Liver stiffness values in apparently healthy subjects: Influence of gender and metabolic syndrome

2008 ◽  
Vol 48 (4) ◽  
pp. 606-613 ◽  
Author(s):  
Dominique Roulot ◽  
Sébastien Czernichow ◽  
Hervé Le Clésiau ◽  
Jean-Luc Costes ◽  
Anne-Claire Vergnaud ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Healthy Subjects ◽  
Liver Stiffness ◽  
Apparently Healthy

Prevalence of metabolic syndrome among apparently healthy adults in Ogun state, Nigeria

2017 ◽  
Vol 47 (6) ◽  
pp. 780-794 ◽  
Author(s):  
Yetunde Aderonke Adeyemi ◽  
Oluseye Olusegun Onabanjo ◽  
Silifat Ajoke Sanni ◽  
Regina Ngozi Ugbaja ◽  
David Olaulowa Afolabi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Social Services ◽  
Healthy Subjects ◽  
Density Lipoprotein ◽  
Population Based ◽  
Lipoprotein Cholesterol ◽  
Normal Body Mass Index ◽  
Cross Sectional ◽  
Content Type ◽  
Apparently Healthy

Purpose There is a global increase in the prevalence of metabolic syndrome (MetS) with relative paucity of data on the burden of this syndrome in developing countries like Nigeria. This study evaluated the prevalence of MetS among apparently healthy subjects in Nigeria. Design/methodology/approach A population-based cross-sectional study was conducted with 550 (249 men, 301 women) healthy subjects recruited using multi-stage technique. Anthropometric measurements were taken using standard procedures and instruments. Systolic and diastolic blood pressure was measured in all the subjects. Blood samples were collected from selected subjects and analyzed for hematological variables. Findings The prevalence of MetS was 36.8 per cent using the IDF criteria and 34.6 per cent using the NCEP-ATP III criteria. In all, 1.64 per cent (9) of respondents were underweight, 22.55 per cent (124) were of normal body mass index, 49.64 per cent (273) were overweight and 26.17 per cent (144) were obese. The mean waist circumference and waist to hip ratio for male and female were 83.27 ± 2.6 cm and 0.84 ± 0.1 and 86.22 ± 13.9 cm and 0.84 ± 0.1, respectively. Total cholesterol was elevated in 16.04 per cent of the respondents, low high-density lipoprotein cholesterol was observed in 41.83 per cent of the respondents. High values of triglycerides were observed in 5.79 per cent of respondents. Elevated low-density lipoprotein cholesterol was observed in 40.85 per cent of the respondents. This study showed that a huge burden of MetS exists among the study population. Research limitations/implications The cross-sectional design of this study limits inference regarding causality and effects. Also, there was no controlled case in the study. Practical implications There is the need for accurate knowledge of the MetS of the population to inform public health policy for mitigation. Social implications MetS has been described as a global time bomb, with a quarter of the world’s adults estimated to be having the condition. It will place a burden on social services if a lot of working population are forced to retire early due to MetS. Originality/value The findings are pointers to the probable magnitude of the co-morbid factors of cardiovascular diseases as encapsulated in the MetS in our environment.

scholarly journals Identification of lipid accumulation product (LAP) as a marker of metabolic syndrome: a study in healthy population of MMU

2021 ◽  
Vol 12 (2) ◽  
pp. 958-966
Author(s):  
Bhumija Sharma ◽  
Suvarna Prasad ◽  
Sunita Manhas ◽  
Bhawani Shankar Modi ◽  
PriyankaTangri
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Accumulation ◽  
Healthy Subjects ◽  
Disease Risk ◽  
Roc Curves ◽  
Public Health Issue ◽  
Healthy Population ◽  
Lipid Accumulation Product ◽  
Related Disease ◽  
Apparently Healthy

Metabolic syndrome (MetS), is a collection of lipid and non-lipid cardiac related disease risk factors, is an important public health issue because of its higher prevalence with development of diabetes mellitus and cardiovascular diseases. Henry Kahn anticipated lipid accumulation product (LAP), as a novel marker of central lipid accumulation, to predict the risk of MetS. This study was conducted in Department of Biochemistry of MMIMSR, Ambala, Haryana. In the current study, we are researching over a new diagnostic tool for diagnosing MetS by LAP use. MetS is diagnosed by National Cholesterol Education Program Adults treatment panel III (NCEPATP III) and then compared with LAP to find its efficacy over other variables. 200 volunteers were enrolled in this study, their biochemical parameters were estimated and anthropometric measurements were taken. MetS was diagnosed in apparently healthy subjects. LAP was calculated by Henry Kahn formula and required statistical tools were applied to analyse results. The parameters of MetS positive cases were compared with LAP and its validity was tested statistically. 56 (28%) out of 200 subjects were positive for MetS. More females (30) than males (26) were diagnosed positive for MetS. LAP values were found to be higher in MetS cases, its efficacy was confirmed by ROC curves. MetS was diagnosed in volunteers who were considering themselves as healthy. Raised LAP and LAP2 were found, in MetS positive subjects than MetS negative. Relation of LAP and MetS came to be strong. Further, researches in this area are definitely recommended.

Concentrations of non-glucose polyols in serum and cerebrospinal fluid from apparently healthy adults and children.

1984 ◽  
Vol 30 (2) ◽  
pp. 188-191 ◽  
Author(s):  
S Yoshioka ◽  
S Saitoh ◽  
S Seki ◽  
K Seki
Keyword(s):  
Mass Spectrometry ◽  
Cerebrospinal Fluid ◽  
Liquid Chromatography ◽  
Healthy Subjects ◽  
Metabolic Diseases ◽  
Gas Liquid Chromatography ◽  
Liquid Chromatography Mass Spectrometry ◽  
Adults And Children ◽  
Healthy Persons ◽  
Apparently Healthy

Abstract Six non-glucose polyols--mannose, fructose, 1-deoxyglucose, mannitol, glucitol, and inositol--were identified and evaluated in human serum and cerebrospinal fluid by gas-liquid chromatography and by gas-liquid chromatography/mass spectrometry. Concentrations of fructose, mannose, and inositol in the serum of healthy persons or children without metabolic diseases varied with age, as already reported for 1-deoxyglucose. Fructose, inositol, and glucitol concentrations in cerebrospinal fluid significantly exceeded those in serum. The method described here for determining polyols and for evaluating polyol patterns in serum, as well as the resulting data on children and healthy subjects, should be useful in investigations of the clinical and physiological significance of polyols.

Simultaneous measurement of two major prostacyclin metabolites in urine

1990 ◽  
Vol 36 (11) ◽  
pp. 1978-1980 ◽  
Author(s):  
S Zureick ◽  
J Nadler ◽  
J Yamamoto ◽  
R Horton
Keyword(s):  
Angiotensin Ii ◽  
Blood Vessels ◽  
Simultaneous Measurement ◽  
Healthy Subjects ◽  
High Accuracy ◽  
High Concentration ◽  
Accuracy And Precision ◽  
Overall Evaluation ◽  
Excretion Rates ◽  
Apparently Healthy

Abstract We describe a combined HPLC-RIA technique to measure both major metabolites of prostacyclin (PGI2): 6-keto PGF1 alpha and 2,3-dinor-6 keto PGF1 alpha. The measurement of the former, which originates from renal blood vessels, and the latter, from systemic vessels and the liver, may provide a better overall evaluation of production than measurement of one metabolite. An aliquot of acidified urine with added 3H-labeled metabolites is adsorbed and then eluted from a C18 Bond-Elut column. The sample is then passed through an HPLC system by use of an isocratic solvent combination that separates the two metabolites from known prostaglandins. The purified metabolites are then quantified by RIA. Using a logit-log10 transform, one can measure between 12 and 250 pg of either metabolite, with high accuracy and precision (CVs of 12% for a low concentration and 7% for a high concentration). Reference values for apparently healthy subjects were, respectively, 107 (SD 45) and 171 (SD 69) ng/g creatinine for 6-keto PGF1 alpha and the dinor metabolite in men (n = 18) and 45 (SD 22) and 141 (SD 28) ng/g creatinine, respectively, in women (n = 15). Indomethacin in standard doses reduced both metabolite values by 50%. Intravenous administration of angiotensin II (5 ng/kg of body wt per minute) did not alter excretion rates, but equipressor doses of norepinephrine (0.1 microgram/kg per minute) increased the production of both metabolites (6-keto greater than dinor).

scholarly journals Exercise-Induced Release of Cardiac Troponins in Adolescent vs. Adult Swimmers

2021 ◽  
Vol 18 (3) ◽  
pp. 1285
Author(s):  
Rafel Cirer-Sastre ◽  
Francisco Corbi ◽  
Isaac López-Laval ◽  
Luis Enrique Carranza-García ◽  
Joaquín Reverter-Masià
Keyword(s):  
Cardiac Troponin ◽  
Healthy Subjects ◽  
Troponin T ◽  
Training Experience ◽  
Post Exercise ◽  
Baseline Values ◽  
Exercise Induced ◽  
Cardiac Troponins ◽  
Similar Peak ◽  
Apparently Healthy

To examine the exercise-induced release of cardiac troponin T (cTnT) in adolescent and adult swimmers. Thirty-two trained male (18 adolescents, 14 adults) swam at maximal pace in a 45 min distance trial, and blood samples were drawn before, immediately and 3 h after exercise for subsequent cTnT analysis and comparison. Having comparable training experience and baseline values of cTnT (p = 0.78 and p = 0.13), adults exercised at lower absolute and relative intensity (p < 0.001 and p < 0.001, respectively), but presented higher immediate cTnT after exercise than adolescents (p < 0.001). Despite that, peak concentrations were observed at 3 h post exercise and peak elevations were comparable between groups (p = 0.074). Fourteen (44%) apparently healthy subjects exceeded the cutoff value for myocardial infarction (MI). Adolescents presented a delayed elevation of cTnT compared with adults, but achieved similar peak values.

scholarly journals Impaired Cardiac Autonomic Functions in Apparently Healthy Subjects with Vitamin D Deficiency

2014 ◽  
Vol 20 (4) ◽  
pp. 378-385 ◽  
Author(s):  
Uğur Canpolat ◽  
Fırat Özcan ◽  
Özcan Özeke ◽  
Osman Turak ◽  
Çağr Yayla ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Healthy Subjects ◽  
Autonomic Functions ◽  
Apparently Healthy
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