The impacts of parenteral vitamin B1, B6, B12 on hemoglobin levels in chronic kidney disease patients undergoing hemodialysis

Chronic kidney disease is a disorder of renal function and structure. The glomerular filtration rate was below the normal value and less than 60 ml/minute /1.73 m2 for more than 3 months. Patients with chronic kidney disease have erythropoietin in small amounts, and cause anemia. Vitamin B1 acts as oxidative decarboxylation reactions, B6 necessary to heme synthesis, and B12 converts homocysteine to methionine. This study aims to measure the impacts of parenteral vitamin B1, B6, B12 on hemoglobin level in chronic renal disease patients undergoing hemodialysis at Bethesda Hospital Yogyakarta and Panti Rapih Hospital Yogyakarta. The design of this study was one group pretest-posttest using secondary data from lab results from medical records. Data were collected from 117 patients using consecutive sampling methods at Bethesda Hospital Yogyakarta and Panti Rapih Hospital Yogyakarta in March 2019. The treatment given was parenteral vitamin B1, B6, B12 twice a week with a dose of 2 ml. Vitamin B was given intravenously after each hemodialysis. Hemoglobin levels were measured 3 times on 1st visit (before vitamin B administration), 2nd visit (after vitamin B administration), and 3rd visit (after vitamin B administration). There were significant differences of hemoglobin levels on 2nd visit compared to 1st visit (p = 0,000); 3rd visit compared to 1st visit (p = 0,000) and 3rd visit compared to 2nd visit (p = 0.010). Parenteral vitamin B1, B6, B12 gave significant impacts on hemoglobin level and was safe for chronic kidney disease patients undergoing hemodialysis.

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Pharmacotherapy assessment in chronic kidney disease: validation of the pair instrument for use in Brazil

Brazilian Journal of Nephrology ◽

10.1590/2175-8239-jbn-2019-0205 ◽

2020 ◽

Author(s):

Alessandra Batista Marquito ◽

Hélady Sanders Pinheiro ◽

Natália Maria da Silva Fernandes ◽

Rogério Baumgratz de Paula

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Clinical Judgment ◽

Medical Records ◽

Chronic Renal Disease ◽

Drug Related Problems ◽

Longitudinal Observational Study ◽

Clinically Significant ◽

Validated Instrument ◽

Level Of Agreement

Abstract Individuals with chronic kidney disease (CKD) use polypharmacy, which, in combination with renal impairment, exposes them to the risk of drug-related problems (DRPs). There are no available tools in Brazil to systematically assess the pharmacotherapy and management of DRPs in this population. Therefore, the objective of this work was to validate the PAIR instrument (Pharmacotherapy Assessment in Chronic Renal Disease) for use in Brazilian Portuguese. This is a retrospective longitudinal observational study. Medical records from 100 CKD patients under conservative treatment, between 2016 and 2017, in a nephrology clinic, were analyzed. PAIR was applied by pharmacists in two consultations of the same patient, with an interval of 6 months. Reliability, conceptual validity, responsiveness of the instrument and prevalence of DRPs in the studied sample were assessed. A mean of 1.26 ± 0.96 DRPs/patient was identified. Inter-rater reliability coefficients (k) ranged from 0.58 to 0.94 and from 0.79 to 1.00 for test-retest, revealing moderate to perfect level of agreement. In conceptual validity, a mean of 1.60 ± 1.24 DRPs/patient was identified by the nephrologist through clinical judgment, compared to 1.33±0.76 DRPs/patient identified by the pharmacist using PAIR (p = 0.07). Therefore PAIR allowed the identification of clinically significant DRPs. In responsiveness, a mean of 1.26 ± 0.96 DRPs/patient was identified at the first consultation and 1.11 ± 1.02 DRPs/patient at the subsequent consultation (p = 0.17) by the pharmacist using PAIR. The number of DRPs between the periods did not change. As a conclusion, the PAIR allowed the identification of clinically significant DRPs in CKD, constituting a new validated instrument to be used in Brazil.

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Perbedaan Kadar Leukosit dan Limfosit Paska Pemberian Kombinasi Vitamin B Parenteral Pada Pasien Penyakit Ginjal Kronik dengan Hemodialisis

Jurnal Ilmiah Kedokteran Wijaya Kusuma ◽

10.30742/jikw.v10i1.1083 ◽

2021 ◽

Vol 10 (1) ◽

pp. 27

Author(s):

Rizaldy Taslim Pinzon ◽

Ester Novitasari ◽

Nining Sri Wuryaningsih

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Leukocyte Count ◽

Vitamin B1 ◽

Water Soluble ◽

P Value ◽

Vitamin B ◽

Quasi Experimental ◽

Change In The Mean ◽

The Mean

Chronic kidney disease is a disease in which kidney function decreases progressively irreversibly with various etiologies. Patients with chronic kidney disease are generally immunosuppressed and susceptible to infection. Some of the causes are abnormalities in polymorphonuclear leukocytes and lymphocytes. The results of several studies indicate that patients undergoing hemodialysis have low levels of water-soluble vitamins. A decrease in the number of leukocytes can also occur due to a decrease in neutrophils and lymphocytes which may be caused by deficiency of vitamins B6 and B12 due to hemodialysis. This study aims to measure the difference in levels of leukocytes and lymphocytes after parenteral vitamin B combination administration in patients with chronic kidney disease undergoing hemodialysis This research is a quasi-experimental design, One Group Pretest Posttest, on 115 selected patients. Patients were given vitamin B1 ,B6 ,B12 parenterally every time doing hemodialysis, twice a week given for 1 month during hemodialysis. The data were taken in the form of leukocyte count, patient lymphocyte percentage, and absolute lymphocyte concentration. The intervention of vitamins B1, B6, B12 was given parenterally to the patient. After collect the data, the leukocyte counts, lymphocyte percentage and absolute lymphocyte concentration before and after the intervention were seen, then it was seen how the effect of parenteral administration of vitamins B1 ,B6 ,B12 on the leukocyte count, lymphocyte percentage and absolute lymphocyte concentration in patients undergoing hemodialysis. From the results of the study, there were 115 patients consisted of 72 men (62.6%) and 43 women (37.4%). There was a difference and effect of giving combination vitamin B in the form of a significant change in the mean number of leukocytes at visits 1-2 with p-value = 0.033. There was a change in the mean of lymphocyte percentage and absolute lymphocyte concentration after administering vitamins B1, B6 ,B12 , but the changes were not significant.

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Benefit administration of vitamin B1, B6, and B12 on the depression symptom in hemodialysis patients

Farmasains Jurnal Farmasi dan Ilmu Kesehatan ◽

10.22219/farmasains.v4i2.8919 ◽

2020 ◽

Vol 4 (2) ◽

Author(s):

Rizaldy Taslim Pinzon ◽

Birgitta Lisbethiara Ardiani

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Vitamin B1 ◽

Depression Score ◽

Depression Symptoms ◽

Vitamin B ◽

Depression Symptom ◽

Significant Difference ◽

Post Test ◽

The Relationship

Chronic kidney disease (CKD) is a disease that causes a decrease in kidney function, which can be seen from GFR (Glomerulus Filtration Rate) value, which is less than 60 ml/minute/1.73 m2 in minimum three months. Depression is a psychological problem in a patient with chronic kidney disease undergoing hemodialysis. The previous study has shown that giving vitamin B combination can improve depression symptoms. To measure the benefit of vitamin B1, B6, B12 parenterally for depression symptoms in chronic kidney disease patients undergoing hemodialysis. This study used an experimental design (one group pre and post-test) in 117 patient that obtained using a consecutive sampling method. Depression score was measured by the HADS questionnaire before given vitamin B (pre-test) and after given vitamin B (post-test). Data were statistically analyzed using a licensed SPSS program with paired t-test/Non-Parametric Wilcoxon. The relationship between the history of the use of the antihypertensive, antidiabetic, folic acid drug, and depression scores were not showing significant results (p > 0.05). The relationship between administration of vitamins B1, B6, and B12 and the patient's depression score showed a decrease but not significant (p = 0.522). There was no significant difference after the administration of vitamin B1, B6, and B12 on the depression score of patients with chronic kidney disease undergoing hemodialysis at Bethesda and Panti Rapih Hospital in Yogyakarta.

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Stroke in chronic renal failure

Orvosi Hetilap ◽

10.1556/oh.2008.28292 ◽

2008 ◽

Vol 149 (15) ◽

pp. 691-696

Author(s):

Dániel Bereczki

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Renal Disease ◽

Chronic Renal Disease ◽

Kidney Diseases ◽

Cerebrovascular Diseases ◽

Lipid Lowering ◽

Increased Risk ◽

Intracerebral Hemorrhages

Chronic kidney diseases and cardiovascular diseases have several common risk factors like hypertension and diabetes. In chronic renal disease stroke risk is several times higher than in the average population. The combination of classical risk factors and those characteristic of chronic kidney disease might explain this increased risk. Among acute cerebrovascular diseases intracerebral hemorrhages are more frequent than in those with normal kidney function. The outcome of stroke is worse in chronic kidney disease. The treatment of stroke (thrombolysis, antiplatelet and anticoagulant treatment, statins, etc.) is an area of clinical research in this patient group. There are no reliable data on the application of thrombolysis in acute stroke in patients with chronic renal disease. Aspirin might be administered. Carefulness, individual considerations and lower doses might be appropriate when using other treatments. The condition of the kidney as well as other associated diseases should be considered during administration of antihypertensive and lipid lowering medications.

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The Unravelled Link between Chronic Kidney Disease and Hepatitis C Infection

New Journal of Science ◽

10.1155/2014/180203 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 7

Author(s):

Fabrizio Fabrizi ◽

Piergiorgio Messa ◽

Paul Martin

Keyword(s):

Chronic Kidney Disease ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Kidney Disease ◽

Renal Disease ◽

Chronic Renal Disease ◽

World Health ◽

Adjusted Relative Risk ◽

Hepatitis C Infection ◽

Increased Risk

The 2011 report of the World Health Organization General Assembly on noncommunicable diseases identified chronic kidney disease as a worldwide health issue posing a heavy economic burden. Hepatitis C virus infection, which is responsible for over 1 million deaths resulting from cirrhosis and liver cancer, is linked to chronic kidney disease in several ways; some forms of renal disease are precipitated by hepatitis C and patients with end-stage chronic renal disease are at increased risk for acquiring HCV. The aim of this review is to update the evidence on the relationship between hepatitis C infection and chronic kidney disease. Information has been accumulated in the last decade indicating that HCV plays an adverse effect on the incidence and progression of chronic kidney disease; a novel meta-analysis of observational studies (seven longitudinal studies; 890,560 unique individuals) found a relationship between hepatitis C seropositivity and incidence of reduced estimated glomerular filtration rate (adjusted relative risk, 1.70; 95% CI, 1.20; 2.39; P=0.002) in the adult general population. In addition to conventional risk factors, hepatitis C may be an additional factor for the development of chronic kidney disease, and an atheromasic activity of hepatitis C virus has been mentioned. The link between hepatitis C and atherosclerosis could also explain the excess risk of cardiovascular mortality that has been observed among hepatitis C virus seropositive patients undergoing maintenance dialysis. A number of biologically plausible mechanisms related to hepatitis C virus have been hypothesized to contribute to atherosclerosis. Implementation of effective treatment intervention towards hepatitis C is required to decrease the healthcare burden of hepatitis C and to prevent the progression of chronic renal disease.

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Gambaran Pasien yang Menjalani Prosedur Bedah Emergensi di RSUP Prof. Dr. R. D. Kandou Manado Periode Januari - September 2019

e-CliniC ◽

10.35790/ecl.v8i1.27356 ◽

2019 ◽

Vol 8 (1) ◽

Author(s):

Utrecht Suleman ◽

Angelica M. J. Wagiu ◽

Stephanus J. Ch. Tangel

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Surgical Procedures ◽

Emergency Surgery ◽

Medical Records ◽

Health Centers ◽

Surgical Patients ◽

Age Group ◽

Adult Age ◽

Epidural Hemorrhage

Abstract: Emergency surgery is performed to avoid further complications of the disease or to save the patient's life. Albeit, there are lack of data in various health centers in Indonesia regarding the evaluation of emergency surgical patients, This study was aimed to obtain the profile of patients undergoing emergency surgical procedures in the Emergency Department of Surgery at Prof. Dr. R. D. Kandou Hospital Manado from January to September 2019. This was a retrospective and descriptive study using patients’ medical records. The results showed that there were 540 patients in this study. Most of the patients were adult age group (18-59 years) as many as 343 patients (63.5%), males 366 patients (67.8%), and non-traumatic cases 436 patients (80.4%). The most common cases of trauma was epidural hemorrhage as many as 23 patients (4.3%) meanwhile the most common non-traumatic cases was chronic kidney disease as many as 122 patients (22.6%). According to the type of surgery, CDL insertion and laparotomy were performed on 131 patients each (24.3%). In conclusion, most patients undergoing emergency surgical procedures were 18-59 years old, males, and non-traumatic cases.Keywords: emergency surgery, traumatic cases, non-traumatic cases Abstrak: Bedah emergensi dilakukan dalam keadaan sangat darurat untuk menghindari komplikasi lanjut dari proses penyakit atau untuk menyelamatkan jiwa pasien. Data mengenai pasien bedah emergensi di berbagai pusat kesehatan di Indonesia masih sangat kurang. Penelitian ini bertujuan untuk mendapatkan gambaran pasien yang menjalani prosedur bedah emergensi di IGD Bedah RSUP Prof. Dr. R. D. Kandou Manado periode Januari sampai September 2019. Jenis penelitian ialah deskriptif retrospektif, menggunakan data rekam medik pasien. Hasil penelitian menunjukkan bahwa dari 540 pasien, didapatkan pasien terbanyak dari golongan usia dewasa (18-59 tahun) yaitu 343 pasien (63,5%), jenis kelamin laki-laki 366 pasien (67,8%), dan kasus non-trauma 436 pasien (80,4%). Kasus trauma terbanyak yaitu epidural hemorrhage pada 23 pasien (4,3%) sedangkan kasus non trauma terbanyak chronic kidney disease pada 122 pasien (22,6%). Menurut jenis tindakan operasi yang terbanyak ialah insersi CDL dan laparotomy, masing-masing 131 pasien (24,3%). Simpulan penelitian ini ialah pasien yang menjalani prosedur bedah emergensi terbanyak ialah usia 18-59 tahun, jenis kelamin laki-laki, dan jenis kasus non-trauma.Kata kunci: bedah emergensi, kasus trauma, kasus non-trauma

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Gambaran Anemia pada Subjek Penyakit Ginjal Kronik Stadium 4 dan 5 di Poliklinik Ginjal-Hipertensi RSUP Prof. Dr. R. D. Kandou

e-CliniC ◽

10.35790/ecl.v8i1.27097 ◽

2019 ◽

Vol 8 (1) ◽

Author(s):

Yordhan Tamsil ◽

Emma Sy. Moeis ◽

Frans Wantania

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Medical Records ◽

Iron Status ◽

Descriptive Study ◽

Transfusion Therapy ◽

Female Age ◽

Stage 4 ◽

Almost All ◽

Age Range

Abstract: Anemia is a complication of chronic kidney disease (CKD) that often occurs. Moreover, it can occur earlier than other complications of CKD in almost all patients with late stage kidney disease. This study was aimed to obtain the profile of anemia in subjects with stage 4 and 5 of chronic kidney disease. This was a retrospective and descriptive study using medical records of patients with CKD associated with anemia for two years. The results showed that of 428 CKD patients, 131 suffered from anemia (30.60%). The majority of patients were female (54.19%), age range 60-69 years (44.27%), non-dialysis stage 5 of CKD patients (74.04%), had sufficient iron status (79.38%). However, 15,26% of the 131 patients got blood transfusion therapy. In conclusion, the majority of CKD patients were stage 5 ND, female, age range of 60-69 years, had sufficient iron status, and were not treated with blood transfusion.Keywords: chronic kidney disease, anemia Abstrak: Anemia merupakan komplikasi penyakit ginjal kronik (PGK) yang sering terjadi, bahkan dapat terjadi lebih awal dibandingkan komplikasi PGK lainnya dan hampir pada semua pasien penyakit ginjal tahap akhir. Penelitian ini bertujuan untuk mengetahui gambaran anemia pada subyek penyakit ginjal kronik stadium 4 dan 5 di Poliklinik Ginjal-Hipertensi RSUP Prof. Dr. R. D. Kandou. Jenis penelitian ialah metode deskriptif retroskpektif dengan mengunakan data rekam medik pasien PGK dengan anemia selama dua tahun. Hasil penelitian memperlihatkan dari 428 pasien PGK didapatkan 131 pasien dengan anemia pada PGK (30,60%). Mayoritas pasien ialah jenis kelamin perempuan (54,19%), usia 60-69 tahun (44,27%), dan PGK derajat 5 non-dialisis (74,04%), memiliki status besi cukup (79,38%). Terdapat 15,26% dari pasien yang mendapatkan terapi transfusi darah. Simpulan penelitian ini ialah pasien terbanyak dengan derajat 5 ND, jenis kelamin perempuan, rentang usia 60-69 tahun, dengan status besi cukup, dan tidak mendapat terapi transfusi darah.Kata kunci: penyakit ginjal kronik, anemia

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ASSESSMENT OF LIPID PROFILE AMONG PATIENTS OF NON-DIABETIC CHRONIC KIDNEY DISEASE AT TERTIARY CARE CENTRE

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i11.753 ◽

2019 ◽

Vol 3 (11) ◽

Author(s):

Dr Bakul Gupta

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Renal Disease ◽

Lipid Profile ◽

Chronic Renal Disease ◽

Tertiary Care ◽

Study Participant ◽

P Value ◽

Additional Risk Factor ◽

Study Participants

Background: Various studies have shown the association between dyslipidemia and cardio-vascular risk among patients of chronic renal disease but the association non-significant than patients with normal renal function. There was lack of evidence exists because patients with chronic renal disease were excluded from the major clinical studies where the association with that target dyslipidemia treatment was being evaluated Material & Methods: The present prospective study was conducted among the patients of Chronic Kidney Disease above 18 years of age and diagnosed on the basis of history, detailed clinical examination, and biochemical and sonological examination based upon National Kidney Foundation (NKF) criteria were enrolled into the study. Clearance from hospital ethics committee was taken before start of study. Written informed consent was taken from each study participant. Results: In the present study out of total study participants of chronic kidney disease 46% were in the 3rd stage of CKD, 38% were in the 4th stage of CKD and 16% were in the 5th stage of CKD. Out of total study participants of chronic kidney disease, 82% were managed by conservative treatment and 18% were being managed by hemodialysis. Out of total study participants of chronic kidney disease, 38% had normal lipid profile while 62% patients had dyslipidemia. We found statistically significant (p value < 0.05) association between dyslipidemia and hemodialysis and association between dyslipidemia and stages of chronic kidney disease was statistically non- significant (p value > 0.05). Conclusion: We concluded from the present study that dyslipidemia is significantly associated as an additional risk factor in patients of Chronic Kidney Disease. We found significant association of hemodialysis with abnormal lipid profile. Key words: Chronic kidney disease, dyslipidemia, hemodialysis.

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Chronic Kidney Failure and Dialysis

10.2310/fm.1168 ◽

2018 ◽

Author(s):

Raghu V Durvasula ◽

Jonathan Himmelfarb

Keyword(s):

United States ◽

Chronic Kidney Disease ◽

Peritoneal Dialysis ◽

Kidney Disease ◽

Renal Disease ◽

Chronic Renal Disease ◽

Clinical Manifestations ◽

Kidney Injury ◽

The United States ◽

Clinical Syndrome

Chronic kidney disease (CKD) is a clinical syndrome arising from progressive kidney injury, formerly known as chronic renal failure, chronic renal disease, and chronic renal insufficiency. It is classified into five stages based primarily on glomerular filtration rate (GFR). This article discusses the epidemiology of CKD and end-stage renal disease (ESRD), as well as etiology and genetics, pathophysiology, and pathogenesis. The section on diagnosis looks at clinical manifestations and physical findings, laboratory (and other) tests, imaging studies, and biopsy. A short section on differential diagnosis is followed by a discussion of treatment, including hemodialysis and peritoneal dialysis. Long-term complications of patients on dialysis include cardiovascular disease, renal osteodystrophy, dialysis-related amyloidosis, and acquired cystic disease (renal cell carcinoma). The final section addresses prognosis and socioeconomic burden. Figures include the classification system for CKD, prevalence of CKD in the United States, rising prevalence, risk of, and leading causes of ESRD in the United States, plus the changing prevalence of ESRD over time, clinical manifestations of uremia, and an overview of hemodialysis circuit. Tables look at the burden of CKD relative to other chronic disorders, the specific hereditary causes of kidney disease, and situations when serum creatinine does not accurately predict GFR. Other tables list equations for estimating GFR, the causes of CKD without shrunken kidneys, and clinical features distinguishing chronic kidney disease from acute kidney injury. ESRD and indications for initiation of dialysis are presented, as well as typical composition of dialysate and reasons for failure of peritoneal dialysis. This chapter contains 71 references.

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