scholarly journals Chemical constituents and cytotoxicity of Aspidistra letreae

2020 ◽  
Vol 129 (1B) ◽  
pp. 31-39
Author(s):  
Duc Viet Ho ◽  
Hanh Nhu Thi Hoang ◽  
Khue Minh Vo ◽  
Anh Tuan Le ◽  
Hoai Thi Nguyen
Keyword(s):  
Human Cancer ◽  
Chemical Constituents ◽  
Hep G2 ◽  
Human Cancer Cell Lines ◽  
Phytochemical Investigation ◽  
Ic50 Values ◽  
Reported Data ◽  
Whole Plants ◽  
First Time

A phytochemical investigation of whole Aspidistra letreae plants led to the isolation of 2H-chromen-2-one (1), α-tocopherol (2), (E)-phytol (3), asparenydiol (4) and (25S)-spirost-1β,3α,5β-triol (5). Their structures were determined on the basis of NMR spectral evidences and in comparison with the reported data. Of these, asparenydiol (4) was isolated from the genus Aspidistra for the first time. This is also the first report on the separation and structural determination of (25S)-spirost-1β,3α,5β-triol (5) as a pure compound. The methanol extract from the whole plants of Aspidistra letreae exhibits moderate cytotoxicity against the LU-1, HeLa, MDA-MB-231, Hep-G2, and MKN-7 human cancer cell lines with IC50 values ranging from 52.58 ± 3.65 to 64.78 ± 4.89 μg/mL.

scholarly journals STUDY ON CHEMICAL CONSTITUENTS AND CYTOTOXICITY OF ASPIDISTRA LETREAE

2020 ◽  
Vol 129 (1B) ◽  
Author(s):  
Duc Viet Ho
Keyword(s):  
Methanol Extract ◽  
Human Cancer ◽  
Chemical Constituents ◽  
Hep G2 ◽  
Pure Compound ◽  
Human Cancer Cell Lines ◽  
Phytochemical Investigation ◽  
Reported Data ◽  
First Time

A phytochemical investigation of whole <em>Aspidistra letreae</em> plants led to the isolation of 2<em>H</em>-chromen-2-one (<strong>1</strong>), <em>α</em>-tocopherol (<strong>2</strong>), (<em>E</em>)-phytol (<strong>3</strong>), asparenydiol (<strong>4</strong>) and (25<em>S</em>)-spirost-1<em>β</em>,3<em>α</em>,5<em>β</em>-triol (<strong>5</strong>). Their structures were determined on the basis of NMR spectral evidences and in comparison with the reported data. Of these, asparenydiol (<strong>4</strong>) was isolated from the genus <em>Aspidistra</em> for the first time. This is also the first report on the separation and structural determination of (25<em>S</em>)-spirost-1<em>β</em>,3<em>α</em>,5<em>β</em>-triol (<strong>5</strong>) as a pure compound. The methanol extract exhibited a moderate cytotoxicity against the LU-1, HeLa, MDA-MB-231, Hep-G2, and MKN-7 human cancer cell lines with <em>IC</em><sub>50</sub> values ranging from 52.58 ± 3.65 to 64.78 ± 4.89 μg/mL.

Phytochemical Constituents of Annona reticulata and their Cytotoxic Activity

2020 ◽  
Vol 17 (3) ◽  
pp. 206-210
Author(s):  
Ty Viet Pham ◽  
Thang Quoc Le ◽  
Anh Tuan Le ◽  
Hung Quoc Vo ◽  
Duc Viet Ho
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Structural Determination ◽  
Phytochemical Investigation ◽  
Ic50 Values ◽  
Phytochemical Constituents ◽  
First Time ◽  
Annona Reticulata

A phytochemical investigation of the leaves of Annona reticulata led to the isolation and structural determination of β-sitosterol (1), ent-pimara-8(14),15-dien-19-oic acid (2), ent-pimara- 8(14),15-dien-19-ol (3), quercetin (4), quercetin 3-O-α-L-arabinopyranoside (5), and a mixture of quercetin 3-O-β-D-galactopyranoside (6a) and quercetin 3-O-β-D-glucopyranoside (6b). Of these, compounds 2 and 3 were isolated from the genus Annona for the first time. Compound 3 showed strong cytotoxicity against SK-LU-1 and SW626 cell lines with IC50 values of 17.64 ± 1.07 and 19.79 ± 1.41 μg mL-1, respectively.

scholarly journals Four New ent-Kaurane Diterpene Glycosides from Isodon henryi

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2736 ◽  
Author(s):  
Liu ◽  
Zhang ◽  
Wu ◽  
Chen ◽  
Li ◽  
...  
Keyword(s):  
Cell Lines ◽  
Human Cancer ◽  
Spectroscopic Methods ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Aerial Parts ◽  
Ic50 Values ◽  
Hct 116 ◽  
Relationship Of ◽  
First Time

To obtain diterpene glycosides from an aqueous extract of the aerial parts of Isodon henryi and further investigate their cytotoxicities, in this study, a total of seven compounds were isolated, including six ent-kaurane diterpene glycosides (1–6) and one diterpene aglycon (7). Among the seven ent-kaurane diterpenes obtained, four were novel compounds, including ent-7,20-epoxy- kaur-16-en-1α,6β,7β,15β-tetrahydroxyl-11-O-β-d-glucopyranoside (1), ent-7,20-epoxy-kaur-16-en- 6β,7β,14β,15β-tetrahydroxyl-1-O-β-d-glucopyranoside (2), ent-7,20-epoxy-kaur-16-en-6β,7β,15β- trihydroxyl-1-O-β-d-glucopyranoside (3), and ent-7,20-epoxy-kaur-16-en-7β,11β,14α,15β-tetrahydr- oxyl-6-O-β-d-glucopyranoside (4), and three were isolated from this plant for the first time (5–7). Their structures were elucidated by utilizing spectroscopic methods and electronic circular dichroism analyses. Furthermore, the cytotoxicities of all seven compounds were investigated in four human cancer cell lines, including A2780, BGC-823, HCT-116, and HepG2. The IC50 values of these diterpenes ranged from 0.18 to 2.44 mM in the tested cell lines. In addition, the structure–cytotoxicity relationship of diterpene glycosides was also evaluated to study the effect of glycosylation on the cytotoxicity of diterpene compounds.

scholarly journals Bioactive Components of Fissistigma cupreonitens

2018 ◽  
Vol 13 (6) ◽  
pp. 1934578X1801300 ◽  
Author(s):  
I-Hsiao Chen ◽  
Ming-Yi Yang ◽  
Shin-Hun Juang ◽  
Chia-Lin Lee ◽  
Tran-Dinh Thang ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Cancer ◽  
Spectroscopic Methods ◽  
Human Cancer Cell ◽  
Bioactive Components ◽  
Standard Drug ◽  
Human Cancer Cell Lines ◽  
Chemical Structures ◽  
Phytochemical Investigation ◽  
First Time

Phytochemical investigation of Fissistigma cupreonitens (Annonaceae) led to the isolation of 34 compounds. The chemical structures of all compounds were determined by spectroscopic methods. Among the isolates, compounds 20–27 and 31–34 were reported from this genus for the first time. From the results of the cytotoxicity assay against three human cancer cell lines (NCI-H226, NPC-TW01, and Jurkat E6–1), oxoaporphine compounds oxoxylopine (1), oxocrebanine (3), kuafumine (4) and lysicamine (5), and the flavonoid adunctin E (26) displayed significant cytotoxicity against NCI-H226 cell line, with IC50 values of 8.45, 8.10, 8.54, 12.83 and 12.00 μM, respectively, in comparison with the standard drug, cisplatin with IC50 of 13.37 μM.

scholarly journals chemical constituents from methanolic extract of Garcinia mackeaniana leaves and their antioxidant activity

2020 ◽  
Vol 58 (4) ◽  
pp. 411
Author(s):  
Ha Nguyen Thi Thu ◽  
Cuong Pham Van ◽  
Tra Nguyen Thanh ◽  
Anh Le Thi Tu ◽  
Cham Ba Thi ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Chemical Constituents ◽  
Spectroscopic Method ◽  
Acetyl Derivative ◽  
Antioxidant Assay ◽  
Chemical Structures ◽  
Phytochemical Investigation ◽  
Ic50 Value ◽  
First Time

A phytochemical investigation of the methanolic extract of Garcinia mackeaniana leaves led to the isolation, and determination of five secondary metabolites, including one benzophenone 4,3',4'-trihydroxy-2,6-dimethoxybenzophenone (1), two flavone C-glucosides vitexin (2) and its 2''-O-acetyl derivative (3), one biflavone amentoflavone (4), and one mono-phenol methyl protocatechuate (5). The chemical structures of these compounds were characterized by the NMR-spectroscopic method. These isolated compounds were isolated from G. mackeaniana species for the first time. Benzophenone derivative 1 has shown to be associated with a significant IC50 value of 14.97±0.8 µg/mL in the DPPH-antioxidant assay.

scholarly journals Chemical Constituents from the Fruit Body of Chlorophyllum Molybdites

2013 ◽  
Vol 8 (9) ◽  
pp. 1934578X1300800
Author(s):  
Zushang Su ◽  
Ping Wang ◽  
Wei Yuan ◽  
Shiyou Li
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Chemical Constituents ◽  
Fruit Body ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
First Time

A new glycoxyuracil and 15 known compounds were isolated from the fruit body of Chlorophyllum molybdites. The structures were determined from their NMR and MS data and by comparison with literature data. Compounds 2–5, 10–11, 13, and 15–16 were isolated from the genus Chlorophyllum for the first time. Compounds (1–9) did not show cytotoxicity against two human cancer cell lines, A549 and Panc-28 (GI50 > 50 μM).

scholarly journals Absolute Configuration of a New Phenethylcyclohexanetriol and a New Natural Bibenzyl From Amomum celsum

2019 ◽  
Vol 14 (5) ◽  
pp. 1934578X1984361 ◽  
Author(s):  
Phan Minh Giang ◽  
Lai Anh Tu ◽  
Vu Minh Trang ◽  
Nguyen Quoc Binh ◽  
Tadashi Hyodo ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Human Cancer ◽  
Ionization Mass ◽  
Hep G2 ◽  
Cytotoxic Assay ◽  
Human Cancer Cell Lines ◽  
X Ray Crystallography ◽  
Sulforhodamine B ◽  
First Time ◽  
Mcf 7

Methanol extracts of the rhizomes or fruit of Amomum celsum Lamxay & M.F. Newman (Zingiberaceae) yielded 5 compounds one of which, 1,3 S,5 S-trihydroxy-1-(4-hydroxyphenylethyl)cyclohexane (2), is new and one, 4-hydroxybibenzyl (1), is reported as a natural product for the first time. In addition, 3 known compounds, 5-hydroxy-3,7,3′,4′-tetramethoxyflavone (3), 3,5-diacetoxy-1,7- bis(3,4-dihydroxyphenyl)heptane (4), and 1,4-hydroquinone (5), were also isolated. Their structures were determined by performing extensive analysis of high-resolution electrospray ionization-mass spectrometry and nuclear magnetic resonance spectroscopic data. The absolute configuration of 2 was unambiguously established by X-ray crystallography and Mosher’s method. Cytotoxicity of compounds 1 and 2 against MCF-7 and Hep-G2 human cancer cell lines were tested in the sulforhodamine B cytotoxic assay. A plausible biosynthesis of 1 and 2 in A. celsum was proposed.

Isolation, Structure Identification and Cytotoxicity Evaluation of Three Steroids from Boletus edulis

2014 ◽  
Vol 675-677 ◽  
pp. 1670-1673
Author(s):  
Qi Lan Liang
Keyword(s):  
Human Cancer ◽  
Structure Identification ◽  
Human Cancer Cell Lines ◽  
Boletus Edulis ◽  
Chemical Structures ◽  
The People ◽  
Bioassay Guided Fractionation ◽  
Ic50 Values ◽  
First Time ◽  
Ht 29

BEL-7402, HT-29, SPC-A1, U-251 bioassay-guided fractionation led to the isolation of the three active constituents from a wild fungi, Boletus edulis Bull. Ex Fr., which collected from Changbai Montain area. These three compounds’ chemical structures were elucidated on the base of spectroscopic data and comparison with known compounds as 5-cholestene-2,3-oxide (1), β-sitosterol (2), stigmasterol (3). All of the three compounds were extracted from Boletus edulis for the first time, and compound 1 was significantly cytotoxic against the four human cancer cell lines (BEL-7402, HT-29, SPC-A1 and U-251) with IC50 values 6.29, 6.98, 4.79 and 7.54 μM, respectively. Results of the study could supply referencs to the people to find the new drug from the fungus.

Chemical Constituents of Nepeta Distans

2010 ◽  
Vol 5 (11) ◽  
pp. 1934578X1000501 ◽  
Author(s):  
Javid Hussain ◽  
Nausheen Bukhari ◽  
Hidayat Hussain ◽  
Najeeb U Rehman ◽  
Syed Murtaza Hussain
Keyword(s):  
Spectral Data ◽  
Phenolic Compound ◽  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Phytochemical Investigation ◽  
Reported Data ◽  
First Time

Phytochemical investigation of Nepeta distans Raul resulted in the isolation of a new phenolic compound, nepatanol (1), and eight known compounds, markhamioside F, netidiol, nepedinol, thymoquinone, eugenol, oleanolic acid, ursolic acid, and β-sitosterol, which have been isolated for the first time from this source. Structures of all the isolates were established on the basis of MS, and 1D and 2D NMR spectral data and by comparison with reported data.

scholarly journals AROMATASE INHIBITORY AND CYTOTOXIC ACTIVITIES OF CHEMICAL CONSTITUENTS FROM THE VIETNAMESE MEDICINAL PLANT BAN-CHI-LIEN (SCUTELLARIA BARBATA D. DON)

2017 ◽  
Vol 25 (2) ◽  
pp. 481-487 ◽  
Author(s):  
Do Thi Thao ◽  
Le Quang Huan ◽  
Do Khac Hieu ◽  
Nguyen Quyet Chien ◽  
Nguyen Van Hung
Keyword(s):  
Medicinal Plant ◽  
Human Cancer ◽  
Chemical Constituents ◽  
Positive Control ◽  
Cytotoxic Activities ◽  
Scutellaria Barbata ◽  
Human Cancer Cell Lines ◽  
Ic50 Value ◽  
Bioassay Guided Fractionation ◽  
Ic50 Values

Aromatase inhibitory and cytotoxic activities were determined for apigenin, luteolin and the new diterpene named scutebarbalactone VN, which were obtained by bioassay-guided fractionation and isolation from the methanol extract of the Vietnamese medicinal plant Banchi-lien (Scutellaria barbata D. Don). In the aromatase inhibition assay, an IC50 value of 3.36 mM was found for scutebarbalactone VN, while IC50  values of 7.2 mM and 7.95 mM were found for the positive controls aminoglutethimide and b-estradiol, respectively. In the cytotoxicity  assays using a panel of human cancer cell lines, scutebarbalactone VN showed promising anticancer activity with IC50  ranging from 2.15 to 8.3 mM compared with those of the positive control ellipticine ranging from 1.0 to 2.1 mM. Apigenin and luteolin were found to be inactive  in both assays.  

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