STUDY ON CHEMICAL CONSTITUENTS AND CYTOTOXICITY OF ASPIDISTRA LETREAE

A phytochemical investigation of whole Aspidistra letreae plants led to the isolation of 2H-chromen-2-one (1), α-tocopherol (2), (E)-phytol (3), asparenydiol (4) and (25S)-spirost-1β,3α,5β-triol (5). Their structures were determined on the basis of NMR spectral evidences and in comparison with the reported data. Of these, asparenydiol (4) was isolated from the genus Aspidistra for the first time. This is also the first report on the separation and structural determination of (25S)-spirost-1β,3α,5β-triol (5) as a pure compound. The methanol extract exhibited a moderate cytotoxicity against the LU-1, HeLa, MDA-MB-231, Hep-G2, and MKN-7 human cancer cell lines with IC50 values ranging from 52.58 ± 3.65 to 64.78 ± 4.89 μg/mL.

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Chemical constituents and cytotoxicity of Aspidistra letreae

HUE UNIVERSITY JOURNAL OF SCIENCE NATURAL SCIENCE ◽

10.26459/hueuni-jns.v129i1b.5656 ◽

2020 ◽

Vol 129 (1B) ◽

pp. 31-39

Author(s):

Duc Viet Ho ◽

Hanh Nhu Thi Hoang ◽

Khue Minh Vo ◽

Anh Tuan Le ◽

Hoai Thi Nguyen

Keyword(s):

Human Cancer ◽

Chemical Constituents ◽

Hep G2 ◽

Human Cancer Cell Lines ◽

Phytochemical Investigation ◽

Ic50 Values ◽

Reported Data ◽

Whole Plants ◽

First Time

A phytochemical investigation of whole Aspidistra letreae plants led to the isolation of 2H-chromen-2-one (1), α-tocopherol (2), (E)-phytol (3), asparenydiol (4) and (25S)-spirost-1β,3α,5β-triol (5). Their structures were determined on the basis of NMR spectral evidences and in comparison with the reported data. Of these, asparenydiol (4) was isolated from the genus Aspidistra for the first time. This is also the first report on the separation and structural determination of (25S)-spirost-1β,3α,5β-triol (5) as a pure compound. The methanol extract from the whole plants of Aspidistra letreae exhibits moderate cytotoxicity against the LU-1, HeLa, MDA-MB-231, Hep-G2, and MKN-7 human cancer cell lines with IC50 values ranging from 52.58 ± 3.65 to 64.78 ± 4.89 μg/mL.

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Bioactive Components of Fissistigma cupreonitens

Natural Product Communications ◽

10.1177/1934578x1801300607 ◽

2018 ◽

Vol 13 (6) ◽

pp. 1934578X1801300 ◽

Cited By ~ 1

Author(s):

I-Hsiao Chen ◽

Ming-Yi Yang ◽

Shin-Hun Juang ◽

Chia-Lin Lee ◽

Tran-Dinh Thang ◽

...

Keyword(s):

Cell Line ◽

Human Cancer ◽

Spectroscopic Methods ◽

Human Cancer Cell ◽

Bioactive Components ◽

Standard Drug ◽

Human Cancer Cell Lines ◽

Chemical Structures ◽

Phytochemical Investigation ◽

First Time

Phytochemical investigation of Fissistigma cupreonitens (Annonaceae) led to the isolation of 34 compounds. The chemical structures of all compounds were determined by spectroscopic methods. Among the isolates, compounds 20–27 and 31–34 were reported from this genus for the first time. From the results of the cytotoxicity assay against three human cancer cell lines (NCI-H226, NPC-TW01, and Jurkat E6–1), oxoaporphine compounds oxoxylopine (1), oxocrebanine (3), kuafumine (4) and lysicamine (5), and the flavonoid adunctin E (26) displayed significant cytotoxicity against NCI-H226 cell line, with IC50 values of 8.45, 8.10, 8.54, 12.83 and 12.00 μM, respectively, in comparison with the standard drug, cisplatin with IC50 of 13.37 μM.

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chemical constituents from methanolic extract of Garcinia mackeaniana leaves and their antioxidant activity

Vietnam Journal of Science and Technology ◽

10.15625/2525-2518/58/4/14680 ◽

2020 ◽

Vol 58 (4) ◽

pp. 411

Author(s):

Ha Nguyen Thi Thu ◽

Cuong Pham Van ◽

Tra Nguyen Thanh ◽

Anh Le Thi Tu ◽

Cham Ba Thi ◽

...

Keyword(s):

Methanolic Extract ◽

Chemical Constituents ◽

Spectroscopic Method ◽

Acetyl Derivative ◽

Antioxidant Assay ◽

Chemical Structures ◽

Phytochemical Investigation ◽

Ic50 Value ◽

First Time

A phytochemical investigation of the methanolic extract of Garcinia mackeaniana leaves led to the isolation, and determination of five secondary metabolites, including one benzophenone 4,3',4'-trihydroxy-2,6-dimethoxybenzophenone (1), two flavone C-glucosides vitexin (2) and its 2''-O-acetyl derivative (3), one biflavone amentoflavone (4), and one mono-phenol methyl protocatechuate (5). The chemical structures of these compounds were characterized by the NMR-spectroscopic method. These isolated compounds were isolated from G. mackeaniana species for the first time. Benzophenone derivative 1 has shown to be associated with a significant IC50 value of 14.97±0.8 µg/mL in the DPPH-antioxidant assay.

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Chemical Constituents from the Fruit Body of Chlorophyllum Molybdites

Natural Product Communications ◽

10.1177/1934578x1300800910 ◽

2013 ◽

Vol 8 (9) ◽

pp. 1934578X1300800

Author(s):

Zushang Su ◽

Ping Wang ◽

Wei Yuan ◽

Shiyou Li

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Chemical Constituents ◽

Fruit Body ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Human Cancer Cell Lines ◽

First Time

A new glycoxyuracil and 15 known compounds were isolated from the fruit body of Chlorophyllum molybdites. The structures were determined from their NMR and MS data and by comparison with literature data. Compounds 2–5, 10–11, 13, and 15–16 were isolated from the genus Chlorophyllum for the first time. Compounds (1–9) did not show cytotoxicity against two human cancer cell lines, A549 and Panc-28 (GI50 > 50 μM).

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Absolute Configuration of a New Phenethylcyclohexanetriol and a New Natural Bibenzyl From Amomum celsum

Natural Product Communications ◽

10.1177/1934578x19843612 ◽

2019 ◽

Vol 14 (5) ◽

pp. 1934578X1984361 ◽

Cited By ~ 2

Author(s):

Phan Minh Giang ◽

Lai Anh Tu ◽

Vu Minh Trang ◽

Nguyen Quoc Binh ◽

Tadashi Hyodo ◽

...

Keyword(s):

Absolute Configuration ◽

Human Cancer ◽

Ionization Mass ◽

Hep G2 ◽

Cytotoxic Assay ◽

Human Cancer Cell Lines ◽

X Ray Crystallography ◽

Sulforhodamine B ◽

First Time ◽

Mcf 7

Methanol extracts of the rhizomes or fruit of Amomum celsum Lamxay & M.F. Newman (Zingiberaceae) yielded 5 compounds one of which, 1,3 S,5 S-trihydroxy-1-(4-hydroxyphenylethyl)cyclohexane (2), is new and one, 4-hydroxybibenzyl (1), is reported as a natural product for the first time. In addition, 3 known compounds, 5-hydroxy-3,7,3′,4′-tetramethoxyflavone (3), 3,5-diacetoxy-1,7- bis(3,4-dihydroxyphenyl)heptane (4), and 1,4-hydroquinone (5), were also isolated. Their structures were determined by performing extensive analysis of high-resolution electrospray ionization-mass spectrometry and nuclear magnetic resonance spectroscopic data. The absolute configuration of 2 was unambiguously established by X-ray crystallography and Mosher’s method. Cytotoxicity of compounds 1 and 2 against MCF-7 and Hep-G2 human cancer cell lines were tested in the sulforhodamine B cytotoxic assay. A plausible biosynthesis of 1 and 2 in A. celsum was proposed.

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Chemical Constituents of Nepeta Distans

Natural Product Communications ◽

10.1177/1934578x1000501117 ◽

2010 ◽

Vol 5 (11) ◽

pp. 1934578X1000501 ◽

Cited By ~ 3

Author(s):

Javid Hussain ◽

Nausheen Bukhari ◽

Hidayat Hussain ◽

Najeeb U Rehman ◽

Syed Murtaza Hussain

Keyword(s):

Spectral Data ◽

Phenolic Compound ◽

Ursolic Acid ◽

Oleanolic Acid ◽

Chemical Constituents ◽

2D Nmr ◽

Phytochemical Investigation ◽

Reported Data ◽

First Time

Phytochemical investigation of Nepeta distans Raul resulted in the isolation of a new phenolic compound, nepatanol (1), and eight known compounds, markhamioside F, netidiol, nepedinol, thymoquinone, eugenol, oleanolic acid, ursolic acid, and β-sitosterol, which have been isolated for the first time from this source. Structures of all the isolates were established on the basis of MS, and 1D and 2D NMR spectral data and by comparison with reported data.

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Chemical constituents of the root wood of Erythrina sacleuxii and determination of the absolute configuration of suberectin

Bulletin of the Chemical Society of Ethiopia ◽

10.4314/bcse.v34i1.12 ◽

2020 ◽

Vol 34 (1) ◽

pp. 135-140

Author(s):

Japheth O. Ombito ◽

Gomotsang Bojase ◽

Runner R.T. Majinda ◽

Ishmael B. Masesane ◽

Anja Schüffler ◽

...

Keyword(s):

Antifungal Activity ◽

Secondary Metabolites ◽

Absolute Configuration ◽

Chemical Constituents ◽

Pyricularia Oryzae ◽

Phytochemical Investigation ◽

Pure Compounds ◽

The Absolute ◽

First Time

Phytochemical investigation on the root wood of Erythrina sacleuxii (Leguminosae) led to the isolation of nine secondary metabolites (1-9). Compound 1 was isolated from the genus Erythrina for the first time. The pure compounds were identified on the basis of comprehensive spectroscopic and spectrometric analyses, while their absolute configurations were determined based on chiroptical measurements. Compounds 5 and 6 showed weak antifungal activity against Pyricularia oryzae with MIC values of 20 µg/mL. Bull. Chem. Soc. Ethiop. 2020, 34(1), 135-140. DOI: https://dx.doi.org/10.4314/bcse.v34i1.12

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Phytochemical Constituents of Annona reticulata and their Cytotoxic Activity

Letters in Organic Chemistry ◽

10.2174/1570178616666190724123004 ◽

2020 ◽

Vol 17 (3) ◽

pp. 206-210

Author(s):

Ty Viet Pham ◽

Thang Quoc Le ◽

Anh Tuan Le ◽

Hung Quoc Vo ◽

Duc Viet Ho

Keyword(s):

Cytotoxic Activity ◽

Cell Lines ◽

Structural Determination ◽

Phytochemical Investigation ◽

Ic50 Values ◽

Phytochemical Constituents ◽

First Time ◽

Annona Reticulata

A phytochemical investigation of the leaves of Annona reticulata led to the isolation and structural determination of β-sitosterol (1), ent-pimara-8(14),15-dien-19-oic acid (2), ent-pimara- 8(14),15-dien-19-ol (3), quercetin (4), quercetin 3-O-α-L-arabinopyranoside (5), and a mixture of quercetin 3-O-β-D-galactopyranoside (6a) and quercetin 3-O-β-D-glucopyranoside (6b). Of these, compounds 2 and 3 were isolated from the genus Annona for the first time. Compound 3 showed strong cytotoxicity against SK-LU-1 and SW626 cell lines with IC50 values of 17.64 ± 1.07 and 19.79 ± 1.41 μg mL-1, respectively.

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Synthesis of novel amide and Schiff’s base functionalized novel pyrido[1,2-a] pyrimidin-4-one derivatives and their anticancer activity studies.

Letters in Organic Chemistry ◽

10.2174/1570178618666210512021950 ◽

2021 ◽

Vol 18 ◽

Author(s):

Sailu Betala ◽

Chiranjeevi Abba ◽

Hanumandlu Racha

Keyword(s):

Anticancer Activity ◽

Hydrazine Hydrate ◽

Human Cancer ◽

Aromatic Aldehydes ◽

Human Cancer Cell ◽

Hep G2 ◽

Schiff’S Base ◽

Human Cancer Cell Lines ◽

Amide Derivatives ◽

Mcf 7

Abstract: A series of novel amide and Schiffs base functionalized novel pyrido[1,2-a]pyrimidin-4-one derivatives were prepared starting from 6-(thiophene-2-yl)/phenyl-4-(trifluoromethyl) pyridin-2-amine 1a and 1b. These compounds on reaction with EMME, to afford compounds 2a and 2b, followed by cyclization to afford compounds 3a and 3b. Treatment of compound 3a and 3b with hydrazine hydrate to get compounds 4a and 4b, compounds 4a and 4b on reaction with different substituted aromatic aldehydes to get Schiff’s base derivatives 5a-j, in another way compounds 3a, 3b on reaction with aliphatic amines to get amide derivatives 6a-f. All the compounds 5a-j and 6a-f were screened against four human cancer cell lines (HeLa, COLO205, Hep G2, and MCF 7), among all the derivatives, compounds 5c, 5e, 6a, and 6b showed promising anticancer activity.

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New 9α-Hydroxy-5α,6α-epoxysterols from the Vietnamese Marine Sponge Ircinia echinata

Marine Drugs ◽

10.3390/md16110424 ◽

2018 ◽

Vol 16 (11) ◽

pp. 424 ◽

Cited By ~ 1

Author(s):

Thi Trinh ◽

Bich Truong ◽

Arlette Longeon ◽

Thi Doan ◽

Alexandre Deville ◽

...

Keyword(s):

Marine Sponge ◽

Breast Cancer Cells ◽

Mass Spectra ◽

Human Cancer ◽

Selective Inhibition ◽

2D Nmr ◽

Human Breast ◽

Hep G2 ◽

Human Cancer Cell Lines ◽

Mcf 7

Chemical investigation of the methanol extract of the Vietnamese marine sponge Ircinia echinata led to the isolation of six new 9α-hydroxy-5α,6α-epoxysterols: 5α,6α-epoxycholesta-7,22(E)-dien-3β,9α-diol (1), 5α,6α-epoxycholesta-7,24(28)-dien-3β,9α-diol (2), (24R)-5α,6α-epoxy-24-ethyl-cholesta-7-en-3β,9α-diol (3), 5α,6α-epoxycholesta-7-en-3β,9α-diol (4), (24S)-5α,6α-epoxyergosta-7,22-dien-3β,9α-diol (5), and (24R)-5α,6α-epoxy-24-methyl-cholesta-7-en-3β,9α-diol (6) along with the known 5α-6α-epoxysterols: 5α,6α-epoxystigmasta-7-en-3β-ol (7), 5α,6α-epoxystigmasta-7,22-dien-3β-ol (8), and 5α,6α-epoxyergosta-7-en-3β-ol (9). Their structures and their configurations were established on the basis of high resolution mass spectra and extensive 1D and 2D NMR spectroscopic data and by comparison with the literature. Their cytotoxic activity, evaluated against three human cancer cell lines, MCF-7, Hep-G2 and LU-1, revealed that only compounds 3 and 4 exhibited significant antiproliferative activity and compound 3 showed a selective inhibition towards the MCF-7 human breast cancer cells.

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