scholarly journals Dynamics of Changes in the Indicators of Mathematical Analysis of Heart Rate in Conditions of Adrenaline Myocardial Dystrophy against the Background of Different Functional Activity of the Pineal Gland

2021 ◽  
Vol 6 (6) ◽  
pp. 300-307
Author(s):  
L. D. Chebotar ◽  
◽  
O. M. Larycheva ◽  
H. V. Niepieina ◽  
M. M. Alieksieieva ◽  
...  

The purpose of the study was to examine the features of heart rate variability in experimental hyper- and hypofunction of the pineal gland, complicated by adrenal myocardial dystrophy. Materials and methods. To solve the set tasks, three models of functional states were created: hypo-, hyperfunction of the pineal gland, adrenaline myocardial dystrophy. Hypermelatoninemia was reproduced by administering melatonin. The hypofunction of the pineal gland was simulated by round-the-clock lighting. An experimental model of cardiac pathology, namely adrenaline myocardial dystrophy, was reproduced by administering adrenaline hydrochloride. The degree of tension of regulatory mechanisms and mechanisms of nervous regulation was assessed by mathematical analysis of heart rate variability. Results and discussion. The task of mathematical analysis is to extract “hidden information” and thereby assess the state and degree of tension of the regulatory mechanisms of the whole organism. According to the authors, mathematical analysis allows a differentiated approach to the assessment of regulatory effects, which is done by the nervous autonomic system, subcortical structures and the cerebral cortex. The data obtained by the authors suggest that the introduction of adrenaline in conditions of hypofunction of the pineal gland have cause-and-effect changes. These changes lead to disorders of autonomic regulation and possibly a trigger mechanism for a decrease in melatonin production by the pineal gland. Studies have shown that one of the advantages in conditions of hyperfunction of the pineal gland is the dominant role of parasympathetic processes in the mechanisms of adaptation of the heart to conditions of adrenal myocardial dystrophy. Timely and sufficient activation of melatonin provides a high efficiency of compensatory-adaptive changes and a positive role in increasing myocardial resistance. Conclusion. The results of the study showed that the dynamics of changes in the values of the indicators of the mathematical analysis of the heart rate in adrenal myocardial dystrophy against the background of hypo- and hyperfunction of the pineal gland revealed unidirectional changes. These changes are manifested in a decrease in heart rate, stress index and vegetative balance indicator. Consequently, the results obtained suggest that the introduction of melatonin against the background of adrenal myocardial dystrophy has a general corrective effect on the restoration of the functional state of the heart. Based on the results, the authors consider it appropriate to continue the study of the influence of various stressors on the functional state of the heart in conditions of different physiological activity of the pineal gland

Author(s):  
Alexandr E. Nosov ◽  
Nina V. Zaitseva ◽  
Vitalii G. Kostarev ◽  
Julia A. Ivashova ◽  
Maksim A. Savinkov ◽  
...  

Introduction. Currently, the violation of heart rate variability as one of the main pathogenetic mechanisms of the damaging effect of pollutants, associated effects on the cardiovascular system. The study aims to explore the dynamics of the influence of the autonomic nervous system (ANS) on heart rate variability (HRV) in workers of a potassium ore processing enterprise exposed to industrial pollutants (fine fractions of potassium chloride dust, formaldehyde, hexane, heptane) with an assessment of changes in dependence from work experience, establishment of cause-and-effect relationships of violations of heart rate variability with exposure to chemical compounds. Materials and methods. The object of the study was 140 employees of a potash ore processing enterprise, assigned to the observation group, and 76 employees of the administrative and technical apparatus, who made up the comparison group. Samples were taken from the air of the working medium for the content of saturated hydrocarbons (hexane, heptane), the vapors of formhehyde were considered, and the presence of fine particles PM2.5 and PM10 was established. Investigation of biological media (blood, urine) of workers at the enterprise determination of formaldehyde in blood, hexane and heptane in urine. Evaluation of heart rate variability was carried out on a computer electrocardiograph "Poli-Spectr-8/EX" using a cardiorhythmographic program using the method of time analysis, variation pulsometry and spectral analysis. Results. The concentration of fine particles in the air at the workplaces of the observation group was 12-111 times higher for PM2.5, and 5.6-74.6 times higher for PM10 than for the work places of the comparison group. The concentration of formaldehyde, hexane and heptane in the air did not exceed hygienic standards. In the observation group relative to the comparison group, formaldehyde blood was 1.5 times (p<0.001), in the urine of hexane - 1.2 times (p=0.011), heptane - 1.3 times (p=0.046). It was found that with an experience of up to 10 years, formaldehyde in the blood of workers in the observation group was 1.4 times higher than that in the comparison group (p=0.011), with an experience of more than 10 years - 1.7 times (p=0.005). In the urine of workers in the observation group with work experience of up to 10 years, an excess of 1.3 (p=0.026) relative to the comparison group of hexane was found. HRV data analysis. With damage to the length of service in the observation group, there was a significant decrease in the temporal analysis indicators (SDNN, ms, RMSSD, ms, pNN50, %, CV, %), while in the comparison group, only the CV, % decrease was statistically significant; the values of IN conventional units, AMo, % significantly increased (p=0.03 and p=0.003, respectively). A statistically significant relationship was established between the likelihood of an increase depending on the content of heptane in urine (b0=0.22; b1=10.6; F=21.5; R2=0.09; p=0.0001) and formaldehyde in the blood (b0=0.02; b1=6.55; F=69.6; R2=0.25; p=0.0001) in the surveyed workers. Conclusions. Activation of central ergotropic and humoral-metabolic mechanisms, a tendency towards a decrease in parasympathetic influences. The method of logistic regression analysis established a statistically significant relationship between the probability of an increase in the stress index depending on the heptane content in the blood of the surveyed suppliers.


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S874-S874
Author(s):  
Eunji Kwon ◽  
Eunhee Cho

Abstract Demented older adults experience many internal and external stress inducers that are thought to be a source of behavioral and psychological symptoms of dementia(BPSD). The purpose of this study was to compare the stress index among older adults through salivary cortisol levels and physical stress index. This study was cross-sectional design, including 139 participants who recruited until May of this year(104 demented older adults who visited hospital outpatient neurology and 35 non-demented older adults as control group). The physical stress index was measured by heart rate variability and salivary cortisol levels(4 samples/day, 1 days). Salivary cortisol levels were measured at four times after wake up, after breakfast, before dinner and after dinner. The data were analyzed using independent t-test and generalized estimating equations. In salivary cortisol levels measured after wake up, the demented older adults reported about 1.5 times higher than non-demented older adults(p=.042). And the salivary cortisol levels measured after breakfast were about 2.3 times higher in the demented older adults than in control groups(p=.002). Accordingly, the results can be concluded that demented older adults have higher stress levels than control groups in the morning. Also the physical stress index through heart rate variability(HRV) in the demented older adults(6.30±0.65) had higher than control groups(6.00±0.55, t=2.45, p=.016). There are significant differences in salivary cortisol levels and physical stress index between demented older adults and control groups. As stress inducers affects BPSD for the demented older adults, nursing intervention should be tailored to proper way based on their stress inducers.


2019 ◽  
Vol 72 ◽  
pp. 03005
Author(s):  
Olga Shchkvirina ◽  
Dinamutdin Misirov ◽  
Marina Akopyan ◽  
Irina Loseva

An indicators analysis of the first-graders functional state and vegetative homeostasis obtained in the initial period of adaptation to the educational environment revealed gender differences in the rates of the adaptation process to new learning conditions. It has been established that girls’ adaptation mechanisms turn on earlier than boys’, with their similar orientation. The article provides an experimental justification of the indicators use legitimacy for heart rate variability to assess the functional state of the body in the acute period of adaptation to the educational environment. The importance of teacher physiological literacy for the optimization of the educational process is substantiated. The results of the study are convincing evidence of the knowledge importance for the physiological foundations of the occurrence and course of physiological and mental processes, stable individual psycho-physiological characteristics for the organization of the learning environment, corresponding to the functional capabilities of the body. This argument is also confirmed by many years of experience among master students key competencies development, which allow using such an objective criterion as the current functional state of the body to ensure, through the joint efforts of parents, teachers, psychologists, and doctors, the correction of the educational environment and psycho-physiological resistance of individual to it. The established differences in the dynamics of heart rate variability indicators for girls and boys can be used to form a health-saving program in school settings.


Biofeedback ◽  
2013 ◽  
Vol 41 (1) ◽  
pp. 13-25 ◽  
Author(s):  
Fred Shaffer ◽  
John Venner

Heart rate variability (HRV) is generated by the interaction of multiple regulatory mechanisms that operate on different time scales. This article examines the regulation of the heart, the meaning of HRV, Thayer and Lane's neurovisceral integration model, the sources of HRV, HRV frequency and time domain measurements, Porges's polyvagal theory, and resonance frequency breathing. The medical implications of HRV biofeedback for cardiovascular rehabilitation and inflammatory disorders are considered.


2017 ◽  
Vol 18 (3.1) ◽  
pp. 203-209
Author(s):  
A.I. Lukina

It is established hat changing of parameters of student’s electrocardiogram during the exam are shown by shortening of the intervals RR, QT, PQ, and the complex QRS, thus expressiveness of reactions dominates in sample of lefthanders and ambidexters. The values of wave parameters of heart rate variability, including spectral power of heart rate fluctuations in different frequency ranges, increase in left-handers, while ambidexterity and right handed down. The values of statistical indices of HRV, including SDNN, RMSSD and mode cardio intervals in students during the exam are reduced, and also to a greater extent, and ambidexterity for lefties. These changes corresponded to increasing trend of the index and the activity coefficient Baevsky sympathetic nervous system, indicating a greater intensity of regulatory mechanisms in individuals with left profile of motor domination.


2021 ◽  
Vol 23 (5) ◽  
Author(s):  
Ye. L. Mykhaliuk ◽  
V. V. Syvolap ◽  
Ye. Yu. Horokhovskyi

The aim of this study was to compare the indices of heart rate variability, central hemodynamics and physical working capacity in female swimmers with different sports qualifications. Materials and methods. The indices of heart rate variability (HRV), central hemodynamics (CH) and physical development (PD) were studied in 44 female swimmers (mean age 15.00 ± 0.36 years, swimming experience – 7.40 ± 0.35 years) depending on their sports qualifications (MSIC, MS, CMS, first- and second-class athletes). To analyze the autonomic regulation of cardiac activity, power spectral and time-domain indices of HRV were used. CH were examined by the method of automated tetrapolar rheography according to W. Kubiček et al. (1970) in Y. T. Pushkar’s et al. modification (1970). Physical working capacity was measured according to the generally accepted technique on a cycling ergometer using the PWC170 submaximal test. The functional state index (FSI) was calculated using the formula patented by authors. Results. Significant differences were found between the indices of HRV, CH and PD in female swimmers with different qualifications. Thus, in the athletes with the MSIC–MS sports qualifications, heart rate was 61.0 ± 3.8 bpm, cardiac index (CI) – 2.978 ± 0.098 L·min-1·m-2 (there was a trend towards the eukinetic type of hemodynamics (TH)), stress index (SI) – 51.16 ± 12.66 relative units (r.u.), PWC170/kg – 16.98 ± 1.22 kgm·min-1·kg-1, FSI – 6.511 ± 0.422 r.u. A decrease in heart rate among them was correlated with a decrease in SI, and an increase in Mo – with a decrease in CI. In female CMS swimmers, heart rate was 61.37 ± 2.83 beats/min-1, CI – 3.021 ± 0.112 l -1min -1·m -2 , a trend towards the predominantly eukinetic TH, SI – 53.73 ± 9.41 r.u., PWC170 /kg– 14.66 ± 0.683 kgm·min-1·kg -1, FSI – 5.683 ± 0.324 r.u. Reduced values of SI and CI were associated with increased values of Mo and PWC170/kg. In first- and second-class female swimmers, heart rate was 63.05 ± 2.22 beats/min, SI – 50.62 ± 6.4 r.u. This group tended to be eytonic and eukinetic. The mean value of the PWC170/kg was 14.19 ± 0.589 kgm·min-1·kg-1 and FSI – 5.953 ± 0.337 r.u. Correlation analysis confirmed the relationship between the decrease in heart rate and CI and the increase in Mo and PWC170/kg. Conclusions. Long-term training in female swimmers at the distance of 50 to 200 meters is accompanied by the significant increase in the PWC170/kg values with qualification improving, 14.19 ± 0.589 kgm·min-1·kg-1, 14.66 ± 0.683 kgm·min-1·kg-1; 16.98 ± 1.22 kgm·min-1·kg-1, respectively, improvements in HRV (decrease in stress index and increase in Mo) and decrease in CI.


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