, para que possamos dizer que a competitividade de uma empresa agrícola depende da sua própria capacidade de gestão e não um fator contingência como tamanho.

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The Effect of A New Mixture of Sugar and Sugar-Alcohol (Lacritose) on Blood Glucose and Lipids and the Possible Adverse Reactions in Patients with Type 2 Diabetes: A Triple-Blind Randomized Clinical Trial

Journal of Nutrition and Food Security ◽

10.18502/jnfs.v6i4.7620 ◽

2021 ◽

Author(s):

Masoud Rahmanian ◽

Zohreh Mozafari ◽

Danial Chaleshi ◽

Marzieh Shukohifar ◽

Saeedeh Jam-Ashkezari

Keyword(s):

Clinical Trial ◽

Blood Glucose ◽

Randomized Clinical Trial ◽

Fasting Blood Glucose ◽

Resistance Index ◽

Primary Data ◽

Control Group ◽

Diabetic Patients ◽

Diabetes Research

Background: A new sweetener with the commercial name of Lacritose has been recently produced, which is a combination of four simple sugars (lactose, fructose, sucrose, erythritol), with specific ingredients and percentages. This study aimed to assess glycemic response and short term gastrointestinal reactions in type 2 diabetic patients. Methods: In this triple-blind randomized clinical trial, 30 diabetic patients referred to Yazd Diabetes Research Center in 2018 were included. After collecting the primary data, they were assigned into three groups, including sucrose consumers as the control group, sucrose-lactose, and lacritose as the groups of consumers group. They were followed for two weeks, and fasting blood glucose (FBG), 2-hour postprandial test (2HPP), fructose amine, SGOT, SGPT, urea, creatinine, and insulin resistance index (HOMA-IR) were assessed. Results: In lacritose consumers, significant reductions were seen in FBG and 2HPP (P < 0.001 and P = 0.05, respectively), although changes among the groups were not significant. In sucrose-lacritose consumers, FBG and cholesterol levels decreased (P = 0.04 and P = 0.03, respectively). In sucrose consumers, no reduction was seen. HOMA-IR did not significantly decrease, but intergroup changes were obvious. Conclusion: The lacritose effects on FBG and 2HPP were significantly evident, but the other metabolic indices did not show any significant change.

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