scholarly journals Research Progress of Anti-tumor Effects of Curcuma zedoaria and its Active Ingredients Through Immune Regulation Mechanism

2021 ◽  
Vol 5 (4) ◽  
pp. 1-7
Author(s):  
Zhuli Hou ◽  
Gang Fang
Keyword(s):  
Immune Regulation ◽  
Adverse Reactions ◽  
Malignant Tumors ◽  
Research Progress ◽  
Regulation Mechanism ◽  
Curcuma Zedoaria ◽  
Active Ingredients ◽  
Continuous Increase ◽  
Related Literature ◽  
Tumor Drugs

Abstract: The continuous increase in the incidence rate of various fatal malignant tumors in the recent years warrants an imperative search for medications or drugs with obvious anti-tumor effects and reliable curative effects. Previous studies have found that Curcuma zedoaria and its active ingredients, such as turmeric oil, curcumol, and ?-elemene, have obvious anti-tumor effects, and they do not have the adverse reactions and side effects seen in the anti-tumor drugs of Western medicine. Based on the review and inductive analysis of related literature, we summarize in the present article the results of some researchers who investigated the anti-tumor effects of Curcuma zedoaria and its active ingredients through the immune regulation mechanism.

scholarly journals Research Progress on Treatment of Abnormal Uterine Bleeding during Puberty with Traditional Chinese and Western Medicine

2021 ◽  
Vol 5 (4) ◽  
pp. 144-147
Author(s):  
Dan Zhang ◽  
Jing Cai ◽  
Xiaoping Cui ◽  
Xinchun Xiao
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Recurrence Rate ◽  
Western Medicine ◽  
Adverse Reactions ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Research Progress ◽  
Related Literature ◽  
Sudden Collapse

In recent years, the frequency of clinical occurrence of abnormal uterine bleeding in adolescence has gradually increased. In order to fully understand the research progress in the treatment of abnormal uterine bleeding in adolescence, various studies and clinical experience have been reviewed by consulting related literature reports. The results found that currently Western medicine mainly uses hormone drugs in clinical treatment, but there are risks such as more clinical adverse reactions and higher recurrence rate; traditional Chinese medicine (TCM) treatment has achieved satisfactory results, but the advantages of sudden collapse and hemostasis are not obvious. Combined TCM and Western medicine treatment, it can learn from each other and has become a research hotspot in recent years, which is worthy of an in-depth discussion.

scholarly journals Antitumor Research of the Active Ingredients from Traditional Chinese Medical Plant Polygonum Cuspidatum

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Xinnan Wu ◽  
Qi Li ◽  
Yu Feng ◽  
Qing Ji
Keyword(s):  
Malignant Tumors ◽  
Chinese Herb ◽  
Herbal Remedies ◽  
Research Progress ◽  
Polygonum Cuspidatum ◽  
Active Ingredients ◽  
Active Components ◽  
Antitumor Effects ◽  
Scientific Experiments ◽  
Medical Plant

In recent years, the utilization of Chinese native medicine and other plant extracts in the treatment of diseases has attracted extensive attention, especially in the area of malignant tumors. However, lots of herbal remedies active ingredients have not been found or have been discovered but not effectively developed and applied. Therefore, screening new Chinese medicine active components and determining their antitumor effects have become a new breakthrough in the prevention and treatment of tumor disease. In the past years, a large number of studies have demonstrated that Polygonum cuspidatum and its active components like resveratrol showed excellent antitumor activities, including our own antitumor studies about resveratrol in colorectal cancer. The purpose of this review is to summarize the research progress of Chinese herb Polygonum cuspidatum and its active components in tumor diseases and provide theoretical basis for further scientific experiments and clinical applications.

Mesenchymal Stem Cell Therapy for Oral Inflammatory Diseases: Research Progress and Future Perspectives

2020 ◽  
Vol 15 ◽  
Author(s):  
Wang Gong ◽  
Fei Wang ◽  
Yuqing He ◽  
Blake Heath ◽  
Xin Zeng ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Immune Regulation ◽  
Tissue Damage ◽  
Inflammatory Diseases ◽  
Allergic Diseases ◽  
Research Progress ◽  
Epithelial Tissue ◽  
Oral Diseases ◽  
Mesenchymal Stem Cell Therapy

: Mesenchymal stem cell (MSC) therapy for clinical diseases associated with inflammation and tissue damage has become a progressive treatment strategy. MSCs have unique biological functions, such as homing, immune regulation, and differentiation capabilities, which provide the prerequisites for treatment of clinical diseases. Oral diseases are often associated with abnormal immune regulation and epithelial tissue damage. In this review, we summarize previous studies that use MSC therapy to treat various oral inflammatory diseases, including oral ulceration, allergic diseases, chemo/radiotherapy-induced oral mucositis, periodontitis, osteonecrosis of the jaw, Sjögren's syndrome (SS), among other similar diseases. We highlight MSC treatment as a promising approach in the management of oral inflammatory diseases, and discuss the obstacles that remain and must be overcome for MSC treatment to thrive in the future.

scholarly journals Research Progress of circRNAs in Head and Neck Cancers

2021 ◽  
Vol 11 ◽  
Author(s):  
Panchun Li ◽  
Kunjie Zhu ◽  
Yongzhen Mo ◽  
Xiangying Deng ◽  
Xianjie Jiang ◽  
...  
Keyword(s):  
Head And Neck ◽  
Malignant Tumors ◽  
Treatment Resistance ◽  
Disease Diagnosis ◽  
Incidence Rates ◽  
Head And Neck Cancers ◽  
Research Progress ◽  
Circular Rnas ◽  
Patients With Cancer ◽  
High Conservation

Circular RNAs (circRNAs) are a novel type of non-coding RNAs. Because of their characteristics of a closed loop structure, disease- and tissue-specificity, and high conservation and stability, circRNAs have the potential to be biomarkers for disease diagnosis. Head and neck cancers are one of the most common malignant tumors with high incidence rates globally. Affected patients are often diagnosed at the advanced stage with poor prognosis, owing to the concealment of anatomic sites. The characteristics, functions, and specific mechanisms of circRNAs in head and neck cancers are increasingly being discovered, and they have important clinical significance for the early diagnosis, treatment, and prognosis evaluation of patients with cancer. In this study, the generation, characteristics, and functions of circRNAs, along with their regulatory mechanisms in head and neck cancers have been summarized. We report that circRNAs interact with molecules such as transcription and growth factors to influence specific pathways involved in tumorigenesis. We conclude that circRNAs have an important role to play in the proliferation, invasion, metastasis, energy and substance metabolism, and treatment resistance in cancers.

scholarly journals A Review on the Research Progress of Inducible Nitric Oxide Synthase in the Pathogenesis of Pancreatic Malignancy

2021 ◽  
Vol 5 (4) ◽  
pp. 151-153
Author(s):  
Huimin Xiong ◽  
Ruiyao Wang ◽  
Chao Zhang
Keyword(s):  
Nitric Oxide ◽  
Pancreatic Cancer ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Digestive System ◽  
Malignant Tumors ◽  
Research Progress ◽  
Pancreatic Malignancy ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Pancreatic cancer is a common tumor of the digestive system, at present, the pathogenesis is still unclear, but in the current research on the pathogenesis of pancreatic malignant tumors, the research on inducible nitric oxide synthase is particularly extensive. Therefore, this article focuses on the research progress of inducible nitric oxide synthase in the pathogenesis of pancreatic cancer. This is a review.

Research progress in optical field regulation mechanism and optical devices based on non-Hermitian and topological effects (Invited)

2021 ◽  
Vol 50 (1) ◽  
pp. 20211001-20211001
Author(s):  
颜士玲 Shiling Yan ◽  
朱学艺 Xueyi Zhu ◽  
王洪飞 Hongfei Wang ◽  
解碧野 Biye Xie ◽  
张秀娟 Xiujuan Zhang ◽  
...  
Keyword(s):  
Optical Devices ◽  
Optical Field ◽  
Research Progress ◽  
Regulation Mechanism

scholarly journals MKL-1 regulates the stem cell marker. CD44 in breast cancer cells

2019 ◽  
Vol 78 ◽  
pp. 01002
Author(s):  
Zhou-Tong Dai ◽  
Ao Yao ◽  
Yuan Xiang ◽  
Jia Peng Li ◽  
Wei Guo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Malignant Tumors ◽  
Regulation Of Gene Expression ◽  
Gene Promoter ◽  
Expression Regulation ◽  
Stem Cell Marker ◽  
Luciferase Reporter ◽  
Regulation Mechanism ◽  
Luciferase Reporter Gene ◽  
Factors Affecting

CD44, cluster of differentiation 44 is a typical marker of stem cells. At present, it has been found that CD44 is prevalent in various human malignant tumors, but its expression regulation mechanism is still not clear. The initiation of gene expression, the modification of RNA levels, and the regulation of protein levels are the main factors affecting the expression level of genes, and the most critical one is the regulation of gene expression by signaling pathways. Up to now, there has been no report on the role of MKL-1 in the cloning of the cd44 promoter. Therefore, this study intends to clone the cd44 gene promoter, construct its luciferase reporter gene vector, transfect the MKL-1 overexpression vector, and analyze how it affects transcriptional activity, in order to further study the expression regulation of cd44. The mechanism provides a powerful tool in the future.

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