scholarly journals Spontaneous regression of breast carcinoma: A radio-pathological case report and review of the literature

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1546-1550
Author(s):  
Marlina Tanty Ramli Hamid ◽  
Shamsiah Abdul Hamid ◽  
Nazimah Ab Mumin ◽  
Norliana Dalila Mohamad Ali ◽  
Khariah Mat Nor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Spontaneous Regression ◽  
Region Of Interest ◽  
Herbal Remedies ◽  
Complete Regression ◽  
Axillary Lymph ◽  
Breast Cancers ◽  
Pet Ct ◽  
History Of ◽  
Breast Cancer Mri

Spontaneous regression (SR) is defined as complete or partial disappearance of a proven malignant tumor without adequate medical treatment. Although there have been reports on SR of breast cancers, this phenomenon remains rare. We report a case of SR of breast cancer in a 62-year-old woman who presented to our hospital with a few months history of a painless breast lump. Initial radiological investigations reveal a suspicious mass in the left upper outer quadrant. Histopathology confirms the presence of invasive cancer. The patient initially refused any surgical or medical interventional and defaulted follow-up. The patient presented again after four months with consent for surgical treatment. Repeat ultrasound just before the hook wire localization procedure demonstrated the absence of tumor in the region of interest. The subsequent repeat mammogram and MRI also demonstrated complete regression of breast cancer. MRI however, does reveal a suspicious left axillary lymph node, which was also deemed suspicious on PET-CT. In view of these findings, the patient was counsel for surgery. The exact mechanism of SR of cancer remains unclear in our patient. We are unable to identify the exact mechanism triggering and influencing the SR in our patient. Our hypotheses include substance within the herbal remedies or a carcinoma-directed immune response triggered by the biopsy. Further research is needed to determine causes for spontaneous regressions of cancer and towards finding a possible cure for cancer.

scholarly journals Estrogens and Progestogens in Triple Negative Breast Cancer: Do They Harm?

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2506
Author(s):  
Mark van Barele ◽  
Bernadette A. M. Heemskerk-Gerritsen ◽  
Yvonne V. Louwers ◽  
Mijntje B. Vastbinder ◽  
John W. M. Martens ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Hormone Replacement ◽  
Breast Cancers ◽  
Younger Women ◽  
Alternative Pathways ◽  
Increased Risk ◽  
History Of ◽  
Hormone Sensitive

Triple-negative breast cancers (TNBC) occur more frequently in younger women and do not express estrogen receptor (ER) nor progesterone receptor (PR), and are therefore often considered hormone-insensitive. Treatment of premenopausal TNBC patients almost always includes chemotherapy, which may lead to premature ovarian insufficiency (POI) and can severely impact quality of life. Hormone replacement therapy (HRT) is contraindicated for patients with a history of hormone-sensitive breast cancer, but the data on safety for TNBC patients is inconclusive, with a few randomized trials showing increased risk-ratios with wide confidence intervals for recurrence after HRT. Here, we review the literature on alternative pathways from the classical ER/PR. We find that for both estrogens and progestogens, potential alternatives exist for exerting their effects on TNBC, ranging from receptor conversion, to alternative receptors capable of binding estrogens, as well as paracrine pathways, such as RANK/RANKL, which can cause progestogens to indirectly stimulate growth and metastasis of TNBC. Finally, HRT may also influence other hormones, such as androgens, and their effects on TNBCs expressing androgen receptors (AR). Concluding, the assumption that TNBC is completely hormone-insensitive is incorrect. However, the direction of the effects of the alternative pathways is not always clear, and will need to be investigated further.

scholarly journals Spontaneous regression of breast carcinoma: review of English publications from 1753 to 1897

2012 ◽  
Vol 6 (2) ◽  
pp. 22 ◽  
Author(s):  
Wilson I.B. Onuigbo
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Spontaneous Regression ◽  
Current Knowledge ◽  
English Literature ◽  
Important Phenomenon ◽  
History Of ◽  
Historical Accounts ◽  
History Of Cancer ◽  
Cancer Regression

Regression is an important phenomenon in oncology. Two reviews in 2011 dealt at length with what in modern parlance may be called its permutations and combinations. Specifically, in both 1982 and 1987, when its occurrence in breast cancer was presented from two centers, the oldest accounts of it were dated back to 1900. Therefore, a search for much older English literature was undertaken in order to widen current knowledge of this important problem. Consequently, a published long case dating back to 1897 is abridged and a short 1846 case is also noted. Furthermore, general etiological concepts are exemplified as far back as 1753. It is concluded that the history of cancer regression is like fishing in an ocean of this illness. However, the findings are deemed to complement what modern historical accounts lack.

scholarly journals Can We Identify or Exclude Extensive Axillary Nodal Involvement in Breast Cancer Patients Preoperatively?

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Martijn Leenders ◽  
Gaëlle Kramer ◽  
Kamar Belghazi ◽  
Katya Duvivier ◽  
Petrousjka van den Tol ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Needle Biopsy ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Nodal Involvement ◽  
Ultrasound Guided ◽  
Axillary Ultrasound ◽  
Pet Ct

Background. Breast cancer treatment has rapidly changed in the last few years. Particularly, treatment of patients with axillary nodal involvement has evolved after publication of several randomized clinical trials. Omitting axillary lymph node dissection in selected early breast cancer patients with one or two positive sentinel nodes did not compromise overall survival nor regional disease control in these trials. Hence, either excluding or identifying extensive axillary nodal involvement becomes increasingly important. Purpose. To evaluate whether the current diagnostic modalities can accurately identify or exclude extensive axillary nodal involvement. Evaluated modalities were axillary ultrasound, ultrasound-guided needle biopsy, MRI, and PET/CT. Methods. A literature search was performed in the Cochrane Library, EMBASE, and PubMed databases up to June 2019. The search strategy included terms for breast cancer, lymph nodes, and the different imaging modalities. Only articles that reported pathological N-stage or the total number of positive axillary lymph nodes were considered for inclusion. Studies with patients undergoing neoadjuvant systemic therapy were excluded. Conclusion. There is no evidence that any of the current preoperative axillary imaging modalities can accurately exclude or identify breast cancer patients with extensive nodal involvement. Both negative PET/CT and negative MRI scans (with gadolinium-based contrast agents) are promising in excluding extensive nodal involvement. Larger studies should be performed to strengthen this conclusion. False-negative rates of axillary ultrasound and ultrasound-guided needle biopsy are too high to rely on negative results of these modalities in excluding extensive nodal involvement.

Immunohistochemical Study of Ten Cases of Argyrophilic Carcinoma (Carcinoid) of the Breast

1988 ◽  
Vol 74 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Salvatore Andreola ◽  
Emanuela Di Re ◽  
Mirella Merson ◽  
Lorenza Maggiulli ◽  
Patrizia De Palma
Keyword(s):  
Breast Cancer ◽  
Natural History ◽  
Human Breast Cancer ◽  
Immunohistochemical Study ◽  
Secretory Activity ◽  
Controversial Issue ◽  
Breast Cancers ◽  
Human Breast ◽  
History Of

The significance of argyrophilia in human breast cancer is still a controversial issue. We tested immunohistochemically 10 cases of argyrophilic carcinomas of the breast and found evidence of immunoreactivity with neuroendocrine markers: chromogranin, NSE, gastrin, insulin and bombesin. Argyrophilia was demonstrated in breast cancers of the usual types and was found to be related to the secretory activity of neoplastic cells. Unfortunately, no adequate follow-up data are available to clarify the natural history of argyrophilic breast cancer. A clinical treatment different from that of conventional breast cancer is not at present justified.

scholarly journals Management and Outcomes of Male Breast Cancer in Zaria, Nigeria

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Adamu Ahmed ◽  
Yahaya Ukwenya ◽  
Adamu Abdullahi ◽  
Iliyasu Muhammad
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Advanced Disease ◽  
Radical Mastectomy ◽  
Male Breast ◽  
Tumor Diameter ◽  
Axillary Lymph ◽  
Breast Cancers ◽  
Modified Radical Mastectomy ◽  
Male Patients

Male breast cancer is an uncommon disease accounting for only 1% of all breast cancers. We present the evaluation, treatment and outcome of male patients seen with breast cancer in our institution. Male patients that had histological diagnosis of breast cancer from 2001 to 2010 were retrospectively evaluated. After evaluation patients were treated with modified radical mastectomy. Combination chemotherapy was given to patients with positive axillary lymph nodes. Radiotherapy and hormonal therapy were also employed. There were 57 male patients with breast cancer which accounted for 9% of all breast cancers seen during the study period. Their mean age was 59 ± 2.3 years. The mean tumor diameter was 13 ± 2.5 cm. Fifty three (93%) patients presented with advanced disease including 15 with distant metastasis. Four patients with stage II disease were treated with modified radical mastectomy, chemotherapy and tamoxifen. Of the 30 patients with sage III disease that had modified radical mastectomy, complete axillary clearance and tumor free margins were achieved in 25. Overall 21 (36.8%) patients were tumor free at one year. Overall 5-year survival was 22.8%. In conclusion, male patients with breast cancer present with advanced disease which is associated with poor outcome of treatment.

Massive inflammatory reaction following the removal of a ruptured silicone implant masking the invasive breast cancer – case report and literature review

2016 ◽  
Vol 88 (1) ◽  
Author(s):  
Piotr Nowaczyk ◽  
Aleksandra Budnicka ◽  
Mateusz Wichtowski ◽  
Paweł Kurzawa ◽  
Dawid Murawa
Keyword(s):  
Breast Cancer ◽  
Histopathological Examination ◽  
Breast Implants ◽  
Breast Cancer Case ◽  
Left Breast ◽  
Cancer Case ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Breast Cancers ◽  
Inflammatory Infiltration

AbstractThis paper presents a case of a patient with invasive ductal breast cancer following breast augmentation. Following breast implants rupture in March 2013 the breast implants have been removed – histopathological examination revealed leaked silicone with inflammatory infiltration, without evidence of cancerous lesions. Diagnostic imaging revealed multiple encapsulated silicone particles and clusters of post-inflammatory macrocalcifications in both breasts. In January 2014 the patient presented with symptoms of massive inflammation of the left breast. Following surgical consultation the patient had undergone radical left-sided mastectomy with lymphadenectomy. Postoperative histopathological examination revealed a multifocal advanced invasive ductal cancer G3 pT3pN3a (vascular invasion, metastases in 11 of 12 examined axillary lymph nodes). Following surgery the patient was qualified for further treatment – chemotherapy, radiotherapy, hormone therapy. The discussion includes a review of literature on the risk evaluation of co-occurrence of breast cancers in women with silicone breast implants and presents diagnostic challenges of breast cancer in this patient group.

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