scholarly journals Range of values for lipid accumulation product (LAP) in healthy residents of the European north of Russia

2020 ◽  
Vol 17 (2) ◽  
pp. 179-186
Author(s):  
Anastasiya M. Kaneva ◽  
Natalya N. Potolitsyna ◽  
Evgeny R. Bojko
Keyword(s):  
Sex Differences ◽  
Lipid Accumulation ◽  
Healthy Subjects ◽  
Metabolic Disorders ◽  
Visceral Obesity ◽  
Lipid Accumulation Product ◽  
Major Health Problem ◽  
Wide Range ◽  
Variation Range ◽  
Apparently Healthy

BACKGROUND: Obesity is a major health problem in modern society and its prevalence throughout the world has reached the epidemic level. The unfavorable outcomes of obesity are associated with a high risk of numerous diseases due to metabolic disorders. Finding of diagnostic criteria for early detection of obesity is a priority in biomedical research. Therefore, of particular interest is the new visceral obesity marker lipid accumulation product (LAP). Meanwhile, to date, the reference values for LAP are not defined, and data on sex- and age-related changes are contradictory. AIMS: The aim of this study was to determine the variation range, sex and age differences in LAP values in healthy subjects. MATERIALS AND METHODS: The study was conducted on apparently healthy subjects (455 men and 286 women) aged 2059 years selected at routine examinations at the base of the central clinic in Arkhangelsk. Examination of subjects consisted of physical examination with measurement of anthropometric and clinical parameters, filling out a questionnaire, and evaluation of serum lipid levels. RESULTS: The LAP values in the subjects varied in a wide range (0.5156.5 cmmmol/l in men; 0.4 to 116.2 cmmmol/l in women), but at the same they in 75% of the participants did not exceed 30 cmmmol/l. Sex differences in LAP with the prevalence of values in men were observed in the age groups up to 40 years old, later they disappeared. LAP in men and women increased with age, but these changes were unequal. The LAP values increased to reach a plateau in men up to 30 years of age and in women up to 40 years of age. CONCLUSIONS: LAP is a combined index that simultaneously reflects distribution of adipose tissue and changes in blood lipids, and is considered a marker of obesity associated with the risk of metabolic disorders. This study was the first to determine the variation range, sex differences and age dynamics for LAP in the apparently healthy subjects.

scholarly journals Identification of lipid accumulation product (LAP) as a marker of metabolic syndrome: a study in healthy population of MMU

2021 ◽  
Vol 12 (2) ◽  
pp. 958-966
Author(s):  
Bhumija Sharma ◽  
Suvarna Prasad ◽  
Sunita Manhas ◽  
Bhawani Shankar Modi ◽  
PriyankaTangri
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Accumulation ◽  
Healthy Subjects ◽  
Disease Risk ◽  
Roc Curves ◽  
Public Health Issue ◽  
Healthy Population ◽  
Lipid Accumulation Product ◽  
Related Disease ◽  
Apparently Healthy

Metabolic syndrome (MetS), is a collection of lipid and non-lipid cardiac related disease risk factors, is an important public health issue because of its higher prevalence with development of diabetes mellitus and cardiovascular diseases. Henry Kahn anticipated lipid accumulation product (LAP), as a novel marker of central lipid accumulation, to predict the risk of MetS. This study was conducted in Department of Biochemistry of MMIMSR, Ambala, Haryana. In the current study, we are researching over a new diagnostic tool for diagnosing MetS by LAP use. MetS is diagnosed by National Cholesterol Education Program Adults treatment panel III (NCEPATP III) and then compared with LAP to find its efficacy over other variables. 200 volunteers were enrolled in this study, their biochemical parameters were estimated and anthropometric measurements were taken. MetS was diagnosed in apparently healthy subjects. LAP was calculated by Henry Kahn formula and required statistical tools were applied to analyse results. The parameters of MetS positive cases were compared with LAP and its validity was tested statistically. 56 (28%) out of 200 subjects were positive for MetS. More females (30) than males (26) were diagnosed positive for MetS. LAP values were found to be higher in MetS cases, its efficacy was confirmed by ROC curves. MetS was diagnosed in volunteers who were considering themselves as healthy. Raised LAP and LAP2 were found, in MetS positive subjects than MetS negative. Relation of LAP and MetS came to be strong. Further, researches in this area are definitely recommended.

scholarly journals Dysfunctional adiposity index as a marker of adipose tissue morpho-functional abnormalities and metabolic disorders in apparently healthy subjects

Adipocyte ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 142-152
Author(s):  
Juan Reyes-Barrera ◽  
Victor H. Sainz-Escárrega ◽  
Aida X. Medina-Urritia ◽  
Esteban Jorge-Galarza ◽  
Horacio Osorio-Alonso ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Healthy Subjects ◽  
Metabolic Disorders ◽  
Adiposity Index ◽  
Apparently Healthy

Association Between Lipid Accumulation Product and Mild Cognitive Impairment in Patients with Type 2 Diabetes

2020 ◽  
Vol 77 (1) ◽  
pp. 367-374
Author(s):  
Zi-Wei Yu ◽  
Xin Li ◽  
Ying Wang ◽  
Yu-Hong Fu ◽  
Xin-Yuan Gao
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Lipid Accumulation ◽  
Glycosylated Hemoglobin ◽  
Visceral Obesity ◽  
Lipid Accumulation Product ◽  
Increased Risk ◽  
Normal Cognition

Background: Diabetes may increase the risk of conversion of mild cognitive impairment (MCI) to dementia. Lipid accumulation product (LAP), an index of visceral obesity, has been shown to be a powerful predictor of insulin resistance and type 2 diabetes (T2D). However, little attention has been paid to the relationship between LAP and MCI in T2D. Objective: We aimed to investigate the association between the LAP index and MCI in patients with T2D. Methods: In total, 220 hospitalized patients with T2D, including 113 MCI patients and 107 patients with normal cognition, were enrolled in this cross-sectional study. We collected demographic, anthropometric, and biochemical data on each subject. The LAP index was calculated according to the following formulas: [waist circumference (WC) (cm) – 65]×triglyceride (TG) (mmol/L) for males and [WC (cm) – 58] ×TG (mmol/L) for females. Results: Compared with patients with normal cognition, MCI patients were older and had a higher LAP index, WC, body mass index, and glycosylated hemoglobin A1c level, as well as a lower Montreal Cognitive Assessment score and education level (p < 0.05). After adjusting for confounding factors, LAP index was associated with MCI (OR = 1.047, 95% CI = 1.031–1.063, p < 0.01). The area under the ROC curve (AUC) for the LAP index was higher than that for WC and BMI. Conclusion: A high LAP index is associated with an increased risk of MCI in T2D patients. The LAP index appears to be a good indicator of risk of MCI in patients with T2D.

scholarly journals The Effect of Lipid Accumulation Product and Its Interaction With Family History of Hypertension on Hypertension Risk in Population With Nondiabetic in Eastern China: A Cross-sectional Study

2021 ◽  
Author(s):  
Li Shu ◽  
Lina Song ◽  
Yanqi Shen ◽  
Jinchen Wang ◽  
Ziyan Han ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Family History ◽  
Lipid Accumulation ◽  
Visceral Obesity ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Lipid Accumulation Product ◽  
Cross Sectional ◽  
Physical Measurements ◽  
History Of

Abstract Background: Lipid Accumulation Product (LAP) was proposed as a useful indicator of visceral obesity, the visceral obesity and cardiovascular diseases are closely related. However, the empirical evidences of LAP and hypertension (HTN) are limited. Our study sought to assess the risk factors of HTN and prehypertension (PHT), and provide an insight into the possible interacting influences of LAP with family history of HTN on the risk of HTN in the nondiabetic Eastern Chinese population. Methods: A large cross-sectional study was conducted in community health service centers in urban Bengbu of Anhui province, China. All elderly person aged 45 years and older were performed an interview questionnaire, physical measurements and biochemical indicators examinations by trained staffs. Common indexes to screen obese persons such as body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR) and LAP were calculated. Multivariate logistic regression was used to test the prevalence of HTN and PHT in relation to each quartile increase in LAP level and family history of HTN. The receiver operating characteristic (ROC) analysis was applied to calculate the best cut-off value of LAP and identify the superior obesity indicator. The interaction effects were evaluated by relative excess risk of interaction (RERI), attributable proportion due to interaction (AP) and synergy index (SI). Results: 7733 subjects were enrolled in our study, the overall prevalence rates of normotension, PHT and HTN were 38.1%, 37.1% and 24.8%, respectively. The prevalence of HTN increased rapidly across LAP quartiles in males and females, the LAP values in the top quartile were significantly higher than those in the bottom quartile (31.8% vs. 17.6% in males, p for trend <0.001; 31.4% vs. 18.8% in females, p for trend <0.001). The AUC value of LAP were superior to BMI in males (Z=6.627, p<0.001) and females (Z=8.045, p<0.001). Multinomial logistic regression analysis showed that compared with subjects in LAP quartile 1, those in quartile 3 (OR: 1.612, 95% CI: 1.386-1.876) and quartile 4 (OR: 1.942, 95% CI: 1.673-2.253) had significantly higher risk of HTN (p for trend<0.001) after adjusting for confounding factors. A significant interaction was observed between LAP and family history of HTN in males (AP: 0.1663, 95% CI: 0.0027-0.3299; SI: 1.4035, 95% CI: 1.0597-1.8590) and females (RERI: 1.4109, 95% CI: 0.1455-2.9674; AP: 0.1664, 95% CI: 0.0088-0.3240; SI: 1.3884, 95% CI: 1.0565-1.8245). Conclusion: LAP is a simple and convenient index to predict the HTN risk, higher LAP values have relatively associated with higher blood pressure (BP). The results demonstrated that interactive effects of LAP with family history of HTN may synergistically influence the development of HTN.

scholarly journals Lipid Accumulation Product: An Effective Obesity Index to Predict Metabolic Syndrome

2022 ◽  
Vol 40 (1) ◽  
pp. 5-9
Author(s):  
Mariya Tabassum ◽  
Miliva Mozaffor ◽  
Md Matiur Rahman ◽  
Reaz Mahmud Huda
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Accumulation ◽  
Predictive Value ◽  
Significant Risk ◽  
Area Under The Curve ◽  
Lipid Accumulation Product ◽  
Roc Curve Analysis ◽  
Cross Sectional ◽  
Obesity Index ◽  
Apparently Healthy

Background: Obesity is a significant risk factor in the development of metabolic syndrome (MetS). Lipid Accumulation Product (LAP) is an obesity index and has been proposed to be a predictor of metabolic syndrome. The present study aims to see the effectiveness of Lipid Accumulation Product as an obesity index to predict metabolic syndrome in a Bangladeshi population. Methods: This cross-sectional study was conducted in Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, between March 2016 and February 2017. A total of 200 apparently healthy subjects (127 men and 73 women) were selected for the study, attending out-patient-departments of the same institution. Anthropometric measurements were recorded, which included their height, weight, waist circumference (WC) and body mass index (BMI). Overnight fasting blood samples were collected to estimate fasting serum glucose and lipid profile. Then LAP was calculated and evaluated as a tool in prediction of MetS in the study subjects. Receiver operating characteristic (ROC) curves were plotted to assess the performance of LAP in MetS prediction by gender. The power of MetS prediction was quantified by the area under the curve (AUC) with 95% confidence intervals. Results: Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NVP) of LAP in predicting MetS were 70.45%, 78.57%, 72.09% and 77.19% in male study subjects and 20.45%, 96.43%, 81.82% and 60.67% in female subjects respectively. ROC curve analysis showed that the optimal cutoff value of LAP in male study subjects was 40.72, while area under the curve was 0.92; in female study subjects, the values were 51.69 and 0.91 respectively (P<0.001). Conclusion: Lipid Accumulation Product was found simple, accessible and effective obesity index to predict metabolic syndrome in apparently healthy adults. J Bangladesh Coll Phys Surg 2022; 40: 5-9

Value of lipid accumulation product for the assessment of metabolic syndrome in women with polycystic ovary syndrome

2013 ◽  
Author(s):  
Antic Ivana Bozic ◽  
Jelica Bjekic-Macut ◽  
Dimitrios Panidis ◽  
Danijela Vojnovic Milutinovic ◽  
Biljana Kastratovic ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Polycystic Ovary Syndrome ◽  
Lipid Accumulation ◽  
Polycystic Ovary ◽  
Lipid Accumulation Product ◽  
Ovary Syndrome

Multiple Myeloma or Brucellosis: A Case Report

2020 ◽  
Vol 20 (1) ◽  
pp. 102-105 ◽  
Author(s):  
Hossein A. Rahdar ◽  
Mansoor Kodori ◽  
Mohamad R. Salehi ◽  
Mahsa Doomanlou ◽  
Morteza Karami-Zarandi ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Brucella Melitensis ◽  
Severe Disease ◽  
Correct Diagnosis ◽  
Clinical Manifestations ◽  
Bone Marrow Aspiration ◽  
Major Health Problem ◽  
Brucella Infection ◽  
Wide Range ◽  
Parental Treatment

Background: Brucellosis, a major health problem in developing countries, is a multisystem infection with a broad spectrum of clinical manifestations. Hematological complications, ranging from an intravascular coagulopathy to mild homeostasis disorders (such as gammopathy), have been reported in brucella infection. These signs and symptoms may lead to misdiagnosis of brucellosis with other hematological diseases. Case: A 65-year-old male whose occupation was shepherding was referred to our hospital as a known case of multiple myeloma with continuous fever, muscle weakness, and night sweating after taking 2 courses of chemotherapy. The laboratory diagnosis of multiple myeloma had been based on the observation of a high percent of plasma cells in the bone marrow aspiration. At follow- up, the result of patient's fever workup, with 2 sets of blood cultures, was positive for Brucella melitensis. Isolated brucella was confirmed as B. melitensis by 16S rRNA sequencing. Brucellosis serologic test was performed by agglutination test and positive results were obtained. The patient was discharged with the cessation of fever and general improvement after the end of the parental treatment phase of brucella bacteremia. Conclusions: Brucella infection may cause a severe disease, mimicking a primary hematological disease, which could complicate the correct diagnosis. In brucellosis cases, due to the wide range of symptoms, in addition to cultivation and serological methods, molecular methods should also be used to prevent inappropriate diagnosis and additional costs.

Reflections on Death by Spiritually Mature Elders

1994 ◽  
Vol 29 (3) ◽  
pp. 177-185 ◽  
Author(s):  
L. Eugene Thomas
Keyword(s):  
Sex Differences ◽  
Personal Experience ◽  
Fear Of Death ◽  
Men And Women ◽  
Wide Range ◽  
Spatial Terms ◽  
Present Life

Beliefs and feelings about death are excerpted from interviews conducted with elderly English men and women, who were viewed as spiritually mature by those in their community. Respondents reported a wide range of beliefs about death, reflecting their personal experience, but none reported fear of death. Subtle sex differences were noted: men tended to picture death in spatial terms, of moving into a new dimension, while women tended to describe death in terms of relationships. Overall the respondents indicated that they placed a positive value on death, viewing it as a continuation of, and source of meaning for their present life.

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